| Compound ID |
Compound Name |
Compound Formula |
|
CP0384206
|
CHEMBL4541658
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|
C28H35FO4
|
1
|
| 1 |
EC50 = 0.11 nM
|
|
|
|
CP0459378
|
(2S,3R)-3-cyclopropyl-3-[3-[[4-(2-fluoro-5-methoxyphenyl)cyclohexyl]methoxy]phenyl]-2-methylpropanoic acid
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|
C27H33FO4
|
1
|
| 1 |
EC50 = 0.2 nM
|
|
|
|
CP0098493
|
CHEMBL4457303
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|
C27H32F2O4
|
1
|
| 1 |
EC50 = 0.25 nM
|
|
|
|
CP0104146
|
2-[(3S)-6-[[3-[2,6-dimethyl-4-(3-methylsulfonylpropoxy)phenyl]phenyl]methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid
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|
C29H32O7S
|
9
|
| 1 |
EC50 = 0.35 nM
|
|
|
| 2 |
EC50 = 1.9 nM
|
|
|
| 3 |
EC50 = 9.333 nM
|
|
|
| 4 |
EC50 = 12 nM
|
|
|
| 5 |
EC50 = 31 nM
|
|
|
| 6 |
EC50 = 39 nM
|
|
|
| 7 |
EC50 = 80 nM
|
|
|
| 8 |
EC50 = 160 nM
|
|
|
| 9 |
EC50 = 5100 nM
|
|
|
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CP0426504
|
(3S)-3-[4-[[5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)thiophen-2-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C31H31NO3S
|
3
|
| 1 |
EC50 = 0.6 nM
|
|
|
| 2 |
EC50 = 5.3 nM
|
|
|
| 3 |
EC50 = 12 nM
|
|
|
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CP0386267
|
(3S)-3-[4-[[3-[[thiophen-3-ylmethyl(2,2,2-trifluoroethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C27H26F3NO3S
|
1
|
| 1 |
EC50 = 0.8 nM
|
|
|
|
CP0389992
|
sodium;(2S,3R)-3-cyclopropyl-3-[(2S)-2-[2-fluoro-4-(2-methoxypyridin-4-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-2-methylpropanoate
Show/Hide
|
C28H27FNNaO4
|
2
|
| 1 |
EC50 = 0.8 nM
|
|
|
| 2 |
EC50 = 35 nM
|
|
|
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CP0384165
|
(3S)-3-cyclopropyl-3-[3-[[4-(2-fluoro-5-methoxyphenyl)cyclohexyl]methoxy]phenyl]propanoic acid
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|
C26H31FO4
|
1
|
| 1 |
EC50 = 0.94 nM
|
|
|
|
CP0546043
|
(3S)-3-[4-[[4-methyl-5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)thiophen-2-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C32H33NO3S
|
3
|
| 1 |
EC50 = 0.98 nM
|
|
|
| 2 |
EC50 = 2.9 nM
|
|
|
| 3 |
EC50 = 3.9 nM
|
|
|
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CP0402867
|
(3S)-3-[4-[[2-[4-(difluoromethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C26H21F2N3O4
|
3
|
| 1 |
EC50 = 1 nM
|
|
|
| 2 |
EC50 = 166 nM
|
|
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| 3 |
Ki = 60 nM
|
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CP0396276
|
(2S,3R)-3-cyclopropyl-3-[(2S)-2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-2-methylpropanoic acid
Show/Hide
|
C29H29FO4
|
2
|
| 1 |
EC50 = 1.1 nM
|
|
|
| 2 |
EC50 = 146 nM
|
|
|
|
CP0431559
|
CHEMBL4534836
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|
C26H30F2O4
|
1
|
| 1 |
EC50 = 1.1 nM
|
|
|
|
CP0425645
|
(3S)-3-[4-[[4-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-3-(trifluoromethyl)phenyl]methoxy]phenyl]hex-4-ynoic acid
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|
C34H32F3NO3
|
3
|
| 1 |
EC50 = 1.1 nM
|
|
|
| 2 |
EC50 = 1.9 nM
|
|
|
| 3 |
EC50 = 20 nM
|
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|
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CP0013323
|
(3S)-3-[4-[[4-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoic acid
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|
C33H33NO3
|
5
|
| 1 |
EC50 = 1.2 nM
|
|
|
| 2 |
EC50 = 8.7 nM
|
|
|
| 3 |
EC50 = 9.1 nM
|
|
|
| 4 |
EC50 = 134 nM
|
|
|
| 5 |
Ki = 4.7 nM
|
|
|
|
CP0179633
|
AMG-837
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|
C26H21F3O3
|
5
|
| 1 |
EC50 = 1.3 nM
|
|
|
| 2 |
EC50 = 2.2 nM
|
|
|
| 3 |
EC50 = 11 nM
|
|
|
| 4 |
EC50 = 15 nM
|
|
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| 5 |
EC50 = 154.88 nM
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CP0558375
|
(3S)-3-[4-[[3-[[2-methylpropyl(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C29H33NO3S
|
1
|
| 1 |
EC50 = 1.4 nM
|
|
|
|
CP0425647
|
(3S)-3-[4-[[4-[(1-phenylspiro[2H-indole-3,4'-piperidine]-1'-yl)methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C38H38N2O3
|
3
|
| 1 |
EC50 = 1.5 nM
|
|
|
| 2 |
EC50 = 2.1 nM
|
|
|
| 3 |
EC50 = 21 nM
|
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CP0422239
|
(3S)-3-[4-[[5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)furan-2-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C31H31NO4
|
3
|
| 1 |
EC50 = 1.6 nM
|
|
|
| 2 |
EC50 = 22 nM
|
|
|
| 3 |
EC50 = 62 nM
|
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|
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CP0492817
|
(3S)-3-[4-[[3-methyl-4-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C34H35NO3
|
3
|
| 1 |
EC50 = 1.7 nM
|
|
|
| 2 |
EC50 = 4.2 nM
|
|
|
| 3 |
EC50 = 23 nM
|
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|
|
CP0385199
|
(3S)-3-[4-[[3-[[pyridin-4-ylmethyl(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C31H30N2O3S
|
1
|
| 1 |
EC50 = 1.9 nM
|
|
|
|
CP0558376
|
(3S)-3-[4-[[3-[[cyclopropyl(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C28H29NO3S
|
1
|
| 1 |
EC50 = 1.9 nM
|
|
|
|
CP0563726
|
(3S)-3-[4-[[3-[[cyclohexyl(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C31H35NO3S
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
|
CP0407280
|
(3S)-3-[4-[[2-(4-propan-2-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C28H27N3O3
|
3
|
| 1 |
EC50 = 2 nM
|
|
|
| 2 |
EC50 = 67 nM
|
|
|
| 3 |
Ki = 32 nM
|
|
|
|
CP0521402
|
(2S,3R)-3-cyclopropyl-3-[2-fluoro-3-[[(1R)-5-(5-fluoro-2-methoxypyridin-4-yl)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]-2-methylpropanoic acid
Show/Hide
|
C28H27F2NO4
|
2
|
| 1 |
EC50 = 2 nM
|
|
|
| 2 |
EC50 = 245 nM
|
|
|
|
CP0143308
|
US9688642, 2
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|
C27H30FN3O4
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
|
CP0552973
|
US9688642, 1
Show/Hide
|
C29H33FN2O4
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
|
CP0386272
|
(3S)-3-[4-[[3-[[bis(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C30H29NO3S2
|
1
|
| 1 |
EC50 = 2.1 nM
|
|
|
|
CP0459377
|
(2R,3R)-3-cyclopropyl-3-[3-[[4-(2-fluoro-5-methoxyphenyl)cyclohexyl]methoxy]phenyl]-2-methylpropanoic acid
Show/Hide
|
C27H33FO4
|
1
|
| 1 |
EC50 = 2.2 nM
|
|
|
|
CP0422245
|
(3S)-3-[4-[[3-fluoro-4-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C33H32FNO3
|
3
|
| 1 |
EC50 = 2.3 nM
|
|
|
| 2 |
EC50 = 9.3 nM
|
|
|
| 3 |
EC50 = 17 nM
|
|
|
|
CP0535099
|
US9688642, 3
Show/Hide
|
C28H31FN2O4
|
1
|
| 1 |
EC50 = 2.5 nM
|
|
|
|
CP0517455
|
(2S,3R)-3-cyclopropyl-3-[(2R)-2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-2-methylpropanoic acid
Show/Hide
|
C29H29FO4
|
2
|
| 1 |
EC50 = 2.6 nM
|
|
|
| 2 |
EC50 = 127 nM
|
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|
|
CP0492791
|
(3S)-3-[4-[[5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-1,3-thiazol-2-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C30H30N2O3S
|
3
|
| 1 |
EC50 = 2.8 nM
|
|
|
| 2 |
EC50 = 12 nM
|
|
|
| 3 |
EC50 = 84 nM
|
|
|
|
CP0422249
|
(3S)-3-[4-[[4-[[1-methyl-5-(trifluoromethyl)spiro[2H-indole-3,4'-piperidine]-1'-yl]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C34H35F3N2O3
|
3
|
| 1 |
EC50 = 2.9 nM
|
|
|
| 2 |
EC50 = 4.7 nM
|
|
|
| 3 |
EC50 = 14 nM
|
|
|
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CP0008406
|
(3S)-3-[4-[[5-[(8-methoxy-3,4-dihydro-2H-quinolin-1-yl)methyl]thiophen-2-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C28H29NO4S
|
3
|
| 1 |
EC50 = 3 nM
|
|
|
| 2 |
EC50 = 7 nM
|
|
|
| 3 |
Ki = 27 nM
|
|
|
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CP0384382
|
(2S,3R)-3-cyclopropyl-3-[2-fluoro-3-[[(1R)-5-(2-fluoro-5-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]-2-methylpropanoic acid
Show/Hide
|
C29H28F2O4
|
2
|
| 1 |
EC50 = 3 nM
|
|
|
| 2 |
EC50 = 127 nM
|
|
|
|
CP0536756
|
(2S,3R)-3-cyclopropyl-3-[3-[[(1R)-5-(5-fluoro-2-methoxypyridin-4-yl)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]-2-methylpropanoic acid
Show/Hide
|
C28H28FNO4
|
2
|
| 1 |
EC50 = 3 nM
|
|
|
| 2 |
EC50 = 867 nM
|
|
|
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CP0426505
|
(3S)-3-[4-[[4-[(7-chloro-1-methylspiro[2H-indole-3,4'-piperidine]-1'-yl)methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C33H35ClN2O3
|
3
|
| 1 |
EC50 = 3.3 nM
|
|
|
| 2 |
EC50 = 11 nM
|
|
|
| 3 |
EC50 = 17 nM
|
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CP0532759
|
(3S)-3-[4-[[3-chloro-4-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C33H32ClNO3
|
3
|
| 1 |
EC50 = 3.3 nM
|
|
|
| 2 |
EC50 = 4.9 nM
|
|
|
| 3 |
EC50 = 32 nM
|
|
|
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CP0064202
|
(3S)-3-cyclopropyl-3-[3-[[3-(5,5-dimethylcyclopenten-1-yl)-4-(2-fluoro-5-methoxyphenyl)phenyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C33H35FO4
|
3
|
| 1 |
EC50 = 3.5 nM
|
|
|
| 2 |
EC50 = 130 nM
|
|
|
| 3 |
EC50 = 392 nM
|
|
|
|
CP0422248
|
(3S)-3-[4-[[4-[(1,5-dimethylspiro[2H-indole-3,4'-piperidine]-1'-yl)methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C34H38N2O3
|
3
|
| 1 |
EC50 = 3.5 nM
|
|
|
| 2 |
EC50 = 25 nM
|
|
|
| 3 |
EC50 = 61 nM
|
|
|
|
CP0536755
|
(2S,3R)-3-cyclopropyl-3-[3-[[(1R)-4-fluoro-5-(2-fluoro-5-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]-2-methylpropanoic acid
Show/Hide
|
C29H28F2O4
|
2
|
| 1 |
EC50 = 3.9 nM
|
|
|
| 2 |
EC50 = 810 nM
|
|
|
|
CP0464179
|
(3S)-3-[4-[[3-[[benzyl(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C32H31NO3S
|
1
|
| 1 |
EC50 = 4.4 nM
|
|
|
|
CP0425644
|
(3S)-3-[4-[[2-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-1,3-thiazol-5-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C30H30N2O3S
|
3
|
| 1 |
EC50 = 4.4 nM
|
|
|
| 2 |
EC50 = 5.2 nM
|
|
|
| 3 |
EC50 = 170 nM
|
|
|
|
CP0330777
|
(2S,3R)-3-cyclopropyl-3-[3-[[(1R)-5-(2-fluoro-5-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]-2-methylpropanoic acid
Show/Hide
|
C29H29FO4
|
2
|
| 1 |
EC50 = 4.5 nM
|
|
|
| 2 |
EC50 = 388 nM
|
|
|
|
CP0555828
|
US9688642, 6
Show/Hide
|
C30H32FN3O4
|
1
|
| 1 |
EC50 = 4.5 nM
|
|
|
|
CP0558064
|
(3S)-3-[4-[[3-[[cyclopentyl(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C30H33NO3S
|
1
|
| 1 |
EC50 = 4.6 nM
|
|
|
|
CP0384163
|
(2S,3S)-3-cyclopropyl-2-fluoro-3-[3-[[4-(2-fluoro-5-methoxyphenyl)cyclohexyl]methoxy]phenyl]-2-methylpropanoic acid
Show/Hide
|
C27H32F2O4
|
1
|
| 1 |
EC50 = 6.1 nM
|
|
|
|
CP0010598
|
(3S)-3-[4-[[5-(spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylmethyl)thiophen-2-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C31H33NO3S
|
3
|
| 1 |
EC50 = 6.1 nM
|
|
|
| 2 |
EC50 = 7.9 nM
|
|
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| 3 |
EC50 = 8 nM
|
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CP0422242
|
(3S)-3-[4-[[4-(spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C33H35NO3
|
3
|
| 1 |
EC50 = 6.2 nM
|
|
|
| 2 |
EC50 = 11 nM
|
|
|
| 3 |
EC50 = 19 nM
|
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CP0385200
|
(3S)-3-[4-[[3-[[ethylsulfonyl(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C27H29NO5S2
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0392825
|
(3S)-3-cyclopropyl-3-[2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
Show/Hide
|
C28H27FO4
|
2
|
| 1 |
EC50 = 7 nM
|
|
|
| 2 |
EC50 = 1227 nM
|
|
|
|
CP0471349
|
(3S)-3-[4-[[3-methoxy-4-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C34H35NO4
|
3
|
| 1 |
EC50 = 7.4 nM
|
|
|
| 2 |
EC50 = 10 nM
|
|
|
| 3 |
EC50 = 17 nM
|
|
|
|
CP0486856
|
US9688642, 10
Show/Hide
|
C32H31FN2O4
|
1
|
| 1 |
EC50 = 7.5 nM
|
|
|
|
CP0386269
|
(3S)-3-[4-[[3-[[oxan-4-yl(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C30H33NO4S
|
1
|
| 1 |
EC50 = 7.7 nM
|
|
|
|
CP0386270
|
(3S)-3-[4-[[3-[[thian-4-yl(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C30H33NO3S2
|
1
|
| 1 |
EC50 = 7.9 nM
|
|
|
|
CP0402871
|
(3S)-3-[4-[(5-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylthiophen-2-yl)methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C30H31NO3S
|
2
|
| 1 |
EC50 = 8 nM
|
|
|
| 2 |
Ki = 8.2 nM
|
|
|
|
CP0396643
|
sodium;(2S,3R)-3-cyclopropyl-3-[2-[2-fluoro-4-(2-methoxypyridin-4-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-2-methylpropanoate
Show/Hide
|
C28H27FNNaO4
|
2
|
| 1 |
EC50 = 8.2 nM
|
|
|
| 2 |
EC50 = 920 nM
|
|
|
|
CP0538129
|
(3S)-3-[4-[[4-[(1-propan-2-ylspiro[2H-indole-3,4'-piperidine]-1'-yl)methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C35H40N2O3
|
3
|
| 1 |
EC50 = 8.2 nM
|
|
|
| 2 |
EC50 = 11 nM
|
|
|
| 3 |
EC50 = 24 nM
|
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|
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CP0422243
|
(3S)-3-[4-[[4-[(4-oxospiro[3H-chromene-2,4'-piperidine]-1'-yl)methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C33H33NO5
|
3
|
| 1 |
EC50 = 8.3 nM
|
|
|
| 2 |
EC50 = 26 nM
|
|
|
| 3 |
EC50 = 65 nM
|
|
|
|
CP0385196
|
(3S)-3-[4-[[3-[[propan-2-yl(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C28H31NO3S
|
1
|
| 1 |
EC50 = 8.6 nM
|
|
|
|
CP0386268
|
(3S)-3-[4-[[3-[[2-methoxyethyl(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C28H31NO4S
|
1
|
| 1 |
EC50 = 8.6 nM
|
|
|
|
CP0419788
|
(3S)-3-[4-[[2-(4-cyanophenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C26H20N4O3
|
3
|
| 1 |
EC50 = 9 nM
|
|
|
| 2 |
EC50 = 443 nM
|
|
|
| 3 |
Ki = 35 nM
|
|
|
|
CP0528431
|
US9688642, 8
Show/Hide
|
C28H29FN2O4
|
1
|
| 1 |
EC50 = 9.4 nM
|
|
|
|
CP0533141
|
(3S)-3-cyclopropyl-3-[3-[[6-(5,5-dimethylcyclopenten-1-yl)-5-(2-fluoro-5-methoxyphenyl)pyridin-2-yl]methoxy]phenyl]propanoic acid
Show/Hide
|
C32H34FNO4
|
1
|
| 1 |
EC50 = 9.4 nM
|
|
|
|
CP0555829
|
US9688642, 14
Show/Hide
|
C28H31FN2O5
|
1
|
| 1 |
EC50 = 9.6 nM
|
|
|
|
CP0464180
|
(3S)-3-[4-[[3-[[cyclopropylsulfonyl(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C28H29NO5S2
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0422241
|
(3S)-3-[4-[[4-methyl-5-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-1,3-thiazol-2-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C31H32N2O3S
|
3
|
| 1 |
EC50 = 10 nM
|
|
|
| 2 |
EC50 = 11 nM
|
|
|
| 3 |
EC50 = 58 nM
|
|
|
|
CP0385201
|
calcium;(3S)-3-[4-[[3-[[propan-2-yl(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoate
Show/Hide
|
C56H60CaN2O6S2
|
2
|
| 1 |
EC50 = 10.5 nM
|
|
|
| 2 |
EC50 = 11.6 nM
|
|
|
|
CP0098306
|
(3S)-3-[4-[[2-(2,6-dimethylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C27H25N3O3
|
3
|
| 1 |
EC50 = 11 nM
|
|
|
| 2 |
EC50 = 108 nM
|
|
|
| 3 |
Ki = 15 nM
|
|
|
|
CP0389996
|
(3S)-3-cyclopropyl-3-[2-[4-(5-fluoro-2-methoxypyridin-4-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
Show/Hide
|
C27H26FNO4
|
2
|
| 1 |
EC50 = 11 nM
|
|
|
| 2 |
EC50 = 1206 nM
|
|
|
|
CP0521403
|
(2S,3R)-3-cyclopropyl-3-[3-[[(1R)-5-(2-methoxypyridin-4-yl)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]-2-methylpropanoic acid
Show/Hide
|
C28H29NO4
|
2
|
| 1 |
EC50 = 11 nM
|
|
|
| 2 |
EC50 = 3550 nM
|
|
|
|
CP0486855
|
(3S)-3-cyclopropyl-3-[3-[[4-(5,5-dimethylcyclopenten-1-yl)-5-(2-fluoro-5-methoxyphenyl)pyridin-2-yl]methoxy]phenyl]propanoic acid
Show/Hide
|
C32H34FNO4
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
|
CP0555830
|
US9688642, 15
Show/Hide
|
C30H32FN3O4
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
|
CP0164260
|
3-(4(2'-Methylbiphenyl-3-ylmethylamino)phenyl)propanoic acid
Show/Hide
|
C23H23NO2
|
2
|
| 1 |
EC50 = 11.22 nM
|
|
|
| 2 |
EC50 = 12.88 nM
|
|
|
|
CP0385195
|
(3S)-3-[4-[[3-[[2-hydroxyethyl(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C27H29NO4S
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0492793
|
(3S)-3-[4-[[4-[(1-methylspiro[2H-indole-3,4'-piperidine]-1'-yl)methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C33H36N2O3
|
3
|
| 1 |
EC50 = 12 nM
|
|
|
| 2 |
EC50 = 55 nM
|
|
|
| 3 |
EC50 = 56 nM
|
|
|
|
CP0528432
|
(3S)-3-cyclopropyl-3-[3-[[4-(5,5-dimethylcyclopenten-1-yl)-5-(2-fluoro-5-methoxyphenyl)pyrimidin-2-yl]methoxy]phenyl]propanoic acid
Show/Hide
|
C31H33FN2O4
|
1
|
| 1 |
EC50 = 12.4 nM
|
|
|
|
CP0425646
|
(3S)-3-(1,2-oxazol-3-yl)-3-[4-[(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)methoxy]phenyl]propanoic acid
Show/Hide
|
C25H20N4O4
|
3
|
| 1 |
EC50 = 14 nM
|
|
|
| 2 |
EC50 = 68 nM
|
|
|
| 3 |
EC50 = 600 nM
|
|
|
|
CP0425642
|
(3R)-3-[2-fluoro-4-[[4-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C33H32FNO3
|
3
|
| 1 |
EC50 = 14 nM
|
|
|
| 2 |
EC50 = 18 nM
|
|
|
| 3 |
EC50 = 36 nM
|
|
|
|
CP0381623
|
3-[2-fluoro-4-[[3-[2-methyl-4-(3-methylsulfonylpropoxy)phenyl]phenyl]methylamino]phenyl]propanoic acid
Show/Hide
|
C27H30FNO5S
|
3
|
| 1 |
EC50 = 14.13 nM
|
|
|
| 2 |
EC50 = 45.71 nM
|
|
|
| 3 |
EC50 = 1949.84 nM
|
|
|
|
CP0521404
|
(2S,3R)-3-cyclopropyl-3-[3-[[(7R)-3-(2-fluoro-5-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl]oxy]phenyl]-2-methylpropanoic acid
Show/Hide
|
C28H28FNO4
|
2
|
| 1 |
EC50 = 15 nM
|
|
|
| 2 |
EC50 = 3323 nM
|
|
|
|
CP0516486
|
(3S)-3-cyclopropyl-3-[2-[5-(2-fluoro-5-methoxyphenyl)pyridin-2-yl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
Show/Hide
|
C27H26FNO4
|
2
|
| 1 |
EC50 = 16 nM
|
|
|
| 2 |
EC50 = 2530 nM
|
|
|
|
CP0415365
|
(3S)-3-[4-[[2-[4-(2-methoxyethoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C28H27N3O5
|
3
|
| 1 |
EC50 = 16 nM
|
|
|
| 2 |
EC50 = 681 nM
|
|
|
| 3 |
Ki = 102 nM
|
|
|
|
CP0459598
|
(3S)-3-cyclopropyl-2,2-difluoro-3-[3-[[4-(2-fluoro-5-methoxyphenyl)cyclohexyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C26H29F3O4
|
1
|
| 1 |
EC50 = 16 nM
|
|
|
|
CP0521398
|
(3S)-3-cyclopropyl-3-[3-[[(3R)-6-(2-fluoro-5-methoxyphenyl)-2,3-dihydro-1-benzofuran-3-yl]oxy]phenyl]propanoic acid
Show/Hide
|
C27H25FO5
|
2
|
| 1 |
EC50 = 16 nM
|
|
|
| 2 |
EC50 = 7353 nM
|
|
|
|
CP0563725
|
(3S)-3-[4-[[3-[[cyclopropylmethyl(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C29H31NO3S
|
1
|
| 1 |
EC50 = 16.1 nM
|
|
|
|
CP0372137
|
3-{4-[(2'-Methylbiphenyl-3-yl)methoxy]phenyl}propanic Acid
Show/Hide
|
C23H22O3
|
1
|
| 1 |
EC50 = 16.6 nM
|
|
|
|
CP0385197
|
(3S)-3-[4-[[3-[[(1,1-dioxothian-4-yl)-(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C30H33NO5S2
|
1
|
| 1 |
EC50 = 16.7 nM
|
|
|
|
CP0422240
|
(3S)-3-[4-[[4-methyl-2-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)-1,3-thiazol-5-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C31H32N2O3S
|
3
|
| 1 |
EC50 = 17 nM
|
|
|
| 2 |
EC50 = 72 nM
|
|
|
| 3 |
EC50 = 520 nM
|
|
|
|
CP0058022
|
3-[4-[2-[2-(cyanomethyl)phenyl]ethynyl]-2-fluorophenyl]propanoic acid
Show/Hide
|
C19H14FNO2
|
3
|
| 1 |
EC50 = 18.62 nM
|
|
|
| 2 |
EC50 = 22.91 nM
|
|
|
| 3 |
EC50 = 26.3 nM
|
|
|
|
CP0392813
|
(3S)-3-cyclopropyl-3-[2-[4-(2-methoxypyridin-4-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
Show/Hide
|
C27H27NO4
|
2
|
| 1 |
EC50 = 19 nM
|
|
|
| 2 |
EC50 = 2561 nM
|
|
|
|
CP0958108
|
(S)-3-(4-(4-((R)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)benzyloxy)phenyl)hex-4-ynoic acid
Show/Hide
|
C30H29NO4
|
1
|
| 1 |
EC50 = 20 nM
|
|
|
|
CP0528430
|
(3S)-3-cyclopropyl-3-[3-[[5-(5,5-dimethylcyclopenten-1-yl)-6-(2-fluoro-5-methoxyphenyl)pyridin-3-yl]methoxy]phenyl]propanoic acid
Show/Hide
|
C32H34FNO4
|
1
|
| 1 |
EC50 = 21.3 nM
|
|
|
|
CP0389997
|
(3S)-3-cyclopropyl-3-[2-[4-(3-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
Show/Hide
|
C28H28O4
|
2
|
| 1 |
EC50 = 23 nM
|
|
|
| 2 |
EC50 = 4033 nM
|
|
|
|
CP0511744
|
(3S)-3-[4-[[4-[(5-methoxy-1-methylspiro[2H-indole-3,4'-piperidine]-1'-yl)methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C34H38N2O4
|
3
|
| 1 |
EC50 = 23 nM
|
|
|
| 2 |
EC50 = 100 nM
|
|
|
| 3 |
EC50 = 130 nM
|
|
|
|
CP0136178
|
3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid
Show/Hide
|
C22H21NO3
|
3
|
| 1 |
EC50 = 28.18 nM
|
|
|
| 2 |
EC50 = 48 nM
|
|
|
| 3 |
EC50 = 50.12 nM
|
|
|
|
CP0396274
|
(3S)-3-cyclopropyl-3-[2-[4-(2-fluoro-5-methoxyphenyl)-3-(trifluoromethoxy)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
Show/Hide
|
C29H26F4O5
|
2
|
| 1 |
EC50 = 29 nM
|
|
|
| 2 |
EC50 = 416 nM
|
|
|
|
CP0551416
|
(3S)-3-[4-[[3-[[acetyl(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C27H27NO4S
|
1
|
| 1 |
EC50 = 29.6 nM
|
|
|
|
CP0491438
|
US9688642, 46
Show/Hide
|
C31H33FN2O4
|
1
|
| 1 |
EC50 = 37 nM
|
|
|
|
CP0558063
|
(3S)-3-[4-[[3-[[methyl(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C26H27NO3S
|
1
|
| 1 |
EC50 = 38 nM
|
|
|
|
CP0949262
|
(S)-3-(4-(4-((S)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)benzyloxy)phenyl)hex-4-ynoic acid
Show/Hide
|
C30H29NO4
|
1
|
| 1 |
EC50 = 39 nM
|
|
|
|
CP0471351
|
3-[2-fluoro-4-[[4-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C30H30FNO3
|
3
|
| 1 |
EC50 = 39 nM
|
|
|
| 2 |
EC50 = 180 nM
|
|
|
| 3 |
EC50 = 340 nM
|
|
|
|
CP0542344
|
(3S)-3-[4-[[(3S)-6-(4-methoxyphenyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C28H26O6
|
1
|
| 1 |
EC50 = 40 nM
|
|
|
|
CP0854587
|
3-(4-(4-(1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)benzyloxy)phenyl)hex-4-ynoic acid
Show/Hide
|
C30H29NO4
|
1
|
| 1 |
EC50 = 42 nM
|
|
|
|
CP0466425
|
(3S)-3-[4-[[5-[4-(4-fluorophenyl)piperazine-1-carbonyl]thiophen-2-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C28H27FN2O4S
|
1
|
| 1 |
EC50 = 47 nM
|
|
|
|
CP0930056
|
3-(4-((5-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)furan-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
|
C27H25NO5
|
1
|
| 1 |
EC50 = 50 nM
|
|
|
|
CP0104147
|
(3S)-3-[4-[[(3S)-6-chloro-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C21H19ClO5
|
1
|
| 1 |
EC50 = 50 nM
|
|
|
|
CP0949270
|
3-(4-((5-(4-(4-fluorophenyl)piperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
|
C28H27FN2O4S
|
1
|
| 1 |
EC50 = 54 nM
|
|
|
|
CP0384162
|
(2S,3S)-3-cyclopropyl-2-fluoro-3-[3-[[4-(2-fluoro-5-methoxyphenyl)cyclohexyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C26H30F2O4
|
1
|
| 1 |
EC50 = 54 nM
|
|
|
|
CP0891615
|
5-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)-2-methylbenzyl)thiazolidine-2,4-dione
Show/Hide
|
C17H12ClF3N2O3S
|
1
|
| 1 |
EC50 = 54.95 nM
|
|
|
|
CP0882541
|
3-(4-((5-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
|
C27H25NO4S
|
1
|
| 1 |
EC50 = 57 nM
|
|
|
|
CP0384387
|
(2R,3R)-3-cyclopropyl-3-[3-[[(1R)-5-(2-fluoro-5-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]-2-methylpropanoic acid
Show/Hide
|
C29H29FO4
|
2
|
| 1 |
EC50 = 59 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0521399
|
(2S,3R)-3-cyclopropyl-3-[3-[[(1S)-5-(2-fluoro-5-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]-2-methylpropanoic acid
Show/Hide
|
C29H29FO4
|
2
|
| 1 |
EC50 = 60 nM
|
|
|
| 2 |
EC50 = 5486 nM
|
|
|
|
CP0153669
|
3-[4-[2-[2-(cyanomethyl)phenyl]ethynyl]phenyl]propanoic acid
Show/Hide
|
C19H15NO2
|
3
|
| 1 |
EC50 = 61.66 nM
|
|
|
| 2 |
EC50 = 69.18 nM
|
|
|
| 3 |
EC50 = 239.88 nM
|
|
|
|
CP0404981
|
3-{4-[(3-Phenoxybenzyl)oxy]phenyl}propanoic Acid
Show/Hide
|
C22H20O4
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0521401
|
(3S)-3-cyclopropyl-3-[3-[[(1R)-5-(2-fluoro-5-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]propanoic acid
Show/Hide
|
C28H27FO4
|
2
|
| 1 |
EC50 = 64 nM
|
|
|
| 2 |
EC50 = 5951 nM
|
|
|
|
CP0085623
|
3-(4-(o-Tolylethynyl)phenyl)propanoic acid
Show/Hide
|
C18H16O2
|
1
|
| 1 |
EC50 = 67.61 nM
|
|
|
|
CP0473977
|
(3S)-3-[4-[[(3S)-6-(2,4-dichlorophenyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C27H22Cl2O5
|
1
|
| 1 |
EC50 = 70 nM
|
|
|
|
CP0402869
|
(3S)-3-[4-[[2-[4-(3-hydroxy-3-methylbutoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C30H31N3O5
|
3
|
| 1 |
EC50 = 72 nM
|
|
|
| 2 |
EC50 = 301 nM
|
|
|
| 3 |
Ki = 37 nM
|
|
|
|
CP0930547
|
3-(4-((5-(4-phenylpiperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
|
C28H28N2O4S
|
1
|
| 1 |
EC50 = 72 nM
|
|
|
|
CP0377499
|
3-[4-[(3-bromophenyl)methoxy]phenyl]propanoic acid
Show/Hide
|
C16H15BrO3
|
1
|
| 1 |
EC50 = 75.86 nM
|
|
|
|
CP0393322
|
(3S)-3-cyclopropyl-3-[3-[[4-(2-fluoro-5-methoxyphenyl)phenyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C26H25FO4
|
2
|
| 1 |
EC50 = 79 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0879067
|
3-(4-((5-(1,2,3,4-tetrahydroquinoline-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
|
C27H25NO4S
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
|
CP0391078
|
(3S)-3-[4-[[(3S)-6-(4-chlorophenyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C27H23ClO5
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
|
CP0473973
|
(3S)-3-[4-[[(3S)-6-(2-chlorophenyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C27H23ClO5
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
|
CP0406065
|
3-[4-[(3-phenylphenyl)methylamino]phenyl]propanoic acid
Show/Hide
|
C22H21NO2
|
1
|
| 1 |
EC50 = 83.18 nM
|
|
|
|
CP0422238
|
3-[2-chloro-4-[[4-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C30H30ClNO3
|
3
|
| 1 |
EC50 = 86 nM
|
|
|
| 2 |
EC50 = 140 nM
|
|
|
| 3 |
EC50 = 740 nM
|
|
|
|
CP0476711
|
(3S)-3-[4-[[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C21H20O5
|
1
|
| 1 |
EC50 = 90 nM
|
|
|
|
CP0521405
|
(2S,3R)-3-cyclopropyl-3-[3-[[(7R)-3-(2-fluoro-5-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]oxy]phenyl]-2-methylpropanoic acid
Show/Hide
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C28H28FNO4
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2
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| 1 |
EC50 = 90 nM
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| 2 |
EC50 = 4902 nM
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CP0425922
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3-[4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]propanoic acid
Show/Hide
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C17H15F3O3
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1
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| 1 |
EC50 = 91.2 nM
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CP0905198
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3-(4-((5-(4-(2-nitrophenyl)piperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
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C28H27N3O6S
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1
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| 1 |
EC50 = 94 nM
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CP0946840
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3-(4-((5-(4-(3-fluorophenyl)piperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
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C28H27FN2O4S
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1
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| 1 |
EC50 = 97 nM
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CP0422154
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3-(4-{[(4-phenoxyphenyl)methyl]amino}phenyl)propanoic acid
Show/Hide
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C22H21NO3
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1
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| 1 |
EC50 = 97.72 nM
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CP0455387
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3-[4-[(6-chloro-2,3-dihydro-1,4-benzodioxin-3-yl)methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C21H19ClO5
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1
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| 1 |
EC50 = 100 nM
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CP0854588
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3-(4-(4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzyloxy)phenyl)hex-4-ynoic acid
Show/Hide
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C29H27NO4
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1
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| 1 |
EC50 = 106 nM
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CP0963647
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3-(4-((5-(1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
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C28H27NO4S
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1
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| 1 |
EC50 = 109 nM
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CP0406069
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3-[4-[(4-chloro-2-phenylphenyl)methoxy]phenyl]propanoic acid
Show/Hide
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C22H19ClO3
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1
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| 1 |
EC50 = 109.65 nM
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CP0546587
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(3S)-3-[4-[[(2S)-6-chloro-2,3-dihydro-1,4-benzodioxin-2-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C21H19ClO5
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1
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| 1 |
EC50 = 110 nM
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CP0893239
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3-(4-((5-(4-(2-fluorophenyl)piperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
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C28H27FN2O4S
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1
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| 1 |
EC50 = 113 nM
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CP0943891
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3-(4-(4-(4-(4-fluorophenyl)piperazine-1-carbonyl)benzyloxy)phenyl)hex-4-ynoic acid
Show/Hide
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C30H29FN2O4
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1
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| 1 |
EC50 = 114 nM
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CP0415364
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(3S)-3-[4-[[2-[2,6-dimethyl-4-(3-methylsulfonylpropoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C31H33N3O6S
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3
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| 1 |
EC50 = 117 nM
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| 2 |
EC50 = 1490 nM
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| 3 |
Ki = 63 nM
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CP0385194
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(3S)-3-[4-[[3-[(thiophen-3-ylmethylamino)methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C25H25NO3S
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1
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| 1 |
EC50 = 118.3 nM
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CP0429225
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(3S)-3-[4-[[(3S)-6-methyl-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C22H22O5
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1
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| 1 |
EC50 = 120 nM
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CP0437863
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(3S)-3-[4-[[(3S)-6-(4-fluorophenyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C27H23FO5
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1
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| 1 |
EC50 = 120 nM
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CP0472180
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(3S)-3-[4-[[(3S)-6-(2,6-dimethylphenyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C29H28O5
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1
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| 1 |
EC50 = 120 nM
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CP0491546
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(3S)-3-[4-[[(3S)-6-methoxy-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C22H22O6
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1
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| 1 |
EC50 = 130 nM
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CP0457216
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(3S)-3-cyclopropyl-3-[2-(4-phenylphenyl)-3,4-dihydro-2H-chromen-7-yl]propanoic acid
Show/Hide
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C27H26O3
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2
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| 1 |
EC50 = 133 nM
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| 2 |
EC50 = 5442 nM
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CP0852847
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3-(4-((5-(4-(4-chlorophenyl)piperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
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C28H27ClN2O4S
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1
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| 1 |
EC50 = 133 nM
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CP0914982
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3-(4-((5-(1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)furan-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
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C28H27NO5
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1
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| 1 |
EC50 = 133 nM
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CP0930062
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3-(4-((5-(4-(pyridin-2-yl)piperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
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C27H27N3O4S
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1
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| 1 |
EC50 = 138 nM
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CP0386271
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(3S)-3-[4-[[3-[[(1-methylpiperidin-4-yl)-(thiophen-3-ylmethyl)amino]methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C31H36N2O3S
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1
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| 1 |
EC50 = 140 nM
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CP0879065
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3-(4-((2-(1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)thiazol-5-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
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C27H26N2O4S
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1
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| 1 |
EC50 = 144 nM
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CP0534590
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(3S)-3-[4-[[(3S)-6,7-dichloro-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C21H18Cl2O5
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1
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| 1 |
EC50 = 150 nM
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CP0547195
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(3S)-3-[4-[[(3S)-6-(4-cyanophenyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C28H23NO5
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1
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| 1 |
EC50 = 150 nM
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CP0536754
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(2S,3R)-3-cyclopropyl-3-[3-[[(5R)-2-(2-fluoro-5-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-5-yl]oxy]phenyl]-2-methylpropanoic acid
Show/Hide
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C28H28FNO4
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2
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| 1 |
EC50 = 151 nM
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| 2 |
EC50 > 10000 nM
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CP0404980
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3-{4-[(4-Phenoxybenzyl)oxy]phenyl}propanoic Acid
Show/Hide
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C22H20O4
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1
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| 1 |
EC50 = 154.88 nM
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CP0963648
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3-(4-((5-(4-benzylpiperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
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C29H30N2O4S
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1
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| 1 |
EC50 = 155 nM
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CP0384380
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(2S,3R)-3-cyclopropyl-3-[3-[[(1R)-6-fluoro-5-(2-fluoro-5-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]-2-methylpropanoic acid
Show/Hide
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C29H28F2O4
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2
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| 1 |
EC50 = 155 nM
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| 2 |
EC50 > 10000 nM
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CP0433982
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(3S)-3-[4-[[(3S)-6-phenyl-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C27H24O5
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1
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| 1 |
EC50 = 160 nM
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CP0389994
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(3S)-3-cyclopropyl-3-[2-[4-(3-methylsulfanylphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
Show/Hide
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C28H28O3S
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2
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| 1 |
EC50 = 165 nM
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| 2 |
EC50 = 5174 nM
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CP0372138
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3-[4-[(4-bromophenyl)methoxy]phenyl]propanoic acid
Show/Hide
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C16H15BrO3
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1
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| 1 |
EC50 = 165.96 nM
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CP0457360
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(3S)-3-[4-[[(2S)-5-chloro-2,3-dihydro-1,4-benzodioxin-2-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C21H19ClO5
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1
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| 1 |
EC50 = 170 nM
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CP0438000
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3-[4-(4-cyanonaphthalen-1-yl)oxyphenyl]hex-4-ynoic acid
Show/Hide
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C23H17NO3
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2
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| 1 |
EC50 = 172 nM
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| 2 |
EC50 = 247 nM
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CP0953628
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3-(4-((5-(spiro[indene-1,4'-piperidine]-1'-ylcarbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
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C31H29NO4S
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1
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| 1 |
EC50 = 172 nM
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CP0946841
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3-(4-(4-(spiro[indene-1,4'-piperidine]-1'-ylcarbonyl)benzyloxy)phenyl)hex-4-ynoic acid
Show/Hide
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C33H31NO4
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1
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| 1 |
EC50 = 179 nM
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CP0905199
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3-(4-((5-(4-(3-nitrophenyl)piperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
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C28H27N3O6S
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1
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| 1 |
EC50 = 187 nM
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CP0426503
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(3S)-3-[2-fluoro-4-[[4-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C33H32FNO3
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3
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| 1 |
EC50 = 190 nM
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| 2 |
EC50 = 440 nM
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| 3 |
EC50 = 680 nM
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CP0422117
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3-[4-[[3-(trifluoromethyl)phenyl]methylamino]phenyl]propanoic acid
Show/Hide
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C17H16F3NO2
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1
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| 1 |
EC50 = 199.53 nM
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CP0457377
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(3S)-3-[4-[[(2S)-6-bromo-7-chloro-2,3-dihydro-1,4-benzodioxin-2-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C21H18BrClO5
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1
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| 1 |
EC50 = 200 nM
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CP0532834
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(3S)-3-[4-[[(3S)-6-(2-fluoro-4-methoxyphenyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C28H25FO6
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1
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| 1 |
EC50 = 200 nM
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CP0949263
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3-(4-((2-(4-(4-fluorophenyl)piperazine-1-carbonyl)thiazol-5-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
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C27H26FN3O4S
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1
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| 1 |
EC50 = 203 nM
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CP0196069
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2-[(2R,4R)-1-[4-[[4-(2-fluoro-5-methoxyphenyl)-2-methylphenyl]methyl]phenyl]-4-(trifluoromethyl)pyrrolidin-2-yl]acetic acid
Show/Hide
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C28H27F4NO3
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1
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| 1 |
EC50 = 210 nM
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CP0405536
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(3S)-3-[4-[[(3S)-6-fluoro-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C21H19FO5
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1
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| 1 |
EC50 = 210 nM
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CP0405538
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(3S)-3-[4-[[(3S)-6-chloro-7-fluoro-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C21H18ClFO5
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1
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| 1 |
EC50 = 210 nM
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CP0538940
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(3S)-3-[4-[[(3S)-6-bromo-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C21H19BrO5
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1
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| 1 |
EC50 = 210 nM
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CP0958109
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3-(4-((5-(4-p-tolylpiperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
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C29H30N2O4S
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1
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| 1 |
EC50 = 211 nM
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CP0404722
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3-(4-{[(4-phenylphenyl)methyl]amino}phenyl)propanoic acid
Show/Hide
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C22H21NO2
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1
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| 1 |
EC50 = 218.78 nM
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CP0472179
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(3S)-3-[4-[[(3S)-6-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C28H23F3O5
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1
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| 1 |
EC50 = 220 nM
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CP0532833
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(3S)-3-[4-[[(3S)-6-pyridin-3-yl-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C26H23NO5
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1
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| 1 |
EC50 = 220 nM
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CP0915404
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rac-5-(1-(4-(2-(difluoromethoxy)-4-(trifluoromethyl)phenoxy)phenyl)but-2-ynyl)oxazolidine-2,4-dione
Show/Hide
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C21H14F5NO5
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2
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| 1 |
EC50 = 224 nM
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| 2 |
EC50 = 249 nM
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CP0963683
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3-(4-((5-(4-(4-nitrophenyl)piperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
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C28H27N3O6S
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1
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| 1 |
EC50 = 231 nM
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CP0377498
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3-(4-{[(3-bromophenyl)methyl]amino}phenyl)propanoic acid
Show/Hide
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C16H16BrNO2
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1
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| 1 |
EC50 = 239.88 nM
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CP0391079
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(3S)-3-[4-[[(3S)-6-(4-methylphenyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C28H26O5
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1
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| 1 |
EC50 = 240 nM
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CP0429224
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(3S)-3-[4-[[(3R)-6-chloro-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C21H19ClO5
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1
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| 1 |
EC50 = 260 nM
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CP0405543
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(3S)-3-[4-[[(3S)-6-propan-2-yloxy-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C24H26O6
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1
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| 1 |
EC50 = 280 nM
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CP0893240
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3-(4-((5-(4-(4-methoxyphenyl)piperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
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C29H30N2O5S
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1
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| 1 |
EC50 = 289 nM
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CP0559473
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(3S)-3-[4-[[(3S)-6-[4-(trifluoromethoxy)phenyl]-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C28H23F3O6
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1
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| 1 |
EC50 = 290 nM
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CP0451744
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(3S)-3-[2-[3-cyano-4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-3-cyclopropylpropanoic acid
Show/Hide
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C29H26FNO4
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2
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| 1 |
EC50 = 296 nM
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| 2 |
EC50 = 5450 nM
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CP0439923
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(3S)-3-[4-[[(3S)-6-(3,4-dichlorophenyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C27H22Cl2O5
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1
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| 1 |
EC50 = 300 nM
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CP0389990
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(3S)-3-cyclopropyl-3-[2-[4-(6-methoxypyridin-2-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
Show/Hide
|
C27H27NO4
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2
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| 1 |
EC50 = 304 nM
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| 2 |
EC50 > 10000 nM
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CP0271790
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3-[4-[2-(difluoromethoxy)-4-(trifluoromethyl)phenoxy]-2-fluorophenyl]hex-4-ynoic acid
Show/Hide
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C20H14F6O4
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2
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| 1 |
EC50 = 306 nM
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| 2 |
EC50 = 349 nM
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CP0852845
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3-(4-((5-(4-(4-fluorophenyl)piperazine-1-carbonyl)furan-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
|
C28H27FN2O5
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1
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| 1 |
EC50 = 308 nM
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CP0553127
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(2S,3R)-3-cyclopropyl-3-[3-[[(1R)-4-(5,5-dimethylcyclopenten-1-yl)-5-(2-fluoro-5-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]-2-methylpropanoic acid
Show/Hide
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C36H39FO4
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2
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| 1 |
EC50 = 326 nM
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| 2 |
EC50 = 5450 nM
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CP0532749
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(3R)-3-[4-[[4-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C33H33NO3
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3
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| 1 |
EC50 = 360 nM
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| 2 |
EC50 = 540 nM
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| 3 |
EC50 = 2800 nM
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CP0392632
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3-[4-[[3-(2,6-dimethylphenyl)phenyl]methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C24H20O3
|
1
|
| 1 |
EC50 = 380 nM
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CP0520040
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(3S)-3-cyclopropyl-3-[2-[4-(3-hydroxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
Show/Hide
|
C27H26O4
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2
|
| 1 |
EC50 = 391 nM
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| 2 |
EC50 = 4580 nM
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CP0443762
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(3S)-3-[4-[[(3S)-6-(3-chlorophenyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C27H23ClO5
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1
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| 1 |
EC50 = 400 nM
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CP0434127
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3-[4-[[5-chloro-2-(4-methylphenyl)phenyl]methoxy]phenyl]propanoic acid
Show/Hide
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C23H21ClO3
|
1
|
| 1 |
EC50 = 407.38 nM
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CP0377859
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3-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]hex-4-ynoic acid
Show/Hide
|
C18H13ClF3NO3
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1
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| 1 |
EC50 = 409 nM
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CP0906545
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3-(4-((5-(4-(4-tert-butylphenyl)piperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
|
C32H36N2O4S
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1
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| 1 |
EC50 = 417 nM
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CP0164279
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3-[4-[2-(difluoromethoxy)-4-(trifluoromethyl)phenoxy]phenyl]hex-4-ynoic acid
Show/Hide
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C20H15F5O4
|
2
|
| 1 |
EC50 = 436 nM
|
|
|
| 2 |
EC50 = 455 nM
|
|
|
|
CP0416655
|
3-[4-[(2-bromophenyl)methoxy]phenyl]propanoic acid
Show/Hide
|
C16H15BrO3
|
1
|
| 1 |
EC50 = 457.09 nM
|
|
|
|
CP0530144
|
3-[4-[[(3S)-6-(4-chlorophenyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]-2-fluorophenyl]propanoic acid
Show/Hide
|
C24H20ClFO5
|
1
|
| 1 |
EC50 = 460 nM
|
|
|
|
CP0416654
|
3-[4-[[2-(4-chlorophenyl)phenyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C22H19ClO3
|
1
|
| 1 |
EC50 = 512.86 nM
|
|
|
|
CP0377836
|
3-[4-(2-chloro-4-cyanophenoxy)phenyl]hex-4-ynoic acid
Show/Hide
|
C19H14ClNO3
|
2
|
| 1 |
EC50 = 519 nM
|
|
|
| 2 |
EC50 = 597 nM
|
|
|
|
CP0405542
|
(3S)-3-[4-[[(3S)-5-chloro-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C21H19ClO5
|
1
|
| 1 |
EC50 = 520 nM
|
|
|
|
CP0489466
|
3-[4-[[2-(3-methylphenyl)phenyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C23H22O3
|
1
|
| 1 |
EC50 = 524.81 nM
|
|
|
|
CP0879066
|
3-(4-((2-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)thiazol-5-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
|
C26H24N2O4S
|
1
|
| 1 |
EC50 = 531 nM
|
|
|
|
CP0424816
|
Benzyloxyphenylpropanoic acid
Show/Hide
|
C16H16O3
|
1
|
| 1 |
EC50 = 549.54 nM
|
|
|
|
CP0432473
|
3-[4-[(5-chloro-2-phenylphenyl)methoxy]phenyl]propanoic acid
Show/Hide
|
C22H19ClO3
|
1
|
| 1 |
EC50 = 602.56 nM
|
|
|
|
CP0476103
|
3-[4-[[2-(2-methylphenyl)phenyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C23H22O3
|
1
|
| 1 |
EC50 = 602.56 nM
|
|
|
|
CP0854589
|
3-(4-((5-(4-(4-fluorophenyl)piperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)propanoic acid
Show/Hide
|
C25H25FN2O4S
|
1
|
| 1 |
EC50 = 610 nM
|
|
|
|
CP0434989
|
3-[4-[[3-(2-methylphenyl)phenyl]methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C23H18O3
|
1
|
| 1 |
EC50 = 610 nM
|
|
|
|
CP0406067
|
3-[4-[[2-[4-(trifluoromethoxy)phenyl]phenyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C23H19F3O4
|
1
|
| 1 |
EC50 = 630.96 nM
|
|
|
|
CP0526088
|
3-[4-[[2-(4-methylphenyl)phenyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C23H22O3
|
1
|
| 1 |
EC50 = 630.96 nM
|
|
|
|
CP0450688
|
3-[4-[(6-chloro-2,3-dihydro-1,4-benzodioxin-3-yl)methoxy]phenyl]-3-ethoxypropanoic acid
Show/Hide
|
C20H21ClO6
|
1
|
| 1 |
EC50 = 640 nM
|
|
|
|
CP0352619
|
3-[4-(Biphenyl-3-ylmethoxy)phenyl]propanoic Acid
Show/Hide
|
C22H20O3
|
1
|
| 1 |
EC50 = 676.08 nM
|
|
|
|
CP0392633
|
3-[4-[[3-(2-chlorophenyl)phenyl]methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C22H15ClO3
|
1
|
| 1 |
EC50 = 690 nM
|
|
|
|
CP0538939
|
(3S)-3-[4-[[(3S)-6-(trifluoromethoxy)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C22H19F3O6
|
1
|
| 1 |
EC50 = 700 nM
|
|
|
|
CP0422153
|
3-[4-[(3-cyanophenyl)methoxy]phenyl]propanoic acid
Show/Hide
|
C17H15NO3
|
1
|
| 1 |
EC50 = 741.31 nM
|
|
|
|
CP0473796
|
2-[(3S)-6-[[3-(2-benzyl-3,4-dihydro-1H-isoquinolin-7-yl)phenyl]methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid;hydrochloride
Show/Hide
|
C33H32ClNO4
|
1
|
| 1 |
EC50 = 800 nM
|
|
|
|
CP0902987
|
3-(4-((3-(2-benzyl-1,2,3,4-tetrahydroisoquinolin-5-yl)benzyl)oxy)phenyl)-3-methylbutanoic acid hydrochloride
Show/Hide
|
C34H36ClNO3
|
1
|
| 1 |
EC50 = 800 nM
|
|
|
|
CP0545534
|
3-[2-[3-(5,5-dimethylcyclopenten-1-yl)-4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
Show/Hide
|
C32H33FO4
|
2
|
| 1 |
EC50 = 816 nM
|
|
|
| 2 |
EC50 = 3120 nM
|
|
|
|
CP0930059
|
3-(4-((5-(4-cyclohexylpiperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
|
C28H34N2O4S
|
1
|
| 1 |
EC50 = 820 nM
|
|
|
|
CP0538938
|
3-[4-[(6-chloro-2,3-dihydro-1,4-benzodioxin-3-yl)methoxy]-2-fluorophenyl]propanoic acid
Show/Hide
|
C18H16ClFO5
|
1
|
| 1 |
EC50 = 830 nM
|
|
|
|
CP0497742
|
3-[4-[[2-(4-bromophenyl)phenyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C22H19BrO3
|
1
|
| 1 |
EC50 = 851.14 nM
|
|
|
|
CP0434128
|
3-[4-[[2-(4-fluorophenyl)phenyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C22H19FO3
|
1
|
| 1 |
EC50 = 933.25 nM
|
|
|
|
CP0389995
|
(3S)-3-cyclopropyl-3-[2-[4-[3-(trifluoromethoxy)phenyl]phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
Show/Hide
|
C28H25F3O4
|
2
|
| 1 |
EC50 = 934 nM
|
|
|
| 2 |
EC50 = 6431 nM
|
|
|
|
CP0467364
|
3-[4-[(5-fluoro-2-phenylphenyl)methoxy]phenyl]propanoic acid
Show/Hide
|
C22H19FO3
|
1
|
| 1 |
EC50 = 954.99 nM
|
|
|
|
CP0455386
|
3-[4-[(6-bromo-2,3-dihydro-1,4-benzodioxin-2-yl)methoxy]-2-fluorophenyl]propanoic acid
Show/Hide
|
C18H16BrFO5
|
1
|
| 1 |
EC50 = 980 nM
|
|
|
|
CP0411056
|
2-[3-[4-[[(3S)-6-(4-chlorophenyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]oxetan-3-yl]acetic acid
Show/Hide
|
C26H23ClO6
|
1
|
| 1 |
EC50 = 1020 nM
|
|
|
|
CP0478738
|
3-[4-[(6-chloro-2,3-dihydro-1,4-benzodioxin-3-yl)methoxy]phenyl]-3-(1,3-oxazol-5-yl)propanoic acid
Show/Hide
|
C21H18ClNO6
|
1
|
| 1 |
EC50 = 1030 nM
|
|
|
|
CP0457741
|
3-[4-[(3-phenoxyphenyl)methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C22H16O4
|
1
|
| 1 |
EC50 = 1100 nM
|
|
|
|
CP0915471
|
3-(4-((5-(4-(pyridin-3-yl)piperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
|
C27H27N3O4S
|
1
|
| 1 |
EC50 = 1136 nM
|
|
|
|
CP0406064
|
3-[4-(benzylamino)phenyl]propanoic acid
Show/Hide
|
C16H17NO2
|
1
|
| 1 |
EC50 = 1148.15 nM
|
|
|
|
CP0476559
|
3-[4-[[2-[4-(trifluoromethyl)phenyl]phenyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C23H19F3O3
|
1
|
| 1 |
EC50 = 1148.15 nM
|
|
|
|
CP0445716
|
3-[4-[(6-chloro-2,3-dihydro-1,4-benzodioxin-3-yl)methoxy]phenyl]-3-pyridin-4-ylpropanoic acid
Show/Hide
|
C23H20ClNO5
|
1
|
| 1 |
EC50 = 1170 nM
|
|
|
|
CP0574407
|
2-[(3S)-6-[[3-(2-benzyl-3,4-dihydro-1H-isoquinolin-6-yl)phenyl]methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid;hydrochloride
Show/Hide
|
C33H32ClNO4
|
1
|
| 1 |
EC50 = 1200 nM
|
|
|
|
CP0517456
|
(3S)-3-cyclopropyl-3-[2-[3-(5,5-dimethylcyclopenten-1-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
Show/Hide
|
C28H32O3
|
2
|
| 1 |
EC50 = 1252 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0429221
|
3-[2-fluoro-4-[(6-methoxy-2,3-dihydro-1,4-benzodioxin-3-yl)methoxy]phenyl]propanoic acid
Show/Hide
|
C19H19FO6
|
1
|
| 1 |
EC50 = 1470 nM
|
|
|
|
CP0542343
|
3-[4-[[(3R)-6-(4-chlorophenyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]-2-fluorophenyl]propanoic acid
Show/Hide
|
C24H20ClFO5
|
1
|
| 1 |
EC50 = 1780 nM
|
|
|
|
CP0552535
|
3-[4-[[3-(3-fluorophenyl)phenyl]methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C22H15FO3
|
1
|
| 1 |
EC50 = 1800 nM
|
|
|
|
CP0414409
|
3-[(2R)-6-(2-cyclobutyloxy-5-fluoropyridin-4-yl)-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Show/Hide
|
C21H22FNO4
|
1
|
| 1 |
EC50 = 2000 nM
|
|
|
|
CP0425923
|
3-[4-[[2-(4-methoxyphenyl)phenyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C23H22O4
|
1
|
| 1 |
EC50 = 2041.74 nM
|
|
|
|
CP0408970
|
3-[(2R)-6-[2-fluoro-5-(trifluoromethoxy)phenyl]-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Show/Hide
|
C19H16F4O4
|
1
|
| 1 |
EC50 = 2100 nM
|
|
|
|
CP0405537
|
(3S)-3-[4-[[(3S)-6-cyano-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C22H19NO5
|
1
|
| 1 |
EC50 = 2100 nM
|
|
|
|
CP0546585
|
3-[2-fluoro-4-[(7-methoxy-3,4-dihydro-2H-chromen-2-yl)methoxy]phenyl]propanoic acid
Show/Hide
|
C20H21FO5
|
1
|
| 1 |
EC50 = 2110 nM
|
|
|
|
CP0521400
|
(3S)-3-cyclopropyl-3-[3-[[(1R)-7-fluoro-5-(2-fluoro-5-methoxyphenyl)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]propanoic acid
Show/Hide
|
C28H26F2O4
|
2
|
| 1 |
EC50 = 2156 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0414422
|
3-[(2R)-6-[3-chloro-2-fluoro-5-(trifluoromethoxy)phenyl]-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Show/Hide
|
C19H15ClF4O4
|
1
|
| 1 |
EC50 = 2200 nM
|
|
|
|
CP0472028
|
2-[(3S)-6-[[3-(2-benzoyl-3,4-dihydro-1H-isoquinolin-5-yl)phenyl]methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid
Show/Hide
|
C33H29NO5
|
1
|
| 1 |
EC50 = 2200 nM
|
|
|
|
CP0484649
|
3-[4-[(6-bromo-2,3-dihydro-1,4-benzodioxin-3-yl)methoxy]-2-fluorophenyl]propanoic acid
Show/Hide
|
C18H16BrFO5
|
1
|
| 1 |
EC50 = 2240 nM
|
|
|
|
CP0445715
|
3-[2-fluoro-4-[[7-(2-methoxyethoxy)-3,4-dihydro-2H-chromen-2-yl]methoxy]phenyl]propanoic acid
Show/Hide
|
C22H25FO6
|
1
|
| 1 |
EC50 = 2370 nM
|
|
|
|
CP0471894
|
2-[(2S,4S)-1-[4-[[4-(2-fluoro-5-methoxyphenyl)-2-methylphenyl]methyl]phenyl]-4-(trifluoromethyl)pyrrolidin-2-yl]acetic acid
Show/Hide
|
C28H27F4NO3
|
2
|
| 1 |
EC50 = 2400 nM
|
|
|
| 2 |
Ki = 45 nM
|
|
|
|
CP0464376
|
2-[3-[2-cyano-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecan-9-yl]acetic acid
Show/Hide
|
C20H23F3N2O3
|
1
|
| 1 |
EC50 = 2500 nM
|
|
|
|
CP0392469
|
3-[4-[[3-[2-(trifluoromethoxy)phenyl]phenyl]methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C23H15F3O4
|
1
|
| 1 |
EC50 = 2850 nM
|
|
|
|
CP0514115
|
3-[4-[[3-(2,4,6-trimethylphenyl)phenyl]methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C25H22O3
|
1
|
| 1 |
EC50 = 2870 nM
|
|
|
|
CP0023108
|
(9,12,15)-linolenic acid
Show/Hide
|
C18H30O2
|
2
|
| 1 |
EC50 = 2884.03 nM
|
|
|
| 2 |
EC50 = 11090 nM
|
|
|
|
CP0429318
|
2-[(3S)-6-[[3-(2-benzyl-1,3-dihydroisoindol-5-yl)phenyl]methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid;hydrochloride
Show/Hide
|
C32H30ClNO4
|
1
|
| 1 |
EC50 = 3000 nM
|
|
|
|
CP0394455
|
3-[4-[(6-chloro-2,3-dihydro-1,4-benzodioxin-3-yl)methoxy]phenyl]-3-(3-methylimidazol-4-yl)propanoic acid
Show/Hide
|
C22H21ClN2O5
|
1
|
| 1 |
EC50 = 3060 nM
|
|
|
|
CP0455388
|
(3R)-3-[4-[[(3S)-6-chloro-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C21H19ClO5
|
1
|
| 1 |
EC50 = 3400 nM
|
|
|
|
CP0406068
|
3-[4-[[2-(4-methylsulfanylphenyl)phenyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C23H22O3S
|
1
|
| 1 |
EC50 = 3548.13 nM
|
|
|
|
CP0432202
|
3-[(2R)-6-(5-cyclobutyloxy-2-fluorophenyl)-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Show/Hide
|
C22H23FO4
|
1
|
| 1 |
EC50 = 3600 nM
|
|
|
|
CP0537393
|
3-[4-[(3-phenylphenyl)methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C22H16O3
|
1
|
| 1 |
EC50 = 3770 nM
|
|
|
|
CP0479589
|
3-[4-[(6-chloro-2,3-dihydro-1,4-benzodioxin-3-yl)methoxy]phenyl]-3-(3-methyltriazol-4-yl)propanoic acid
Show/Hide
|
C21H20ClN3O5
|
1
|
| 1 |
EC50 = 3870 nM
|
|
|
|
CP0457746
|
3-[4-[[3-(2-propan-2-ylphenyl)phenyl]methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C25H22O3
|
1
|
| 1 |
EC50 = 3980 nM
|
|
|
|
CP0472029
|
2-[(3S)-6-[[3-[2-(2-phenylethyl)-3,4-dihydro-1H-isoquinolin-6-yl]phenyl]methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid;hydrochloride
Show/Hide
|
C34H34ClNO4
|
1
|
| 1 |
EC50 = 4000 nM
|
|
|
|
CP0523485
|
3-[4-[(4-phenoxyphenyl)methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C22H16O4
|
1
|
| 1 |
EC50 = 4020 nM
|
|
|
|
CP0479590
|
3-[4-[(6-chloro-2,3-dihydro-1,4-benzodioxin-3-yl)methoxy]phenyl]-3-(4-fluorophenyl)propanoic acid
Show/Hide
|
C24H20ClFO5
|
1
|
| 1 |
EC50 = 4310 nM
|
|
|
|
CP0466963
|
3-[(2R)-6-[2-fluoro-3-methoxy-5-(trifluoromethoxy)phenyl]-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Show/Hide
|
C20H18F4O5
|
1
|
| 1 |
EC50 = 4400 nM
|
|
|
|
CP0406066
|
3-[4-[[2-(4-ethoxyphenyl)phenyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C24H24O4
|
1
|
| 1 |
EC50 = 4466.84 nM
|
|
|
|
CP0372134
|
3-[4-[(2-phenylphenyl)methylamino]phenyl]propanoic acid
Show/Hide
|
C22H21NO2
|
1
|
| 1 |
EC50 = 4786.3 nM
|
|
|
|
CP0023295
|
(9Z,12Z)-octadeca-9,12-dienoic acid
Show/Hide
|
C18H32O2
|
1
|
| 1 |
EC50 = 4800 nM
|
|
|
|
CP0405535
|
(3R)-3-[4-[[(3R)-6-chloro-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C21H19ClO5
|
1
|
| 1 |
EC50 = 5040 nM
|
|
|
|
CP0472027
|
2-[(3S)-6-[[3-(2-benzyl-3,4-dihydro-1H-isoquinolin-5-yl)phenyl]methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid;hydrochloride
Show/Hide
|
C33H32ClNO4
|
1
|
| 1 |
EC50 = 5400 nM
|
|
|
|
CP0457375
|
3-[4-[(6-chloro-2,3-dihydro-1,4-benzodioxin-3-yl)methoxy]phenyl]-3-(1-methylimidazol-2-yl)propanoic acid
Show/Hide
|
C22H21ClN2O5
|
1
|
| 1 |
EC50 = 5880 nM
|
|
|
|
CP0396176
|
2-[3-(3,5-dichlorophenyl)-3-azaspiro[5.5]undecan-9-yl]acetic acid
Show/Hide
|
C18H23Cl2NO2
|
1
|
| 1 |
EC50 = 6300 nM
|
|
|
|
CP0411058
|
(3S)-3-[4-[[(3S)-6-(3-methoxyphenyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C28H26O6
|
1
|
| 1 |
EC50 = 6500 nM
|
|
|
|
CP0155897
|
CHEBI:30805
Show/Hide
|
C12H24O2
|
1
|
| 1 |
EC50 = 7943.28 nM
|
|
|
|
CP0478740
|
2-[3-[4-[(6-chloro-2,3-dihydro-1,4-benzodioxin-3-yl)methoxy]phenyl]oxetan-3-yl]acetic acid
Show/Hide
|
C20H19ClO6
|
1
|
| 1 |
EC50 = 8060 nM
|
|
|
|
CP0523484
|
3-[4-[[3-(2-chloro-4-methylphenyl)phenyl]methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C23H17ClO3
|
1
|
| 1 |
EC50 = 8080 nM
|
|
|
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CP0461738
|
2-[3-(3-chloro-2,5-difluorophenyl)-3-azaspiro[5.5]undecan-9-yl]acetic acid
Show/Hide
|
C18H22ClF2NO2
|
1
|
| 1 |
EC50 = 8100 nM
|
|
|
|
CP0373416
|
4-{4-[2-(Phenyl-2-pyridinylamino)ethoxy]phenyl}butyric Acid
Show/Hide
|
C23H24N2O3
|
1
|
| 1 |
EC50 = 9772.37 nM
|
|
|
|
CP0406070
|
3-[4-(Biphenyl-2-ylmethoxy)phenyl]propanoic Acid
Show/Hide
|
C22H20O3
|
1
|
| 1 |
EC50 = 10000 nM
|
|
|
|
CP0048202
|
3-[(2R)-6-[3,4-difluoro-6-(3-methoxycyclobutyl)oxypyridin-2-yl]-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Show/Hide
|
C22H23F2NO5
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0219930
|
3-[(2R)-6-[3-fluoro-4-methoxy-6-(3-methoxycyclobutyl)oxypyridin-2-yl]-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Show/Hide
|
C23H26FNO6
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0377505
|
5-[2-[(2R)-6-(5-cyclobutyloxy-2-fluorophenyl)-3,4-dihydro-2H-chromen-2-yl]ethyl]-2H-tetrazole
Show/Hide
|
C22H23FN4O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0380758
|
3-[(2R)-6-(6-cyclobutyloxy-3-fluoropyridin-2-yl)-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Show/Hide
|
C21H22FNO4
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0380759
|
3-[(2S)-6-[2-fluoro-5-(trifluoromethoxy)phenyl]-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Show/Hide
|
C19H16F4O4
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0380760
|
3-[(2R)-6-(6-cyclobutyloxy-3-fluoro-4-methoxypyridin-2-yl)-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Show/Hide
|
C22H24FNO5
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0398696
|
5-[2-[(2R)-6-[2,3-difluoro-5-(3-methoxycyclobutyl)oxyphenyl]-3,4-dihydro-2H-chromen-2-yl]ethyl]-2H-tetrazole
Show/Hide
|
C23H24F2N4O3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0399970
|
3-[(2R)-6-[3-chloro-2-fluoro-5-[(5-methyl-1,3-thiazol-2-yl)oxy]phenyl]-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Show/Hide
|
C22H19ClFNO4S
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0410368
|
(1R,2R)-2-[(2R)-6-[2-fluoro-5-(trifluoromethoxy)phenyl]-3,4-dihydro-2H-chromen-2-yl]cyclopropane-1-carboxylic acid
Show/Hide
|
C20H16F4O4
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0414416
|
(1R,2R)-2-[(2R)-6-(6-cyclobutyloxy-3-fluoro-4-methoxypyridin-2-yl)-3,4-dihydro-2H-chromen-2-yl]cyclopropane-1-carboxylic acid
Show/Hide
|
C23H24FNO5
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0414419
|
5-[2-[(2R)-6-[2-fluoro-3-methoxy-5-(trifluoromethoxy)phenyl]-3,4-dihydro-2H-chromen-2-yl]ethyl]-2H-tetrazole
Show/Hide
|
C20H18F4N4O3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0414423
|
(1R,2R)-2-[(2R)-6-[2,3-difluoro-5-(3-methoxycyclobutyl)oxyphenyl]-3,4-dihydro-2H-chromen-2-yl]cyclopropane-1-carboxylic acid
Show/Hide
|
C24H24F2O5
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0414856
|
3-[(2R)-6-(3-chloro-5-cyclobutyloxy-2-fluorophenyl)-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Show/Hide
|
C22H22ClFO4
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0432166
|
5-[2-[(2R)-6-(5-cyclopropyloxy-2-fluoro-3-methoxyphenyl)-3,4-dihydro-2H-chromen-2-yl]ethyl]-2H-tetrazole
Show/Hide
|
C22H23FN4O3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0432167
|
3-[(2R)-6-(5-cyclobutyloxy-2-fluoro-3-methoxyphenyl)-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Show/Hide
|
C23H25FO5
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0432168
|
5-[2-[(2R)-6-[2-fluoro-3-methoxy-5-(3-methoxycyclobutyl)oxyphenyl]-3,4-dihydro-2H-chromen-2-yl]ethyl]-2H-tetrazole
Show/Hide
|
C24H27FN4O4
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0432201
|
3-[(2R)-6-(5-cyclobutyloxy-2,3-difluorophenyl)-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Show/Hide
|
C22H22F2O4
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0432203
|
3-[(2R)-6-[2-fluoro-3-methoxy-5-[(5-methyl-1,3-thiazol-2-yl)oxy]phenyl]-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Show/Hide
|
C23H22FNO5S
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0447470
|
(1R,2R)-2-[(2R)-6-[2-fluoro-3-methoxy-5-(3-methoxycyclobutyl)oxyphenyl]-3,4-dihydro-2H-chromen-2-yl]cyclopropane-1-carboxylic acid
Show/Hide
|
C25H27FO6
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0447471
|
(1R,2R)-2-[(2R)-6-(5-cyclobutyloxy-2-fluoro-3-methoxyphenyl)-3,4-dihydro-2H-chromen-2-yl]cyclopropane-1-carboxylic acid
Show/Hide
|
C24H25FO5
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0451470
|
3-[(2R)-6-(5-cyclobutyloxy-2-fluoropyridin-3-yl)-3,4-dihydro-2H-chromen-2-yl]propanoic acid
Show/Hide
|
C21H22FNO4
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0452049
|
(1S,2S)-2-[(2R)-6-[2-fluoro-5-(trifluoromethoxy)phenyl]-3,4-dihydro-2H-chromen-2-yl]cyclopropane-1-carboxylic acid
Show/Hide
|
C20H16F4O4
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0508098
|
5-[2-[(2R)-6-[2-fluoro-5-(trifluoromethoxy)phenyl]-3,4-dihydro-2H-chromen-2-yl]ethyl]-2H-tetrazole
Show/Hide
|
C19H16F4N4O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0172418
|
2-[3-[2-chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecan-9-yl]acetic acid
Show/Hide
|
C19H23ClF3NO3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0396175
|
2-[3-[2-fluoro-5-(trifluoromethyl)phenyl]-3-azaspiro[5.5]undecan-9-yl]acetic acid
Show/Hide
|
C19H23F4NO2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0464379
|
2-[3-[3-cyano-5-(trifluoromethylsulfanyl)phenyl]-3-azaspiro[5.5]undecan-9-yl]acetic acid
Show/Hide
|
C20H23F3N2O2S
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0466653
|
2-[3-[2-fluoro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecan-9-yl]acetic acid
Show/Hide
|
C19H23F4NO3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0469180
|
2-[3-(2-chlorophenyl)-3-azaspiro[5.5]undecan-9-yl]acetic acid
Show/Hide
|
C18H24ClNO2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0500271
|
2-[3-[4-(trifluoromethyl)pyridin-2-yl]-3-azaspiro[5.5]undecan-9-yl]acetic acid
Show/Hide
|
C18H23F3N2O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0503952
|
2-[3-(2-chloro-5-methoxyphenyl)-3-azaspiro[5.5]undecan-9-yl]acetic acid
Show/Hide
|
C19H26ClNO3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0516513
|
2-[3-(5-chloro-2,2-dimethyl-3H-1-benzofuran-7-yl)-3-azaspiro[5.5]undecan-9-yl]acetic acid
Show/Hide
|
C22H30ClNO3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0392630
|
3-[4-[[3-[3-(trifluoromethyl)phenyl]phenyl]methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C23H15F3O3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0392631
|
3-[4-[(3-phenylmethoxyphenyl)methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C23H18O4
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0438153
|
3-[4-[[3-[4-(trifluoromethoxy)phenyl]phenyl]methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C23H15F3O4
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0476749
|
3-[4-[[3-(2,5-difluorophenyl)phenyl]methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C22H14F2O3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0518128
|
3-[4-[[3-(3-methylphenyl)phenyl]methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C23H18O3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0536667
|
3-[4-[[3-(4-fluorophenyl)phenyl]methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C22H15FO3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0542417
|
3-[4-[[3-(4-methylsulfonylphenyl)phenyl]methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C23H18O5S
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0552536
|
3-[4-[[3-(4-tert-butylphenyl)phenyl]methoxy]phenyl]prop-2-ynoic acid
Show/Hide
|
C26H24O3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0405540
|
3-[4-[(6-chloro-2,3-dihydro-1,4-benzodioxin-3-yl)methylamino]-2-fluorophenyl]propanoic acid
Show/Hide
|
C18H17ClFNO4
|
1
|
| 1 |
EC50 = 13570 nM
|
|
|
|
CP0463287
|
2-[(2S,4S)-1-[4-(2-methylphenoxy)phenyl]-4-(trifluoromethyl)pyrrolidin-2-yl]acetic acid
Show/Hide
|
C20H20F3NO3
|
2
|
| 1 |
EC50 > 20000 nM
|
|
|
| 2 |
Ki = 35 nM
|
|
|
|
CP0538941
|
(3S)-3-[4-[[(3S)-6-methylsulfonyl-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C22H22O7S
|
1
|
| 1 |
EC50 = 27200 nM
|
|
|
|
CP0405544
|
(3S)-3-[4-[[(3S)-6-(dimethylcarbamoyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C24H25NO6
|
1
|
| 1 |
EC50 > 30000 nM
|
|
|
|
CP0457376
|
(3S)-3-[4-[[(3S)-6-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C22H22O6
|
1
|
| 1 |
EC50 > 30000 nM
|
|
|
|
CP0484638
|
(3S)-3-[4-[[(3S)-6-acetyl-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C23H22O6
|
1
|
| 1 |
EC50 > 30000 nM
|
|
|
|
CP0445717
|
3-[2-fluoro-4-[[7-(3-methylsulfonylpropoxy)-3,4-dihydro-2H-chromen-2-yl]methoxy]phenyl]propanoic acid
Show/Hide
|
C23H27FO7S
|
1
|
| 1 |
EC50 = 36270 nM
|
|
|
|
CP0491552
|
(3S)-3-[4-[[(3S)-6-(morpholine-4-carbonyl)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C26H27NO7
|
1
|
| 1 |
EC50 > 50000 nM
|
|
|
|
CP0145583
|
3-[4-[[5-fluoro-2-(4-methylphenyl)phenyl]methoxy]phenyl]propanoic acid
Show/Hide
|
C23H21FO3
|
1
|
| 1 |
EC50 = 64565.42 nM
|
|
|
|
CP0385193
|
(3S)-3-[4-[[3-[(pyridin-4-ylmethylamino)methyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Show/Hide
|
C26H26N2O3
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0962403
|
3-cyclopropyl-3-(4-((5-(4-(4-fluorophenyl)piperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)propanoic acid
Show/Hide
|
C28H29FN2O4S
|
1
|
| 1 |
EC50 > 1667 nM
|
|
|
|
CP0963681
|
2-(6-((5-(4-(4-fluorophenyl)piperazine-1-carbonyl)thiophen-2-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid
Show/Hide
|
C26H25FN2O5S
|
1
|
| 1 |
EC50 > 1667 nM
|
|
|
|
CP0903478
|
3-(4-((5-(4-(pyridin-4-yl)piperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
|
C27H27N3O4S
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0949264
|
3-(4-((5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
|
C23H26N2O4S
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0962402
|
(R)-3-(4-((5-(4-(4-fluorophenyl)piperazine-1-carbonyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Show/Hide
|
C28H27FN2O4S
|
1
|
| 1 |
EC50 > 5000 nM
|
|
|
|
CP0506400
|
(3R,4R)-3-(4-(3,5-dimethylphenoxy)phenyl)-1-oxo-2-propyl-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid
Show/Hide
|
C27H27NO4
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0535504
|
(3R,4R)-3-(4-(3,4-dimethylphenoxy)phenyl)-1-oxo-2-propyl-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid
Show/Hide
|
C27H27NO4
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0535506
|
(3R,4R)-2-(cyclopropylmethyl)-1-oxo-3-(4-phenoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid
Show/Hide
|
C26H23NO4
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0479375
|
(3R,4R)-3-(3,4-dichlorophenyl)-2-(2-ethylbutyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid
Show/Hide
|
C22H23Cl2NO3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0510058
|
(3R,4R)-3-(4-((cis)-4-methylcyclohexyloxy)phenyl)-1-oxo-2-propyl-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid
Show/Hide
|
C26H31NO4
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0517000
|
(3R,4R)-3-(benzo[d]thiazol-2-yl)-2-(2-ethylbutyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid
Show/Hide
|
C23H24N2O3S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0517092
|
(3R,4R)-2-ethyl-1-oxo-3-(4-phenoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid
Show/Hide
|
C24H21NO4
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0535498
|
(3R,4R)-3-(3,4-dichlorophenyl)-2-((S)-2-methylbutyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid
Show/Hide
|
C21H21Cl2NO3
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0503450
|
(3R,4R)-3-(benzofuran-2-yl)-2-((S)-2-methylbutyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid
Show/Hide
|
C23H23NO4
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0474553
|
(3R,4R)-1-oxo-2-propyl-3-(4-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid
Show/Hide
|
C25H21F3N2O4
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0521091
|
(3R,4R)-3-(3,4-dichlorophenyl)-1-oxo-2-propyl-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid
Show/Hide
|
C19H17Cl2NO3
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0485569
|
(3R,4R)-3-(4-(benzyloxy)phenyl)-1-oxo-2-propyl-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid
Show/Hide
|
C26H25NO4
|
1
|
| 1 |
IC50 = 96 nM
|
|
|
|
CP0485570
|
(3R,4R)-3-(benzofuran-2-yl)-1-oxo-2-propyl-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid
Show/Hide
|
C21H19NO4
|
1
|
| 1 |
IC50 = 119 nM
|
|
|
|
CP0521090
|
(3R,4R)-2-methyl-1-oxo-3-(4-phenoxyphenyl)-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid
Show/Hide
|
C23H19NO4
|
1
|
| 1 |
IC50 = 156 nM
|
|
|
|
CP0517094
|
(3R,4R)-3-(3-chlorophenyl)-1-oxo-2-propyl-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid
Show/Hide
|
C19H18ClNO3
|
1
|
| 1 |
IC50 = 228 nM
|
|
|
|
CP0509913
|
(3R,4R)-3-(4-methoxyphenyl)-1-oxo-2-propyl-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid
Show/Hide
|
C20H21NO4
|
1
|
| 1 |
IC50 = 2100 nM
|
|
|
|
CP0511735
|
2-[(2S,4S)-1-[4-(2-methyl-4-phenylmethoxyphenoxy)phenyl]-4-(trifluoromethyl)pyrrolidin-2-yl]acetic acid
Show/Hide
|
C27H26F3NO4
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0463292
|
2-[(2S,4S)-1-[4-(3-chloro-2-methylphenoxy)phenyl]-4-(trifluoromethyl)pyrrolidin-2-yl]acetic acid
Show/Hide
|
C20H19ClF3NO3
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0511737
|
2-[(2S,4S)-1-[4-(4-methoxy-2-methylphenoxy)phenyl]-4-(trifluoromethyl)pyrrolidin-2-yl]acetic acid
Show/Hide
|
C21H22F3NO4
|
1
|
| 1 |
Ki = 39 nM
|
|
|
|
CP0463293
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2-[(2S,4S)-1-[4-[3-[(2-fluoro-5-methoxyphenyl)methyl]-2-methylphenoxy]phenyl]-4-(trifluoromethyl)pyrrolidin-2-yl]acetic acid
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C28H27F4NO4
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1
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| 1 |
Ki = 49 nM
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CP0493252
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2-[(2S,4S)-1-[4-(2,3-dimethylphenoxy)phenyl]-4-(trifluoromethyl)pyrrolidin-2-yl]acetic acid
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C21H22F3NO3
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1
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| 1 |
Ki = 60 nM
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CP0493203
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2-[(2S,4S)-1-[4-[(2-methylphenyl)methyl]phenyl]-4-(trifluoromethyl)pyrrolidin-2-yl]acetic acid
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C21H22F3NO2
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1
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| 1 |
Ki = 73 nM
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CP0463297
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2-[(2R,4S)-4-fluoro-1-[4-[(2-methylphenyl)methyl]phenyl]pyrrolidin-2-yl]acetic acid
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C20H22FNO2
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1
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| 1 |
Ki = 180 nM
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CP0392624
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2-[(2R,3S)-3-methyl-1-[4-[(2-methylphenyl)methyl]phenyl]pyrrolidin-2-yl]acetic acid
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C21H25NO2
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1
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| 1 |
Ki = 310 nM
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CP0519964
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2-[(2S)-1-[4-[[4-(2-fluoro-5-methoxyphenyl)-2-methylphenyl]methyl]phenyl]pyrrolidin-2-yl]acetic acid
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C27H28FNO3
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1
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| 1 |
Ki = 310 nM
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CP0471892
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2-[(2S,4S)-4-methyl-1-[4-[(2-methylphenyl)methyl]phenyl]pyrrolidin-2-yl]acetic acid
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C21H25NO2
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1
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| 1 |
Ki = 360 nM
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CP0331637
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2-[(2S)-1-[4-[(2,4-dichlorophenyl)methoxy]phenyl]pyrrolidin-2-yl]acetic acid
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C19H19Cl2NO3
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1
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| 1 |
Ki = 890 nM
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CP0472877
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2-[(2S)-1-[4-(2-fluorophenoxy)phenyl]pyrrolidin-2-yl]acetic acid
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C18H18FNO3
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1
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| 1 |
Ki = 1300 nM
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CP0540516
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2-[(2S)-1-[4-[(2-methylphenyl)methyl]phenyl]pyrrolidin-2-yl]acetic acid
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C20H23NO2
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1
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| 1 |
Ki = 1300 nM
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CP0389233
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2-[(2S)-1-[6-[(2-methylphenyl)methoxy]pyridin-3-yl]pyrrolidin-2-yl]acetic acid
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C19H22N2O3
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1
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| 1 |
Ki = 1800 nM
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CP0389252
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2-[(2S)-1-[4-(2-methylphenoxy)phenyl]pyrrolidin-2-yl]acetic acid
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C19H21NO3
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1
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| 1 |
Ki = 4400 nM
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CP0493209
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2-[(2S)-1-(4-phenoxyphenyl)pyrrolidin-2-yl]acetic acid
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C18H19NO3
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1
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| 1 |
Ki = 6500 nM
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CP0411765
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2-[(2S,4S)-4-methoxy-1-[4-(2-methylphenoxy)phenyl]pyrrolidin-2-yl]acetic acid
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C20H23NO4
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1
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| 1 |
Ki = 9000 nM
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CP0511736
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2-[(2S)-2-methyl-1-[4-[(2-methylphenyl)methyl]phenyl]pyrrolidin-2-yl]acetic acid
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C21H25NO2
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1
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| 1 |
Ki = 23000 nM
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CP0519960
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2-[(2S,4R)-1-[4-[(2-methylphenyl)methyl]phenyl]-4-phenylpyrrolidin-2-yl]acetic acid
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C26H27NO2
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1
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| 1 |
Ki > 25000 nM
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CP0485782
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2-[(2S)-1-[4-(2-methylbenzoyl)phenyl]pyrrolidin-2-yl]acetic acid
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C20H21NO3
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1
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| 1 |
Ki > 33000 nM
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