General Information of the Compound
Compound ID
CP0112599
Compound Name
US8569511, 2
    Show/Hide
Structure
Formula
C23H22F2N6O2
Molecular Weight
452.465
Canonical SMILES
CC1CN(CCO1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccc(NC(=O)C3CC3(F)F)cc12
    Show/Hide
InChI
InChI=1S/C23H22F2N6O2/c1-12-11-31(6-7-33-12)14-3-5-18-19(9-14)28-21(27-18)20-15-8-13(2-4-17(15)29-30-20)26-22(32)16-10-23(16,24)25/h2-5,8-9,12,16H,6-7,10-11H2,1H3,(H,26,32)(H,27,28)(H,29,30)
    Show/Hide
InChIKey
ZBBDKEHQTOTGRO-UHFFFAOYSA-N
Physicochemical Property
logP
3.925
Rotatable Bonds
4
Heavy Atom Count
33
Polar Areas
98.93
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 136118610
SID: 148136470
ChEMBL ID
CHEMBL3659991
Table of Molecular Bioactivities Related to the Compound
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat Homo sapiens (Human)  1
1
IC50 = 385 nM
   TI
   LI
   LO
   TS
CL000002 K-562 Homo sapiens (Human)  1
1
IC50 = 944 nM
   TI
   LI
   LO
   TS
CL000017 HeLa Homo sapiens (Human)  1
1
IC50 = 1360 nM
   TI
   LI
   LO
   TS
CL000067 HCT 116 Homo sapiens (Human)  1
1
IC50 = 692 nM
   TI
   LI
   LO
   TS
CL000068 A-549 Homo sapiens (Human)  1
1
IC50 = 9560 nM
   TI
   LI
   LO
   TS
CL000082 HEL Homo sapiens (Human)  1
1
IC50 = 217 nM
   TI
   LI
   LO
   TS
CL000084 SK-OV-3 Homo sapiens (Human)  1
1
IC50 = 1540 nM
   TI
   LI
   LO
   TS
CL000111 MDA-MB-231 Homo sapiens (Human)  1
1
IC50 = 3540 nM
   TI
   LI
   LO
   TS
CL000141 LNCaP Homo sapiens (Human)  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CL000203 T24 Homo sapiens (Human)  1
1
IC50 = 4700 nM
   TI
   LI
   LO
   TS
CL000242 SK-MEL-5 Homo sapiens (Human)  1
1
IC50 = 3240 nM
   TI
   LI
   LO
   TS
CL000249 OVCAR-3 Homo sapiens (Human)  1
1
IC50 = 5550 nM
   TI
   LI
   LO
   TS
CL000275 AGS Homo sapiens (Human)  1
1
IC50 = 3830 nM
   TI
   LI
   LO
   TS
CL000303 AN3-CA Homo sapiens (Human)  1
1
IC50 < 30 nM
   TI
   LI
   LO
   TS
CL000364 Hs 578T Homo sapiens (Human)  1
1
IC50 = 947 nM
   TI
   LI
   LO
   TS
CL000434 KG-1 Homo sapiens (Human)  1
1
IC50 = 171 nM
   TI
   LI
   LO
   TS
CL000448 BxPC-3 Homo sapiens (Human)  1
1
IC50 = 430 nM
   TI
   LI
   LO
   TS
CL000552 T98G Homo sapiens (Human)  1
1
IC50 = 2630 nM
   TI
   LI
   LO
   TS
CL000996 RT-4 Homo sapiens (Human)  1
1
IC50 = 1010 nM
   TI
   LI
   LO
   TS