General Information of the Compound
Compound ID
CP0087522
Compound Name
(12S)-12-[(1R)-2-[[(4S)-6-ethylspiro[3,4-dihydrochromene-2,1'-cyclobutane]-4-yl]amino]-1-hydroxyethyl]-17-pyrrolidin-1-yl-1,13-diazatricyclo[13.3.1.16,10]icosa-6(20),7,9,15(19),16-pentaene-14,18-dione
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Structure
Formula
C38H48N4O4
Molecular Weight
624.826
Canonical SMILES
CCc1ccc2OC3(CCC3)C[C@H](NC[C@@H](O)[C@@H]3Cc4cccc(CCCCn5cc(cc(N6CCCC6)c5=O)C(=O)N3)c4)c2c1
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InChI
InChI=1S/C38H48N4O4/c1-2-26-12-13-35-30(20-26)32(23-38(46-35)14-8-15-38)39-24-34(43)31-21-28-11-7-10-27(19-28)9-3-4-18-42-25-29(36(44)40-31)22-33(37(42)45)41-16-5-6-17-41/h7,10-13,19-20,22,25,31-32,34,39,43H,2-6,8-9,14-18,21,23-24H2,1H3,(H,40,44)/t31-,32-,34+/m0/s1
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InChIKey
NNIPUJZFEKQESE-VDCPHJTRSA-N
Physicochemical Property
logP
5.0853
Rotatable Bonds
6
Heavy Atom Count
46
Polar Areas
95.83
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
46

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 73346002
ChEMBL ID
CHEMBL2407490
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01020, Beta-secretase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2.5 nM