General Information of the Compound
Compound ID
CP0156929
Compound Name
N-[(2S,3R)-4-[[(4S)-6-ethylspiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-(3-prop-2-enylphenyl)butan-2-yl]-6-oxo-1-prop-2-enyl-5-pyrrolidin-1-ylpyridine-3-carboxamide
    Show/Hide
Structure
Formula
C40H50N4O4
Molecular Weight
650.864
Canonical SMILES
CCc1ccc2OC3(CCC3)C[C@H](NC[C@@H](O)[C@H](Cc3cccc(CC=C)c3)NC(=O)c3cc(N4CCCC4)c(=O)n(CC=C)c3)c2c1
    Show/Hide
InChI
InChI=1S/C40H50N4O4/c1-4-11-29-12-9-13-30(21-29)23-33(42-38(46)31-24-35(43-19-7-8-20-43)39(47)44(27-31)18-5-2)36(45)26-41-34-25-40(16-10-17-40)48-37-15-14-28(6-3)22-32(34)37/h4-5,9,12-15,21-22,24,27,33-34,36,41,45H,1-2,6-8,10-11,16-20,23,25-26H2,3H3,(H,42,46)/t33-,34-,36+/m0/s1
    Show/Hide
InChIKey
QNIIVMQBRZCEHX-IXQHYERASA-N
Physicochemical Property
logP
5.6635
Rotatable Bonds
14
Heavy Atom Count
48
Polar Areas
95.83
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
48

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 73355087
ChEMBL ID
CHEMBL2407342
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01020, Beta-secretase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 85 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 10 nM