Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(4S)-3'-(3,3-difluoropyrrolidin-1-yl)-7'-(2-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine
    Show/Hide
 PubChem ID
CID: 58466300
Canonical SMILES
NC1=N[C@@]2(CO1)c1cc(ccc1Oc1cnc(cc21)N1CCC(F)(F)C1)-c1cccnc1F
    Show/Hide
Compound Formula C23H18F3N5O2
Compound Structure
Protein Name
 Protein Info 
Beta-secretase 1
Protein Classification
Enzyme
>
Protease
>
Aspartic protease
>
Aspartic protease AA clan
>
Aspartic protease A1A subfamily
Uniprot ID
P56817
Gene Name
BACE1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 4.1 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.6 nM