General Information of the Protein
Protein ID
PT05347
Protein Name
Short transient receptor potential channel 3
Secondarily
Protein Name
Transient receptor protein 3
Gene Name
TRPC3
Secondarily
Gene Name
TRP3
Sequence
MSTKVRKCKEQARVTFPAPEEEEDEGEDEGAEPQRRRRGWRGVNGGLEPRSAPSQREPHGYCPPPFSHGPDLSMEGSPSLRRMTVMREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSMLRCE
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Transient receptor potential channel
Function
Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:8646775, PubMed:9417057, PubMed:9930701, PubMed:20095964, PubMed:30139744, PubMed:29726814, PubMed:35051376). May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors (PubMed:8646775).
    Show/Hide
Uniprot ID
Primary ID:
Q13507

Secondarily ID:
A7VJS1
E9PCJ9
O00593
Q15660
Q52M35
Q5G1L5
    Show/Hide
HGNC ID
HGNC:12335
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL001016 , HEKMSR2
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0522694
 Compound Info 
[5-chloro-2-[(6-fluoro-1,3-benzodioxol-5-yl)amino]-1,3-thiazol-4-yl]-(2,3-dimethylpiperidin-1-yl)methanone
   Show/Hide
C18H19ClFN3O3S
  1
1
IC50 = 32 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0476517
 Compound Info 
[2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-(2,3-dimethylpiperidin-1-yl)methanone
   Show/Hide
C18H21N3O3S
  1
1
IC50 = 80 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0087710
 Compound Info 
[2-(4-chloro-2-fluoroanilino)-5-methyl-1,3-thiazol-4-yl]-[(2S,3S)-2,3-dimethylpiperidin-1-yl]methanone
   Show/Hide
C18H21ClFN3OS
  1
1
IC50 = 100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0397505
 Compound Info 
(2,3-dimethylpiperidin-1-yl)-[2-[(6-fluoro-1,3-benzodioxol-5-yl)amino]-5-methyl-1,3-thiazol-4-yl]methanone
   Show/Hide
C19H22FN3O3S
  1
1
IC50 = 160 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0227780
 Compound Info 
(2,3-dimethylpiperidin-1-yl)-[2-(4-methylanilino)-1,3-thiazol-4-yl]methanone
   Show/Hide
C18H23N3OS
  1
1
IC50 = 250 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0906685
 Compound Info 
rac-N-(2-fluoro-4-chlorophenyl)-4-[(2,3-dimethyl-1-piperidinyl)carbonyl]-1,3-(5-methyl)thiazol-2-amine
   Show/Hide
C18H21ClFN3OS
  1
1
IC50 = 250 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0407559
 Compound Info 
[2-(1,3-benzodioxol-5-ylamino)-5-methyl-1,3-thiazol-4-yl]-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)methanone
   Show/Hide
C22H21N3O3S
  1
1
IC50 = 316 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0433281
 Compound Info 
[2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)methanone
   Show/Hide
C21H19N3O3S
  1
1
IC50 = 316 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0500911
 Compound Info 
[2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
   Show/Hide
C17H19N3O3S
  1
1
IC50 = 400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0483017
 Compound Info 
[2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-(3,4-dihydro-1H-isoquinolin-2-yl)methanone
   Show/Hide
C20H17N3O3S
  1
1
IC50 = 500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0476516
 Compound Info 
[2-(4-methylanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
   Show/Hide
C17H21N3OS
  1
1
IC50 = 630 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0397507
 Compound Info 
[2-(4-methylanilino)-1,3-thiazol-4-yl]-(2-methylpiperidin-1-yl)methanone
   Show/Hide
C17H21N3OS
  1
1
IC50 = 800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0397509
 Compound Info 
[2-(4-methoxyanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
   Show/Hide
C17H21N3O2S
  1
1
IC50 = 800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0397638
 Compound Info 
[2-(4-chloroanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
   Show/Hide
C16H18ClN3OS
  1
1
IC50 = 800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0407560
 Compound Info 
[2-(4-chloro-2-fluoroanilino)-5-methyl-1,3-thiazol-4-yl]-[(2R,3R)-2,3-dimethylpiperidin-1-yl]methanone
   Show/Hide
C18H21ClFN3OS
  1
1
IC50 = 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0479031
 Compound Info 
3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone
   Show/Hide
C20H19N3O2S
  1
1
IC50 = 1260 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0397508
 Compound Info 
[2-(4-chloro-2-fluoroanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
   Show/Hide
C16H17ClFN3OS
  1
1
IC50 = 1600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0483021
 Compound Info 
[2-(4-methoxyanilino)-1,3-thiazol-4-yl]-(4-phenylpiperidin-1-yl)methanone
   Show/Hide
C22H23N3O2S
  1
1
IC50 = 2500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0476515
 Compound Info 
[2-(2-chloroanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
   Show/Hide
C16H18ClN3OS
  1
1
IC50 = 6300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0483019
 Compound Info 
(4-cyclohexylpiperidin-1-yl)-[2-(4-methylanilino)-1,3-thiazol-4-yl]methanone
   Show/Hide
C22H29N3OS
  1
1
IC50 = 6300 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0397639
 Compound Info 
[2-(1,3-benzodioxol-5-ylamino)-5-methyl-1,3-thiazol-4-yl]-(5-methyl-7,8-dihydro-5H-1,6-naphthyridin-6-yl)methanone
   Show/Hide
C21H20N4O3S
  1
1
IC50 = 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0433283
 Compound Info 
[2-(4-methylanilino)-1,3-thiazol-4-yl]-(2-phenylpiperidin-1-yl)methanone
   Show/Hide
C22H23N3OS
  1
1
IC50 = 12600 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0504718
 Compound Info 
[2-(4-chloro-2-fluoroanilino)-5-methyl-1,3-thiazol-4-yl]-(7,8-dihydro-5H-1,6-naphthyridin-6-yl)methanone
   Show/Hide
C19H16ClFN4OS
  1
1
IC50 = 20000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0397506
 Compound Info 
[2-(4-methylanilino)-1,3-thiazol-4-yl]-(3-phenylpiperidin-1-yl)methanone
   Show/Hide
C22H23N3OS
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0002100
 Compound Info 
ethyl 1-[4-(2,3,3-trichloroprop-2-enoylamino)phenyl]-5-(trifluoromethyl)pyrazole-4-carboxylate
   Show/Hide
C16H11Cl3F3N3O3
  1
1 IC50 = 700 nM
Clinical Information about the Protein
Target 1 ( Short transient receptor potential channel 3 (TRPC3) )
Target Type Literature-reported Target
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT04958 Short transient receptor potential channel 6 Homo sapiens, Human
 Protein Info 
PT06402 Short transient receptor potential channel 6 Mus musculus, Mouse
 Protein Info 
PT06627 Short transient receptor potential channel 7 Homo sapiens, Human
 Protein Info