General Information of the Protein
Protein ID
PT04958
Protein Name
Short transient receptor potential channel 6
Secondarily
Protein Name
Transient receptor protein 6
Gene Name
TRPC6
Secondarily
Gene Name
TRP6
Sequence
MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGSDNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRELGEKLSMEPNQEETNR
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Organism
Homo sapiens, Human
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Transient receptor potential channel
Function
Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion.
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Uniprot ID
Primary ID:
Q9Y210

Secondarily ID:
Q52M59
Q9HCW3
Q9NQA8
Q9NQA9
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Ensembl ID
ENSG00000137672
HGNC ID
HGNC:12338
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL001016 , HEKMSR2
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0522694
 Compound Info 
[5-chloro-2-[(6-fluoro-1,3-benzodioxol-5-yl)amino]-1,3-thiazol-4-yl]-(2,3-dimethylpiperidin-1-yl)methanone
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C18H19ClFN3O3S
  1
1
IC50 = 4 nM
 Bioactivity Info 
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CP0087710
 Compound Info 
[2-(4-chloro-2-fluoroanilino)-5-methyl-1,3-thiazol-4-yl]-[(2S,3S)-2,3-dimethylpiperidin-1-yl]methanone
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C18H21ClFN3OS
  1
1
IC50 = 16 nM
 Bioactivity Info 
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CP0476517
 Compound Info 
[2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-(2,3-dimethylpiperidin-1-yl)methanone
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C18H21N3O3S
  1
1
IC50 = 16 nM
 Bioactivity Info 
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CP0397505
 Compound Info 
(2,3-dimethylpiperidin-1-yl)-[2-[(6-fluoro-1,3-benzodioxol-5-yl)amino]-5-methyl-1,3-thiazol-4-yl]methanone
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C19H22FN3O3S
  1
1
IC50 = 25 nM
 Bioactivity Info 
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CP0407559
 Compound Info 
[2-(1,3-benzodioxol-5-ylamino)-5-methyl-1,3-thiazol-4-yl]-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)methanone
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C22H21N3O3S
  1
1
IC50 = 32 nM
 Bioactivity Info 
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CP0906685
 Compound Info 
rac-N-(2-fluoro-4-chlorophenyl)-4-[(2,3-dimethyl-1-piperidinyl)carbonyl]-1,3-(5-methyl)thiazol-2-amine
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C18H21ClFN3OS
  1
1
IC50 = 50 nM
 Bioactivity Info 
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CP0433281
 Compound Info 
[2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)methanone
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C21H19N3O3S
  1
1
IC50 = 63 nM
 Bioactivity Info 
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CP0227780
 Compound Info 
(2,3-dimethylpiperidin-1-yl)-[2-(4-methylanilino)-1,3-thiazol-4-yl]methanone
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C18H23N3OS
  1
1
IC50 = 80 nM
 Bioactivity Info 
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CP0483017
 Compound Info 
[2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-(3,4-dihydro-1H-isoquinolin-2-yl)methanone
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C20H17N3O3S
  1
1
IC50 = 160 nM
 Bioactivity Info 
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CP0500911
 Compound Info 
[2-(1,3-benzodioxol-5-ylamino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
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C17H19N3O3S
  1
1
IC50 = 160 nM
 Bioactivity Info 
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CP0476516
 Compound Info 
[2-(4-methylanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
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C17H21N3OS
  1
1
IC50 = 400 nM
 Bioactivity Info 
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CP0479031
 Compound Info 
3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone
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C20H19N3O2S
  1
1
IC50 = 500 nM
 Bioactivity Info 
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CP0397507
 Compound Info 
[2-(4-methylanilino)-1,3-thiazol-4-yl]-(2-methylpiperidin-1-yl)methanone
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C17H21N3OS
  1
1
IC50 = 630 nM
 Bioactivity Info 
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CP0397508
 Compound Info 
[2-(4-chloro-2-fluoroanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
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C16H17ClFN3OS
  1
1
IC50 = 630 nM
 Bioactivity Info 
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CP0397509
 Compound Info 
[2-(4-methoxyanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
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C17H21N3O2S
  1
1
IC50 = 800 nM
 Bioactivity Info 
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CP0397638
 Compound Info 
[2-(4-chloroanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
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C16H18ClN3OS
  1
1
IC50 = 800 nM
 Bioactivity Info 
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CP0397639
 Compound Info 
[2-(1,3-benzodioxol-5-ylamino)-5-methyl-1,3-thiazol-4-yl]-(5-methyl-7,8-dihydro-5H-1,6-naphthyridin-6-yl)methanone
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C21H20N4O3S
  1
1
IC50 = 1260 nM
 Bioactivity Info 
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CP0407560
 Compound Info 
[2-(4-chloro-2-fluoroanilino)-5-methyl-1,3-thiazol-4-yl]-[(2R,3R)-2,3-dimethylpiperidin-1-yl]methanone
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C18H21ClFN3OS
  1
1
IC50 = 1600 nM
 Bioactivity Info 
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CP0483021
 Compound Info 
[2-(4-methoxyanilino)-1,3-thiazol-4-yl]-(4-phenylpiperidin-1-yl)methanone
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C22H23N3O2S
  1
1
IC50 = 1600 nM
 Bioactivity Info 
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CP0476515
 Compound Info 
[2-(2-chloroanilino)-1,3-thiazol-4-yl]-(4-methylpiperidin-1-yl)methanone
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C16H18ClN3OS
  1
1
IC50 = 3160 nM
 Bioactivity Info 
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CP0483019
 Compound Info 
(4-cyclohexylpiperidin-1-yl)-[2-(4-methylanilino)-1,3-thiazol-4-yl]methanone
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C22H29N3OS
  1
1
IC50 = 4000 nM
 Bioactivity Info 
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CP0504718
 Compound Info 
[2-(4-chloro-2-fluoroanilino)-5-methyl-1,3-thiazol-4-yl]-(7,8-dihydro-5H-1,6-naphthyridin-6-yl)methanone
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C19H16ClFN4OS
  1
1
IC50 = 6300 nM
 Bioactivity Info 
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CP0433283
 Compound Info 
[2-(4-methylanilino)-1,3-thiazol-4-yl]-(2-phenylpiperidin-1-yl)methanone
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C22H23N3OS
  1
1
IC50 = 15800 nM
 Bioactivity Info 
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CP0397506
 Compound Info 
[2-(4-methylanilino)-1,3-thiazol-4-yl]-(3-phenylpiperidin-1-yl)methanone
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C22H23N3OS
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
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Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Clinical Information about the Protein
Target 1 ( Short transient receptor potential channel 6 (TRPC6) )
Target Type Literature-reported Target
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT05347 Short transient receptor potential channel 3 Homo sapiens, Human
 Protein Info 
PT06402 Short transient receptor potential channel 6 Mus musculus, Mouse
 Protein Info 
PT06627 Short transient receptor potential channel 7 Homo sapiens, Human
 Protein Info