General Information of the Compound
Compound ID
CP0445760
Compound Name
(3R,5R)-3-(8-cyanoquinolin-5-yl)-5-methyl-N-(1-methylpiperidin-4-yl)piperidine-1-carboxamide
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Structure
Formula
C23H29N5O
Molecular Weight
391.519
Canonical SMILES
C[C@@H]1C[C@@H](CN(C1)C(=O)NC1CCN(C)CC1)c1ccc(C#N)c2ncccc12
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InChI
InChI=1S/C23H29N5O/c1-16-12-18(20-6-5-17(13-24)22-21(20)4-3-9-25-22)15-28(14-16)23(29)26-19-7-10-27(2)11-8-19/h3-6,9,16,18-19H,7-8,10-12,14-15H2,1-2H3,(H,26,29)/t16-,18+/m1/s1
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InChIKey
DBHNEWFBAUQGLN-AEFFLSMTSA-N
Physicochemical Property
logP
3.33568
Rotatable Bonds
2
Heavy Atom Count
29
Polar Areas
72.26
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 134237255
ChEMBL ID
CHEMBL4289796
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02160, Toll-like receptor 7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 < 1000 nM
   TI
   LI
   LO
   TS