Brief Information of the Compound and Protein
Compound Name
2-[(3R)-3-Methylmorpholin-4-yl]-8-(1H-pyrazol-5-yl)-4-(tetrahydro-2H-pyran-4-yl)-1,7-naphthyridine
    Show/Hide
PubChem ID
CID: 118869550
Canonical SMILES
C[C@@H]1COCCN1c1cc(C2CCOCC2)c2ccnc(-c3ccn[nH]3)c2n1
    Show/Hide
Compound Formula C21H25N5O2
Compound Structure
Protein Name
Serine/threonine-protein kinase ATR
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
Atypical protein kinase group
>
Atypical protein kinase PIKK family
Uniprot ID
Q13535
Gene Name
ATR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000154 HEK293-EBNA1-6E Homo sapiens (Human)  1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CL000007 HT-29 Homo sapiens (Human)  1
1
IC50 = 66 nM
   TI
   LI
   LO
   TS