Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT01388 , Melanin-concentrating hormone receptor 1
Gene Name MCHR1
Organism Rattus norvegicus, Rat
Protein Classification Membrane receptor
Uniprot ID P97639
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011  Protein ID: PT01388
 
Compound ID Compound Name Compound Formula
CP0383206
4-(4-fluorophenyl)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
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C28H26FN3O
 2
1
IC50 = 1 nM
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2
IC50 = 1.7 nM
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CP0421013
4-butoxy-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
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C26H31N3O2
 1
1
IC50 = 1.2 nM
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CP0383012
4-(cyclopropylmethoxy)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
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C26H29N3O2
 1
1
IC50 = 1.6 nM
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CP0383034
4-(cyclopropylmethoxy)-N-[8-methyl-3-[(1R)-1-pyrrolidin-1-ylethyl]quinolin-7-yl]benzamide
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C27H31N3O2
 1
1
IC50 = 1.9 nM
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CP0475742
4-(2-cyclopropylethoxy)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
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C27H31N3O2
 1
1
IC50 = 2 nM
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CP0498841
4-(4-chlorophenyl)-N-[6-(pyrrolidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
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C28H27ClN2O
 1
1
IC50 = 2.2 nM
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CP0526610
4-(4-methylphenyl)-N-[6-(pyrrolidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
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C29H30N2O
 1
1
IC50 = 2.4 nM
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CP0526881
N-[3-[(1R)-1-(2-acetamidoethylamino)ethyl]-8-methylquinolin-7-yl]-4-(cyclopropylmethoxy)benzamide
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C27H32N4O3
 1
1
IC50 = 2.4 nM
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CP0472693
4-(4-chlorophenyl)-N-[6-(piperidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
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C29H29ClN2O
 1
1
IC50 = 2.5 nM
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CP0425471
4-(4-chlorophenyl)-N-[6-[(dimethylamino)methyl]-7,8-dihydronaphthalen-2-yl]benzamide
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C26H25ClN2O
 1
1
IC50 = 2.7 nM
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CP0515596
4-(cyclopropylmethoxy)-N-[3-[1-[(2-hydroxy-2-methylpropyl)amino]ethyl]-8-methylquinolin-7-yl]benzamide
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C27H33N3O3
 1
1
IC50 = 2.7 nM
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CP0489108
N-[3-[1-(2-acetamidoethylamino)ethyl]-8-methylquinolin-7-yl]-4-(cyclopropylmethoxy)benzamide
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C27H32N4O3
 1
1
IC50 = 3.4 nM
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CP0498842
4-(4-methoxyphenyl)-N-[6-(pyrrolidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
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C29H30N2O2
 1
1
IC50 = 3.7 nM
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CP0428326
4-(4-fluorophenyl)-N-[6-(pyrrolidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
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C28H27FN2O
 2
1
IC50 = 4.1 nM
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2
IC50 = 11 nM
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CP0494822
4-(cyclopropylmethoxy)-N-[8-methyl-3-(1-pyrrolidin-1-ylethyl)quinolin-7-yl]benzamide
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C27H31N3O2
 1
1
IC50 = 4.2 nM
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CP0426176
4-(4-chlorophenyl)-N-[6-[(4-methylpiperazin-1-yl)methyl]-7,8-dihydronaphthalen-2-yl]benzamide
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C29H30ClN3O
 1
1
IC50 = 5.3 nM
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CP0416008
N-[3-[1-(azepan-1-yl)ethyl]-8-methylquinolin-7-yl]-4-(cyclopropylmethoxy)benzamide
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C29H35N3O2
 1
1
IC50 = 5.6 nM
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CP0459932
4-(4-chlorophenyl)-N-[6-[[methyl(propanoyl)amino]methyl]-7,8-dihydronaphthalen-2-yl]benzamide
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C28H27ClN2O2
 1
1
IC50 = 6.2 nM
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CP0407716
N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-2-[4-(trifluoromethoxy)phenoxy]acetamide
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C20H18F3N3O3
 1
1
IC50 = 6.3 nM
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CP0475139
4-[4-(4-chlorophenyl)piperidin-1-yl]-1-(3-ethylsulfonyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)butan-1-one
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C27H35ClN2O3S
 1
1
IC50 = 6.4 nM
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CP0383014
4-(cyclopropylmethoxy)-N-[8-methyl-3-[(2-methylpyrrolidin-1-yl)methyl]quinolin-7-yl]benzamide
   Show/Hide
C27H31N3O2
 1
1
IC50 = 6.7 nM
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CP0416006
4-(2-methylpropoxy)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide
   Show/Hide
C26H31N3O2
 1
1
IC50 = 6.7 nM
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CP0475339
4-[4-(4-chlorophenyl)piperidin-1-yl]-1-[3-(cyclopropanecarbonyl)-1,2,4,5-tetrahydro-3-benzazepin-7-yl]butan-1-one
   Show/Hide
C29H35ClN2O2
 1
1
IC50 = 7.3 nM
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CP0452187
1-(3-butanoyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butan-1-one
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C29H37ClN2O2
 1
1
IC50 = 7.5 nM
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CP0407728
4-[(5-chlorothiophen-3-yl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2-one
   Show/Hide
C21H18ClN3O2S
 1
1
IC50 = 7.5 nM
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CP0407714
N-(2,3-dimethylimidazo[1,2-a]pyridin-6-yl)-2-[4-(trifluoromethoxy)phenoxy]acetamide
   Show/Hide
C18H16F3N3O3
 1
1
IC50 = 7.8 nM
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CP0421009
4-(cyclopropylmethoxy)-N-[8-methyl-3-[(1S)-1-pyrrolidin-1-ylethyl]quinolin-7-yl]benzamide
   Show/Hide
C27H31N3O2
 1
1
IC50 = 8 nM
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CP0383008
4-(cyclopropylmethoxy)-N-[8-methyl-3-(1-piperidin-1-ylethyl)quinolin-7-yl]benzamide
   Show/Hide
C28H33N3O2
 1
1
IC50 = 8.3 nM
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CP0526882
4-(cyclopropylmethoxy)-N-[8-methyl-3-(2-pyrrolidin-1-ylpropan-2-yl)quinolin-7-yl]benzamide
   Show/Hide
C28H33N3O2
 1
1
IC50 = 8.3 nM
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CP0400414
4-[4-(4-chlorophenyl)piperidin-1-yl]-1-(3-propanoyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)butan-1-one
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C28H35ClN2O2
 1
1
IC50 = 8.4 nM
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CP0903416
4'-Chloro-N-[6-(methylamino)methyl]-7,8-dihydro-2-naphthalenyl][1,1'-biphenyl]-4-carboxamide 2,2,2-trifluoroacetate
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C27H24ClF3N2O3
 1
1
IC50 = 8.5 nM
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CP0387991
4-[4-(4-chlorophenyl)piperidin-1-yl]-1-(3-methylsulfonyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)butan-1-one
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C26H33ClN2O3S
 1
1
IC50 = 8.5 nM
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CP0452306
4-[(4-bromophenyl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2-one
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C23H20BrN3O2
 1
1
IC50 = 9.3 nM
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CP0490517
4-[(5-chlorothiophen-3-yl)methoxy]-1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)pyridin-2-one
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C21H18ClN3O2S
 1
1
IC50 = 9.3 nM
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CP0392050
7-[4-[4-(4-chlorophenyl)piperidin-1-yl]butanoyl]-N-ethyl-1,2,4,5-tetrahydro-3-benzazepine-3-carboxamide
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C28H36ClN3O2
 1
1
IC50 = 11 nM
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CP0400412
1-(2-acetyl-3,4-dihydro-1H-isoquinolin-7-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butan-1-one
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C26H31ClN2O2
 1
1
IC50 = 11 nM
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CP0400415
1-[7-[4-[4-(4-chlorophenyl)piperidin-1-yl]butanoyl]-1,2,4,5-tetrahydro-3-benzazepin-3-yl]pentan-1-one
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C30H39ClN2O2
 1
1
IC50 = 11 nM
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CP0505227
2-(4-chlorophenyl)-5-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)furo[3,2-c]pyridin-4-one
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C24H18ClN3O2
 1
1
IC50 = 11 nM
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CP0380259
4-[(5-chlorothiophen-2-yl)methoxy]-1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)pyridin-2-one
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C21H18ClN3O2S
 1
1
IC50 = 11 nM
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CP0396718
N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-methylphenyl)benzamide
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C27H30N2O
 1
1
IC50 = 12 nM
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CP0457411
4-(4-chlorophenyl)-N-[6-(morpholin-4-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
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C28H27ClN2O2
 1
1
IC50 = 12 nM
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CP0472692
4-phenyl-N-[6-(pyrrolidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
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C28H28N2O
 1
1
IC50 = 12 nM
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CP0494590
4-(4-chlorophenyl)-N-[6-[[methyl(2-phenylethyl)amino]methyl]-7,8-dihydronaphthalen-2-yl]benzamide
   Show/Hide
C33H31ClN2O
 1
1
IC50 = 12 nM
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CP0417411
5-(4-fluorophenyl)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]-5-oxopentanamide
   Show/Hide
C26H28FN3O2
 1
1
IC50 = 12 nM
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CP0421008
5-(4-fluorophenyl)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]pentanamide
   Show/Hide
C26H30FN3O
 1
1
IC50 = 12 nM
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CP0481426
N-[3-[(1S)-1-(2-acetamidoethylamino)ethyl]-8-methylquinolin-7-yl]-4-(cyclopropylmethoxy)benzamide
   Show/Hide
C27H32N4O3
 1
1
IC50 = 12 nM
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CP0494230
N-[6-[[acetyl(methyl)amino]methyl]-7,8-dihydronaphthalen-2-yl]-4-(4-chlorophenyl)benzamide
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C27H25ClN2O2
 1
1
IC50 = 13 nM
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CP0499067
4-(cyclopropylmethoxy)-N-[3-[1-(2-hydroxyethylamino)ethyl]-8-methylquinolin-7-yl]benzamide
   Show/Hide
C25H29N3O3
 1
1
IC50 = 13 nM
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CP0376292
1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)-4-[[5-(trifluoromethyl)thiophen-2-yl]methoxy]pyridin-2-one
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C22H18F3N3O2S
 1
1
IC50 = 13 nM
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CP0425459
4-(4-chlorophenyl)-N-[6-(diethylaminomethyl)-7,8-dihydronaphthalen-2-yl]benzamide
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C28H29ClN2O
 1
1
IC50 = 14 nM
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CP0511825
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-[[5-(trifluoromethyl)thiophen-3-yl]methoxy]pyridin-2-one
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C22H18F3N3O2S
 1
1
IC50 = 15 nM
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CP0387992
methyl 7-[4-[4-(4-chlorophenyl)piperidin-1-yl]butanoyl]-1,2,4,5-tetrahydro-3-benzazepine-3-carboxylate
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C27H33ClN2O3
 1
1
IC50 = 17 nM
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CP0469560
1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)-4-[[4-(trifluoromethyl)thiophen-2-yl]methoxy]pyridin-2-one
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C22H18F3N3O2S
 1
1
IC50 = 17 nM
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CP0409752
4-[(4-chlorothiophen-2-yl)methoxy]-1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)pyridin-2-one
   Show/Hide
C21H18ClN3O2S
 1
1
IC50 = 18 nM
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CP0410727
4-(cyclopropylmethoxy)-N-[3-[1-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl]-8-methylquinolin-7-yl]benzamide
   Show/Hide
C27H31N3O3
 1
1
IC50 = 19 nM
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CP0443346
4-[(5-chloropyridin-2-yl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2-one
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C22H19ClN4O2
 1
1
IC50 = 19 nM
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CP0457412
4-(4-chlorophenyl)-N-[6-[(N-methylanilino)methyl]-7,8-dihydronaphthalen-2-yl]benzamide
   Show/Hide
C31H27ClN2O
 1
1
IC50 = 20 nM
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CP0526880
4-(cyclopropylmethoxy)-N-[8-methyl-3-[1-(4-methylpiperazin-1-yl)ethyl]quinolin-7-yl]benzamide
   Show/Hide
C28H34N4O2
 1
1
IC50 = 20 nM
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CP0407713
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2-one
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C23H20ClN3O2
 1
1
IC50 = 20 nM
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CP0396715
N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-ethylphenyl)benzamide
   Show/Hide
C28H32N2O
 1
1
IC50 = 21 nM
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CP0385724
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)pyridin-2-one
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C23H20ClN3O2
 1
1
IC50 = 21 nM
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CP0457410
N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-methoxyphenyl)benzamide
   Show/Hide
C27H30N2O2
 1
1
IC50 = 22 nM
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CP0472705
4-(2-chlorophenyl)-N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]benzamide
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C26H27ClN2O
 1
1
IC50 = 23 nM
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CP0376428
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylindazol-5-yl)pyridin-2-one
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C23H20ClN3O2
 1
1
IC50 = 23 nM
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CP0413189
4''-Fluoro-biphenyl-4-carboxylic acid (6-dimethylaminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-amide
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C26H27FN2O
 1
1
IC50 = 24 nM
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CP0045532
1-(2-cyclopropyl-3-methylindazol-5-yl)-4-[[5-(trifluoromethyl)thiophen-3-yl]methoxy]pyridin-2-one
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C22H18F3N3O2S
 1
1
IC50 = 26 nM
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CP0514947
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-phenylmethoxypyridin-2-one
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C23H21N3O2
 1
1
IC50 = 28 nM
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CP0541020
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
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C23H20FN3O2
 1
1
IC50 = 28 nM
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CP0493956
1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
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C23H20FN3O2
 1
1
IC50 = 28 nM
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CP0401611
1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)-4-(thiophen-3-ylmethoxy)pyridin-2-one
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C21H19N3O2S
 1
1
IC50 = 29 nM
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CP0535732
1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)-4-[[5-(trifluoromethyl)thiophen-3-yl]methoxy]pyridin-2-one
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C22H18F3N3O2S
 1
1
IC50 = 29 nM
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CP0541023
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyrimidin-2-one
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C22H19ClN4O2
 1
1
IC50 = 30 nM
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CP0566686
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-ethylbenzimidazol-5-yl)pyridin-2-one
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C24H22ClN3O2
 1
1
IC50 = 34 nM
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CP0386236
1-(2-cyclopropyl-3-methylindazol-5-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
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C23H20FN3O2
 1
1
IC50 = 35 nM
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CP0431626
4-[(4-chlorophenyl)methoxy]-1-(2,3-dimethylindazol-5-yl)pyridin-2-one
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C21H18ClN3O2
 1
1
IC50 = 36 nM
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CP0483332
1-(2,3-dimethylindazol-5-yl)-4-[[4-(trifluoromethyl)thiophen-2-yl]methoxy]pyridin-2-one
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C20H16F3N3O2S
 1
1
IC50 = 38 nM
   TI
   LI
   LO
   TS
CP0386059
1-(2-ethyl-3-methylbenzimidazol-5-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
   Show/Hide
C22H20FN3O2
 1
1
IC50 = 38 nM
   TI
   LI
   LO
   TS
CP0534663
4-[(4-fluorophenyl)methoxy]-1-(3-methyl-2-propylbenzimidazol-5-yl)pyridin-2-one
   Show/Hide
C23H22FN3O2
 1
1
IC50 = 39 nM
   TI
   LI
   LO
   TS
CP0499816
1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)-4-phenylmethoxypyridin-2-one
   Show/Hide
C23H21N3O2
 1
1
IC50 = 43 nM
   TI
   LI
   LO
   TS
CP0409754
4-[(5-chloropyridin-2-yl)methoxy]-1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)pyridin-2-one
   Show/Hide
C22H19ClN4O2
 1
1
IC50 = 47 nM
   TI
   LI
   LO
   TS
CP0414890
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-(thiophen-3-ylmethoxy)pyridin-2-one
   Show/Hide
C21H19N3O2S
 1
1
IC50 = 54 nM
   TI
   LI
   LO
   TS
CP0514948
2-(4-chlorophenyl)-6-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-3,4-dihydro-2H-pyrano[3,2-c]pyridin-5-one
   Show/Hide
C25H22ClN3O2
 1
1
IC50 = 62 nM
   TI
   LI
   LO
   TS
CP0499146
ethyl N-[[6-[[4-(4-chlorophenyl)benzoyl]amino]-3,4-dihydronaphthalen-2-yl]methyl]-N-methylcarbamate
   Show/Hide
C28H27ClN2O3
 1
1
IC50 = 64 nM
   TI
   LI
   LO
   TS
CP0399280
4-[(4-chlorophenyl)methoxy]-1-(2-ethyl-3-methylindazol-5-yl)pyridin-2-one
   Show/Hide
C22H20ClN3O2
 1
1
IC50 = 65 nM
   TI
   LI
   LO
   TS
CP0386058
1-(2,3-dimethylbenzimidazol-5-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
   Show/Hide
C21H18FN3O2
 1
1
IC50 = 65 nM
   TI
   LI
   LO
   TS
CP0457413
4-(4-chlorophenyl)-N-[6-[[ethylcarbamoyl(methyl)amino]methyl]-7,8-dihydronaphthalen-2-yl]benzamide
   Show/Hide
C28H28ClN3O2
 1
1
IC50 = 70 nM
   TI
   LI
   LO
   TS
CP0483333
1-(2,3-dimethylindazol-5-yl)-4-[[5-(trifluoromethyl)thiophen-3-yl]methoxy]pyridin-2-one
   Show/Hide
C20H16F3N3O2S
 1
1
IC50 = 70 nM
   TI
   LI
   LO
   TS
CP0380257
4-[(3-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)pyridin-2-one
   Show/Hide
C23H20ClN3O2
 1
1
IC50 = 72 nM
   TI
   LI
   LO
   TS
CP0469562
1-(2,3-dimethylindazol-5-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
   Show/Hide
C21H18FN3O2
 1
1
IC50 = 76 nM
   TI
   LI
   LO
   TS
CP0508802
1-(2,3-dimethylindazol-5-yl)-4-[[4-(trifluoromethyl)-1,3-thiazol-2-yl]methoxy]pyridin-2-one
   Show/Hide
C19H15F3N4O2S
 1
1
IC50 = 76 nM
   TI
   LI
   LO
   TS
CP0418771
1-(3-benzoyl-1,2,4,5-tetrahydro-3-benzazepin-7-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butan-1-one
   Show/Hide
C32H35ClN2O2
 1
1
IC50 = 79 nM
   TI
   LI
   LO
   TS
CP0393454
4-[4-(4-chlorophenyl)piperidin-1-yl]-1-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl)butan-1-one
   Show/Hide
C26H32ClNO
 1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
CP0414880
1-(2,3-dimethylimidazo[1,2-a]pyridin-6-yl)-4-phenylmethoxypyridin-2-one
   Show/Hide
C21H19N3O2
 1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
CP0468317
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-[[4-(trifluoromethyl)phenyl]methoxy]pyridin-2-one
   Show/Hide
C24H20F3N3O2
 1
1
IC50 = 82 nM
   TI
   LI
   LO
   TS
CP0394860
1-(2-acetyl-1,3,4,5-tetrahydro-2-benzazepin-8-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butan-1-one
   Show/Hide
C27H33ClN2O2
 1
1
IC50 = 86 nM
   TI
   LI
   LO
   TS
CP0475744
N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]-4-(pentanoylamino)benzamide
   Show/Hide
C27H32N4O2
 1
1
IC50 = 90 nM
   TI
   LI
   LO
   TS
CP0469563
1-(2,3-dimethylindazol-5-yl)-4-[[5-(trifluoromethyl)thiophen-2-yl]methoxy]pyridin-2-one
   Show/Hide
C20H16F3N3O2S
 1
1
IC50 = 90 nM
   TI
   LI
   LO
   TS
CP0472704
N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-phenylbenzamide
   Show/Hide
C26H28N2O
 1
1
IC50 = 95 nM
   TI
   LI
   LO
   TS
CP0468318
5-[(4-chlorophenyl)methoxy]-2-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridazin-3-one
   Show/Hide
C22H19ClN4O2
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0549408
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-propylbenzimidazol-5-yl)pyridin-2-one
   Show/Hide
C25H24ClN3O2
 1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
CP0407715
1-(2-ethyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-phenylmethoxypyridin-2-one
   Show/Hide
C22H21N3O2
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0380258
1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)-4-(thiophen-2-ylmethoxy)pyridin-2-one
   Show/Hide
C21H19N3O2S
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0468327
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-(thiophen-2-ylmethoxy)pyridin-2-one
   Show/Hide
C21H19N3O2S
 1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0399279
4-[(4-chlorophenyl)methoxy]-1-(3-methyl-2-propylindazol-5-yl)pyridin-2-one
   Show/Hide
C23H22ClN3O2
 1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0535734
1-(2,3-dimethylindazol-5-yl)-4-[[2-(trifluoromethyl)-1,3-thiazol-4-yl]methoxy]pyridin-2-one
   Show/Hide
C19H15F3N4O2S
 1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0452309
6-[(4-chlorophenyl)methoxy]-3-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyrimidin-4-one
   Show/Hide
C22H19ClN4O2
 1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS
CP0420422
4-[(2-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)pyridin-2-one
   Show/Hide
C23H20ClN3O2
 1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS
CP0490511
1-[2-(cyclopropylmethyl)-3-methylbenzimidazol-5-yl]-4-[(4-fluorophenyl)methoxy]pyridin-2-one
   Show/Hide
C24H22FN3O2
 1
1
IC50 = 140 nM
   TI
   LI
   LO
   TS
CP0443354
4-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-5-methylpyridin-2-one
   Show/Hide
C24H22ClN3O2
 1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0541022
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-(pyridin-2-ylmethoxy)pyridin-2-one
   Show/Hide
C22H20N4O2
 1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0468316
2-[6-[4-[(4-fluorophenyl)methoxy]-2-oxopyridin-1-yl]-3-methylimidazo[1,2-a]pyridin-2-yl]acetonitrile
   Show/Hide
C22H17FN4O2
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0466561
N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-propylphenyl)benzamide
   Show/Hide
C29H34N2O
 1
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0386061
1-(2-cyclobutyl-3-methylbenzimidazol-5-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
   Show/Hide
C24H22FN3O2
 1
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0501684
4-(3-chlorophenyl)-N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]benzamide
   Show/Hide
C26H27ClN2O
 1
1
IC50 = 220 nM
   TI
   LI
   LO
   TS
CP0407718
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-3-[4-(trifluoromethoxy)phenoxy]pyridin-2-one
   Show/Hide
C23H18F3N3O3
 1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
CP0565750
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-[(4-propan-2-ylphenyl)methoxy]pyridin-2-one
   Show/Hide
C26H27N3O2
 1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
CP0425456
tert-butyl N-[[6-[[4-(4-chlorophenyl)benzoyl]amino]-3,4-dihydronaphthalen-2-yl]methyl]-N-methylcarbamate
   Show/Hide
C30H31ClN2O3
 1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
CP0466399
[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl] 4-phenylbenzoate
   Show/Hide
C26H27NO2
 1
1
IC50 = 280 nM
   TI
   LI
   LO
   TS
CP0511116
1-(2-cyclopentyl-3-methylbenzimidazol-5-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
   Show/Hide
C25H24FN3O2
 1
1
IC50 = 460 nM
   TI
   LI
   LO
   TS
CP0443353
3-[(4-chlorophenyl)methoxy]-1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)pyridin-2-one
   Show/Hide
C23H20ClN3O2
 1
1
IC50 = 650 nM
   TI
   LI
   LO
   TS
CP0566685
4-[(5-chloropyrimidin-2-yl)methoxy]-1-(2-cyclopropyl-3-methylbenzimidazol-5-yl)pyridin-2-one
   Show/Hide
C21H18ClN5O2
 1
1
IC50 = 900 nM
   TI
   LI
   LO
   TS
CP0407717
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-[4-(trifluoromethoxy)phenoxy]pyridin-2-one
   Show/Hide
C23H18F3N3O3
 1
1
IC50 = 950 nM
   TI
   LI
   LO
   TS
CP0498830
N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-phenylbenzenesulfonamide
   Show/Hide
C25H28N2O2S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0526609
6-[(dimethylamino)methyl]-N-[(4-phenylphenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-amine
   Show/Hide
C26H30N2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0443347
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-(pyrimidin-5-ylmethoxy)pyridin-2-one
   Show/Hide
C21H19N5O2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0443348
4-[(4-fluorophenyl)methoxy]-1-[2-(methoxymethyl)-3-methylimidazo[1,2-a]pyridin-6-yl]pyridin-2-one
   Show/Hide
C22H20FN3O3
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0443349
4-[(4-fluorophenyl)methoxy]-1-[2-(hydroxymethyl)-3-methylimidazo[1,2-a]pyridin-6-yl]pyridin-2-one
   Show/Hide
C21H18FN3O3
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0443355
6-[4-[(4-fluorophenyl)methoxy]-2-oxopyridin-1-yl]-N,N,3-trimethylimidazo[1,2-a]pyridine-2-carboxamide
   Show/Hide
C23H21FN4O3
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0443357
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-(pyridin-3-ylmethoxy)pyridin-2-one
   Show/Hide
C22H20N4O2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0452304
6-[4-[(4-fluorophenyl)methoxy]-2-oxopyridin-1-yl]-3-methylimidazo[1,2-a]pyridine-2-carbonitrile
   Show/Hide
C21H15FN4O2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0452345
1-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-(pyridin-4-ylmethoxy)pyridin-2-one
   Show/Hide
C22H20N4O2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0468319
1-(2-acetyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4-[(4-fluorophenyl)methoxy]pyridin-2-one
   Show/Hide
C22H18FN3O3
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0505228
1-[2-(cyclopropanecarbonyl)-3-methylimidazo[1,2-a]pyridin-6-yl]-4-[(4-fluorophenyl)methoxy]pyridin-2-one
   Show/Hide
C24H20FN3O3
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0541019
N-(2-cyclopropyl-3-methylindolizin-6-yl)-2-[4-(trifluoromethoxy)phenoxy]acetamide
   Show/Hide
C21H19F3N2O3
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0541024
N-(2,3-dimethyl-1-benzofuran-5-yl)-2-[4-(trifluoromethoxy)phenoxy]acetamide
   Show/Hide
C19H16F3NO4
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0380256
1-[2-(2,2-dimethylpropyl)-3-methylbenzimidazol-5-yl]-4-[(4-fluorophenyl)methoxy]pyridin-2-one
   Show/Hide
C25H26FN3O2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS