General Information of the Compound
Compound ID
CP0198628
Compound Name
(4S)-2'-(2,2-dimethylpropoxy)-7'-(5-methoxypyridin-3-yl)spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
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Structure
Formula
C26H27N3O4
Molecular Weight
445.519
Canonical SMILES
COc1cncc(c1)-c1ccc2Oc3ccc(OCC(C)(C)C)cc3[C@]3(COC(N)=N3)c2c1
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InChI
InChI=1S/C26H27N3O4/c1-25(2,3)14-31-18-6-8-23-21(11-18)26(15-32-24(27)29-26)20-10-16(5-7-22(20)33-23)17-9-19(30-4)13-28-12-17/h5-13H,14-15H2,1-4H3,(H2,27,29)/t26-/m0/s1
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InChIKey
ZTVRKPQAQQUAMM-SANMLTNESA-N
Physicochemical Property
logP
4.8763
Rotatable Bonds
4
Heavy Atom Count
33
Polar Areas
88.19
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 89997990
ChEMBL ID
CHEMBL3354708
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01020, Beta-secretase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 4 nM
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki > 15000 nM
   TI
   LI
   LO
   TS