General Information of the Compound
Compound ID
CP0360374
Compound Name
2-[cyclopropylmethyl(propyl)amino]-N-[(2S)-1-(3,5-difluorophenyl)-3-hydroxypropan-2-yl]-6-[methyl(propan-2-ylsulfonyl)amino]pyridine-4-carboxamide
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Structure
Formula
C26H36F2N4O4S
Molecular Weight
538.661
Canonical SMILES
CCCN(CC1CC1)c1cc(cc(n1)N(C)S(=O)(=O)C(C)C)C(=O)N[C@H](CO)Cc1cc(F)cc(F)c1
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InChI
InChI=1S/C26H36F2N4O4S/c1-5-8-32(15-18-6-7-18)25-13-20(12-24(30-25)31(4)37(35,36)17(2)3)26(34)29-23(16-33)11-19-9-21(27)14-22(28)10-19/h9-10,12-14,17-18,23,33H,5-8,11,15-16H2,1-4H3,(H,29,34)/t23-/m0/s1
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InChIKey
IKGRUPPYIQOVJN-QHCPKHFHSA-N
Physicochemical Property
logP
3.494
Rotatable Bonds
13
Heavy Atom Count
37
Polar Areas
102.84
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44426295
ChEMBL ID
CHEMBL394850
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01020, Beta-secretase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 350 nM