General Information of the Compound
Compound ID
CP0564625
Compound Name
5-[(3R,5R)-5-methyl-1-[2-(4-methylpiperazin-1-yl)acetyl]piperidin-3-yl]quinoline-8-carbonitrile
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Structure
Formula
C23H29N5O
Molecular Weight
391.519
Canonical SMILES
C[C@@H]1C[C@@H](CN(C1)C(=O)CN1CCN(C)CC1)c1ccc(C#N)c2ncccc12
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InChI
InChI=1S/C23H29N5O/c1-17-12-19(20-6-5-18(13-24)23-21(20)4-3-7-25-23)15-28(14-17)22(29)16-27-10-8-26(2)9-11-27/h3-7,17,19H,8-12,14-16H2,1-2H3/t17-,19+/m1/s1
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InChIKey
GXPHGRGREUNSQX-MJGOQNOKSA-N
Physicochemical Property
logP
2.30588
Rotatable Bonds
3
Heavy Atom Count
29
Polar Areas
63.47
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 134229210
ChEMBL ID
CHEMBL4279529
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02160, Toll-like receptor 7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 < 1000 nM
   TI
   LI
   LO
   TS