General Information of the Compound
Compound ID
CP0569173
Compound Name
[4-[[2-amino-4-(butylamino)pyrido[3,2-d]pyrimidin-6-yl]methyl]phenyl]methyl-trimethylazanium;chloride
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Structure
Formula
C22H31ClN6
Molecular Weight
414.985
Canonical SMILES
[Cl-].CCCCNc1nc(N)nc2ccc(Cc3ccc(C[N+](C)(C)C)cc3)nc12
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InChI
InChI=1S/C22H31N6.ClH/c1-5-6-13-24-21-20-19(26-22(23)27-21)12-11-18(25-20)14-16-7-9-17(10-8-16)15-28(2,3)4;/h7-12H,5-6,13-15H2,1-4H3,(H3,23,24,26,27);1H/q+1;/p-1
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InChIKey
ZBXIEZGSSPSVNJ-UHFFFAOYSA-M
Physicochemical Property
logP
0.62
Rotatable Bonds
8
Heavy Atom Count
29
Polar Areas
76.72
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 166625937
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02160, Toll-like receptor 7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 5000 nM
   TI
   LI
   LO
   TS
Protein ID: PT02546, Toll-like receptor 8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 3000 nM
   TI
   LI
   LO
   TS