General Information of the Compound
Compound ID
CP0143308
Compound Name
US9688642, 2
    Show/Hide
Structure
Formula
C27H30FN3O4
Molecular Weight
479.552
Canonical SMILES
COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1CC(C)C
    Show/Hide
InChI
InChI=1S/C27H30FN3O4/c1-16(2)9-24-27(22-11-25(34-3)29-14-23(22)28)30-13-19(31-24)15-35-20-6-4-5-18(10-20)21(12-26(32)33)17-7-8-17/h4-6,10-11,13-14,16-17,21H,7-9,12,15H2,1-3H3,(H,32,33)/t21-/m0/s1
    Show/Hide
InChIKey
FNXMDDKBLZLDDD-NRFANRHFSA-N
Physicochemical Property
logP
5.4321
Rotatable Bonds
11
Heavy Atom Count
35
Polar Areas
94.43
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 118645756
ChEMBL ID
CHEMBL4764485
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02522, Free fatty acid receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  2
1
Activity = 572 nM
   TI
   LI
   LO
   TS
2
EC50 = 547 nM
   TI
   LI
   LO
   TS
CL000230 INS-1 832/13 Rattus norvegicus (Rat)  1
1
Activity = 1174 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
Protein ID: PT02793, Free fatty acid receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  2
1
Activity = 1042 nM
   TI
   LI
   LO
   TS
2
EC50 = 894 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 2 nM
   TI
   LI
   LO
   TS