General Information of the Compound
Compound ID
CP0156925
Compound Name
(3S)-3-[(1R)-2-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-hydroxyethyl]-4-azabicyclo[10.3.1]hexadeca-1(15),12(16),13-trien-5-one
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Structure
Formula
C33H47N3O3
Molecular Weight
533.757
Canonical SMILES
CC(C)(C)Cc1cnc2OC3(CCC3)C[C@H](NC[C@@H](O)[C@@H]3Cc4cccc(CCCCCCC(=O)N3)c4)c2c1
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InChI
InChI=1S/C33H47N3O3/c1-32(2,3)19-25-17-26-28(20-33(14-9-15-33)39-31(26)35-21-25)34-22-29(37)27-18-24-12-8-11-23(16-24)10-6-4-5-7-13-30(38)36-27/h8,11-12,16-17,21,27-29,34,37H,4-7,9-10,13-15,18-20,22H2,1-3H3,(H,36,38)/t27-,28-,29+/m0/s1
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InChIKey
BZWOXVWMNGPFPN-YTCPBCGMSA-N
Physicochemical Property
logP
5.6011
Rotatable Bonds
5
Heavy Atom Count
39
Polar Areas
83.48
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71726699
ChEMBL ID
CHEMBL2407487
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01020, Beta-secretase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 5.9 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 6.1 nM