Protein Information

General Information of the Protein

Protein ID	PT02160
Protein Name	Toll-like receptor 7
Gene Name	TLR7
Secondarily Gene Name	UNQ248/PRO285
Sequence	MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNALATDNHVAYSQVFKETV Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Toll-like and Il-1 receptors
Function	Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612). Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:31608988, PubMed:27742543, PubMed:12738885, PubMed:32706371, PubMed:35477763). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:27742543). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed:27742543, PubMed:32706371). Show/Hide
Uniprot ID	Primary ID: Q9NYK1 Secondarily ID: D1CS69 Q9NR98 Show/Hide
Ensembl ID	ENSG00000196664
HGNC ID	HGNC:15631
Subcellular Location	Endoplasmic reticulum membrane Endosome Lysosome Cytoplasmic vesicle Phagosome

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000006 , HEK293

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0499801 Compound Info	6-amino-2-(butylamino)-9-[[6-(4-methylpiperazin-1-yl)pyridin-3-yl]methyl]-7H-purin-8-one Show/Hide	C20H29N9O	1
1	EC50 = 5.4 nM Bioactivity Info	TI LI LO TS
CP0428690 Compound Info	6-amino-2-(butylamino)-9-[[4-(4-methylpiperazin-1-yl)phenyl]methyl]-7H-purin-8-one Show/Hide	C21H30N8O	1
1	EC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0238921 Compound Info	6-amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]pyridin-3-yl]methyl]-7H-purin-8-one Show/Hide	C19H28N8O2	1
1	EC50 = 7.2 nM Bioactivity Info	TI LI LO TS
CP0522880 Compound Info	6-amino-2-(butylamino)-9-[[6-[3-(dimethylamino)pyrrolidin-1-yl]pyridin-3-yl]methyl]-7H-purin-8-one Show/Hide	C21H31N9O	1
1	EC50 = 7.4 nM Bioactivity Info	TI LI LO TS
CP0488548 Compound Info	6-amino-2-(butylamino)-9-[(4-piperidin-1-ylphenyl)methyl]-7H-purin-8-one Show/Hide	C21H29N7O	1
1	EC50 = 7.6 nM Bioactivity Info	TI LI LO TS
CP0542643 Compound Info	methyl 2-[5-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]-2-methoxyphenyl]acetate Show/Hide	C20H25N5O5	1
1	EC50 = 8.1 nM Bioactivity Info	TI LI LO TS
CP0388784 Compound Info	1-(4-Amino-2-butyl-1H-imidazo-[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol Show/Hide	C18H24N4O	2
1	EC50 = 8.58 nM Bioactivity Info	TI LI LO TS
2	EC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0528782 Compound Info	6-amino-2-(butylamino)-9-[[4-(dimethylamino)phenyl]methyl]-7H-purin-8-one Show/Hide	C18H25N7O	1
1	EC50 = 9.3 nM Bioactivity Info	TI LI LO TS
CP0538347 Compound Info	6-amino-2-(butylamino)-9-[[6-[4-(dimethylamino)piperidin-1-yl]pyridin-3-yl]methyl]-7H-purin-8-one Show/Hide	C22H33N9O	1
1	EC50 = 9.4 nM Bioactivity Info	TI LI LO TS
CP0510039 Compound Info	methyl 2-[4-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]phenyl]acetate Show/Hide	C19H23N5O4	1
1	EC50 = 10.3 nM Bioactivity Info	TI LI LO TS
CP0499802 Compound Info	6-amino-2-(butylamino)-9-[[6-[4-(dimethylamino)butoxy]pyridin-3-yl]methyl]-7H-purin-8-one Show/Hide	C21H32N8O2	1
1	EC50 = 15.2 nM Bioactivity Info	TI LI LO TS
CP0511300 Compound Info	6-amino-2-(butylamino)-9-[[6-[3-(dimethylamino)propoxy]pyridin-3-yl]methyl]-7H-purin-8-one Show/Hide	C20H30N8O2	1
1	EC50 = 19.6 nM Bioactivity Info	TI LI LO TS
CP0568712 Compound Info	4-N-butyl-6-[[4-[(dimethylamino)methyl]-2-methoxyphenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C22H30N6O	1
1	EC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0489364 Compound Info	4-N-butyl-6-[[4-[(dimethylamino)methyl]phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C21H28N6	1
1	EC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0533138 Compound Info	methyl 2-[5-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]-2-fluorophenyl]acetate Show/Hide	C19H22FN5O4	1
1	EC50 = 25.7 nM Bioactivity Info	TI LI LO TS
CP0528674 Compound Info	4-N-butyl-6-[[4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C24H30N6O	1
1	EC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0568471 Compound Info	4-N-butyl-6-[[4-[2-(dimethylamino)ethyl]phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C22H30N6	1
1	EC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0511301 Compound Info	6-amino-2-(butylamino)-9-[(6-methoxypyridin-3-yl)methyl]-7H-purin-8-one Show/Hide	C16H21N7O2	1
1	EC50 = 28.1 nM Bioactivity Info	TI LI LO TS
CP0511302 Compound Info	6-amino-2-(butylamino)-9-[(3-piperidin-1-ylphenyl)methyl]-7H-purin-8-one Show/Hide	C21H29N7O	1
1	EC50 = 30.1 nM Bioactivity Info	TI LI LO TS
CP0440135 Compound Info	6-amino-2-(butylamino)-9-[(6-methylpyridin-3-yl)methyl]-7H-purin-8-one Show/Hide	C16H21N7O	1
1	EC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0573940 Compound Info	4-N-butyl-6-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C23H30N6	1
1	EC50 = 33 nM Bioactivity Info	TI LI LO TS
CP0188207 Compound Info	3-[5-amino-2-[2-[4-[2-[2-(3,3-difluoro-3-phosphonopropoxy)ethoxy]ethoxy]-2-methylphenyl]ethyl]benzo[f][1,7]naphthyridin-8-yl]propanoic acid Show/Hide	C31H36F2N3O8P	1
1	EC50 = 39 nM Bioactivity Info	TI LI LO TS
CP0528677 Compound Info	6-[[4-[(dimethylamino)methyl]phenyl]methyl]-4-N-(2-methoxyethyl)pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C20H26N6O	1
1	EC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0389723 Compound Info	4-N-butyl-6-methyl-5-(3-morpholin-4-ylpropyl)pyrimidine-2,4-diamine Show/Hide	C16H29N5O	1
1	EC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0528676 Compound Info	4-N-butyl-6-[[4-[(dimethylamino)methyl]-3-methoxyphenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C22H30N6O	1
1	EC50 = 47 nM Bioactivity Info	TI LI LO TS
CP0511298 Compound Info	6-amino-2-(butylamino)-9-[(6-piperazin-1-ylpyridin-3-yl)methyl]-7H-purin-8-one Show/Hide	C19H27N9O	1
1	EC50 = 48.5 nM Bioactivity Info	TI LI LO TS
CP0576625 Compound Info	4-N-(2-methoxyethyl)-6-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C22H28N6O	1
1	EC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0447803 Compound Info	methyl 2-[3-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]phenyl]acetate Show/Hide	C19H23N5O4	1
1	EC50 = 50.1 nM Bioactivity Info	TI LI LO TS
CP0511299 Compound Info	6-amino-2-(butylamino)-9-[[6-(2-morpholin-4-ylethoxy)pyridin-3-yl]methyl]-7H-purin-8-one Show/Hide	C21H30N8O3	1
1	EC50 = 50.2 nM Bioactivity Info	TI LI LO TS
CP0542642 Compound Info	methyl 3-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]benzoate Show/Hide	C18H21N5O4	1
1	EC50 = 51.5 nM Bioactivity Info	TI LI LO TS
CP0511303 Compound Info	6-amino-2-(butylamino)-9-[(4-morpholin-4-ylphenyl)methyl]-7H-purin-8-one Show/Hide	C20H27N7O2	1
1	EC50 = 58 nM Bioactivity Info	TI LI LO TS
CP0496496 Compound Info	4-N-butyl-6-[[4-(morpholin-4-ylmethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C23H30N6O	1
1	EC50 = 58 nM Bioactivity Info	TI LI LO TS
CP0336253 Compound Info	1-Benzyl-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine Show/Hide	C21H22N4	1
1	EC50 = 59.1 nM Bioactivity Info	TI LI LO TS
CP0384699 Compound Info	US10457681, Compound B Show/Hide	C16H19N5O2	1
1	EC50 = 63.7 nM Bioactivity Info	TI LI LO TS
CP0190289 Compound Info	3-[5-amino-2-[2-[2-methyl-4-(3-phosphonopropoxy)phenyl]ethyl]benzo[f][1,7]naphthyridin-8-yl]propanoic acid Show/Hide	C27H30N3O6P	1
1	EC50 = 65 nM Bioactivity Info	TI LI LO TS
CP0576626 Compound Info	4-N-butyl-6-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C22H30N6O	1
1	EC50 = 66 nM Bioactivity Info	TI LI LO TS
CP0571145 Compound Info	4-N-butyl-6-[[3-[(dimethylamino)methyl]phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C21H28N6	1
1	EC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0575146 Compound Info	4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]-N,N-dimethylbenzamide Show/Hide	C21H26N6O	1
1	EC50 = 71 nM Bioactivity Info	TI LI LO TS
CP0476807 Compound Info	6-amino-2-(butylamino)-9-[[6-[3-(dimethylamino)propyl-methylamino]pyridin-3-yl]methyl]-7H-purin-8-one Show/Hide	C21H33N9O	1
1	EC50 = 72.8 nM Bioactivity Info	TI LI LO TS
CP0533135 Compound Info	methyl 4-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]benzoate Show/Hide	C18H21N5O4	1
1	EC50 = 72.9 nM Bioactivity Info	TI LI LO TS
CP0539608 Compound Info	methyl 2-[3-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]phenyl]propanoate Show/Hide	C20H25N5O4	1
1	EC50 = 75 nM Bioactivity Info	TI LI LO TS
CP0233638 Compound Info	1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol Show/Hide	C17H22N4O2	6
1	EC50 = 75 nM Bioactivity Info	TI LI LO TS
2	EC50 = 260.1 nM Bioactivity Info	TI LI LO TS
3	EC50 = 750 nM Bioactivity Info	TI LI LO TS
4	EC50 = 1340 nM Bioactivity Info	TI LI LO TS
5	EC50 = 1400 nM Bioactivity Info	TI LI LO TS
6	EC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0573314 Compound Info	4-N-(2-methoxyethyl)-6-[[4-(morpholin-4-ylmethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C22H28N6O2	1
1	EC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0537794 Compound Info	methyl 3-[3-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]phenyl]propanoate Show/Hide	C20H25N5O4	1
1	EC50 = 87.5 nM Bioactivity Info	TI LI LO TS
CP0089990 Compound Info	2-[5-amino-2-[2-(4-methoxy-2-methylphenyl)ethyl]benzo[f][1,7]naphthyridin-8-yl]ethylphosphonic acid Show/Hide	C24H26N3O4P	1
1	EC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0406790 Compound Info	1-Benzyl-2-pentyl-1H-imidazo[4,5-c]quinolin-4-amine Show/Hide	C22H24N4	1
1	EC50 = 91.5 nM Bioactivity Info	TI LI LO TS
CP0576627 Compound Info	[4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]phenyl]-pyrrolidin-1-ylmethanone Show/Hide	C23H28N6O	1
1	EC50 = 95 nM Bioactivity Info	TI LI LO TS
CP0859647 Compound Info	4-(5-(6-amino-2-butoxy-8-oxo-7H-purin-9(8H)-yl)pentyl)piperidinium chloride Show/Hide	C19H33ClN6O2	2
1	EC50 = 100 nM Bioactivity Info	TI LI LO TS
2	EC50 = 450 nM Bioactivity Info	TI LI LO TS
CP0463739 Compound Info	methyl 2-[3-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]-4-methoxyphenyl]acetate Show/Hide	C20H25N5O5	1
1	EC50 = 108 nM Bioactivity Info	TI LI LO TS
CP0569259 Compound Info	4-N-butyl-6-[[2-[(dimethylamino)methyl]phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C21H28N6	1
1	EC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0428688 Compound Info	6-amino-2-(butylamino)-9-[[3-(4-methylpiperazin-1-yl)phenyl]methyl]-7H-purin-8-one Show/Hide	C21H30N8O	1
1	EC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0573268 Compound Info	4-N-butyl-6-[2-[4-[(dimethylamino)methyl]phenyl]ethyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C22H30N6	1
1	EC50 = 136 nM Bioactivity Info	TI LI LO TS
CP0378722 Compound Info	4-N-butyl-5-(3-indol-1-ylpropyl)-6-methylpyrimidine-2,4-diamine Show/Hide	C20H27N5	1
1	EC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0858002 Compound Info	4-(2-(6-amino-2-butoxy-8-oxo-7H-purin-9(8H)-yl)ethyl)piperidinium chloride Show/Hide	C16H27ClN6O2	1
1	EC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0916759 Compound Info	4-(4-(6-amino-2-butoxy-8-oxo-7H-purin-9(8H)-yl)butyl)piperidinium chloride Show/Hide	C18H31ClN6O2	1
1	EC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0190288 Compound Info	[(E)-2-[5-amino-2-[2-(4-methoxy-2-methylphenyl)ethyl]benzo[f][1,7]naphthyridin-8-yl]ethenyl]phosphonic acid Show/Hide	C24H24N3O4P	1
1	EC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0550014 Compound Info	4-N-butyl-6-[[4-(methoxymethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C20H25N5O	1
1	EC50 = 156 nM Bioactivity Info	TI LI LO TS
CP0569291 Compound Info	[4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]phenyl]-morpholin-4-ylmethanone Show/Hide	C23H28N6O2	1
1	EC50 = 156 nM Bioactivity Info	TI LI LO TS
CP0528781 Compound Info	6-amino-2-(butylamino)-9-[[6-[2-(methylamino)ethoxy]pyridin-3-yl]methyl]-7H-purin-8-one Show/Hide	C18H26N8O2	1
1	EC50 = 165.7 nM Bioactivity Info	TI LI LO TS
CP0440136 Compound Info	6-amino-2-(butylamino)-9-[(4-methylphenyl)methyl]-7H-purin-8-one Show/Hide	C17H22N6O	1
1	EC50 = 166 nM Bioactivity Info	TI LI LO TS
CP0486405 Compound Info	methyl 4-amino-1-[[4-(aminomethyl)phenyl]methyl]-2-butylimidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C24H27N5O2	1
1	EC50 = 180 nM Bioactivity Info	TI LI LO TS
CP0532371 Compound Info	ethyl 2-[3-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]phenyl]acetate Show/Hide	C20H25N5O4	1
1	EC50 = 187.9 nM Bioactivity Info	TI LI LO TS
CP0378694 Compound Info	4-N-butyl-6-methyl-5-(3-phenylpropyl)pyrimidine-2,4-diamine Show/Hide	C18H26N4	1
1	EC50 = 194 nM Bioactivity Info	TI LI LO TS
CP0190263 Compound Info	[(E)-2-[5-amino-2-[2-(4-methoxy-2-methylphenyl)ethyl]benzo[f][1,7]naphthyridin-8-yl]-1-fluoroethenyl]phosphonic acid Show/Hide	C24H23FN3O4P	1
1	EC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0406788 Compound Info	1-Benzyl-2-(but-3-ynyl)-1H-imidazo-[4,5-c]quinolin-4-amine Show/Hide	C21H18N4	1
1	EC50 = 209 nM Bioactivity Info	TI LI LO TS
CP0864483 Compound Info	4-(6-(6-amino-2-butoxy-8-oxo-7H-purin-9(8H)-yl)hexyl)piperidinium chloride Show/Hide	C20H35ClN6O2	1
1	EC50 = 230 nM Bioactivity Info	TI LI LO TS
CP0307253 Compound Info	3-[4-[2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl]-3-methylphenoxy]propylphosphonic acid Show/Hide	C25H28N3O4P	1
1	EC50 = 230 nM Bioactivity Info	TI LI LO TS
CP0190290 Compound Info	3-[5-amino-2-[2-[4-(4,4-difluoro-4-phosphonobutoxy)-2-methylphenyl]ethyl]benzo[f][1,7]naphthyridin-8-yl]propanoic acid Show/Hide	C28H30F2N3O6P	1
1	EC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0859648 Compound Info	6-amino-2-[(1S)-1-methylbutoxy]-9-[5-(4-piperidyl)pentyl]-7H-purin-8-one Hydrochloride Show/Hide	C20H35ClN6O2	1
1	EC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0378714 Compound Info	4-N-butyl-6-methyl-5-[3-(4-methylpiperazin-1-yl)propyl]pyrimidine-2,4-diamine Show/Hide	C17H32N6	1
1	EC50 = 251 nM Bioactivity Info	TI LI LO TS
CP0405976 Compound Info	1-Benzyl-2-(but-3-enyl)-1H-imidazo[4,5-c]quinolin-4-amine Show/Hide	C21H20N4	1
1	EC50 = 262 nM Bioactivity Info	TI LI LO TS
CP0441185 Compound Info	4-N-butyl-6-methyl-5-(4-phenylbutyl)pyrimidine-2,4-diamine Show/Hide	C19H28N4	1
1	EC50 = 262 nM Bioactivity Info	TI LI LO TS
CP0378705 Compound Info	4-N-butyl-6-methyl-5-(5-phenylpentyl)pyrimidine-2,4-diamine Show/Hide	C20H30N4	1
1	EC50 = 265 nM Bioactivity Info	TI LI LO TS
CP0528675 Compound Info	4-N-butyl-6-[[4-[(dimethylamino)methyl]phenyl]methyl]quinazoline-2,4-diamine Show/Hide	C22H29N5	1
1	EC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0533307 Compound Info	[4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]phenyl]methanol Show/Hide	C19H23N5O	1
1	EC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0188206 Compound Info	[4-[4-[2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl]-3-methylphenoxy]-1,1-difluorobutyl]phosphonic acid Show/Hide	C26H28F2N3O4P	1
1	EC50 = 310 nM Bioactivity Info	TI LI LO TS
CP0510862 Compound Info	methyl 2-[3-[[6-amino-2-(2-methoxyethoxy)-8-oxo-7H-purin-9-yl]methyl]phenyl]acetate Show/Hide	C18H21N5O5	1
1	EC50 = 312.3 nM Bioactivity Info	TI LI LO TS
CP0188208 Compound Info	3-[5-amino-2-[2-[2-methyl-4-[2-[2-(2-phosphonoethoxy)ethoxy]ethoxy]phenyl]ethyl]benzo[f][1,7]naphthyridin-8-yl]propanoic acid Show/Hide	C30H36N3O8P	1
1	EC50 = 350 nM Bioactivity Info	TI LI LO TS
CP0269934 Compound Info	4-N-butyl-5-[3-(1,3-dihydroisoindol-2-yl)propyl]-6-methylpyrimidine-2,4-diamine Show/Hide	C20H29N5	1
1	EC50 = 375 nM Bioactivity Info	TI LI LO TS
CP0097851 Compound Info	4-N-butyl-6-methyl-5-[3-(2-methylbenzimidazol-1-yl)propyl]pyrimidine-2,4-diamine Show/Hide	C20H28N6	1
1	EC50 = 379 nM Bioactivity Info	TI LI LO TS
CP0493255 Compound Info	1-Benzyl-2-((ethylamino)methyl)-1H-imidazo[4,5-c]quinolin-4-amine Show/Hide	C20H21N5	1
1	EC50 = 385 nM Bioactivity Info	TI LI LO TS
CP0350278 Compound Info	[2-[5-amino-2-[2-(4-methoxy-2-methylphenyl)ethyl]benzo[f][1,7]naphthyridin-8-yl]-1,1-difluoro-2-oxoethyl]phosphonic acid Show/Hide	C24H22F2N3O5P	1
1	EC50 = 390 nM Bioactivity Info	TI LI LO TS
CP0378723 Compound Info	4-N-butyl-6-methyl-5-(3-pyrazol-1-ylpropyl)pyrimidine-2,4-diamine Show/Hide	C15H24N6	1
1	EC50 = 398 nM Bioactivity Info	TI LI LO TS
CP0229826 Compound Info	6-amino-9-benzyl-2-(2-methoxyethoxy)-7H-purin-8(9H)-one Show/Hide	C15H17N5O3	2
1	EC50 = 399.4 nM Bioactivity Info	TI LI LO TS
2	EC50 = 1170 nM Bioactivity Info	TI LI LO TS
CP0569171 Compound Info	4-N-butyl-6-[[4-(diethoxyphosphorylmethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C23H32N5O3P	1
1	EC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0447802 Compound Info	methyl 2-[2-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]phenyl]acetate Show/Hide	C19H23N5O4	1
1	EC50 = 466.8 nM Bioactivity Info	TI LI LO TS
CP0405975 Compound Info	1-Benzyl-2-ethyl-1H-imidazo[4,5-c]quinolin-4-amine Show/Hide	C19H18N4	1
1	EC50 = 472 nM Bioactivity Info	TI LI LO TS
CP0438838 Compound Info	1-Benzyl-2-hexyl-1H-imidazo[4,5-c]quinolin-4-amine Show/Hide	C23H26N4	1
1	EC50 = 479 nM Bioactivity Info	TI LI LO TS
CP0389724 Compound Info	4-N-butyl-6-methyl-5-pentylpyrimidine-2,4-diamine Show/Hide	C14H26N4	1
1	EC50 = 510 nM Bioactivity Info	TI LI LO TS
CP0378706 Compound Info	4-N-butyl-6-methyl-5-(3-pyrrolidin-1-ylpropyl)pyrimidine-2,4-diamine Show/Hide	C16H29N5	1
1	EC50 = 562 nM Bioactivity Info	TI LI LO TS
CP0378704 Compound Info	4-N,5-dibutyl-6-methylpyrimidine-2,4-diamine Show/Hide	C13H24N4	1
1	EC50 = 590 nM Bioactivity Info	TI LI LO TS
CP0476287 Compound Info	methyl 4-amino-1-(5-aminopentyl)-2-butylimidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C21H29N5O2	1
1	EC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0430856 Compound Info	methyl 2-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]benzoate Show/Hide	C18H21N5O4	1
1	EC50 = 609.1 nM Bioactivity Info	TI LI LO TS
CP0858003 Compound Info	4-(3-(6-amino-2-butoxy-8-oxo-7H-purin-9(8H)-yl)propyl)piperidinium chloride Show/Hide	C17H29ClN6O2	1
1	EC50 = 620 nM Bioactivity Info	TI LI LO TS
CP0573262 Compound Info	4-N-butyl-6-[(2-methoxyphenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C19H23N5O	1
1	EC50 = 630 nM Bioactivity Info	TI LI LO TS
CP0506154 Compound Info	1-Benzyl-2-propyl-1H-imidazo[4,5-c]quinolin-4-amine Show/Hide	C20H20N4	1
1	EC50 = 647 nM Bioactivity Info	TI LI LO TS
CP0120000 Compound Info	4-N-butyl-6-methyl-5-(3-piperidin-1-ylpropyl)pyrimidine-2,4-diamine Show/Hide	C17H31N5	1
1	EC50 = 710 nM Bioactivity Info	TI LI LO TS
CP0378716 Compound Info	4-N-butyl-6-methyl-5-(3-thiomorpholin-4-ylpropyl)pyrimidine-2,4-diamine Show/Hide	C16H29N5S	1
1	EC50 = 714 nM Bioactivity Info	TI LI LO TS
CP0411245 Compound Info	N-(1-benzyl-2-butylimidazo[4,5-c]quinolin-4-yl)hydroxylamine Show/Hide	C21H22N4O	1
1	EC50 = 723 nM Bioactivity Info	TI LI LO TS
CP0441193 Compound Info	5-[3-(azepan-1-yl)propyl]-4-N-butyl-6-methylpyrimidine-2,4-diamine Show/Hide	C18H33N5	1
1	EC50 = 730 nM Bioactivity Info	TI LI LO TS
CP0551606 Compound Info	4-N-butyl-6-[[4-(methylaminomethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C20H26N6	1
1	EC50 = 760 nM Bioactivity Info	TI LI LO TS
CP0575148 Compound Info	4-N-butyl-6-[(4-methoxyphenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C19H23N5O	1
1	EC50 = 795 nM Bioactivity Info	TI LI LO TS
CP0406791 Compound Info	1-Benzyl-2-heptyl-1H-imidazo[4,5-c]quinolin-4-amine Show/Hide	C24H28N4	1
1	EC50 = 822 nM Bioactivity Info	TI LI LO TS
CP0411246 Compound Info	1-Benzyl-2-butyl-4-hydrazinyl-1Himidazo[4,5-c]quinoline Show/Hide	C21H23N5	1
1	EC50 = 873 nM Bioactivity Info	TI LI LO TS
CP0496501 Compound Info	4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzoic acid Show/Hide	C19H21N5O2	1
1	EC50 = 890 nM Bioactivity Info	TI LI LO TS
CP0405974 Compound Info	1-Benzyl-2-methyl-1H-imidazo[4,5-c]quinolin-4-amine Show/Hide	C18H16N4	1
1	EC50 = 955 nM Bioactivity Info	TI LI LO TS
CP0441187 Compound Info	4-N-butyl-5-[3-(dimethylamino)propyl]-6-methylpyrimidine-2,4-diamine Show/Hide	C14H27N5	1
1	EC50 = 958 nM Bioactivity Info	TI LI LO TS
CP0378700 Compound Info	4-[2-amino-4-(butylamino)-6-methylpyrimidin-5-yl]butan-1-ol Show/Hide	C13H24N4O	1
1	EC50 = 1020 nM Bioactivity Info	TI LI LO TS
CP0406916 Compound Info	4-N-butyl-5-(3-cyclohexylpropyl)-6-methylpyrimidine-2,4-diamine Show/Hide	C18H32N4	1
1	EC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0489380 Compound Info	4-N-butyl-6-[(2-fluorophenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C18H20FN5	1
1	EC50 = 1122 nM Bioactivity Info	TI LI LO TS
CP0378711 Compound Info	4-N-butyl-6-methyl-5-[3-(1,2,4-triazol-1-yl)propyl]pyrimidine-2,4-diamine Show/Hide	C14H23N7	1
1	EC50 = 1160 nM Bioactivity Info	TI LI LO TS
CP0432826 Compound Info	4-N-butyl-6-methyl-5-[3-(4-phenylpiperazin-1-yl)propyl]pyrimidine-2,4-diamine Show/Hide	C22H34N6	1
1	EC50 = 1160 nM Bioactivity Info	TI LI LO TS
CP0496497 Compound Info	6-benzyl-4-N-butylpyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C18H21N5	1
1	EC50 = 1180 nM Bioactivity Info	TI LI LO TS
CP0573267 Compound Info	6-[[4-(aminomethyl)phenyl]methyl]-4-N-butylpyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C19H24N6	1
1	EC50 = 1180 nM Bioactivity Info	TI LI LO TS
CP0573265 Compound Info	4-N-butyl-6-[(3-fluorophenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C18H20FN5	1
1	EC50 = 1190 nM Bioactivity Info	TI LI LO TS
CP0379915 Compound Info	methyl 4-amino-2-butyl-1-(2-hydroxy-2-methylpropyl)imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C20H26N4O3	3
1	EC50 = 1200 nM Bioactivity Info	TI LI LO TS
2	EC50 = 1500 nM Bioactivity Info	TI LI LO TS
3	EC50 = 1690 nM Bioactivity Info	TI LI LO TS
CP0111162 Compound Info	[3-[2-[2-[4-[2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl]-3-methylphenoxy]ethoxy]ethoxy]-1,1-difluoropropyl]phosphonic acid Show/Hide	C29H34F2N3O6P	1
1	EC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0496494 Compound Info	4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzonitrile Show/Hide	C19H20N6	1
1	EC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0389715 Compound Info	4-N-butyl-5-[3-[2-methoxyethyl(methyl)amino]propyl]-6-methylpyrimidine-2,4-diamine Show/Hide	C16H31N5O	1
1	EC50 = 1240 nM Bioactivity Info	TI LI LO TS
CP0546425 Compound Info	6-benzyl-4-N-(2-methoxyethyl)pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C17H19N5O	1
1	EC50 = 1250 nM Bioactivity Info	TI LI LO TS
CP0378698 Compound Info	4-N-butyl-5-ethyl-6-methylpyrimidine-2,4-diamine Show/Hide	C11H20N4	1
1	EC50 = 1270 nM Bioactivity Info	TI LI LO TS
CP0378724 Compound Info	2-[3-[2-amino-4-(butylamino)-6-methylpyrimidin-5-yl]propyl]isoindole-1,3-dione Show/Hide	C20H25N5O2	1
1	EC50 = 1290 nM Bioactivity Info	TI LI LO TS
CP0546370 Compound Info	6-[[2-(aminomethyl)phenyl]methyl]-4-N-butylpyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C19H24N6	1
1	EC50 = 1340 nM Bioactivity Info	TI LI LO TS
CP0568473 Compound Info	4-N-butyl-6-(2-phenylethyl)pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C19H23N5	1
1	EC50 = 1350 nM Bioactivity Info	TI LI LO TS
CP0569172 Compound Info	4-N-butyl-6-[[4-[(2,2,2-trifluoroethylamino)methyl]phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C21H25F3N6	1
1	EC50 = 1360 nM Bioactivity Info	TI LI LO TS
CP0378707 Compound Info	4-N-butyl-6-methyl-5-(4-morpholin-4-ylbutyl)pyrimidine-2,4-diamine Show/Hide	C17H31N5O	1
1	EC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0576624 Compound Info	4-N-butyl-6-[(2-methylphenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C19H23N5	1
1	EC50 = 1550 nM Bioactivity Info	TI LI LO TS
CP0496495 Compound Info	4-N-butyl-6-[(4-methylphenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C19H23N5	1
1	EC50 = 1630 nM Bioactivity Info	TI LI LO TS
CP0847786 Compound Info	N4-Butyl-6-methyl-5-(3-(piperazin-1-yl)propyl)pyrimidine-2,4-diamine trihydrochloride Show/Hide	C16H33Cl3N6	1
1	EC50 = 1640 nM Bioactivity Info	TI LI LO TS
CP0569661 Compound Info	methyl 4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzoate Show/Hide	C20H23N5O2	1
1	EC50 = 1650 nM Bioactivity Info	TI LI LO TS
CP0550015 Compound Info	3-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzonitrile Show/Hide	C19H20N6	1
1	EC50 = 1680 nM Bioactivity Info	TI LI LO TS
CP0493569 Compound Info	methyl 4-amino-2-butyl-1-(3-hydroxypropyl)imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C19H24N4O3	1
1	EC50 = 1720 nM Bioactivity Info	TI LI LO TS
CP0394355 Compound Info	methyl 4-amino-2-butyl-1-(5-methoxy-5-oxopentyl)imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C22H28N4O4	1
1	EC50 = 1740 nM Bioactivity Info	TI LI LO TS
CP0568476 Compound Info	6-[[4-(azidomethyl)phenyl]methyl]-4-N-butylpyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C19H22N8	1
1	EC50 = 1790 nM Bioactivity Info	TI LI LO TS
CP0493807 Compound Info	8-hydroxy-1-(2-methylpropyl)chromeno[3,4-d]imidazol-4-one Show/Hide	C14H14N2O3	1
1	EC50 = 1800 nM Bioactivity Info	TI LI LO TS
CP0551612 Compound Info	4-N-butyl-6-[(3-methylphenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C19H23N5	1
1	EC50 = 1835 nM Bioactivity Info	TI LI LO TS
CP0496499 Compound Info	2-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzonitrile Show/Hide	C19H20N6	1
1	EC50 = 1960 nM Bioactivity Info	TI LI LO TS
CP0417827 Compound Info	1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol Show/Hide	C17H23N5O	1
1	EC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0094682 Compound Info	1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine Show/Hide	C14H16N4	5
1	EC50 = 2120 nM Bioactivity Info	TI LI LO TS
2	EC50 = 6200 nM Bioactivity Info	TI LI LO TS
3	EC50 = 10700 nM Bioactivity Info	TI LI LO TS
4	EC50 = 11400 nM Bioactivity Info	TI LI LO TS
5	EC50 = 12100 nM Bioactivity Info	TI LI LO TS
CP0576623 Compound Info	4-N-butyl-6-(naphthalen-2-ylmethyl)pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C22H23N5	1
1	EC50 = 2152 nM Bioactivity Info	TI LI LO TS
CP0389765 Compound Info	methyl 4-amino-2-butyl-1-(2-hydroxypropyl)imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C19H24N4O3	2
1	EC50 = 2220 nM Bioactivity Info	TI LI LO TS
2	EC50 = 3300 nM Bioactivity Info	TI LI LO TS
CP0573939 Compound Info	methyl 3-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzoate Show/Hide	C20H23N5O2	1
1	EC50 = 2320 nM Bioactivity Info	TI LI LO TS
CP0471265 Compound Info	methyl 4-amino-2-butyl-1-(2-phenylmethoxyethyl)imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C25H28N4O3	1
1	EC50 = 2420 nM Bioactivity Info	TI LI LO TS
CP0575147 Compound Info	4-N-butyl-6-[(3-methoxyphenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C19H23N5O	1
1	EC50 = 2560 nM Bioactivity Info	TI LI LO TS
CP0433985 Compound Info	methyl 4-amino-1-(2-hydroxy-2-methylpropyl)-2-pentylimidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C21H28N4O3	1
1	EC50 = 2600 nM Bioactivity Info	TI LI LO TS
CP0283441 Compound Info	N-[4-(4-amino-2-ethylimidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamide Show/Hide	C17H23N5O2S	1
1	EC50 = 2657 nM Bioactivity Info	TI LI LO TS
CP0859645 Compound Info	6-amino-2-[(1S)-1-methylbutoxy]-9-(4-piperidylmethyl)-7H-purin-8-one Hydrochloride Show/Hide	C16H27ClN6O2	1
1	EC50 = 2680 nM Bioactivity Info	TI LI LO TS
CP0569170 Compound Info	methyl 2-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzoate Show/Hide	C20H23N5O2	1
1	EC50 = 2750 nM Bioactivity Info	TI LI LO TS
CP0389719 Compound Info	4-N-butyl-6-methyl-5-(2-phenylethyl)pyrimidine-2,4-diamine Show/Hide	C17H24N4	1
1	EC50 = 2820 nM Bioactivity Info	TI LI LO TS
CP0378702 Compound Info	5-[2-amino-4-(butylamino)-6-methylpyrimidin-5-yl]-2-methylpentan-2-ol Show/Hide	C15H28N4O	1
1	EC50 = 2890 nM Bioactivity Info	TI LI LO TS
CP0574719 Compound Info	methyl 4-amino-2-butyl-1-(6-methoxy-6-oxohexyl)imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C23H30N4O4	1
1	EC50 = 2890 nM Bioactivity Info	TI LI LO TS
CP0574720 Compound Info	methyl 4-amino-2-butyl-1-(2-methylsulfanylethyl)imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C19H24N4O2S	1
1	EC50 = 2890 nM Bioactivity Info	TI LI LO TS
CP0505005 Compound Info	methyl 4-amino-2-butyl-1-[(2S)-2-hydroxypropyl]imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C19H24N4O3	1
1	EC50 = 2900 nM Bioactivity Info	TI LI LO TS
CP0394342 Compound Info	methyl 1-(2-acetyloxypropyl)-4-amino-2-butylimidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C21H26N4O4	1
1	EC50 = 3060 nM Bioactivity Info	TI LI LO TS
CP0217014 Compound Info	2-[2-[2-[4-[2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl]-3-methylphenoxy]ethoxy]ethoxy]ethylphosphonic acid Show/Hide	C28H34N3O6P	1
1	EC50 = 3100 nM Bioactivity Info	TI LI LO TS
CP0566681 Compound Info	methyl 4-amino-2-butyl-1-(4-hydroxybutyl)imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C20H26N4O3	1
1	EC50 = 3210 nM Bioactivity Info	TI LI LO TS
CP0569064 Compound Info	4-N-butyl-6-[(4-fluorophenyl)methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C18H20FN5	1
1	EC50 = 3250 nM Bioactivity Info	TI LI LO TS
CP0378701 Compound Info	4-[2-amino-4-(butylamino)-6-methylpyrimidin-5-yl]-2-methylbutan-2-ol Show/Hide	C14H26N4O	1
1	EC50 = 3260 nM Bioactivity Info	TI LI LO TS
CP0536576 Compound Info	methyl 4-amino-2-butyl-1-(2-methoxy-2-oxoethyl)imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C19H22N4O4	1
1	EC50 = 3330 nM Bioactivity Info	TI LI LO TS
CP0406792 Compound Info	1-Benzyl-2-nonyl-1H-imidazo[4,5-c]quinolin-4-amine Show/Hide	C26H32N4	1
1	EC50 = 3350 nM Bioactivity Info	TI LI LO TS
CP0378719 Compound Info	4-N-butyl-5,6-dimethylpyrimidine-2,4-diamine Show/Hide	C10H18N4	1
1	EC50 = 3400 nM Bioactivity Info	TI LI LO TS
CP0566680 Compound Info	methyl 4-amino-2-butyl-1-(3-methoxy-3-oxopropyl)imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C20H24N4O4	1
1	EC50 = 3640 nM Bioactivity Info	TI LI LO TS
CP0569214 Compound Info	methyl 4-amino-2-butyl-1-(3-methylsulfanylpropyl)imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C20H26N4O2S	1
1	EC50 = 3840 nM Bioactivity Info	TI LI LO TS
CP0859646 Compound Info	4-((6-amino-2-butoxy-8-oxo-7H-purin-9(8H)-yl)methyl)piperidinium chloride Show/Hide	C15H25ClN6O2	2
1	EC50 = 3950 nM Bioactivity Info	TI LI LO TS
2	EC50 = 19800 nM Bioactivity Info	TI LI LO TS
CP0496498 Compound Info	4-N-butyl-6-[[2-(trifluoromethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C19H20F3N5	1
1	EC50 = 3950 nM Bioactivity Info	TI LI LO TS
CP0520501 Compound Info	4-(3-methylpiperidin-1-yl)-2-(trifluoromethyl)quinazoline Show/Hide	C15H16F3N3	1
1	EC50 = 4000 nM Bioactivity Info	TI LI LO TS
CP0859644 Compound Info	6-amino-9-[[1-(2-hydroxyethyl)-4-piperidyl]methyl]-2-[(1S)-1-methylbutoxy]-7H-purin-8-one Hydrochloride Show/Hide	C18H31ClN6O3	1
1	EC50 = 4060 nM Bioactivity Info	TI LI LO TS
CP0434076 Compound Info	methyl 4-amino-2-butyl-1-[(2R)-2-hydroxypropyl]imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C19H24N4O3	1
1	EC50 = 4400 nM Bioactivity Info	TI LI LO TS
CP0489763 Compound Info	N-(2-methylpropyl)-2-(trifluoromethyl)quinazolin-4-amine Show/Hide	C13H14F3N3	1
1	EC50 = 4400 nM Bioactivity Info	TI LI LO TS
CP0551605 Compound Info	4-N-butyl-6-[[4-(trifluoromethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C19H20F3N5	1
1	EC50 = 4500 nM Bioactivity Info	TI LI LO TS
CP0476288 Compound Info	methyl 4-amino-2-butyl-1-(4-methoxy-4-oxobutyl)imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C21H26N4O4	1
1	EC50 = 4530 nM Bioactivity Info	TI LI LO TS
CP0461772 Compound Info	methyl 4-amino-2-benzyl-1-(2-hydroxy-2-methylpropyl)imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C23H24N4O3	1
1	EC50 = 4800 nM Bioactivity Info	TI LI LO TS
CP0569173 Compound Info	[4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]phenyl]methyl-trimethylazanium;chloride Show/Hide	C22H31ClN6	1
1	EC50 = 5000 nM Bioactivity Info	TI LI LO TS
CP0190262 Compound Info	[5-amino-2-[2-(4-methoxy-2-methylphenyl)ethyl]benzo[f][1,7]naphthyridine-8-carbonyl]phosphonic acid Show/Hide	C23H22N3O5P	1
1	EC50 = 5600 nM Bioactivity Info	TI LI LO TS
CP0389763 Compound Info	methyl 4-amino-2-butyl-1-(2-methoxyethyl)imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C19H24N4O3	1
1	EC50 = 5700 nM Bioactivity Info	TI LI LO TS
CP0568474 Compound Info	methyl 4-[2-[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]ethyl]benzoate Show/Hide	C21H25N5O2	1
1	EC50 = 6060 nM Bioactivity Info	TI LI LO TS
CP0476733 Compound Info	N-(2-methylpropyl)-2-(trifluoromethyl)quinolin-4-amine Show/Hide	C14H15F3N2	1
1	EC50 = 6300 nM Bioactivity Info	TI LI LO TS
CP0486404 Compound Info	methyl 4-amino-2-butyl-1-(2-ethylsulfanylethyl)imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C20H26N4O2S	1
1	EC50 = 6670 nM Bioactivity Info	TI LI LO TS
CP0870709 Compound Info	6-amino-9-[[1-(2-aminoethyl)-4-piperidyl]methyl]-2-[(1S)-1-methylbutoxy]-7H-purin-8-one Hydrochloride Show/Hide	C18H32ClN7O2	1
1	EC50 = 6710 nM Bioactivity Info	TI LI LO TS
CP0446608 Compound Info	1-(4-Amino-2-((diethylamino)methyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol Show/Hide	C19H27N5O	1
1	EC50 = 7710 nM Bioactivity Info	TI LI LO TS
CP0520499 Compound Info	N-cyclohexyl-2-(trifluoromethyl)quinazolin-4-amine Show/Hide	C15H16F3N3	1
1	EC50 = 8300 nM Bioactivity Info	TI LI LO TS
CP0504044 Compound Info	3-(((4-Amino-1-(2-hydroxy-2-methylpropyl)-1H-imidazo[4,5-c]quinolin-2-yl)methyl)(ethyl)amino)-propanenitrile Show/Hide	C20H26N6O	1
1	EC50 = 8390 nM Bioactivity Info	TI LI LO TS
CP0573266 Compound Info	4-N-butyl-6-[[3-(trifluoromethyl)phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C19H20F3N5	1
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0441019 Compound Info	N-cyclopentyl-2-(trifluoromethyl)quinazolin-4-amine Show/Hide	C14H14F3N3	1
1	EC50 = 10900 nM Bioactivity Info	TI LI LO TS
CP0496500 Compound Info	2-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzoic acid Show/Hide	C19H21N5O2	1
1	EC50 = 10900 nM Bioactivity Info	TI LI LO TS
CP0546368 Compound Info	3-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]benzoic acid Show/Hide	C19H21N5O2	1
1	EC50 = 10900 nM Bioactivity Info	TI LI LO TS
CP0489353 Compound Info	6-benzyl-4-N-butylpteridine-2,4-diamine Show/Hide	C17H20N6	1
1	EC50 = 13000 nM Bioactivity Info	TI LI LO TS
CP0461771 Compound Info	methyl 4-amino-2-butyl-1-(2-hydroxyethyl)imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C18H22N4O3	2
1	EC50 = 14370 nM Bioactivity Info	TI LI LO TS
2	EC50 = 23000 nM Bioactivity Info	TI LI LO TS
CP0476732 Compound Info	N-(cyclopropylmethyl)-2-(trifluoromethyl)quinazolin-4-amine Show/Hide	C13H12F3N3	1
1	EC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0550013 Compound Info	[4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]phenyl]methylphosphonic acid Show/Hide	C19H24N5O3P	1
1	EC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0539440 Compound Info	4-pyrrolidin-1-yl-2-(trifluoromethyl)quinazoline Show/Hide	C13H12F3N3	1
1	EC50 = 15400 nM Bioactivity Info	TI LI LO TS
CP0423712 Compound Info	N-cyclopropyl-2-(trifluoromethyl)quinazolin-4-amine Show/Hide	C12H10F3N3	1
1	EC50 = 16800 nM Bioactivity Info	TI LI LO TS
CP0402138 Compound Info	6-amino-2-butoxy-9-[[1-(2-hydroxyethyl)piperidin-4-yl]methyl]-7H-purin-8-one;hydrochloride Show/Hide	C17H29ClN6O3	1
1	EC50 = 23100 nM Bioactivity Info	TI LI LO TS
CP0381975 Compound Info	methyl 4-amino-1-(2-hydroxy-2-methylpropyl)-2-propylimidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C19H24N4O3	1
1	EC50 = 23800 nM Bioactivity Info	TI LI LO TS
CP0544699 Compound Info	4-N-butyl-6-(4-methoxyphenyl)pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C18H21N5O	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0550012 Compound Info	4-N-butyl-6-(1-phenylethyl)pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C19H23N5	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0568470 Compound Info	4-N-butyl-6-phenylpyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C17H19N5	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0568472 Compound Info	6-benzyl-4-butylsulfanylpyrido[3,2-d]pyrimidin-2-amine Show/Hide	C18H20N4S	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0568475 Compound Info	4-N-butyl-6-[(E)-2-phenylethenyl]pyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C19H21N5	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0568701 Compound Info	6-benzyl-4-piperidin-1-ylpyrido[3,2-d]pyrimidin-2-amine Show/Hide	C19H21N5	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0569660 Compound Info	6-benzyl-4-N-butyl-4-N-methylpyrido[3,2-d]pyrimidine-2,4-diamine Show/Hide	C19H23N5	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0573264 Compound Info	6-benzyl-4-butoxypyrido[3,2-d]pyrimidin-2-amine Show/Hide	C18H20N4O	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0573937 Compound Info	6-benzyl-4-morpholin-4-ylpyrido[3,2-d]pyrimidin-2-amine Show/Hide	C18H19N5O	1
1	EC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0508687 Compound Info	methyl 4-amino-2-ethyl-1-(2-hydroxy-2-methylpropyl)imidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C18H22N4O3	1
1	EC50 = 29100 nM Bioactivity Info	TI LI LO TS
CP0520500 Compound Info	7-(diethylamino)-1-(2-methylpropyl)chromeno[3,4-d]imidazol-4-one Show/Hide	C18H23N3O2	1
1	EC50 = 29900 nM Bioactivity Info	TI LI LO TS
CP0437656 Compound Info	6-amino-9-[[1-(2-aminoethyl)piperidin-4-yl]methyl]-2-butoxy-7H-purin-8-one;hydrochloride Show/Hide	C17H30ClN7O2	1
1	EC50 = 30000 nM Bioactivity Info	TI LI LO TS
CP0859661 Compound Info	6-amino-2-[(1R)-1-methylbutoxy]-9-(4-piperidylmethyl)-7H-purin-8-one Hydrochloride Show/Hide	C16H27ClN6O2	1
1	EC50 = 35800 nM Bioactivity Info	TI LI LO TS
CP0516848 Compound Info	6-amino-2-(butylamino)-9-(piperidin-4-ylmethyl)-7H-purin-8-one;hydrochloride Show/Hide	C15H26ClN7O	1
1	EC50 = 40000 nM Bioactivity Info	TI LI LO TS
CP0423715 Compound Info	N-propyl-2-(trifluoromethyl)quinazolin-4-amine Show/Hide	C12H12F3N3	1
1	EC50 = 44000 nM Bioactivity Info	TI LI LO TS
CP0389766 Compound Info	methyl 4-amino-1-(2-hydroxy-2-methylpropyl)-2-methylimidazo[4,5-c]quinoline-7-carboxylate Show/Hide	C17H20N4O3	1
1	EC50 = 49200 nM Bioactivity Info	TI LI LO TS
CP0539437 Compound Info	N-propan-2-yl-2-(trifluoromethyl)quinazolin-4-amine Show/Hide	C12H12F3N3	1
1	EC50 = 57400 nM Bioactivity Info	TI LI LO TS
CP0441021 Compound Info	N-(1-cyclopropylpiperidin-4-yl)-2-(trifluoromethyl)quinazolin-4-amine Show/Hide	C17H19F3N4	1
1	EC50 = 66600 nM Bioactivity Info	TI LI LO TS
CP0379914 Compound Info	1-(4-aminoimidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol Show/Hide	C14H16N4O	1
1	EC50 = 95000 nM Bioactivity Info	TI LI LO TS
CP0950854 Compound Info	2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole Show/Hide	C23H29N3	1
1	IC50 = 0.7 nM Bioactivity Info	TI LI LO TS
CP0574442 Compound Info	US10660877, Example 73 Show/Hide	C22H26FN3	1
1	IC50 = 0.8 nM Bioactivity Info	TI LI LO TS
CP0543450 Compound Info	US10660877, Example 77 Show/Hide	C23H28FN3	1
1	IC50 = 0.9 nM Bioactivity Info	TI LI LO TS
CP0543454 Compound Info	2-(2-fluoro-6-methylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole Show/Hide	C22H26FN3	1
1	IC50 = 1.8 nM Bioactivity Info	TI LI LO TS
CP0568589 Compound Info	US10660877, Example 46 Show/Hide	C23H29N3O	1
1	IC50 = 1.9 nM Bioactivity Info	TI LI LO TS
CP0579429 Compound Info	US10660877, Example 31 Show/Hide	C23H29N3	1
1	IC50 = 2.6 nM Bioactivity Info	TI LI LO TS
CP0543452 Compound Info	US10660877, Example 5 Show/Hide	C22H27N3	1
1	IC50 = 6.1 nM Bioactivity Info	TI LI LO TS
CP0543449 Compound Info	US10660877, Example 39 Show/Hide	C24H31N3	1
1	IC50 = 7.2 nM Bioactivity Info	TI LI LO TS
CP0579792 Compound Info	US10660877, Example 75 Show/Hide	C23H29N3	1
1	IC50 = 8.2 nM Bioactivity Info	TI LI LO TS
CP0576818 Compound Info	US10660877, Example 83 Show/Hide	C21H23F2N3	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0569162 Compound Info	US10660877, Example 82 Show/Hide	C22H27N3	1
1	IC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0547011 Compound Info	US10660877, Example 74 Show/Hide	C23H26F3N3	1
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0568586 Compound Info	2-(2-cyclopropyl-6-methylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole Show/Hide	C25H31N3	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0575860 Compound Info	US10660877, Example 63 Show/Hide	C21H25N3	1
1	IC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0543453 Compound Info	US10660877, Example 30 Show/Hide	C23H29N3	1
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0547004 Compound Info	US10660877, Example 6 Show/Hide	C22H24F3N3	1
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0543448 Compound Info	US10660877, Example 38 Show/Hide	C21H25N3	1
1	IC50 = 29 nM Bioactivity Info	TI LI LO TS
CP0568588 Compound Info	2-(2-ethyl-6-methylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole Show/Hide	C24H31N3	1
1	IC50 = 57 nM Bioactivity Info	TI LI LO TS
CP0547009 Compound Info	3-isopropyl-2-(2-methoxypyridin-4-yl)-5-(piperidin-4-yl)-1H-indole Show/Hide	C22H27N3O	1
1	IC50 = 74 nM Bioactivity Info	TI LI LO TS
CP0571722 Compound Info	US10660877, Example 22 Show/Hide	C22H27N3O	1
1	IC50 = 81 nM Bioactivity Info	TI LI LO TS
CP0571037 Compound Info	2-(2-cyclopropylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole Show/Hide	C24H29N3	1
1	IC50 = 92 nM Bioactivity Info	TI LI LO TS
CP0578452 Compound Info	US10660877, Example 23 Show/Hide	C22H27N3	1
1	IC50 = 97 nM Bioactivity Info	TI LI LO TS
CP0568585 Compound Info	US10660877, Example 19 Show/Hide	C22H27N3O	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0388427 Compound Info	2-[4-[2-(3,4-dimethoxyphenyl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine Show/Hide	C25H33N3O2	1
1	IC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0001611 Compound Info	2-(2,4-dichlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide Show/Hide	C16H10Cl2N4O2S	1
1	IC50 = 260 nM Bioactivity Info	TI LI LO TS
CP0547005 Compound Info	US10660877, Example 43 Show/Hide	C25H33N3	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0429768 Compound Info	2-(3,5-dichlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide Show/Hide	C16H10Cl2N4O2S	1
1	IC50 = 440 nM Bioactivity Info	TI LI LO TS
CP0545848 Compound Info	2-(2,3-dichlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide Show/Hide	C16H10Cl2N4O2S	1
1	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0547003 Compound Info	US10660877, Example 777 Show/Hide	C23H30N4O	1
1	IC50 = 520 nM Bioactivity Info	TI LI LO TS
CP0543455 Compound Info	US10660877, Example 776 Show/Hide	C22H28N4	1
1	IC50 = 550 nM Bioactivity Info	TI LI LO TS
CP0578600 Compound Info	US10660877, Example 81 Show/Hide	C21H24FN3	1
1	IC50 = 610 nM Bioactivity Info	TI LI LO TS
CP0389058 Compound Info	3,5-bis[(4-methoxyphenyl)methyl]-2-phenylimidazo[4,5-c]quinolin-5-ium Show/Hide	C32H28N3O2+	3
1	IC50 = 820 nM Bioactivity Info	TI LI LO TS
2	IC50 = 2790 nM Bioactivity Info	TI LI LO TS
3	IC50 = 4550 nM Bioactivity Info	TI LI LO TS
CP0478025 Compound Info	2-(3-bromophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide Show/Hide	C16H11BrN4O2S	1
1	IC50 = 900 nM Bioactivity Info	TI LI LO TS
CP0545847 Compound Info	N'-(pyridine-2-carbonyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-4-carbohydrazide Show/Hide	C17H11F3N4O2S	1
1	IC50 = 990 nM Bioactivity Info	TI LI LO TS
CP0390876 Compound Info	2-(3-chlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide Show/Hide	C16H11ClN4O2S	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0575424 Compound Info	(3R,5R)-N-cyclopropyl-3-methyl-5-[8-(trifluoromethyl)quinolin-5-yl]piperidine-1-carboxamide Show/Hide	C20H22F3N3O	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0534466 Compound Info	N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-bromo-6-fluorobenzamide Show/Hide	C21H11BrF7NO2	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0429769 Compound Info	N'-(pyridine-2-carbonyl)-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-4-carbohydrazide Show/Hide	C17H11F3N4O2S	1
1	IC50 = 1020 nM Bioactivity Info	TI LI LO TS
CP0476504 Compound Info	N-[3,5-bis(trifluoromethyl)phenyl]-2-chloro-6-fluorobenzamide Show/Hide	C15H7ClF7NO	1
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0545846 Compound Info	2-(4-methylphenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide Show/Hide	C17H14N4O2S	1
1	IC50 = 1830 nM Bioactivity Info	TI LI LO TS
CP0429770 Compound Info	2-[4-(dimethylamino)phenyl]-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide Show/Hide	C18H17N5O2S	1
1	IC50 = 1900 nM Bioactivity Info	TI LI LO TS
CP0351217 Compound Info	6-(3-pyrrolidin-1-ylpropoxy)-2-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-1,3-benzoxazole Show/Hide	C27H35N3O3	1
1	IC50 = 1990 nM Bioactivity Info	TI LI LO TS
CP0429766 Compound Info	2-(4-chlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide Show/Hide	C16H11ClN4O2S	1
1	IC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0390877 Compound Info	2-(4-ethylphenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide Show/Hide	C18H16N4O2S	1
1	IC50 = 2400 nM Bioactivity Info	TI LI LO TS
CP0141465 Compound Info	1-pentyl-4-(2-phenylmethoxyphenyl)imidazol-2-amine;hydrochloride Show/Hide	C21H26ClN3O	1
1	IC50 = 2400 nM Bioactivity Info	TI LI LO TS
CP0532739 Compound Info	2-(3-fluorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide Show/Hide	C16H11FN4O2S	1
1	IC50 = 2600 nM Bioactivity Info	TI LI LO TS
CP0533372 Compound Info	2-chloro-6-fluoro-N-[4-[3-(trifluoromethyl)phenoxy]phenyl]benzamide Show/Hide	C20H12ClF4NO2	1
1	IC50 = 2650 nM Bioactivity Info	TI LI LO TS
CP0438452 Compound Info	N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-chloro-6-fluorobenzamide Show/Hide	C21H11ClF7NO2	1
1	IC50 = 2880 nM Bioactivity Info	TI LI LO TS
CP0476471 Compound Info	N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-chloro-6-fluoro-N-methylbenzamide Show/Hide	C22H13ClF7NO2	1
1	IC50 = 2900 nM Bioactivity Info	TI LI LO TS
CP0549061 Compound Info	2-(4-methoxyphenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide Show/Hide	C17H14N4O3S	1
1	IC50 = 3090 nM Bioactivity Info	TI LI LO TS
CP0577540 Compound Info	2-[4-[2-(5-methoxypyridin-3-yl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine Show/Hide	C23H30N4O	1
1	IC50 = 3300 nM Bioactivity Info	TI LI LO TS
CP0547502 Compound Info	2-(3,4-dimethoxyphenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide Show/Hide	C18H16N4O4S	1
1	IC50 = 3900 nM Bioactivity Info	TI LI LO TS
CP0549493 Compound Info	2-(4-fluorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide Show/Hide	C16H11FN4O2S	1
1	IC50 = 4400 nM Bioactivity Info	TI LI LO TS
CP0238617 Compound Info	1-methyl-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]piperidin-4-amine Show/Hide	C26H34N4O2	1
1	IC50 = 4570 nM Bioactivity Info	TI LI LO TS
CP0241920 Compound Info	4-[(dimethylamino)methyl]-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]benzamide Show/Hide	C30H34N4O3	1
1	IC50 = 4710 nM Bioactivity Info	TI LI LO TS
CP0574225 Compound Info	N-[4-[3,5-bis(trifluoromethyl)phenoxy]-2-hydroxyphenyl]-2-fluoro-6-iodobenzamide Show/Hide	C21H11F7INO3	1
1	IC50 = 4730 nM Bioactivity Info	TI LI LO TS
CP0512943 Compound Info	3-(2-nonylimidazo[4,5-c]quinolin-3-yl)propan-1-ol Show/Hide	C22H31N3O	1
1	IC50 = 4810 nM Bioactivity Info	TI LI LO TS
CP0351219 Compound Info	2-(3-piperidin-4-ylphenyl)-6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazole Show/Hide	C25H31N3O2	1
1	IC50 = 4990 nM Bioactivity Info	TI LI LO TS
CP0539158 Compound Info	2-[4-[2-(4-methoxyphenyl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine Show/Hide	C24H31N3O	1
1	IC50 = 5500 nM Bioactivity Info	TI LI LO TS
CP0549060 Compound Info	2-phenyl-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide Show/Hide	C16H12N4O2S	1
1	IC50 = 5800 nM Bioactivity Info	TI LI LO TS
CP0540174 Compound Info	2-[4-[2-(3-methoxyphenyl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine Show/Hide	C24H31N3O	1
1	IC50 = 6200 nM Bioactivity Info	TI LI LO TS
CP0476503 Compound Info	4-[3,5-bis(trifluoromethyl)phenoxy]-N-(2-chloro-6-fluorophenyl)benzamide Show/Hide	C21H11ClF7NO2	1
1	IC50 = 7100 nM Bioactivity Info	TI LI LO TS
CP0521006 Compound Info	N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]piperidin-4-amine Show/Hide	C25H32N4O2	1
1	IC50 = 7550 nM Bioactivity Info	TI LI LO TS
CP0545845 Compound Info	3-hydroxy-N'-[4-(trifluoromethoxy)benzoyl]pyridine-2-carbohydrazide Show/Hide	C14H10F3N3O4	1
1	IC50 = 7900 nM Bioactivity Info	TI LI LO TS
CP0315415 Compound Info	1-benzyl-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]piperidin-4-amine Show/Hide	C32H38N4O2	1
1	IC50 = 8090 nM Bioactivity Info	TI LI LO TS
CP0571764 Compound Info	6-(3-pyrrolidin-1-ylpropoxy)-2-[3-(1,2,3,6-tetrahydropyridin-4-yl)phenyl]-1,3-benzoxazole Show/Hide	C25H29N3O2	1
1	IC50 = 8300 nM Bioactivity Info	TI LI LO TS
CP0438010 Compound Info	2-nonyl-3-prop-2-ynylimidazo[4,5-c]quinoline Show/Hide	C22H27N3	1
1	IC50 = 8580 nM Bioactivity Info	TI LI LO TS
CP0543451 Compound Info	2-[4-[2-(6-methoxypyridin-2-yl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine Show/Hide	C23H30N4O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0572227 Compound Info	N-methyl-2-[4-(3-methyl-2-pyridin-3-yl-1H-indol-5-yl)piperidin-1-yl]ethanamine Show/Hide	C22H28N4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0572228 Compound Info	2-[4-[2-(6-methoxypyridin-3-yl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine Show/Hide	C23H30N4O	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0483629 Compound Info	3-methyl-2-nonylimidazo[4,5-c]quinoline Show/Hide	C20H27N3	1
1	IC50 = 10140 nM Bioactivity Info	TI LI LO TS
CP0509533 Compound Info	1-[3-[4-[6-[3-(3-aminopyrrolidin-1-yl)propoxy]-1,3-benzoxazol-2-yl]phenoxy]propyl]pyrrolidin-3-amine Show/Hide	C27H37N5O3	1
1	IC50 = 10840 nM Bioactivity Info	TI LI LO TS
CP0429760 Compound Info	3-hydroxy-N'-[4-(trifluoromethyl)benzoyl]pyridine-2-carbohydrazide Show/Hide	C14H10F3N3O3	1
1	IC50 = 13400 nM Bioactivity Info	TI LI LO TS
CP0414886 Compound Info	2-propan-2-yl-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide Show/Hide	C13H14N4O2S	1
1	IC50 = 14000 nM Bioactivity Info	TI LI LO TS
CP0390870 Compound Info	3-hydroxy-N'-[3-(trifluoromethyl)benzoyl]pyridine-2-carbohydrazide Show/Hide	C14H10F3N3O3	1
1	IC50 = 14200 nM Bioactivity Info	TI LI LO TS
CP0458275 Compound Info	2-methyl-1-(2-nonylimidazo[4,5-c]quinolin-3-yl)propan-2-ol Show/Hide	C23H33N3O	1
1	IC50 = 14400 nM Bioactivity Info	TI LI LO TS
CP0494470 Compound Info	2-phenyl-3-prop-2-ynylimidazo[4,5-c]quinoline Show/Hide	C19H13N3	1
1	IC50 = 14850 nM Bioactivity Info	TI LI LO TS
CP0390871 Compound Info	N'-[3-(trifluoromethyl)benzoyl]pyridine-2-carbohydrazide Show/Hide	C14H10F3N3O2	1
1	IC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0538666 Compound Info	3-amino-N'-[3-(trifluoromethyl)benzoyl]pyridine-2-carbohydrazide Show/Hide	C14H11F3N4O2	1
1	IC50 = 16000 nM Bioactivity Info	TI LI LO TS
CP0389965 Compound Info	N'-(4-bromobenzoyl)pyridine-2-carbohydrazide Show/Hide	C13H10BrN3O2	1
1	IC50 = 17000 nM Bioactivity Info	TI LI LO TS
CP0549492 Compound Info	N'-[4-(trifluoromethyl)benzoyl]pyridine-2-carbohydrazide Show/Hide	C14H10F3N3O2	1
1	IC50 = 17000 nM Bioactivity Info	TI LI LO TS
CP0429765 Compound Info	N'-(4-bromobenzoyl)-3-hydroxypyridine-2-carbohydrazide Show/Hide	C13H10BrN3O3	1
1	IC50 = 17260 nM Bioactivity Info	TI LI LO TS
CP0512937 Compound Info	3-[(4-methoxyphenyl)methyl]-2-nonylimidazo[4,5-c]quinoline Show/Hide	C27H33N3O	1
1	IC50 = 19440 nM Bioactivity Info	TI LI LO TS
CP0459645 Compound Info	2-cyclohexyl-3-[(4-methoxyphenyl)methyl]imidazo[4,5-c]quinoline Show/Hide	C24H25N3O	1
1	IC50 = 19900 nM Bioactivity Info	TI LI LO TS
CP0412004 Compound Info	1-[(3R,5S)-3-methyl-5-[8-(trifluoromethyl)quinolin-5-yl]piperidin-1-yl]-3-pyrazol-1-ylpropan-1-one Show/Hide	C22H23F3N4O	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0476472 Compound Info	2-[4-(3-iodo-2-nitrophenoxy)phenyl]-1,3,4-oxadiazole Show/Hide	C14H8IN3O4	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0483628 Compound Info	3-(2-cyclohexylimidazo[4,5-c]quinolin-3-yl)propan-1-ol Show/Hide	C19H23N3O	1
1	IC50 = 20320 nM Bioactivity Info	TI LI LO TS
CP0438019 Compound Info	N-[2-(ethylaminomethyl)-3-(2-hydroxy-2-methylpropyl)imidazo[4,5-c]quinolin-4-yl]benzamide Show/Hide	C24H27N5O2	1
1	IC50 = 21170 nM Bioactivity Info	TI LI LO TS
CP0459646 Compound Info	3-methyl-2-phenylimidazo[4,5-c]quinoline Show/Hide	C17H13N3	1
1	IC50 = 21630 nM Bioactivity Info	TI LI LO TS
CP0459647 Compound Info	2-cyclohexyl-3-prop-2-ynylimidazo[4,5-c]quinoline Show/Hide	C19H19N3	1
1	IC50 = 21870 nM Bioactivity Info	TI LI LO TS
CP0540505 Compound Info	N'-[4-(trifluoromethoxy)benzoyl]pyridine-2-carbohydrazide Show/Hide	C14H10F3N3O3	1
1	IC50 = 22000 nM Bioactivity Info	TI LI LO TS
CP0459648 Compound Info	2-cyclohexyl-3-methylimidazo[4,5-c]quinoline Show/Hide	C17H19N3	1
1	IC50 = 22040 nM Bioactivity Info	TI LI LO TS
CP0542695 Compound Info	N'-(pyridine-2-carbonyl)-2-pyridin-3-yl-1,3-thiazole-4-carbohydrazide Show/Hide	C15H11N5O2S	1
1	IC50 = 23200 nM Bioactivity Info	TI LI LO TS
CP0558565 Compound Info	N'-(4-chlorobenzoyl)pyridine-2-carbohydrazide Show/Hide	C13H10ClN3O2	1
1	IC50 = 24700 nM Bioactivity Info	TI LI LO TS
CP0429764 Compound Info	3-amino-N'-[4-(trifluoromethyl)benzoyl]pyrazine-2-carbohydrazide Show/Hide	C13H10F3N5O2	1
1	IC50 = 25000 nM Bioactivity Info	TI LI LO TS
CP0438009 Compound Info	N-[(3-prop-2-ynylimidazo[4,5-c]quinolin-2-yl)methyl]ethanamine Show/Hide	C16H16N4	1
1	IC50 = 26100 nM Bioactivity Info	TI LI LO TS
CP0477803 Compound Info	3-amino-N'-[4-(trifluoromethoxy)benzoyl]pyrazine-2-carbohydrazide Show/Hide	C13H10F3N5O3	1
1	IC50 = 27000 nM Bioactivity Info	TI LI LO TS
CP0390874 Compound Info	N'-(4-chlorobenzoyl)-3-hydroxypyridine-2-carbohydrazide Show/Hide	C13H10ClN3O3	1
1	IC50 = 27800 nM Bioactivity Info	TI LI LO TS
CP0397888 Compound Info	N-[[3-[(4-methoxyphenyl)methyl]imidazo[4,5-c]quinolin-2-yl]methyl]ethanamine Show/Hide	C21H22N4O	1
1	IC50 = 28020 nM Bioactivity Info	TI LI LO TS
CP0429763 Compound Info	2-methyl-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazide Show/Hide	C11H10N4O2S	1
1	IC50 = 30000 nM Bioactivity Info	TI LI LO TS
CP0459643 Compound Info	N-[(3-methylimidazo[4,5-c]quinolin-2-yl)methyl]ethanamine Show/Hide	C14H16N4	1
1	IC50 = 30440 nM Bioactivity Info	TI LI LO TS
CP0494469 Compound Info	3-(2-phenylimidazo[4,5-c]quinolin-3-yl)propan-1-ol Show/Hide	C19H17N3O	1
1	IC50 = 37240 nM Bioactivity Info	TI LI LO TS
CP0390872 Compound Info	3-amino-N'-[3-(trifluoromethyl)benzoyl]pyrazine-2-carbohydrazide Show/Hide	C13H10F3N5O2	1
1	IC50 = 38000 nM Bioactivity Info	TI LI LO TS
CP0503006 Compound Info	2-methyl-1-(2-phenylimidazo[4,5-c]quinolin-3-yl)propan-2-ol Show/Hide	C20H19N3O	1
1	IC50 = 38420 nM Bioactivity Info	TI LI LO TS
CP0389057 Compound Info	1-(2-cyclohexylimidazo[4,5-c]quinolin-3-yl)-2-methylpropan-2-ol Show/Hide	C20H25N3O	1
1	IC50 = 38730 nM Bioactivity Info	TI LI LO TS
CP0429762 Compound Info	N'-(4-chlorobenzoyl)-2-methyl-1,3-thiazole-4-carbohydrazide Show/Hide	C12H10ClN3O2S	1
1	IC50 = 44800 nM Bioactivity Info	TI LI LO TS
CP0397890 Compound Info	1-[2-(ethylaminomethyl)-5-oxidoimidazo[4,5-c]quinolin-5-ium-3-yl]-2-methylpropan-2-ol Show/Hide	C17H22N4O2	1
1	IC50 = 46500 nM Bioactivity Info	TI LI LO TS
CP0438454 Compound Info	N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodobenzamide Show/Hide	C21H11F7INO2	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0438457 Compound Info	N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-3-fluoropyridine-2-carboxamide Show/Hide	C20H11F7N2O2	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0482366 Compound Info	N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-(trifluoromethoxy)benzamide Show/Hide	C22H11F10NO3	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0482367 Compound Info	N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluorobenzamide Show/Hide	C21H12F7NO2	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0485612 Compound Info	4-amino-N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluorobenzamide Show/Hide	C21H13F7N2O2	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0492032 Compound Info	N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-4-iodobenzamide Show/Hide	C21H11F7INO2	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0534960 Compound Info	N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-3H-benzimidazole-5-carboxamide Show/Hide	C22H13F6N3O2	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0534961 Compound Info	N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-1H-indole-6-carboxamide Show/Hide	C23H14F6N2O2	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0553749 Compound Info	4-[3,5-bis(trifluoromethyl)phenoxy]-N-[(2-chloro-6-fluorophenyl)methyl]aniline Show/Hide	C21H13ClF7NO	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0388424 Compound Info	2-[4-[2-(3,4-dimethoxyphenyl)-3-propan-2-yl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine Show/Hide	C27H37N3O2	1
1	IC50 > 50000 nM Bioactivity Info	TI LI LO TS
CP0397891 Compound Info	1-(2-((ethylamino)methyl)-3H-imidazo[4,5-c]quinolin-3-yl)-2-methylpropan-2-ol bis(2,2,2-trifluoroacetate) Show/Hide	C17H22N4O	1
1	IC50 = 56310 nM Bioactivity Info	TI LI LO TS
CP0545832 Compound Info	N'-(3-chlorobenzoyl)-2-methyl-1,3-thiazole-4-carbohydrazide Show/Hide	C12H10ClN3O2S	1
1	IC50 = 60000 nM Bioactivity Info	TI LI LO TS
CP0548732 Compound Info	4-(aminomethyl)-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]benzamide Show/Hide	C28H30N4O3	1
1	IC50 = 66170 nM Bioactivity Info	TI LI LO TS
CP0379721 Compound Info	2-[4-[4-[7-(3-morpholin-4-ylpropyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-yl]phenyl]piperazin-1-yl]ethanol Show/Hide	C25H36N6O2	1
1	IC50 > 970 nM Bioactivity Info	TI LI LO TS
CP0412002 Compound Info	5-[(3R,5R)-5-methyl-1-[2-(3-methyl-3-azabicyclo[3.1.1]heptan-6-yl)acetyl]piperidin-3-yl]quinoline-8-carbonitrile Show/Hide	C25H30N4O	1
1	IC50 < 1000 nM Bioactivity Info	TI LI LO TS
CP0412003 Compound Info	5-[5-methyl-1-[(1-methylpyrrolidin-3-yl)methyl]piperidin-3-yl]quinoline-8-carbonitrile Show/Hide	C22H28N4	1
1	IC50 < 1000 nM Bioactivity Info	TI LI LO TS
CP0412005 Compound Info	5-[(3R,5R)-5-methyl-1-[2-(1-methylpiperidin-4-yl)acetyl]piperidin-3-yl]quinoline-8-carbonitrile Show/Hide	C24H30N4O	1
1	IC50 < 1000 nM Bioactivity Info	TI LI LO TS
CP0445760 Compound Info	(3R,5R)-3-(8-cyanoquinolin-5-yl)-5-methyl-N-(1-methylpiperidin-4-yl)piperidine-1-carboxamide Show/Hide	C23H29N5O	1
1	IC50 < 1000 nM Bioactivity Info	TI LI LO TS
CP0540903 Compound Info	1-[(3R,5R)-3-methyl-5-(8-methylquinolin-5-yl)piperidin-1-yl]-2-(1-methylpiperidin-4-yl)ethanone Show/Hide	C24H33N3O	1
1	IC50 < 1000 nM Bioactivity Info	TI LI LO TS
CP0564624 Compound Info	5-[(3S,5R)-1-[2-[(1S,5R)-3-azabicyclo[3.1.0]hexan-6-yl]acetyl]-5-methylpiperidin-3-yl]quinoline-8-carbonitrile Show/Hide	C23H26N4O	1
1	IC50 < 1000 nM Bioactivity Info	TI LI LO TS
CP0564625 Compound Info	5-[(3R,5R)-5-methyl-1-[2-(4-methylpiperazin-1-yl)acetyl]piperidin-3-yl]quinoline-8-carbonitrile Show/Hide	C23H29N5O	1
1	IC50 < 1000 nM Bioactivity Info	TI LI LO TS
CP0566053 Compound Info	(1S,3S,5S)-3-methyl-5-[8-(trifluoromethyl)quinoxalin-5-yl]cyclohexan-1-amine Show/Hide	C16H18F3N3	1
1	IC50 < 1000 nM Bioactivity Info	TI LI LO TS
CP0566304 Compound Info	(1S,3S,5R)-3-methyl-5-[8-(trifluoromethyl)quinoxalin-5-yl]cyclohexan-1-amine Show/Hide	C16H18F3N3	1
1	IC50 < 1000 nM Bioactivity Info	TI LI LO TS
CP0575425 Compound Info	(2S)-2-hydroxy-3,3-dimethyl-N-[(1R,3R,5R)-3-methyl-5-[8-(trifluoromethyl)quinoxalin-5-yl]cyclohexyl]butanamide Show/Hide	C22H28F3N3O2	1
1	IC50 < 1000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000686 , HEK-Blue hTLR7

Cell Line Info

Cell Line ID: CL000870 , HEK-Blue Null1-v

Cell Line Info

Cell Line ID: CL001041 , HEK-SEAP

Cell Line Info

Cell Line ID: CL000148 , Huh-7

Cell Line Info

Cell Line ID: CL000752 , PBMC iPSC #1

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0233638 Compound Info	1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol Show/Hide	C17H22N4O2	1
1	Activity = 39.759534 nM
CP0190289 Compound Info	3-[5-amino-2-[2-[2-methyl-4-(3-phosphonopropoxy)phenyl]ethyl]benzo[f][1,7]naphthyridin-8-yl]propanoic acid Show/Hide	C27H30N3O6P	1
1	EC50 = 290 nM
CP0190290 Compound Info	3-[5-amino-2-[2-[4-(4,4-difluoro-4-phosphonobutoxy)-2-methylphenyl]ethyl]benzo[f][1,7]naphthyridin-8-yl]propanoic acid Show/Hide	C28H30F2N3O6P	1
1	EC50 = 360 nM
CP0089990 Compound Info	2-[5-amino-2-[2-(4-methoxy-2-methylphenyl)ethyl]benzo[f][1,7]naphthyridin-8-yl]ethylphosphonic acid Show/Hide	C24H26N3O4P	1
1	EC50 = 400 nM
CP0188208 Compound Info	3-[5-amino-2-[2-[2-methyl-4-[2-[2-(2-phosphonoethoxy)ethoxy]ethoxy]phenyl]ethyl]benzo[f][1,7]naphthyridin-8-yl]propanoic acid Show/Hide	C30H36N3O8P	1
1	EC50 = 490 nM
CP0111162 Compound Info	[3-[2-[2-[4-[2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl]-3-methylphenoxy]ethoxy]ethoxy]-1,1-difluoropropyl]phosphonic acid Show/Hide	C29H34F2N3O6P	1
1	EC50 = 980 nM
CP0188206 Compound Info	[4-[4-[2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl]-3-methylphenoxy]-1,1-difluorobutyl]phosphonic acid Show/Hide	C26H28F2N3O4P	1
1	EC50 = 1600 nM
CP0190288 Compound Info	[(E)-2-[5-amino-2-[2-(4-methoxy-2-methylphenyl)ethyl]benzo[f][1,7]naphthyridin-8-yl]ethenyl]phosphonic acid Show/Hide	C24H24N3O4P	1
1	EC50 = 1700 nM
CP0188207 Compound Info	3-[5-amino-2-[2-[4-[2-[2-(3,3-difluoro-3-phosphonopropoxy)ethoxy]ethoxy]-2-methylphenyl]ethyl]benzo[f][1,7]naphthyridin-8-yl]propanoic acid Show/Hide	C31H36F2N3O8P	1
1	EC50 = 2100 nM
CP0190263 Compound Info	[(E)-2-[5-amino-2-[2-(4-methoxy-2-methylphenyl)ethyl]benzo[f][1,7]naphthyridin-8-yl]-1-fluoroethenyl]phosphonic acid Show/Hide	C24H23FN3O4P	1
1	EC50 = 3400 nM
CP0350278 Compound Info	[2-[5-amino-2-[2-(4-methoxy-2-methylphenyl)ethyl]benzo[f][1,7]naphthyridin-8-yl]-1,1-difluoro-2-oxoethyl]phosphonic acid Show/Hide	C24H22F2N3O5P	1
1	EC50 = 7800 nM
CP0217014 Compound Info	2-[2-[2-[4-[2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl]-3-methylphenoxy]ethoxy]ethoxy]ethylphosphonic acid Show/Hide	C28H34N3O6P	1
1	EC50 = 8200 nM
CP0307253 Compound Info	3-[4-[2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl]-3-methylphenoxy]propylphosphonic acid Show/Hide	C25H28N3O4P	1
1	EC50 = 30000 nM
CP0388424 Compound Info	2-[4-[2-(3,4-dimethoxyphenyl)-3-propan-2-yl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine Show/Hide	C27H37N3O2	1
1	IC50 = 11 nM
CP0513268 Compound Info	4-[4-(cyclopentylmethyl)piperazin-1-yl]-6-methoxy-N,N-dimethyl-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amine Show/Hide	C28H44N6O2	1
1	IC50 = 700 nM
CP0076708 Compound Info	CHEBI:5801 Show/Hide	C18H26ClN3O	1
1	IC50 = 800 nM
CP0228854 Compound Info	4-(4-cyclopentylpiperazin-1-yl)-6-methoxy-2-(4-methylpiperazin-1-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazoline Show/Hide	C30H47N7O2	1
1	IC50 = 1200 nM
CP0243980 Compound Info	[4-[2-(dimethylamino)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]piperazin-1-yl]-phenylmethanone Show/Hide	C29H38N6O3	1
1	IC50 = 1200 nM
CP0558204 Compound Info	7-cyclopentyloxy-6-methoxy-N,N-dimethyl-4-(4-methylpiperazin-1-yl)quinazolin-2-amine Show/Hide	C21H31N5O2	1
1	IC50 = 1300 nM
CP0365487 Compound Info	6-methoxy-N,N-dimethyl-7-phenylmethoxy-4-piperazin-1-ylquinazolin-2-amine Show/Hide	C22H27N5O2	1
1	IC50 = 1400 nM
CP0365488 Compound Info	4-(4-cyclopentylpiperazin-1-yl)-6-methoxy-N,N-dimethyl-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amine Show/Hide	C27H42N6O2	1
1	IC50 = 1400 nM
CP0351217 Compound Info	6-(3-pyrrolidin-1-ylpropoxy)-2-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-1,3-benzoxazole Show/Hide	C27H35N3O3	1
1	IC50 = 1550 nM
CP0514111 Compound Info	4-(4-benzylpiperazin-1-yl)-6-methoxy-N,N-dimethyl-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amine Show/Hide	C29H40N6O2	1
1	IC50 = 4400 nM
CP0238617 Compound Info	1-methyl-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]piperidin-4-amine Show/Hide	C26H34N4O2	1
1	IC50 = 4570 nM
CP0351216 Compound Info	7-cyclopentyloxy-6-methoxy-N,N-dimethyl-4-piperazin-1-ylquinazolin-2-amine Show/Hide	C20H29N5O2	1
1	IC50 = 4600 nM
CP0241920 Compound Info	4-[(dimethylamino)methyl]-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]benzamide Show/Hide	C30H34N4O3	1
1	IC50 = 4710 nM
CP0426350 Compound Info	4-(4-cyclopentylpiperazin-1-yl)-N-[(4-fluorophenyl)methyl]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amine Show/Hide	C32H43FN6O2	1
1	IC50 = 4900 nM
CP0351219 Compound Info	2-(3-piperidin-4-ylphenyl)-6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazole Show/Hide	C25H31N3O2	1
1	IC50 = 4990 nM
CP0513270 Compound Info	1-[4-[2-(dimethylamino)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]piperazin-1-yl]-2-methylpropan-1-one Show/Hide	C26H40N6O3	1
1	IC50 = 5400 nM
CP0422349 Compound Info	6-methoxy-N,N-dimethyl-4-piperazin-1-yl-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amine Show/Hide	C22H34N6O2	1
1	IC50 = 5600 nM
CP0426349 Compound Info	4-(4-cyclopentylpiperazin-1-yl)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline Show/Hide	C25H37N5O2	1
1	IC50 = 5700 nM
CP0392596 Compound Info	6-methoxy-N,N-dimethyl-4-(4-methylpiperazin-1-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amine Show/Hide	C23H36N6O2	1
1	IC50 = 5800 nM
CP0521006 Compound Info	N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]piperidin-4-amine Show/Hide	C25H32N4O2	1
1	IC50 = 7550 nM
CP0571764 Compound Info	6-(3-pyrrolidin-1-ylpropoxy)-2-[3-(1,2,3,6-tetrahydropyridin-4-yl)phenyl]-1,3-benzoxazole Show/Hide	C25H29N3O2	1
1	IC50 = 8300 nM
CP0365489 Compound Info	[4-(aminomethyl)phenyl]-[4-[2-(dimethylamino)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]piperazin-1-yl]methanone Show/Hide	C30H41N7O3	1
1	IC50 = 8700 nM
CP0411533 Compound Info	6-methoxy-N,N-dimethyl-4-(4-propan-2-ylsulfonylpiperazin-1-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amine Show/Hide	C25H40N6O4S	1
1	IC50 = 9600 nM
CP0513269 Compound Info	7-cyclopentyloxy-6-methoxy-N,N-dimethyl-4-piperidin-1-ylquinazolin-2-amine Show/Hide	C21H30N4O2	1
1	IC50 = 11000 nM
CP0537435 Compound Info	cyclopentyl-[4-[2-(dimethylamino)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]piperazin-1-yl]methanone Show/Hide	C28H42N6O3	1
1	IC50 = 11000 nM
CP0228855 Compound Info	4-(4-cyclopentylpiperazin-1-yl)-6-methoxy-N-[3-(4-methylpiperazin-1-yl)propyl]-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amine Show/Hide	C33H54N8O2	1
1	IC50 = 16000 nM
CP0392408 Compound Info	4-[7-cyclopentyloxy-2-(dimethylamino)-6-methoxyquinazolin-4-yl]-N,N-dimethylpiperazine-1-carboxamide Show/Hide	C23H34N6O3	1
1	IC50 = 17000 nM
CP0457733 Compound Info	4-(4-cyclopentylpiperazin-1-yl)-N-(3-imidazol-1-ylpropyl)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amine Show/Hide	C31H46N8O2	1
1	IC50 = 17000 nM
CP0476443 Compound Info	6-methoxy-4-(4-methylpiperazin-1-yl)-N-[3-(4-methylpiperazin-1-yl)propyl]-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amine Show/Hide	C29H48N8O2	1
1	IC50 = 17000 nM
CP0558205 Compound Info	1-[4-[7-cyclopentyloxy-2-(dimethylamino)-6-methoxyquinazolin-4-yl]piperazin-1-yl]-2-methylpropan-1-one Show/Hide	C24H35N5O3	1
1	IC50 = 20700 nM
CP0176609 Compound Info	6-methoxy-N,N-dimethyl-4-(4-methylpiperazin-1-yl)-7-phenylmethoxyquinazolin-2-amine Show/Hide	C23H29N5O2	1
1	IC50 = 22000 nM
CP0440121 Compound Info	[4-[2-(dimethylamino)-6-methoxy-7-phenylmethoxyquinazolin-4-yl]piperazin-1-yl]-phenylmethanone Show/Hide	C29H31N5O3	1
1	IC50 = 31000 nM
CP0432289 Compound Info	4-[2-(dimethylamino)-6-methoxy-7-phenylmethoxyquinazolin-4-yl]-N,N-dimethylpiperazine-1-sulfonamide Show/Hide	C24H32N6O4S	1
1	IC50 = 52000 nM
CP0466655 Compound Info	tert-butyl 4-[2-(dimethylamino)-6-methoxy-7-phenylmethoxyquinazolin-4-yl]piperazine-1-carboxylate Show/Hide	C27H35N5O4	1
1	IC50 = 53000 nM

Clinical Information about the Protein

Target 1 ( Toll-like receptor 7 (TLR7) )

Target Type	Successful Target
Disease	8 Target-related Diseases				8
1	Malaria [ICD-11: 1F40-1F45]
2	Skin cancer [ICD-11: 2C30-2C37]
3	Systemic lupus erythematosus [ICD-11: 4A40.0]
4	Hepatitis B virus infection [ICD-11: 1E51.0]
5	Immune System disease [ICD-11: 4A01-4B41]
6	Actinic keratosis [ICD-11: EK90.0]
7	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
8	Melanoma [ICD-11: 2C30]
Approved Drug(s)	2 Approved Drugs				2
1	Hydroxychloroquine	Drug Info	Approved	Malaria
2	Imiquimod	Drug Info	Approved	Skin cancer
Clinical Trial Drug(s)	6 Clinical Trial Drugs				6
1	Afimetoran	Drug Info	Phase 2	Systemic lupus erythematosus
2	GS-9620	Drug Info	Phase 2	Hepatitis B virus infection
3	LOXORIBINE	Drug Info	Phase 2	Immune System disease
4	Resiquimod	Drug Info	Phase 2	Actinic keratosis
5	LHC165	Drug Info	Phase 1	Solid tumour/cancer
6	PF-4878691	Drug Info	Phase 2	Melanoma

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han