General Information of the Compound
Compound ID
CP0528677
Compound Name
6-[[4-[(dimethylamino)methyl]phenyl]methyl]-4-N-(2-methoxyethyl)pyrido[3,2-d]pyrimidine-2,4-diamine
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Structure
Formula
C20H26N6O
Molecular Weight
366.469
Canonical SMILES
COCCNc1nc(N)nc2ccc(Cc3ccc(CN(C)C)cc3)nc12
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InChI
InChI=1S/C20H26N6O/c1-26(2)13-15-6-4-14(5-7-15)12-16-8-9-17-18(23-16)19(22-10-11-27-3)25-20(21)24-17/h4-9H,10-13H2,1-3H3,(H3,21,22,24,25)
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InChIKey
UQHYCVOVYJQJOY-UHFFFAOYSA-N
Physicochemical Property
logP
2.3177
Rotatable Bonds
8
Heavy Atom Count
27
Polar Areas
89.19
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 166635267
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02160, Toll-like receptor 7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 40 nM
   TI
   LI
   LO
   TS
Protein ID: PT02546, Toll-like receptor 8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 23 nM
   TI
   LI
   LO
   TS