General Information of the Protein
Protein ID
PT06402
Protein Name
Short transient receptor potential channel 6
Secondarily
Protein Name
Calcium entry channel
Transient receptor protein 6
Gene Name
TRPC6
Secondarily
Gene Name
Trp6
Trrp6
Sequence
MSQSPRFVTRRGGSLKAAPGAGTRRNESQDYLLMDELGDDGYPQLPLPPYGYYPSFRGNENRLTHRRQTILREKGRRLANRGPAYMFNDHSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCTECSQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYRKLSMQCKDFVVGLLDLCRNTEEVEAILNGDAETRQPGDFGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWCAPCSKMGKILRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNARQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPTDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLLYLLLKFKKWMCELIQGQKQGFQEDAEMNKRNEEKKFGISGSHEDLSKFSLDKNQLAHNKQSSTRSSEDYHLNSFSNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRKLGERLSLEPKLEESRR
    Show/Hide
Organism
Mus musculus, Mouse
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Transient receptor potential channel
Function
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
    Show/Hide
Uniprot ID
Primary ID:
Q61143

Secondarily ID:
B9EIW2
Q9Z2J1
    Show/Hide
Ensembl ID
ENSG00000137672
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0386836
 Compound Info 
CHEMBL4085233
   Show/Hide
C22H23F3N4O3
  2
1
EC50 = 890 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 1385 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0386837
 Compound Info 
ethyl 4-[3-(4-fluorophenyl)-2-methyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidin-5-yl]piperidine-1-carboxylate
   Show/Hide
C21H23FN4O3
  4
1
EC50 = 1400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 2500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
EC50 = 4660 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
4
EC50 = 7200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0519446
 Compound Info 
ethyl 4-[2-methyl-3-(4-nitrophenyl)-7-oxo-1H-pyrazolo[1,5-a]pyrimidin-5-yl]piperidine-1-carboxylate
   Show/Hide
C21H23N5O5
  1
1
EC50 = 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0386835
 Compound Info 
benzyl 4-[3-(4-chlorophenyl)-2-methyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidin-5-yl]piperidine-1-carboxylate
   Show/Hide
C26H25ClN4O3
  2
1
EC50 = 2050 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 7790 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0393949
 Compound Info 
CHEMBL4060400
   Show/Hide
C26H25FN4O3
  2
1
EC50 = 3240 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 3910 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0564251
 Compound Info 
CHEMBL4069075
   Show/Hide
C22H25N5O5
  1
1
EC50 = 8000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0519456
 Compound Info 
5-[1-(6-bromopyridine-3-carbonyl)piperidin-4-yl]-3-(4-fluorophenyl)-2-methyl-1H-pyrazolo[1,5-a]pyrimidin-7-one
   Show/Hide
C24H21BrFN5O2
  1
1
EC50 = 12300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0460485
 Compound Info 
3-(4-fluorophenyl)-2-methyl-5-(1-propanoylpiperidin-4-yl)-1H-pyrazolo[1,5-a]pyrimidin-7-one
   Show/Hide
C21H23FN4O2
  1
1
EC50 = 28800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT04958 Short transient receptor potential channel 6 Homo sapiens, Human
 Protein Info 
PT05347 Short transient receptor potential channel 3 Homo sapiens, Human
 Protein Info 
PT06627 Short transient receptor potential channel 7 Homo sapiens, Human
 Protein Info