General Information of the Protein
Protein ID
PT06627
Protein Name
Short transient receptor potential channel 7
Secondarily
Protein Name
Transient receptor protein 7
Gene Name
TRPC7
Secondarily
Gene Name
TRP7
Sequence
MLRNSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNFQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFKKTRYQAGMRNSENLTANNTLSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI
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Organism
Homo sapiens, Human
Protein Classification
Unclassified protein
Function
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.
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Uniprot ID
Primary ID:
Q9HCX4

Secondarily ID:
A1A4Z4
F5H5U9
Q70T26
Q8IWP7
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Ensembl ID
ENSG00000069018
HGNC ID
HGNC:20754
Subcellular Location
Cell membrane
Nucleus envelope
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0386836
 Compound Info 
CHEMBL4085233
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C22H23F3N4O3
  1
1
EC50 = 90 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0386835
 Compound Info 
benzyl 4-[3-(4-chlorophenyl)-2-methyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidin-5-yl]piperidine-1-carboxylate
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C26H25ClN4O3
  1
1
EC50 = 213 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0393949
 Compound Info 
CHEMBL4060400
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C26H25FN4O3
  1
1
EC50 = 314 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0386837
 Compound Info 
ethyl 4-[3-(4-fluorophenyl)-2-methyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidin-5-yl]piperidine-1-carboxylate
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C21H23FN4O3
  2
1
EC50 = 497 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
EC50 = 1130 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Protein
Target 1 ( Short transient receptor potential channel 7 (TRPC7) )
Target Type Literature-reported Target
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT04958 Short transient receptor potential channel 6 Homo sapiens, Human
 Protein Info 
PT05347 Short transient receptor potential channel 3 Homo sapiens, Human
 Protein Info 
PT06402 Short transient receptor potential channel 6 Mus musculus, Mouse
 Protein Info