General Information of the Compound
Compound ID
CP0371121
Compound Name
(4S)-2'-(2,4-difluoropyridin-3-yl)-7'-(2,2-dimethylpropoxy)spiro[5H-1,3-oxazole-4,9'-xanthene]-2-amine
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Structure
Formula
C25H23F2N3O3
Molecular Weight
451.473
Canonical SMILES
CC(C)(C)COc1ccc2Oc3ccc(cc3[C@@]3(COC(N)=N3)c2c1)-c1c(F)ccnc1F
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InChI
InChI=1S/C25H23F2N3O3/c1-24(2,3)12-31-15-5-7-20-17(11-15)25(13-32-23(28)30-25)16-10-14(4-6-19(16)33-20)21-18(26)8-9-29-22(21)27/h4-11H,12-13H2,1-3H3,(H2,28,30)/t25-/m0/s1
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InChIKey
TUOGSKJOBUQMQI-VWLOTQADSA-N
Physicochemical Property
logP
5.1459
Rotatable Bonds
3
Heavy Atom Count
33
Polar Areas
78.96
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 89997911
ChEMBL ID
CHEMBL3354710
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01020, Beta-secretase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 45 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.5 nM
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki > 15000 nM
   TI
   LI
   LO
   TS