2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3,4-dimethyl-6-piperidin-4-yl-9H-carbazole

2-deuterio-5-[(2S,6R)-6-methyl-11-piperidin-4-yloxy-4,7,10-triazatricyclo[7.4.0.02,7]trideca-1(9),10,12-trien-4-yl]quinoline-8-carbonitrile

5-[(2S,6R)-11-[(3S)-3-amino-3-methylpyrrolidin-1-yl]-6-methyl-4,7,10-triazatricyclo[7.4.0.02,7]trideca-1(9),10,12-trien-4-yl]-2-deuterioquinoline-8-carbonitrile

2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-methyl-6-piperidin-4-yl-9H-carbazole

1-[4-[7-(2,6-dimethylpyridin-4-yl)-5-methyl-9H-carbazol-3-yl]piperidin-1-yl]-2-methylpropan-2-ol

2-deuterio-5-[(2S,6R)-11-[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-6-methyl-4,7,10-triazatricyclo[7.4.0.02,7]trideca-1(9),10,12-trien-4-yl]quinoline-8-carbonitrile

2-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-methyl-6-piperidin-4-yl-9H-carbazole

2-(2,6-dimethylpyridin-4-yl)-4-methyl-6-piperidin-4-yl-9H-carbazole

2-deuterio-5-[(2S,6R)-11-[(1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-6-methyl-4,7,10-triazatricyclo[7.4.0.02,7]trideca-1(9),10,12-trien-4-yl]quinoline-8-carbonitrile

5-[(4R,9aR)-8-[5-(6-amino-2-azaspiro[3.3]heptan-2-yl)-3-methylpyridin-2-yl]-4-methyl-3,4,6,7,9,9a-hexahydro-1H-pyrazino[1,2-a]pyrazin-2-yl]-2-deuterioquinoline-8-carbonitrile

5-[(2S,6R)-2-[[6-(3-amino-3-methylazetidin-1-yl)spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]methyl]-6-methylmorpholin-4-yl]-2-deuterioquinoline-8-carbonitrile

5-[(2S,6R)-2-[[6-(3-aminoazetidin-1-yl)spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]methyl]-6-methylmorpholin-4-yl]-2-deuterioquinoline-8-carbonitrile

5-[(4R,9aR)-4-methyl-8-(5,6,7,8-tetrahydro-2,7-naphthyridin-4-yl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[1,2-a]pyrazin-2-yl]quinoline-8-carbonitrile

5-[(2S,6R)-2-[[3-[(4aR,7aR)-3,4,4a,5,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazin-6-yl]spiro[5H-furo[3,4-b]pyridine-7,3'-azetidine]-1'-yl]methyl]-6-methylmorpholin-4-yl]-2-deuterioquinoline-8-carbonitrile

5-[(2S,6R)-2-[[6-(3-amino-3-methylazetidin-1-yl)spiro[1H-furo[3,4-c]pyridine-3,3'-azetidine]-1'-yl]methyl]-6-methylmorpholin-4-yl]-2-deuterioquinoline-8-carbonitrile

4-[(2R,6S)-2-methyl-6-[[6-(6-methyl-2,6-diazaspiro[3.3]heptan-2-yl)spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]methyl]morpholin-4-yl]pyrazolo[1,5-a]pyridine-7-carbonitrile

5-[(4R,9aS)-4-methyl-8-(5,6,7,8-tetrahydro-2,7-naphthyridin-4-yl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[1,2-a]pyrazin-2-yl]quinoline-8-carbonitrile

5-[(4R,9aS)-8-[2-[6-[(3R,4S)-3-amino-4-fluoropyrrolidin-1-yl]pyridin-3-yl]ethyl]-4-methyl-3,4,6,7,9,9a-hexahydro-1H-pyrazino[1,2-a]pyrazin-2-yl]quinoline-8-carbonitrile

2-deuterio-5-[(2S,6R)-11-(2,6-diazaspiro[3.4]octan-6-yl)-6-methyl-4,7,10-triazatricyclo[7.4.0.02,7]trideca-1(9),10,12-trien-4-yl]quinoline-8-carbonitrile

5-[(4R,9aS)-4-methyl-8-(1,2,3,4-tetrahydroisoquinolin-5-yl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[1,2-a]pyrazin-2-yl]quinoline-8-carbonitrile

5-[(4S)-8-[5-[(6R)-6-amino-1,4-oxazepan-4-yl]-3-methylpyridin-2-yl]-4-methyl-3,4,6,7,9,9a-hexahydro-1H-pyrazino[1,2-a]pyrazin-2-yl]-2-deuterioquinoline-8-carbonitrile

2-deuterio-5-[(2R,6S)-2-methyl-6-[[6-(5-oxa-2,8-diazaspiro[3.5]nonan-2-yl)spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]methyl]morpholin-4-yl]quinoline-8-carbonitrile

5-[(2R)-11-(4-amino-4-methylpiperidin-1-yl)-4,7,10-triazatricyclo[7.4.0.02,7]trideca-1(9),10,12-trien-4-yl]quinoline-8-carbonitrile

2-(2,6-dimethylpyridin-4-yl)-6-piperidin-4-yl-9H-carbazole

2-(2,4-dimethoxyphenyl)-7-(4-propan-2-ylpiperazin-1-yl)-3-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridine

2-(2,4-dimethoxyphenyl)-7-piperazin-1-ylimidazo[1,2-a]pyridine

2-(2,4-dimethoxyphenyl)-N-(3-pyrrolidin-1-ylpropyl)imidazo[1,2-a]pyridin-7-amine

7-(4-cyclopentylpiperazin-1-yl)-2-[4-methoxy-2-(3-pyrrolidin-1-ylpropoxy)phenyl]imidazo[1,2-a]pyridine

2-(2,4-dimethoxyphenyl)-7-(4-propan-2-ylpiperazin-1-yl)imidazo[1,2-a]pyridine

4-[3-[2-[7-(4-cyclopentylpiperazin-1-yl)imidazo[1,2-a]pyridin-2-yl]-5-methoxyphenoxy]propyl]morpholine

2-(4-methoxyphenyl)-7-piperazin-1-ylimidazo[1,2-a]pyridine

7-(4-cyclopentylpiperazin-1-yl)-2-(2,4-dimethoxyphenyl)-3-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridine

2-[4-methoxy-2-(3-pyrrolidin-1-ylpropoxy)phenyl]-7-piperazin-1-ylimidazo[1,2-a]pyridine

2-(2,4-dimethoxyphenyl)-N-(3-imidazol-1-ylpropyl)imidazo[1,2-a]pyridin-7-amine

7-cyclopentyloxy-6-methoxy-4-(4-methylpiperazin-1-yl)-N-[3-(4-methylpiperazin-1-yl)propyl]quinazolin-2-amine

2-(4-methoxyphenyl)-N-(3-morpholin-4-ylpropyl)imidazo[1,2-a]pyridin-7-amine

2-(4-methoxy-2-phenylmethoxyphenyl)-7-piperazin-1-ylimidazo[1,2-a]pyridine

6-(4-ethylpiperazin-1-yl)-N-[(4-fluorophenyl)methyl]-9-(3-pyrrolidin-1-ylpropyl)purin-2-amine

2-(4-methoxyphenyl)-7-(4-propan-2-ylpiperazin-1-yl)imidazo[1,2-a]pyridine

4-[3-[5-methoxy-2-(7-piperazin-1-ylimidazo[1,2-a]pyridin-2-yl)phenoxy]propyl]morpholine

2-(2,4-dimethoxyphenyl)-N-(3-morpholin-4-ylpropyl)imidazo[1,2-a]pyridin-7-amine

4-(4-cyclopentylpiperazin-1-yl)-6-methoxy-N-[(4-methoxyphenyl)methyl]-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-2-amine

4-[[7-(4-cyclopentylpiperazin-1-yl)-2-(2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-3-yl]methyl]morpholine

6-methoxy-N,N-dimethyl-2-(4-methylpiperazin-1-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amine

7-(4-cyclopentylpiperazin-1-yl)-2-(2,4-dimethoxyphenyl)imidazo[1,2-a]pyridine

4-[[2-(2,4-dimethoxyphenyl)-7-(4-propan-2-ylpiperazin-1-yl)imidazo[1,2-a]pyridin-3-yl]methyl]morpholine

2-(2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-amine

cyclopentyl-[4-[2-(2,4-dimethoxyphenyl)-3-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridin-7-yl]piperazin-1-yl]methanone

6-(4-ethylpiperazin-1-yl)-N-[(4-methoxyphenyl)methyl]-9-(3-pyrrolidin-1-ylpropyl)purin-2-amine

N-[[4-(diethylamino)phenyl]methyl]-6-(4-ethylpiperazin-1-yl)-9-[3-(4-ethylpiperazin-1-yl)propyl]purin-2-amine

tert-butyl 4-[2-[4-methoxy-2-(3-morpholin-4-ylpropoxy)phenyl]imidazo[1,2-a]pyridin-7-yl]piperazine-1-carboxylate

tert-butyl 4-[2-[4-methoxy-2-(3-pyrrolidin-1-ylpropoxy)phenyl]imidazo[1,2-a]pyridin-7-yl]piperazine-1-carboxylate

7-(4-cyclopentylpiperazin-1-yl)-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine

2-(2,4-dimethoxyphenyl)-N-(2-morpholin-4-ylethyl)imidazo[1,2-a]pyridin-7-amine

2-(2,4-dimethoxyphenyl)-N,N-dimethylimidazo[1,2-a]pyridin-7-amine

2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-7-amine

6-(4-ethylpiperazin-1-yl)-9-[3-(4-ethylpiperazin-1-yl)propyl]purine

N-benzyl-7-(4-cyclopentylpiperazin-1-yl)-2-(2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-3-amine

6-(4-cyclopentylpiperazin-1-yl)-9-(3-pyrrolidin-1-ylpropyl)purin-2-amine

6-(4-ethylpiperazin-1-yl)-9-(3-pyrrolidin-1-ylpropyl)purin-2-amine

6-(4-ethylpiperazin-1-yl)-9-[3-(4-ethylpiperazin-1-yl)propyl]-N-[(4-methoxyphenyl)methyl]purin-2-amine

7-(4-cyclopentylpiperazin-1-yl)-2-(4-methoxy-2-phenylmethoxyphenyl)imidazo[1,2-a]pyridine

N-cyclohexyl-7-(4-cyclopentylpiperazin-1-yl)-2-(2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-3-amine

2-(4-methoxyphenyl)-N,N-dimethylimidazo[1,2-a]pyridin-7-amine

N-[6-(4-cyclopentylpiperazin-1-yl)-9-[3-(4-ethylpiperazin-1-yl)propyl]purin-2-yl]-4-[(dimethylamino)methyl]benzamide

N-benzyl-6-(4-ethylpiperazin-1-yl)-9-[3-(4-ethylpiperazin-1-yl)propyl]purin-2-amine

N-[6-(4-ethylpiperazin-1-yl)-9-[3-(4-ethylpiperazin-1-yl)propyl]purin-2-yl]benzamide

6-(4-cyclopentylpiperazin-1-yl)-N-[[4-(diethylamino)phenyl]methyl]-9-[3-(4-ethylpiperazin-1-yl)propyl]purin-2-amine

[4-[2-[[4-(diethylamino)phenyl]methylamino]-9-[3-(4-ethylpiperazin-1-yl)propyl]purin-6-yl]piperazin-1-yl]-phenylmethanone

6-(4-ethylpiperazin-1-yl)-9-[3-(4-ethylpiperazin-1-yl)propyl]-2-pyrrolidin-1-ylpurine

cyclopentyl-[4-[2-(2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl]piperazin-1-yl]methanone

6-(4-cyclopentylpiperazin-1-yl)-N-[[4-[(dimethylamino)methyl]phenyl]methyl]-9-(3-pyrrolidin-1-ylpropyl)purin-2-amine

cyclopentyl-[4-[2-[[4-(diethylamino)phenyl]methylamino]-9-[3-(4-ethylpiperazin-1-yl)propyl]purin-6-yl]piperazin-1-yl]methanone

6-(4-ethylpiperazin-1-yl)-9-[3-(4-ethylpiperazin-1-yl)propyl]-N-[(4-fluorophenyl)methyl]purin-2-amine

(4-fluorophenyl)-[4-[2-(4-methoxy-2-phenylmethoxyphenyl)imidazo[1,2-a]pyridin-7-yl]piperazin-1-yl]methanone

6-(4-cyclopentylpiperazin-1-yl)-N-[(4-methoxyphenyl)methyl]-9-(3-pyrrolidin-1-ylpropyl)purin-2-amine

6-(4-cyclopentylpiperazin-1-yl)-9-[3-(4-ethylpiperazin-1-yl)propyl]purin-2-amine

6-(4-cyclopentylpiperazin-1-yl)-N-[(4-fluorophenyl)methyl]-9-(3-pyrrolidin-1-ylpropyl)purin-2-amine

6-(4-ethylpiperazin-1-yl)-9-[3-(4-ethylpiperazin-1-yl)propyl]purin-2-amine

N-[[4-[(dimethylamino)methyl]phenyl]methyl]-6-(4-ethylpiperazin-1-yl)-9-(3-pyrrolidin-1-ylpropyl)purin-2-amine

6-methoxy-N-[(4-methoxyphenyl)methyl]-4-(4-methylpiperazin-1-yl)-7-phenylmethoxyquinazolin-2-amine

2-[7-(4-cyclopentylpiperazin-1-yl)imidazo[1,2-a]pyridin-2-yl]-5-methoxyphenol

2-[7-(4-cyclopentylpiperazin-1-yl)-3-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridin-2-yl]-5-methoxyphenol

[4-[2-(4-methoxy-2-phenylmethoxyphenyl)imidazo[1,2-a]pyridin-7-yl]piperazin-1-yl]-phenylmethanone

6-methoxy-N-[(4-methoxyphenyl)methyl]-7-phenylmethoxy-4-piperazin-1-ylquinazolin-2-amine

[4-[2-amino-9-[3-(4-ethylpiperazin-1-yl)propyl]purin-6-yl]piperazin-1-yl]-phenylmethanone

[4-[9-[3-(4-ethylpiperazin-1-yl)propyl]-2-[(4-fluorophenyl)methylamino]purin-6-yl]piperazin-1-yl]-phenylmethanone

6-(4-cyclopentylpiperazin-1-yl)-9-[3-(4-ethylpiperazin-1-yl)propyl]-N-[(4-fluorophenyl)methyl]purin-2-amine

6-(4-cyclopentylpiperazin-1-yl)-9-[3-(4-ethylpiperazin-1-yl)propyl]-N-[(4-methoxyphenyl)methyl]purin-2-amine

[4-[9-[3-(4-ethylpiperazin-1-yl)propyl]-2-pyrrolidin-1-ylpurin-6-yl]piperazin-1-yl]-phenylmethanone

[4-[2-amino-9-[3-(4-ethylpiperazin-1-yl)propyl]purin-6-yl]piperazin-1-yl]-cyclopentylmethanone

cyclopentyl-[4-[9-[3-(4-ethylpiperazin-1-yl)propyl]-2-[(4-methoxyphenyl)methylamino]purin-6-yl]piperazin-1-yl]methanone

cyclopentyl-[4-[9-[3-(4-ethylpiperazin-1-yl)propyl]-2-[(4-fluorophenyl)methylamino]purin-6-yl]piperazin-1-yl]methanone

[4-[9-[3-(4-ethylpiperazin-1-yl)propyl]-2-[(4-methoxyphenyl)methylamino]purin-6-yl]piperazin-1-yl]-phenylmethanone

2-(2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-3-amine

6-methoxy-4-N,4-N-dimethyl-2-N-[3-(4-methylpiperazin-1-yl)propyl]-7-(3-pyrrolidin-1-ylpropoxy)quinazoline-2,4-diamine