Protein Information

General Information of the Protein

Protein ID	PT01934
Protein Name	Serine/threonine-protein kinase ATR
Secondarily Protein Name	Ataxia telangiectasia and Rad3-related protein FRAP-related protein 1
Gene Name	ATR
Secondarily Gene Name	FRP1
Sequence	MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNWIITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLSQLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYGSPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAGYESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWMSLDFYTKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHGMFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKLAFIDNLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDGFIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKSASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELLLRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLSSSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPELKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIKYATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQGKDFTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETNGPGHQLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLITKVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDDQHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDSMVSTVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGVELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKDVTACLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTLWLDYGTKAYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTDKLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Kinase > Protein Kinase > Atypical protein kinase group > Atypical protein kinase PIKK family
Function	Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:27723717, PubMed:27723720, PubMed:33848395, PubMed:9427750, PubMed:9636169, PubMed:21777809). Recognizes the substrate consensus sequence [ST]-Q (PubMed:10597277, PubMed:10608806, PubMed:10859164, PubMed:11721054, PubMed:12791985, PubMed:12814551, PubMed:14657349, PubMed:14729973, PubMed:14742437, PubMed:15210935, PubMed:15496423, PubMed:16260606, PubMed:21144835, PubMed:27723717, PubMed:27723720, PubMed:33848395, PubMed:9427750, PubMed:9636169). Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis (PubMed:9925639, PubMed:11114888, PubMed:11418864, PubMed:11865061, PubMed:21777809). Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism (PubMed:11673449). Required for FANCD2 ubiquitination (PubMed:15314022). Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication (PubMed:12526805). Positively regulates the restart of stalled replication forks following activation by the KHDC3L-OOEP scaffold complex (By similarity). Show/Hide
Uniprot ID	Primary ID: Q13535 Secondarily ID: Q59HB2 Q7KYL3 Q93051 Q9BXK4 Show/Hide
HGNC ID	HGNC:882
Subcellular Location	Nucleus Chromosome

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000007 , HT-29

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0068245 Compound Info	N-methyl-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C21H26N6O3S	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0669285 Compound Info	US8552004, 2.03 Show/Hide	C21H27N7O2S	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0393368 Compound Info	N-methyl-4-[(10S,14R)-14-methyl-6-(2-methylsulfonylpropan-2-yl)-8,12-dioxa-1,3,5-triazatricyclo[8.4.0.02,7]tetradeca-2,4,6-trien-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-amine Show/Hide	C22H28N6O4S	1
1	IC50 < 10 nM Bioactivity Info	TI LI LO TS
CP0393370 Compound Info	N-methyl-1-[(10S,14R)-14-methyl-6-(2-methylsulfonylpropan-2-yl)-8,12-dioxa-1,3,5-triazatricyclo[8.4.0.02,7]tetradeca-2,4,6-trien-4-yl]imidazol-2-amine Show/Hide	C18H26N6O4S	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0445759 Compound Info	2-[(10S,14R)-14-methyl-4-[5-(methylamino)-1H-pyrrolo[2,3-b]pyridin-4-yl]-8,12-dioxa-1,3,5-triazatricyclo[8.4.0.02,7]tetradeca-2,4,6-trien-6-yl]propan-2-ol Show/Hide	C21H26N6O3	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0493027 Compound Info	(10S,14R)-N,14-dimethyl-6-(2-methylsulfonylpropan-2-yl)-N-(1H-pyrazol-5-yl)-8,12-dioxa-1,3,5-triazatricyclo[8.4.0.02,7]tetradeca-2,4,6-trien-4-amine Show/Hide	C18H26N6O4S	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0566052 Compound Info	N-methyl-1-[(10S,14R)-14-methyl-6-(2-methylsulfonylpropan-2-yl)-8,12-dioxa-1,3,5-triazatricyclo[8.4.0.02,7]tetradeca-2,4,6-trien-4-yl]benzimidazol-2-amine Show/Hide	C22H28N6O4S	1
1	IC50 < 10 nM Bioactivity Info	TI LI LO TS
CP0567492 Compound Info	N-ethyl-4-[(10S,14R)-14-methyl-6-(2-methylsulfonylpropan-2-yl)-8,12-dioxa-1,3,5-triazatricyclo[8.4.0.02,7]tetradeca-2,4,6-trien-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-amine Show/Hide	C23H30N6O4S	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0068244 Compound Info	(3R)-3-methyl-4-[6-(1-methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-c]pyridin-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C20H23N5O3S	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0402721 Compound Info	US9428503, CN102399218A: Compound 94 Show/Hide	C20H20N6O2	1
1	IC50 = 12.9 nM Bioactivity Info	TI LI LO TS
CP0893331 Compound Info	(3R)-3-methyl-4-(6-(1-(S-methylsulfonimidoyl)cyclopropyl)-2-(1H-pyrrolo[2,3-c]pyridin-4-yl)pyrimidin-4-yl)morpholine Show/Hide	C20H24N6O2S	1
1	IC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0354837 Compound Info	1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C20H24N6O3S	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0076584 Compound Info	N-[1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-yl]acetamide Show/Hide	C22H26N6O4S	1
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0168855 Compound Info	N-methyl-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-[1-(methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C21H27N7O2S	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0928862 Compound Info	4-{[Diethyl(oxido)-lambda6-sulfanylidene]amino}-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine Show/Hide	C20H26N6O2S	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0946954 Compound Info	3,3-Dimethyl-2-{2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-4-yl}butan-2-ol Show/Hide	C22H29N5O2	1
1	IC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0168728 Compound Info	5-fluoro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C20H23FN6O3S	1
1	IC50 = 35 nM Bioactivity Info	TI LI LO TS
CP0639539 Compound Info	2-[(3R)-3-Methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine Show/Hide	C20H21N7O	1
1	IC50 = 36 nM Bioactivity Info	TI LI LO TS
CP0946950 Compound Info	4-(2-Fluoropyridin-3-yl)-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine Show/Hide	C21H19FN6O	1
1	IC50 = 44 nM Bioactivity Info	TI LI LO TS
CP0068243 Compound Info	(3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine Show/Hide	C21H24N4O3S	2
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
2	IC50 = 61 nM Bioactivity Info	TI LI LO TS
CP0472913 Compound Info	1-(oxan-4-yl)-8-pyridin-3-yl-3H-imidazo[4,5-c]quinolin-2-one Show/Hide	C20H18N4O2	1
1	IC50 = 51 nM Bioactivity Info	TI LI LO TS
CP0076577 Compound Info	1-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C19H22N6O3S	1
1	IC50 = 51 nM Bioactivity Info	TI LI LO TS
CP0413611 Compound Info	US9428503, CN102399218A: Compound 62 Show/Hide	C21H17N5O	1
1	IC50 = 55.3 nM Bioactivity Info	TI LI LO TS
CP0904636 Compound Info	2-[(3R)-3-Methylmorpholin-4-yl]-4-[4-(methylsulfonyl)piperazin-1-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine Show/Hide	C21H27N7O3S	1
1	IC50 = 59 nM Bioactivity Info	TI LI LO TS
CP0529511 Compound Info	US9428503, CN102372711A: Compound 5 Show/Hide	C24H25N5O3	1
1	IC50 = 64.4 nM Bioactivity Info	TI LI LO TS
CP0958487 Compound Info	2-[(3R)-3-Methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-4-(tetrahydro-2H-pyran-4-yl)-1,7-naphthyridine Show/Hide	C21H25N5O2	1
1	IC50 = 66 nM Bioactivity Info	TI LI LO TS
CP0495550 Compound Info	US9428503, CN102399218A: Compound 114 Show/Hide	C23H23N5O4S	1
1	IC50 = 68.6 nM Bioactivity Info	TI LI LO TS
CP0518461 Compound Info	US9428503, CN102372711A: Compound 4 Show/Hide	C24H25N5O4	1
1	IC50 = 68.6 nM Bioactivity Info	TI LI LO TS
CP0901623 Compound Info	N-(4-Fluorophenyl)-N-methyl-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-4-amine Show/Hide	C23H23FN6O	1
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0808811 Compound Info	CERALASERTIB Show/Hide	C20H24N6O2S	1
1	IC50 = 74 nM Bioactivity Info	TI LI LO TS
CP0912067 Compound Info	4-(2-Methyl-1H-imidazol-1-yl)-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine Show/Hide	C20H21N7O	1
1	IC50 = 76 nM Bioactivity Info	TI LI LO TS
CP0901624 Compound Info	4-(6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl)-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine Show/Hide	C22H23N7O	1
1	IC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0076581 Compound Info	4-[6-(1-methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-c]pyridin-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C19H21N5O3S	1
1	IC50 = 85 nM Bioactivity Info	TI LI LO TS
CP0081365 Compound Info	3-[6-(1-methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-c]pyridin-4-yl)pyrimidin-4-yl]-8-oxa-3-azabicyclo[3.2.1]octane Show/Hide	C21H23N5O3S	1
1	IC50 = 86 nM Bioactivity Info	TI LI LO TS
CP0867459 Compound Info	2-[(3R)-3-Methylmorpholin-4-yl]-4-[1-(methylsulfonyl)-cyclopropyl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine Show/Hide	C20H23N5O3S	1
1	IC50 = 86 nM Bioactivity Info	TI LI LO TS
CP0412368 Compound Info	3-methyl-1-(oxan-4-yl)-8-pyridin-3-ylimidazo[4,5-c]quinolin-2-one Show/Hide	C21H20N4O2	1
1	IC50 = 87 nM Bioactivity Info	TI LI LO TS
CP0314495 Compound Info	(3R)-3-methyl-4-[6-[1-[(S)-methylsulfinyl]cyclopropyl]-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C20H23N5O2S	1
1	IC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0076580 Compound Info	(3R)-3-methyl-4-[6-(1-methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C20H23N5O3S	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0145081 Compound Info	3-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-8-oxa-3-azabicyclo[3.2.1]octane Show/Hide	C22H24N4O3S	2
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
2	IC50 = 350 nM Bioactivity Info	TI LI LO TS
CP0514493 Compound Info	6-fluoro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C20H23FN6O3S	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0102647 Compound Info	4-fluoro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C20H23FN6O3S	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0130832 Compound Info	4-[2-(6-fluoro-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C20H21FN4O3S	2
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
2	IC50 = 440 nM Bioactivity Info	TI LI LO TS
CP0958488 Compound Info	4-Isopropoxy-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine Show/Hide	C19H23N5O2	1
1	IC50 = 154 nM Bioactivity Info	TI LI LO TS
CP0406920 Compound Info	US9428503, CN102399218A: Compound 64 Show/Hide	C18H16N6O	1
1	IC50 = 162 nM Bioactivity Info	TI LI LO TS
CP0085622 Compound Info	4-[2-(1H-indol-4-yl)-6-(4-methylsulfonyloxan-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C22H26N4O4S	1
1	IC50 = 180 nM Bioactivity Info	TI LI LO TS
CP0168854 Compound Info	(3R)-3-methyl-4-[6-[1-[(R)-methylsulfinyl]cyclopropyl]-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C20H23N5O2S	1
1	IC50 = 180 nM Bioactivity Info	TI LI LO TS
CP0895134 Compound Info	2-[(3R)-3-Methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-4-(pyridin-3-ylethynyl)-1,7-naphthyridine Show/Hide	C23H20N6O	1
1	IC50 = 227 nM Bioactivity Info	TI LI LO TS
CP0241870 Compound Info	BDBM103466 Show/Hide	C20H24N6O2S	1
1	IC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0081366 Compound Info	8-[6-(1-methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-c]pyridin-4-yl)pyrimidin-4-yl]-3-oxa-8-azabicyclo[3.2.1]octane Show/Hide	C21H23N5O3S	1
1	IC50 = 260 nM Bioactivity Info	TI LI LO TS
CP0902619 Compound Info	4-[2-Methyl-6-(S-methylsulfonimidoyl)pyridin-3-yl]-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine Show/Hide	C23H25N7O2S	1
1	IC50 = 266 nM Bioactivity Info	TI LI LO TS
CP0565273 Compound Info	4-[4-(3,6-dihydro-2H-pyran-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]-1H-indole Show/Hide	C21H21N3O3S	1
1	IC50 = 270 nM Bioactivity Info	TI LI LO TS
CP0157307 Compound Info	4-[2-(1H-indol-4-yl)-6-(2-methylsulfonylpropan-2-yl)pyrimidin-4-yl]morpholine Show/Hide	C20H24N4O3S	1
1	IC50 = 280 nM Bioactivity Info	TI LI LO TS
CP0413610 Compound Info	US9428503, CN102372711A: Compound 1 Show/Hide	C22H23N5O2	1
1	IC50 = 281 nM Bioactivity Info	TI LI LO TS
CP0939308 Compound Info	4-(Diethylphosphoryl)-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-1,7-naphthyridine Show/Hide	C20H26N5O2P	1
1	IC50 = 289 nM Bioactivity Info	TI LI LO TS
CP0102640 Compound Info	4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C20H22N4O3S	2
1	IC50 = 290 nM Bioactivity Info	TI LI LO TS
2	IC50 = 360 nM Bioactivity Info	TI LI LO TS
CP0404754 Compound Info	4-[6-(1-methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C19H21N5O3S	1
1	IC50 = 350 nM Bioactivity Info	TI LI LO TS
CP0514510 Compound Info	(3S)-3-methyl-4-[6-(1-methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-c]pyridin-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C20H23N5O3S	1
1	IC50 = 360 nM Bioactivity Info	TI LI LO TS
CP0287648 Compound Info	3-amino-6-(4-((4-hydroxybutan-2-yl)sulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C21H22N4O4S	1
1	IC50 = 380 nM Bioactivity Info	TI LI LO TS
CP0421059 Compound Info	US10772893, Example 7 Show/Hide	C22H21N5O3S	1
1	IC50 = 380 nM Bioactivity Info	TI LI LO TS
CP0563148 Compound Info	US9428503, CN102399218A: Compound 60 Show/Hide	C22H25N5O3	1
1	IC50 = 418 nM Bioactivity Info	TI LI LO TS
CP0050427 Compound Info	3-amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfonyl)-phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C22H25N5O3S	1
1	IC50 = 420 nM Bioactivity Info	TI LI LO TS
CP0076974 Compound Info	4-[2-(1H-indol-4-yl)-6-(4-methylsulfonylpiperidin-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C22H27N5O3S	1
1	IC50 = 420 nM Bioactivity Info	TI LI LO TS
CP0527886 Compound Info	US10772893, Example 40 Show/Hide	C18H21N5O2	1
1	IC50 = 424 nM Bioactivity Info	TI LI LO TS
CP0222476 Compound Info	(R)-3-amino-N-phenyl-6-(4-((tetrahydrofuran-3-yl)sulfonyl)-phenyl)pyrazine-2-carboxamide Show/Hide	C21H20N4O4S	1
1	IC50 = 460 nM Bioactivity Info	TI LI LO TS
CP0186550 Compound Info	4-[2-(6-methyl-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C21H24N4O3S	1
1	IC50 = 490 nM Bioactivity Info	TI LI LO TS
CP0256504 Compound Info	4-[6-[1-(benzenesulfonyl)cyclopropyl]-2-(1H-indol-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C25H24N4O3S	1
1	IC50 = 590 nM Bioactivity Info	TI LI LO TS
CP0362355 Compound Info	4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C21H20N6O	1
1	IC50 = 640 nM Bioactivity Info	TI LI LO TS
CP0130830 Compound Info	4-[2-(6-chloro-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C20H21ClN4O3S	1
1	IC50 = 720 nM Bioactivity Info	TI LI LO TS
CP0480277 Compound Info	4-(2-ethylbutylamino)-6-pyridin-4-ylquinoline-3-carboxamide Show/Hide	C21H24N4O	1
1	IC50 = 730 nM Bioactivity Info	TI LI LO TS
CP0345264 Compound Info	4-[2-(1H-indol-4-yl)-6-(1-propan-2-ylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C22H26N4O3S	1
1	IC50 = 770 nM Bioactivity Info	TI LI LO TS
CP0304424 Compound Info	4-[2-(6-methoxy-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C21H24N4O4S	1
1	IC50 = 800 nM Bioactivity Info	TI LI LO TS
CP0249222 Compound Info	5-chloro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C20H23ClN6O3S	1
1	IC50 = 870 nM Bioactivity Info	TI LI LO TS
CP0180289 Compound Info	3-amino-6-(4-(isopropylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C20H20N4O3S	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0212807 Compound Info	3-amino-6-(4-(tert-butylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C21H22N4O3S	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0341198 Compound Info	3-amino-6-(4-(azetidine-1-carbonyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C21H19N5O2	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0085620 Compound Info	4-[2-(1H-indol-4-yl)-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine Show/Hide	C18H20N4O3S	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0364430 Compound Info	4-(cyclopentylamino)-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C20H20N4O	1
1	IC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0480891 Compound Info	US9428503, 40 Show/Hide	C25H29N5O3	1
1	IC50 = 1330 nM Bioactivity Info	TI LI LO TS
CP0271874 Compound Info	3-amino-N-phenyl-6-(4-(pyrrolidine-1-carbonyl)phenyl)-pyrazine-2-carboxamide Show/Hide	C22H21N5O2	1
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0508027 Compound Info	US9428503, CN102399218A: Compound 61 Show/Hide	C21H18N6O	1
1	IC50 = 1480 nM Bioactivity Info	TI LI LO TS
CP0199334 Compound Info	3-amino-6-(4-(ethylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C19H18N4O3S	1
1	IC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0130833 Compound Info	4-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1H-indole-6-carbonitrile Show/Hide	C21H21N5O3S	1
1	IC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0199392 Compound Info	3-amino-6-(4-(sec-butylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C21H22N4O3S	1
1	IC50 = 1600 nM Bioactivity Info	TI LI LO TS
CP0234613 Compound Info	4-[[(1R)-1-(4-chlorophenyl)ethyl]amino]-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C23H19ClN4O	1
1	IC50 = 1900 nM Bioactivity Info	TI LI LO TS
CP0050429 Compound Info	3-amino-6-(4-(dimethylcarbamoyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C20H19N5O2	1
1	IC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0171816 Compound Info	3-amino-N-phenyl-6-(4-(propylsulfonyl)phenyl)pyrazine-2-carboxamide Show/Hide	C20H20N4O3S	1
1	IC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0076973 Compound Info	4-[2-(1H-indol-4-yl)-6-(1-pyridin-2-ylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C24H23N5O3S	1
1	IC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0427439 Compound Info	8-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-3-methyl-1-(oxan-4-yl)imidazo[4,5-c][1,5]naphthyridin-2-one Show/Hide	C25H30N6O3	1
1	IC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0265453 Compound Info	4-[2-(2-methyl-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C21H24N4O3S	1
1	IC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0473927 Compound Info	4-(2-ethylbutylamino)-6-pyridazin-4-ylquinoline-3-carboxamide Show/Hide	C20H23N5O	1
1	IC50 = 2600 nM Bioactivity Info	TI LI LO TS
CP0474996 Compound Info	US9428503, 43 Show/Hide	C25H29N5O3	1
1	IC50 = 2690 nM Bioactivity Info	TI LI LO TS
CP0130834 Compound Info	4-[2-(1H-indol-4-yl)-6-[1-(oxan-4-ylsulfonyl)cyclopropyl]pyrimidin-4-yl]morpholine Show/Hide	C24H28N4O4S	1
1	IC50 = 2800 nM Bioactivity Info	TI LI LO TS
CP0310474 Compound Info	4-[2-(1H-indol-4-yl)-6-(1-piperidin-4-ylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C24H29N5O3S	1
1	IC50 = 2900 nM Bioactivity Info	TI LI LO TS
CP0265668 Compound Info	4-(cyclohexylmethylamino)-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C22H24N4O	1
1	IC50 = 3000 nM Bioactivity Info	TI LI LO TS
CP0164861 Compound Info	4-(oxan-4-ylamino)-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C20H20N4O2	1
1	IC50 = 3100 nM Bioactivity Info	TI LI LO TS
CP0556348 Compound Info	4-(cyclohexylamino)-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C21H22N4O	1
1	IC50 = 3200 nM Bioactivity Info	TI LI LO TS
CP0473945 Compound Info	4-[[(1R)-1-(oxan-4-yl)ethyl]amino]-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C22H24N4O2	1
1	IC50 = 3500 nM Bioactivity Info	TI LI LO TS
CP0130829 Compound Info	(3S)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine Show/Hide	C21H24N4O3S	1
1	IC50 = 3700 nM Bioactivity Info	TI LI LO TS
CP0333714 Compound Info	4-[2-(1H-indol-4-yl)-6-(1-methyl-4-methylsulfonylpiperidin-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C23H29N5O3S	1
1	IC50 = 3700 nM Bioactivity Info	TI LI LO TS
CP0451943 Compound Info	US9428503, 41 Show/Hide	C25H29N5O3	1
1	IC50 = 3940 nM Bioactivity Info	TI LI LO TS
CP0472916 Compound Info	US9428503, 42 Show/Hide	C25H29N5O3	2
1	IC50 = 4370 nM Bioactivity Info	TI LI LO TS
2	IC50 = 4400 nM Bioactivity Info	TI LI LO TS
CP0130828 Compound Info	(3R)-3-ethyl-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C22H26N4O3S	1
1	IC50 = 4400 nM Bioactivity Info	TI LI LO TS
CP0180782 Compound Info	6-cyano-4-(2-ethylbutylamino)quinoline-3-carboxamide Show/Hide	C17H20N4O	1
1	IC50 = 4400 nM Bioactivity Info	TI LI LO TS
CP0180780 Compound Info	4-[[(1R)-1-(4-chlorophenyl)ethyl]amino]-6-cyanoquinoline-3-carboxamide Show/Hide	C19H15ClN4O	1
1	IC50 = 4700 nM Bioactivity Info	TI LI LO TS
CP0533485 Compound Info	7-fluoro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C20H23FN6O3S	1
1	IC50 = 5100 nM Bioactivity Info	TI LI LO TS
CP0136765 Compound Info	4-methoxy-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C21H26N6O4S	1
1	IC50 = 5300 nM Bioactivity Info	TI LI LO TS
CP0249202 Compound Info	4-chloro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C20H23ClN6O3S	1
1	IC50 = 5300 nM Bioactivity Info	TI LI LO TS
CP0160334 Compound Info	3-amino-6-(4-(methylsulfinyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C18H16N4O2S	1
1	IC50 = 5400 nM Bioactivity Info	TI LI LO TS
CP0364431 Compound Info	4-(2-ethylbutylamino)-6-(6-methylpyridin-3-yl)quinoline-3-carboxamide Show/Hide	C22H26N4O	1
1	IC50 = 5500 nM Bioactivity Info	TI LI LO TS
CP0839448 Compound Info	2-((2S,3R)-2-Benzyl-3-methylpyrrolidin-1-yl)-6-morpholinopyrimidin-4(3H)-one Show/Hide	C20H26N4O2	1
1	IC50 = 5500 nM Bioactivity Info	TI LI LO TS
CP0127298 Compound Info	US9428503, 1 Show/Hide	C26H31N5O3	2
1	IC50 = 6160 nM Bioactivity Info	TI LI LO TS
2	IC50 = 6200 nM Bioactivity Info	TI LI LO TS
CP0314494 Compound Info	4-[2-(1H-benzimidazol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C19H21N5O3S	2
1	IC50 = 6200 nM Bioactivity Info	TI LI LO TS
2	IC50 = 8900 nM Bioactivity Info	TI LI LO TS
CP0256503 Compound Info	4-[2-(7-methyl-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C21H24N4O3S	1
1	IC50 = 6300 nM Bioactivity Info	TI LI LO TS
CP0199330 Compound Info	3-amino-N-phenyl-6-(4-(piperidine-1-carbonyl)phenyl)pyrazine-2-carboxamide Show/Hide	C23H23N5O2	1
1	IC50 = 6500 nM Bioactivity Info	TI LI LO TS
CP0534989 Compound Info	4-(2-ethylbutylamino)-6-(1-methylpyrazol-4-yl)quinoline-3-carboxamide Show/Hide	C20H25N5O	1
1	IC50 = 7100 nM Bioactivity Info	TI LI LO TS
CP0193494 Compound Info	4-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1H-indole-2-carbonitrile Show/Hide	C21H21N5O3S	1
1	IC50 = 7200 nM Bioactivity Info	TI LI LO TS
CP0457022 Compound Info	US9428503, 66 Show/Hide	C29H35N5O3	1
1	IC50 = 7850 nM Bioactivity Info	TI LI LO TS
CP0955420 Compound Info	(R)-6-(2-Benzylpiperidin-1-yl)-4-morpholinopyridin-2(1H)-one Show/Hide	C21H27N3O2	1
1	IC50 = 8000 nM Bioactivity Info	TI LI LO TS
CP0180814 Compound Info	2-morpholin-4-yl-6-(9H-thioxanthen-4-yl)pyran-4-one Show/Hide	C22H19NO3S	1
1	IC50 = 8500 nM Bioactivity Info	TI LI LO TS
CP0333713 Compound Info	4-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1H-indole-6-carboxamide Show/Hide	C21H23N5O4S	1
1	IC50 = 9200 nM Bioactivity Info	TI LI LO TS
CP0476587 Compound Info	US9428503, 45 Show/Hide	C25H29N5O3	1
1	IC50 = 9600 nM Bioactivity Info	TI LI LO TS
CP0470735 Compound Info	N,N-dimethyl-3-[5-[3-methyl-1-(oxan-4-yl)-2-oxoimidazo[4,5-c]quinolin-8-yl]pyridin-2-yl]oxypropan-1-amine oxide Show/Hide	C26H31N5O4	1
1	IC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0457002 Compound Info	US9428503, 39 Show/Hide	C27H31N5O3	1
1	IC50 = 10700 nM Bioactivity Info	TI LI LO TS
CP0451374 Compound Info	US9428503, 7 Show/Hide	C27H33N5O3	1
1	IC50 = 10800 nM Bioactivity Info	TI LI LO TS
CP0446983 Compound Info	4-(oxan-4-ylmethylamino)-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C21H22N4O2	1
1	IC50 = 11000 nM Bioactivity Info	TI LI LO TS
CP0558413 Compound Info	4-(2-ethylbutylamino)-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C21H24N4O	1
1	IC50 > 11000 nM Bioactivity Info	TI LI LO TS
CP0291454 Compound Info	3-amino-6-(3-chloro-4-(dimethylcarbamoyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C20H18ClN5O2	1
1	IC50 = 12000 nM Bioactivity Info	TI LI LO TS
CP0315929 Compound Info	4-[2-(1H-indazol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C19H21N5O3S	1
1	IC50 = 13000 nM Bioactivity Info	TI LI LO TS
CP0145049 Compound Info	8-[6-(methoxymethyl)pyridin-3-yl]-3-methyl-1-(oxan-4-yl)imidazo[4,5-c]quinolin-2-one Show/Hide	C23H24N4O3	1
1	IC50 > 13000 nM Bioactivity Info	TI LI LO TS
CP0180774 Compound Info	4-(2-ethylbutylamino)-6-[6-(hydroxymethyl)pyridin-3-yl]quinoline-3-carboxamide Show/Hide	C22H26N4O2	1
1	IC50 > 13000 nM Bioactivity Info	TI LI LO TS
CP0953819 Compound Info	6-((1S,2S,5R)-2-Benzyl-3-azabicyclo[3.1.0]hexan-3-yl)-4-((R)-2-methylmorpholino)pyridin-2(1H)-one Show/Hide	C22H27N3O2	1
1	IC50 = 13000 nM Bioactivity Info	TI LI LO TS
CP0180772 Compound Info	4-[[(1S)-1-(oxan-4-yl)ethyl]amino]-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C22H24N4O2	1
1	IC50 > 14000 nM Bioactivity Info	TI LI LO TS
CP0076582 Compound Info	N-methyl-4-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1H-indole-6-carboxamide Show/Hide	C22H25N5O4S	2
1	IC50 = 15000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 16500 nM Bioactivity Info	TI LI LO TS
CP0438313 Compound Info	7-fluoro-8-[6-(hydroxymethyl)pyridin-3-yl]-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-one Show/Hide	C22H21FN4O3	1
1	IC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0444138 Compound Info	5-methoxy-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C21H26N6O4S	1
1	IC50 = 15000 nM Bioactivity Info	TI LI LO TS
CP0549742 Compound Info	4-(2-ethylbutylamino)-6-pyridazin-3-ylquinoline-3-carboxamide Show/Hide	C20H23N5O	1
1	IC50 > 15000 nM Bioactivity Info	TI LI LO TS
CP0497632 Compound Info	US9428503, 67 Show/Hide	C29H35N5O3	1
1	IC50 = 15200 nM Bioactivity Info	TI LI LO TS
CP0145086 Compound Info	4-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1,3-dihydroindol-2-one Show/Hide	C20H22N4O4S	1
1	IC50 = 16000 nM Bioactivity Info	TI LI LO TS
CP0232291 Compound Info	7-fluoro-1-(3-methoxycyclobutyl)-3-methyl-8-[6-(methylsulfonylmethyl)pyridin-3-yl]imidazo[4,5-c]quinolin-2-one Show/Hide	C23H23FN4O4S	1
1	IC50 > 16000 nM Bioactivity Info	TI LI LO TS
CP0497631 Compound Info	US9428503, 55 Show/Hide	C28H33N5O3	1
1	IC50 > 16100 nM Bioactivity Info	TI LI LO TS
CP0861326 Compound Info	US9428503, 35 Show/Hide	C27H31N5O3	1
1	IC50 = 17800 nM Bioactivity Info	TI LI LO TS
CP0180773 Compound Info	4-(2-ethylbutylamino)-6-pyrimidin-5-ylquinoline-3-carboxamide Show/Hide	C20H23N5O	1
1	IC50 > 18000 nM Bioactivity Info	TI LI LO TS
CP0259633 Compound Info	4-[[(1R)-1-(1-methylpyrazol-3-yl)ethyl]amino]-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C21H20N6O	1
1	IC50 > 18000 nM Bioactivity Info	TI LI LO TS
CP0563158 Compound Info	US9428503, 24 Show/Hide	C28H32FN5O3	1
1	IC50 > 18800 nM Bioactivity Info	TI LI LO TS
CP0483520 Compound Info	US9428503, 29 Show/Hide	C28H33N5O3	1
1	IC50 = 19000 nM Bioactivity Info	TI LI LO TS
CP0518510 Compound Info	US9428503, 30 Show/Hide	C28H33N5O3	1
1	IC50 = 19000 nM Bioactivity Info	TI LI LO TS
CP0180777 Compound Info	7-fluoro-6-[6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]quinoline-3-carboxamide Show/Hide	C23H23FN6O2	1
1	IC50 > 19000 nM Bioactivity Info	TI LI LO TS
CP0474997 Compound Info	US9428503, 59 Show/Hide	C28H33N5O3	1
1	IC50 > 19100 nM Bioactivity Info	TI LI LO TS
CP0474823 Compound Info	US9428503, 44 Show/Hide	C25H29N5O3	1
1	IC50 > 19200 nM Bioactivity Info	TI LI LO TS
CP0164866 Compound Info	7-fluoro-8-[6-(methoxymethyl)pyridin-3-yl]-3-methyl-1-(oxan-4-yl)imidazo[4,5-c]quinolin-2-one Show/Hide	C23H23FN4O3	1
1	IC50 > 20000 nM Bioactivity Info	TI LI LO TS
CP0480889 Compound Info	US9428503, 25 Show/Hide	C27H33N5O3	1
1	IC50 > 20700 nM Bioactivity Info	TI LI LO TS
CP0457001 Compound Info	US9428503, 26 Show/Hide	C27H33N5O3	1
1	IC50 > 21800 nM Bioactivity Info	TI LI LO TS
CP0483112 Compound Info	US9428503, 54 Show/Hide	C28H33N5O3	1
1	IC50 > 22400 nM Bioactivity Info	TI LI LO TS
CP0145048 Compound Info	US9428503, 16 Show/Hide	C26H31N5O3	2
1	IC50 > 22800 nM Bioactivity Info	TI LI LO TS
2	IC50 > 23000 nM Bioactivity Info	TI LI LO TS
CP0393906 Compound Info	US9428503, 28 Show/Hide	C28H33N5O3	2
1	IC50 > 22800 nM Bioactivity Info	TI LI LO TS
2	IC50 > 24000 nM Bioactivity Info	TI LI LO TS
CP0491233 Compound Info	4-cyclopentylsulfanyl-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C20H19N3OS	1
1	IC50 > 23000 nM Bioactivity Info	TI LI LO TS
CP0480890 Compound Info	US9428503, 27 Show/Hide	C28H32FN5O3	1
1	IC50 > 23300 nM Bioactivity Info	TI LI LO TS
CP0315928 Compound Info	N,N-dimethyl-4-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1H-indole-6-carboxamide Show/Hide	C23H27N5O4S	1
1	IC50 = 24000 nM Bioactivity Info	TI LI LO TS
CP0164887 Compound Info	US9428503, 38 Show/Hide	C27H31N5O3	2
1	IC50 > 24000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 24400 nM Bioactivity Info	TI LI LO TS
CP0457004 Compound Info	US9428503, 64 Show/Hide	C30H38N6O2	1
1	IC50 > 24100 nM Bioactivity Info	TI LI LO TS
CP0246126 Compound Info	US9428503, 33 Show/Hide	C29H35N5O3	2
1	IC50 > 24700 nM Bioactivity Info	TI LI LO TS
2	IC50 > 2600 nM Bioactivity Info	TI LI LO TS
CP0512613 Compound Info	US9428503, 70 Show/Hide	C27H32FN5O3	1
1	IC50 > 24900 nM Bioactivity Info	TI LI LO TS
CP0180778 Compound Info	6-[2-fluoro-6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]quinoline-3-carboxamide Show/Hide	C23H23FN6O2	1
1	IC50 > 25000 nM Bioactivity Info	TI LI LO TS
CP0907953 Compound Info	US9428503, 12 Show/Hide	C25H29N5O3	1
1	IC50 > 25200 nM Bioactivity Info	TI LI LO TS
CP0497634 Compound Info	US9428503, 46 Show/Hide	C25H29N5O2	1
1	IC50 > 26000 nM Bioactivity Info	TI LI LO TS
CP0235599 Compound Info	7-fluoro-1-(4-methoxycyclohexyl)-8-[6-(methoxymethyl)pyridin-3-yl]-3-methylimidazo[4,5-c]quinolin-2-one Show/Hide	C25H27FN4O3	1
1	IC50 > 26000 nM Bioactivity Info	TI LI LO TS
CP0406927 Compound Info	US9428503, 65 Show/Hide	C30H38N6O2	1
1	IC50 > 26600 nM Bioactivity Info	TI LI LO TS
CP0451372 Compound Info	US9428503, 53 Show/Hide	C29H34FN5O3	2
1	IC50 > 27100 nM Bioactivity Info	TI LI LO TS
2	IC50 > 29000 nM Bioactivity Info	TI LI LO TS
CP0538859 Compound Info	1-(oxan-4-yl)-3-propan-2-yl-8-pyridin-3-ylimidazo[4,5-c]quinolin-2-one Show/Hide	C23H24N4O2	1
1	IC50 > 27600 nM Bioactivity Info	TI LI LO TS
CP0164867 Compound Info	7-fluoro-1-(3-methoxycyclobutyl)-8-[6-(methoxymethyl)pyridin-3-yl]-3-methylimidazo[4,5-c]quinolin-2-one Show/Hide	C23H23FN4O3	1
1	IC50 > 28000 nM Bioactivity Info	TI LI LO TS
CP0451373 Compound Info	US9428503, 58 Show/Hide	C27H31N5O2	1
1	IC50 > 28100 nM Bioactivity Info	TI LI LO TS
CP0472915 Compound Info	US9428503, 2 Show/Hide	C26H31N5O3	2
1	IC50 > 29000 nM Bioactivity Info	TI LI LO TS
2	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0476588 Compound Info	US9428503, 68 Show/Hide	C27H32FN5O3	1
1	IC50 > 29000 nM Bioactivity Info	TI LI LO TS
CP0473312 Compound Info	7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one Show/Hide	C18H20N8O2	1
1	IC50 > 29000 nM Bioactivity Info	TI LI LO TS
CP0483521 Compound Info	US9428503, 37 Show/Hide	C29H35N5O3	1
1	IC50 > 29400 nM Bioactivity Info	TI LI LO TS
CP0476585 Compound Info	US9428503, 11 Show/Hide	C26H30FN5O3	1
1	IC50 > 29600 nM Bioactivity Info	TI LI LO TS
CP0085621 Compound Info	4-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1H-indole-2-carboxamide Show/Hide	C21H23N5O4S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0123538 Compound Info	4-[2-(1H-indol-5-yl)-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine Show/Hide	C18H20N4O3S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0145082 Compound Info	4-[2-(3-methyl-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C21H24N4O3S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0193495 Compound Info	4-[2-(1H-indol-7-yl)-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine Show/Hide	C18H20N4O3S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0265455 Compound Info	4-[2-(1-methylindol-4-yl)-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine Show/Hide	C19H22N4O3S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0315930 Compound Info	3-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]aniline Show/Hide	C18H22N4O3S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0333715 Compound Info	4-[2-(1H-indol-6-yl)-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine Show/Hide	C18H20N4O3S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0345262 Compound Info	4-[2-(5-methyl-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C21H24N4O3S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0345263 Compound Info	4-[6-(1-methylsulfonylcyclopropyl)-2-phenylpyrimidin-4-yl]morpholine Show/Hide	C18H21N3O3S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0093702 Compound Info	US9156831, 1 Show/Hide	C21H29N9O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0093703 Compound Info	US9156831, 7 Show/Hide	C22H31N9O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0143273 Compound Info	US9156831, 3 Show/Hide	C22H31N9O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0173540 Compound Info	US9156831, 6 Show/Hide	C22H31N9O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0283502 Compound Info	US9156831, 8 Show/Hide	C21H27N9O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0068686 Compound Info	US9428503, 18 Show/Hide	C26H30FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0081675 Compound Info	US9428503, 4 Show/Hide	C24H27N5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0145046 Compound Info	US9428503, 17 Show/Hide	C26H31N5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0164865 Compound Info	US9428503, 8 Show/Hide	C26H30FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0228362 Compound Info	US9428503, 5 Show/Hide	C25H29N5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0438311 Compound Info	US9428503, 19 Show/Hide	C26H29F2N5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0438312 Compound Info	US9428503, 6 Show/Hide	C26H30FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0445207 Compound Info	US9428503, 31 Show/Hide	C29H35N5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0451370 Compound Info	US9428503, 47 Show/Hide	C29H34FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0451371 Compound Info	US9428503, 52 Show/Hide	C24H26FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0457000 Compound Info	US9428503, 22 Show/Hide	C26H30FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0457005 Compound Info	US9428503, 71 Show/Hide	C27H32FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0457020 Compound Info	US9428503, 20 Show/Hide	C26H30FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0457021 Compound Info	US9428503, 49 Show/Hide	C25H28FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0457024 Compound Info	US9428503, 3 Show/Hide	C27H32FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0457026 Compound Info	US9428503, 10 Show/Hide	C26H30FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0474824 Compound Info	US9428503, 56 Show/Hide	C27H31N5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0474994 Compound Info	US9428503, 14 Show/Hide	C26H29N5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0474995 Compound Info	US9428503, 15 Show/Hide	C27H31N5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0476586 Compound Info	US9428503, 13 Show/Hide	C25H29N5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0480888 Compound Info	US9428503, 9 Show/Hide	C24H26FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0481097 Compound Info	US9428503, 57 Show/Hide	C28H33N5O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0483063 Compound Info	US9428503, 48 Show/Hide	C26H29F2N5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0483510 Compound Info	US9428503, 32 Show/Hide	C29H35N5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0483512 Compound Info	US9428503, 51 Show/Hide	C25H28FN5O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0483519 Compound Info	US9428503, 21 Show/Hide	C26H30FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0483523 Compound Info	US9428503, 50 Show/Hide	C25H28FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0491473 Compound Info	US9428503, 23 Show/Hide	C28H32FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0492967 Compound Info	US9428503, 69 Show/Hide	C27H32FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0507339 Compound Info	US9428503, 36 Show/Hide	C28H33N5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0512612 Compound Info	US9428503, 61 Show/Hide	C28H32FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0518509 Compound Info	US9428503, 63 Show/Hide	C27H32FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0164862 Compound Info	8-[6-[2-(dimethylamino)ethoxy]pyridin-3-yl]-7-fluoro-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-one Show/Hide	C25H28FN5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0164863 Compound Info	8-[6-[2-(dimethylamino)ethyl-methylamino]pyridin-3-yl]-7-fluoro-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-one Show/Hide	C26H31FN6O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0164864 Compound Info	7-fluoro-8-[6-(methoxymethyl)pyridin-3-yl]-3-methyl-1-[(1S)-1-(oxan-4-yl)ethyl]imidazo[4,5-c]quinolin-2-one Show/Hide	C25H27FN4O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0164868 Compound Info	7-fluoro-1-(3-methoxycyclobutyl)-8-[6-(methoxymethyl)pyridin-3-yl]-3-methylimidazo[4,5-c]quinolin-2-one Show/Hide	C23H23FN4O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0235616 Compound Info	8-[6-[2-(dimethylamino)ethylamino]pyridin-3-yl]-7-fluoro-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-one Show/Hide	C25H29FN6O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0427440 Compound Info	8-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-3-methyl-1-(oxan-4-yl)imidazo[4,5-c]cinnolin-2-one Show/Hide	C25H30N6O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0427456 Compound Info	1-(3-methoxycyclobutyl)-3-methyl-8-[6-(3-morpholin-4-ylpropoxy)pyridin-3-yl]imidazo[4,5-c]quinolin-2-one Show/Hide	C28H33N5O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0438314 Compound Info	4-(dimethylamino)-N-[5-[7-fluoro-1-(3-methoxycyclobutyl)-3-methyl-2-oxoimidazo[4,5-c]quinolin-8-yl]pyridin-2-yl]butanamide Show/Hide	C27H31FN6O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0470728 Compound Info	8-[6-[3-(4-hydroxypiperidin-1-yl)propoxy]pyridin-3-yl]-1-(3-methoxycyclobutyl)-3-methylimidazo[4,5-c]quinolin-2-one Show/Hide	C29H35N5O4	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0474725 Compound Info	4-(2-ethylbutylamino)-7-fluoro-6-[2-(2-pyrrolidin-1-ylethylamino)pyrimidin-5-yl]quinoline-3-carboxamide Show/Hide	C26H34FN7O	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0542830 Compound Info	CHEMBL4176135 Show/Hide	C22H21FN4O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0548185 Compound Info	N-[2-(dimethylamino)ethyl]-5-[7-fluoro-1-(3-methoxycyclobutyl)-3-methyl-2-oxoimidazo[4,5-c]quinolin-8-yl]pyridine-2-carboxamide Show/Hide	C26H29FN6O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0123998 Compound Info	6-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]cinnoline-3-carboxamide Show/Hide	C26H34N6O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0180776 Compound Info	6-[6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]quinoline-3-carboxamide Show/Hide	C24H28N4O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0189386 Compound Info	6-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-N-methyl-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]cinnoline-3-carboxamide Show/Hide	C27H36N6O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0362301 Compound Info	4-[[(1S)-1-(1,4-dimethylpyrazol-3-yl)ethyl]amino]-7-fluoro-6-[6-(methoxymethyl)pyridin-3-yl]quinoline-3-carboxamide Show/Hide	C24H25FN6O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0387521 Compound Info	6-[6-[2-(dimethylamino)ethylamino]pyridin-3-yl]-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]cinnoline-3-carboxamide Show/Hide	C25H33N7O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0429517 Compound Info	6-[6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]cinnoline-3-carboxamide Show/Hide	C22H23N7O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0456091 Compound Info	4-[[(1S)-1-(oxan-4-yl)ethyl]amino]-6-[6-(3-pyrrolidin-1-ylpropoxy)pyridin-3-yl]cinnoline-3-carboxamide Show/Hide	C28H36N6O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0456092 Compound Info	6-[6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]cinnoline-3-carboxamide Show/Hide	C23H27N5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0456093 Compound Info	4-[[(1S)-1-(1,4-dimethylpyrazol-3-yl)ethyl]amino]-6-[6-(methoxymethyl)pyridin-3-yl]cinnoline-3-carboxamide Show/Hide	C23H25N7O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0456094 Compound Info	6-[6-(methoxymethyl)pyridin-3-yl]-N-methyl-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]cinnoline-3-carboxamide Show/Hide	C24H29N5O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0474081 Compound Info	4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]-6-[6-(3-pyrrolidin-1-ylpropoxy)pyridin-3-yl]cinnoline-3-carboxamide Show/Hide	C27H32N8O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0474082 Compound Info	6-[6-[2-(dimethylamino)ethoxy]pyridin-3-yl]-N-methyl-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]cinnoline-3-carboxamide Show/Hide	C26H34N6O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0474083 Compound Info	6-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-4-[[(1S)-1-(1,4-dimethylpyrazol-3-yl)ethyl]amino]-N-methylcinnoline-3-carboxamide Show/Hide	C27H34N8O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0545150 Compound Info	6-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-4-[[(1S)-1-(1,4-dimethylpyrazol-3-yl)ethyl]amino]cinnoline-3-carboxamide Show/Hide	C26H32N8O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0545151 Compound Info	4-[[(1S)-1-(1,4-dimethylpyrazol-3-yl)ethyl]amino]-6-[6-(3-pyrrolidin-1-ylpropoxy)pyridin-3-yl]cinnoline-3-carboxamide Show/Hide	C28H34N8O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0547086 Compound Info	6-[6-[3-(dimethylamino)propoxy]pyridin-3-yl]-4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]cinnoline-3-carboxamide Show/Hide	C25H30N8O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0552478 Compound Info	6-[6-[2-(dimethylamino)ethoxy]pyridin-3-yl]-4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]cinnoline-3-carboxamide Show/Hide	C24H28N8O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0354838 Compound Info	2-amino-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazole-5-carbonitrile Show/Hide	C21H23N7O3S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0016003 Compound Info	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one Show/Hide	C21H17NO3S2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0180775 Compound Info	4-(2-ethylbutylamino)-8-methyl-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C22H26N4O	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0180813 Compound Info	2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine Show/Hide	C17H15N7O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0234610 Compound Info	4-(2-ethylbutylamino)-6-[4-(methylsulfonylmethyl)phenyl]quinoline-3-carboxamide Show/Hide	C24H29N3O3S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0234614 Compound Info	4-(2-ethylbutylamino)-6-[6-(methoxymethyl)pyridin-3-yl]quinoline-3-carboxamide Show/Hide	C23H28N4O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0236325 Compound Info	4-(2-ethylbutylamino)-6-[6-(methylsulfonylmethyl)pyridin-3-yl]quinoline-3-carboxamide Show/Hide	C23H28N4O3S	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0259634 Compound Info	7-fluoro-4-[[(1S)-1-(4-fluoro-1-methylpyrazol-3-yl)ethyl]amino]-6-[6-(methoxymethyl)pyridin-3-yl]quinoline-3-carboxamide Show/Hide	C23H22F2N6O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0362298 Compound Info	8-chloro-4-(oxan-4-ylamino)-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C20H19ClN4O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0362300 Compound Info	7-fluoro-6-[6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]quinoline-3-carboxamide Show/Hide	C24H27FN4O3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0362356 Compound Info	7-chloro-4-(oxan-4-ylamino)-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C20H19ClN4O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0364433 Compound Info	4-(2-ethylbutylamino)-2-methyl-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C22H26N4O	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0446981 Compound Info	4-[[(1R)-1-(4-chlorophenyl)ethyl]amino]-6-pyridin-3-ylquinoline-3-carboxylic acid Show/Hide	C23H18ClN3O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0446982 Compound Info	4-[[(1R)-1-(4-chlorophenyl)ethyl]amino]-N-methyl-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C24H21ClN4O	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0491228 Compound Info	8-fluoro-4-(oxan-4-ylamino)-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C20H19FN4O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0491230 Compound Info	4-(2-ethylbutoxy)-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C21H23N3O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0537595 Compound Info	4-(2-ethylbutylamino)-6-[4-(methoxymethyl)phenyl]quinoline-3-carboxamide Show/Hide	C24H29N3O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0537597 Compound Info	7-fluoro-6-[2-fluoro-6-(methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(1-methylpyrazol-3-yl)ethyl]amino]quinoline-3-carboxamide Show/Hide	C23H22F2N6O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0558418 Compound Info	5-fluoro-4-(oxan-4-ylamino)-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C20H19FN4O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0559691 Compound Info	N-[(1R)-1-(4-chlorophenyl)ethyl]-6-pyridin-3-ylquinolin-4-amine Show/Hide	C22H18ClN3	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0561273 Compound Info	7-fluoro-4-(oxan-4-ylamino)-6-pyridin-3-ylquinoline-3-carboxamide Show/Hide	C20H19FN4O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0946565 Compound Info	(R)-6-(2-Benzylazepan-1-yl)-4-morpholinopyridin-2(1H)-one Show/Hide	C22H29N3O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0953820 Compound Info	6-((1R,2S,5S)-2-Benzyl-3-azabicyclo[3.1.0]hexan-3-yl)-4-morpholinopyridin-2(1H)-one Show/Hide	C21H25N3O2	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0571634 Compound Info	9-[(3R,4R)-4-fluoropyrrolidin-3-yl]-7-methyl-2-[(7-methylquinolin-6-yl)amino]purin-8-one Show/Hide	C20H20FN7O	1
1	IC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0257340 Compound Info	3-amino-N,6-diphenylpyrazine-2-carboxamide Show/Hide	C17H14N4O	1
1	IC50 > 2500 nM Bioactivity Info	TI LI LO TS
CP0540068 Compound Info	US10772893, Example 41 Show/Hide	C19H22N4O2	1
1	IC50 > 3000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000067 , HCT 116

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000154 , HEK293-EBNA1-6E

Cell Line Info

Cell Line ID: CL000017 , HeLa

Cell Line Info

Cell Line ID: CL000043 , U2OS

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0354837 Compound Info	1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C20H24N6O3S	1
1	IC50 = 1 nM
CP0068244 Compound Info	(3R)-3-methyl-4-[6-(1-methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-c]pyridin-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C20H23N5O3S	1
1	IC50 = 2 nM
CP0068245 Compound Info	N-methyl-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C21H26N6O3S	1
1	IC50 = 2 nM
CP0168728 Compound Info	5-fluoro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C20H23FN6O3S	1
1	IC50 = 2 nM
CP0157307 Compound Info	4-[2-(1H-indol-4-yl)-6-(2-methylsulfonylpropan-2-yl)pyrimidin-4-yl]morpholine Show/Hide	C20H24N4O3S	1
1	IC50 = 3 nM
CP0076577 Compound Info	1-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C19H22N6O3S	1
1	IC50 = 3 nM
CP0085622 Compound Info	4-[2-(1H-indol-4-yl)-6-(4-methylsulfonyloxan-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C22H26N4O4S	1
1	IC50 = 4 nM
CP0808811 Compound Info	CERALASERTIB Show/Hide	C20H24N6O2S	2
1	IC50 = 4 nM
2	IC50 = 18 nM
CP0068243 Compound Info	(3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine Show/Hide	C21H24N4O3S	2
1	IC50 = 5 nM
2	IC50 = 61 nM
CP0256504 Compound Info	4-[6-[1-(benzenesulfonyl)cyclopropyl]-2-(1H-indol-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C25H24N4O3S	1
1	IC50 = 5 nM
CP0076580 Compound Info	(3R)-3-methyl-4-[6-(1-methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C20H23N5O3S	1
1	IC50 = 5 nM
CP0076581 Compound Info	4-[6-(1-methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-c]pyridin-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C19H21N5O3S	1
1	IC50 = 5 nM
CP0669285 Compound Info	US8552004, 2.03 Show/Hide	C21H27N7O2S	3
1	IC50 = 5.607 nM
2	IC50 = 6 nM
3	IC50 = 7.053 nM
CP0212807 Compound Info	3-amino-6-(4-(tert-butylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C21H22N4O3S	1
1	IC50 = 6 nM
CP0145081 Compound Info	3-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-8-oxa-3-azabicyclo[3.2.1]octane Show/Hide	C22H24N4O3S	1
1	IC50 = 7 nM
CP0180289 Compound Info	3-amino-6-(4-(isopropylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C20H20N4O3S	1
1	IC50 = 8 nM
CP0287648 Compound Info	3-amino-6-(4-((4-hydroxybutan-2-yl)sulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C21H22N4O4S	1
1	IC50 = 8 nM
CP0102640 Compound Info	4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C20H22N4O3S	1
1	IC50 = 8 nM
CP0186550 Compound Info	4-[2-(6-methyl-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C21H24N4O3S	1
1	IC50 = 8 nM
CP0514493 Compound Info	6-fluoro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C20H23FN6O3S	1
1	IC50 = 8 nM
CP0076974 Compound Info	4-[2-(1H-indol-4-yl)-6-(4-methylsulfonylpiperidin-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C22H27N5O3S	1
1	IC50 = 9 nM
CP0021486 Compound Info	3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-amine Show/Hide	C24H25N5O3S	2
1	IC50 = 9 nM
2	IC50 = 19 nM
CP0199392 Compound Info	3-amino-6-(4-(sec-butylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C21H22N4O3S	1
1	IC50 = 10 nM
CP0222476 Compound Info	(R)-3-amino-N-phenyl-6-(4-((tetrahydrofuran-3-yl)sulfonyl)-phenyl)pyrazine-2-carboxamide Show/Hide	C21H20N4O4S	1
1	IC50 = 10 nM
CP0102647 Compound Info	4-fluoro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C20H23FN6O3S	1
1	IC50 = 10 nM
CP0314495 Compound Info	(3R)-3-methyl-4-[6-[1-[(S)-methylsulfinyl]cyclopropyl]-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C20H23N5O2S	1
1	IC50 = 11 nM
CP0050427 Compound Info	3-amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfonyl)-phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C22H25N5O3S	2
1	IC50 = 12 nM
2	Ki = 6 nM
CP0199334 Compound Info	3-amino-6-(4-(ethylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C19H18N4O3S	1
1	IC50 = 12 nM
CP0345264 Compound Info	4-[2-(1H-indol-4-yl)-6-(1-propan-2-ylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C22H26N4O3S	1
1	IC50 = 13 nM
CP0171816 Compound Info	3-amino-N-phenyl-6-(4-(propylsulfonyl)phenyl)pyrazine-2-carboxamide Show/Hide	C20H20N4O3S	1
1	IC50 = 14 nM
CP0076584 Compound Info	N-[1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-yl]acetamide Show/Hide	C22H26N6O4S	1
1	IC50 = 14 nM
CP0130832 Compound Info	4-[2-(6-fluoro-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C20H21FN4O3S	1
1	IC50 = 15 nM
CP0130830 Compound Info	4-[2-(6-chloro-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C20H21ClN4O3S	1
1	IC50 = 16 nM
CP0168854 Compound Info	(3R)-3-methyl-4-[6-[1-[(R)-methylsulfinyl]cyclopropyl]-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C20H23N5O2S	1
1	IC50 = 16 nM
CP0249202 Compound Info	4-chloro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C20H23ClN6O3S	1
1	IC50 = 17 nM
CP0565273 Compound Info	4-[4-(3,6-dihydro-2H-pyran-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]-1H-indole Show/Hide	C21H21N3O3S	1
1	IC50 = 18 nM
CP0249222 Compound Info	5-chloro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C20H23ClN6O3S	1
1	IC50 = 21 nM
CP0304424 Compound Info	4-[2-(6-methoxy-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C21H24N4O4S	1
1	IC50 = 23 nM
CP0199330 Compound Info	3-amino-N-phenyl-6-(4-(piperidine-1-carbonyl)phenyl)pyrazine-2-carboxamide Show/Hide	C23H23N5O2	1
1	IC50 = 26 nM
CP0265453 Compound Info	4-[2-(2-methyl-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C21H24N4O3S	1
1	IC50 = 28 nM
CP0085620 Compound Info	4-[2-(1H-indol-4-yl)-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine Show/Hide	C18H20N4O3S	1
1	IC50 = 30 nM
CP0076973 Compound Info	4-[2-(1H-indol-4-yl)-6-(1-pyridin-2-ylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C24H23N5O3S	1
1	IC50 = 33 nM
CP0130834 Compound Info	4-[2-(1H-indol-4-yl)-6-[1-(oxan-4-ylsulfonyl)cyclopropyl]pyrimidin-4-yl]morpholine Show/Hide	C24H28N4O4S	1
1	IC50 = 33 nM
CP0130829 Compound Info	(3S)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine Show/Hide	C21H24N4O3S	1
1	IC50 = 34 nM
CP0404754 Compound Info	4-[6-(1-methylsulfonylcyclopropyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C19H21N5O3S	1
1	IC50 = 37 nM
CP0333713 Compound Info	4-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1H-indole-6-carboxamide Show/Hide	C21H23N5O4S	1
1	IC50 = 41 nM
CP0310474 Compound Info	4-[2-(1H-indol-4-yl)-6-(1-piperidin-4-ylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C24H29N5O3S	1
1	IC50 = 46 nM
CP0291454 Compound Info	3-amino-6-(3-chloro-4-(dimethylcarbamoyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C20H18ClN5O2	1
1	IC50 = 48 nM
CP0050429 Compound Info	3-amino-6-(4-(dimethylcarbamoyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C20H19N5O2	1
1	IC50 = 54 nM
CP0271874 Compound Info	3-amino-N-phenyl-6-(4-(pyrrolidine-1-carbonyl)phenyl)-pyrazine-2-carboxamide Show/Hide	C22H21N5O2	1
1	IC50 = 54 nM
CP0160334 Compound Info	3-amino-6-(4-(methylsulfinyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C18H16N4O2S	1
1	IC50 = 56 nM
CP0333714 Compound Info	4-[2-(1H-indol-4-yl)-6-(1-methyl-4-methylsulfonylpiperidin-4-yl)pyrimidin-4-yl]morpholine Show/Hide	C23H29N5O3S	1
1	IC50 = 61 nM
CP0130833 Compound Info	4-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1H-indole-6-carbonitrile Show/Hide	C21H21N5O3S	1
1	IC50 = 66 nM
CP0533485 Compound Info	7-fluoro-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C20H23FN6O3S	1
1	IC50 = 90 nM
CP0341198 Compound Info	3-amino-6-(4-(azetidine-1-carbonyl)phenyl)-N-phenylpyrazine-2-carboxamide Show/Hide	C21H19N5O2	1
1	IC50 = 100 nM
CP0145086 Compound Info	4-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1,3-dihydroindol-2-one Show/Hide	C20H22N4O4S	1
1	IC50 = 120 nM
CP0315929 Compound Info	4-[2-(1H-indazol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C19H21N5O3S	1
1	IC50 = 130 nM
CP0076582 Compound Info	N-methyl-4-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1H-indole-6-carboxamide Show/Hide	C22H25N5O4S	1
1	IC50 = 140 nM
CP0130828 Compound Info	(3R)-3-ethyl-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C22H26N4O3S	1
1	IC50 = 170 nM
CP0193495 Compound Info	4-[2-(1H-indol-7-yl)-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine Show/Hide	C18H20N4O3S	1
1	IC50 = 180 nM
CP0314494 Compound Info	4-[2-(1H-benzimidazol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C19H21N5O3S	1
1	IC50 = 180 nM
CP0256503 Compound Info	4-[2-(7-methyl-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C21H24N4O3S	1
1	IC50 = 220 nM
CP0136765 Compound Info	4-methoxy-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C21H26N6O4S	1
1	IC50 = 270 nM
CP0193494 Compound Info	4-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1H-indole-2-carbonitrile Show/Hide	C21H21N5O3S	1
1	IC50 = 300 nM
CP0345263 Compound Info	4-[6-(1-methylsulfonylcyclopropyl)-2-phenylpyrimidin-4-yl]morpholine Show/Hide	C18H21N3O3S	1
1	IC50 = 360 nM
CP0444138 Compound Info	5-methoxy-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazol-2-amine Show/Hide	C21H26N6O4S	1
1	IC50 = 550 nM
CP0257340 Compound Info	3-amino-N,6-diphenylpyrazine-2-carboxamide Show/Hide	C17H14N4O	1
1	IC50 = 620 nM
CP0315928 Compound Info	N,N-dimethyl-4-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1H-indole-6-carboxamide Show/Hide	C23H27N5O4S	1
1	IC50 = 720 nM
CP0085621 Compound Info	4-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]-1H-indole-2-carboxamide Show/Hide	C21H23N5O4S	1
1	IC50 = 1100 nM
CP0315930 Compound Info	3-[4-(1-methylsulfonylcyclopropyl)-6-morpholin-4-ylpyrimidin-2-yl]aniline Show/Hide	C18H22N4O3S	1
1	IC50 = 1200 nM
CP0333715 Compound Info	4-[2-(1H-indol-6-yl)-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine Show/Hide	C18H20N4O3S	1
1	IC50 = 1500 nM
CP0123538 Compound Info	4-[2-(1H-indol-5-yl)-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine Show/Hide	C18H20N4O3S	1
1	IC50 = 1700 nM
CP0265455 Compound Info	4-[2-(1-methylindol-4-yl)-6-(methylsulfonylmethyl)pyrimidin-4-yl]morpholine Show/Hide	C19H22N4O3S	1
1	IC50 = 3300 nM
CP0354838 Compound Info	2-amino-1-[4-[(3R)-3-methylmorpholin-4-yl]-6-(1-methylsulfonylcyclopropyl)pyrimidin-2-yl]benzimidazole-5-carbonitrile Show/Hide	C21H23N7O3S	1
1	IC50 = 4000 nM
CP0287511 Compound Info	3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaene Show/Hide	C23H28O6	1
1	IC50 = 7200 nM
CP0145082 Compound Info	4-[2-(3-methyl-1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]morpholine Show/Hide	C21H24N4O3S	1
1	IC50 = 14000 nM
CP0016003 Compound Info	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one Show/Hide	C21H17NO3S2	1
1	IC50 > 100000 nM
CP0238623 Compound Info	US8846917, I-1 Show/Hide	C21H20N6O2S	1
1	Ki = 6 nM
CP0639539 Compound Info	2-[(3R)-3-Methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine Show/Hide	C20H21N7O	1
1	Ki = 7 nM
CP0141550 Compound Info	3-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)-5-(4-propan-2-ylsulfonylphenyl)pyrazin-2-amine Show/Hide	C22H22N4O3S	1
1	Ki = 90 nM

Clinical Information about the Protein

Target 1 ( Serine/threonine-protein kinase ATR (FRP1) )

Target Type	Clinical trial Target
Disease	3 Target-related Diseases				3
1	Small-cell lung cancer [ICD-11: 2C25.Y]
2	Lymphoma [ICD-11: 2A80-2A86]
3	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Clinical Trial Drug(s)	4 Clinical Trial Drugs				4
1	AZD6738	Drug Info	Phase 2	Small-cell lung cancer
2	BAY1895344	Drug Info	Phase 1	Lymphoma
3	M4344	Drug Info	Phase 1	Solid tumour/cancer
4	VX-970	Drug Info	Phase 1	Solid tumour/cancer
Investigative Drug(s)	1 Investigative Drug				1
1	VE-821	Drug Info	Investigative	Solid tumour/cancer

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han