Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

2-[(3S)-6-[[3-[2,6-dimethyl-4-(3-methylsulfonylpropoxy)phenyl]phenyl]methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid

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PubChem ID

CID: 24857286

SID: 50088191

Canonical SMILES	Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@H](CC(O)=O)COc3c2)c1 Show/Hide
Compound Formula	C29H32O7S

Compound Structure

Protein Name

Protein Info

Free fatty acid receptor 1

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Lipid-like ligand receptor (family A GPCR)

Free fatty acid receptor

Uniprot ID

O14842

Gene Name

FFAR1

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000094	1321N1 Cell Line Info	Homo sapiens (Human)	2
1	EC50 = 14.13 nM	TI LI LO TS
2	EC50 = 57.54 nM	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	13
1	EC50 = 14 nM	TI LI LO TS
2	EC50 = 16 nM	TI LI LO TS
3	EC50 = 27 nM	TI LI LO TS
4	EC50 = 27.5 nM	TI LI LO TS
5	EC50 = 29.6 nM	TI LI LO TS
6	EC50 = 31.8 nM	TI LI LO TS
7	EC50 = 32.5 nM	TI LI LO TS
8	EC50 = 33.6 nM	TI LI LO TS
9	EC50 = 37.1 nM	TI LI LO TS
10	EC50 = 38.6 nM	TI LI LO TS
11	EC50 = 45 nM	TI LI LO TS
12	EC50 > 1000 nM	TI LI LO TS
13	Kd = 11.9 nM	TI LI LO TS
CL000460	Flp-In-T-REx-293 Cell Line Info	Homo sapiens (Human)	1
1	Ki = 28.84 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	9
1	EC50 = 0.35 nM	TI LI LO TS
2	EC50 = 1.9 nM	TI LI LO TS
3	EC50 = 9.333 nM	TI LI LO TS
4	EC50 = 12 nM	TI LI LO TS
5	EC50 = 31 nM	TI LI LO TS
6	EC50 = 39 nM	TI LI LO TS
7	EC50 = 80 nM	TI LI LO TS
8	EC50 = 160 nM	TI LI LO TS
9	EC50 = 5100 nM	TI LI LO TS

Biochemical Assays

1	EC50 = 53 nM