| Compound ID |
Compound Name |
Compound Formula |
|
CP0575124
|
4-[4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[[(2R,8S)-2-fluoro-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoronaphthalen-2-ol
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|
C33H31F3N6O2
|
1
|
| 1 |
IC50 = 2 nM
|
|
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CP0571951
|
4-[4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-ylmethoxy)pyrido[4,3-d]pyrimidin-7-yl]-5-ethynylnaphthalen-2-ol
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|
C33H33FN6O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
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CP0573768
|
4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-7-(8-ethynyl-7-fluoronaphthalen-1-yl)-8-fluoro-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-ylmethoxy)pyrido[4,3-d]pyrimidine
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|
C33H32F2N6O
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
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CP0577514
|
4-[4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[[(2R,8S)-2-fluoro-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]naphthalen-2-ol
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|
C31H32F2N6O2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
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CP0579154
|
5-chloro-4-[4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-ylmethoxy)pyrido[4,3-d]pyrimidin-7-yl]naphthalen-2-ol
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|
C31H32ClFN6O2
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
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CP0551801
|
4-[4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[[(2S,8R)-2-fluoro-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]naphthalen-2-ol
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|
C31H32F2N6O2
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
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CP0572594
|
4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-7-(8-ethynylnaphthalen-1-yl)-8-fluoro-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-ylmethoxy)pyrido[4,3-d]pyrimidine
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|
C33H33FN6O
|
1
|
| 1 |
IC50 = 71 nM
|
|
|
|
CP0575123
|
4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-7-(7,8-difluoronaphthalen-1-yl)-8-fluoro-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-ylmethoxy)pyrido[4,3-d]pyrimidine
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|
C31H31F3N6O
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0571909
|
7-(8-chloronaphthalen-1-yl)-4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-ylmethoxy)pyrido[4,3-d]pyrimidine
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|
C31H32ClFN6O
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
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CP0567531
|
4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-7-(8-ethylnaphthalen-1-yl)-8-fluoro-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-ylmethoxy)pyrido[4,3-d]pyrimidine
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|
C33H37FN6O
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
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CP0572593
|
4-[4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-ylmethoxy)pyrido[4,3-d]pyrimidin-7-yl]naphthalen-2-ol
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|
C31H33FN6O2
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0579153
|
4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-7-(7-fluoronaphthalen-1-yl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-ylmethoxy)pyrido[4,3-d]pyrimidine
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|
C31H32F2N6O
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
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CP0573914
|
4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-7-(8-fluoronaphthalen-1-yl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-ylmethoxy)pyrido[4,3-d]pyrimidine
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|
C31H32F2N6O
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
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CP0567429
|
4-[4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]naphthalen-2-ol
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|
C29H31FN6O2
|
1
|
| 1 |
IC50 = 530 nM
|
|
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CP0579152
|
4-[4-(3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(2,3,5,6,7,8-hexahydro-1H-indolizin-8a-ylmethoxy)pyrido[4,3-d]pyrimidin-7-yl]naphthalen-2-ol
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|
C32H35FN6O2
|
1
|
| 1 |
IC50 = 650 nM
|
|
|
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CP0543340
|
4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-ylmethoxy)-7-(8-methoxynaphthalen-1-yl)pyrido[4,3-d]pyrimidine
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|
C32H35FN6O2
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0577513
|
US11453683, Example 120
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|
C28H30FN7O
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
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CP0543339
|
4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-ylmethoxy)-7-(8-methylnaphthalen-1-yl)pyrido[4,3-d]pyrimidine
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|
C32H35FN6O
|
1
|
| 1 |
IC50 = 2500 nM
|
|
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CP0545185
|
4-[4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]ethoxy]pyrido[4,3-d]pyrimidin-7-yl]naphthalen-2-ol
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|
C30H31FN6O3
|
1
|
| 1 |
IC50 = 3000 nM
|
|
|
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CP0571949
|
4-[4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[2-(1-methylimidazol-2-yl)ethoxy]pyrido[4,3-d]pyrimidin-7-yl]naphthalen-2-ol
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|
C29H28FN7O2
|
1
|
| 1 |
IC50 = 3500 nM
|
|
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CP0547020
|
[8-[4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-ylmethoxy)pyrido[4,3-d]pyrimidin-7-yl]naphthalen-1-yl]methanol
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|
C32H35FN6O2
|
1
|
| 1 |
IC50 > 10000 nM
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|
|
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CP0567532
|
US11453683, Example 181
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|
C23H20FN5O
|
1
|
| 1 |
IC50 > 10000 nM
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CP0571952
|
4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-ylmethoxy)-7-naphthalen-1-ylpyrido[4,3-d]pyrimidine
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|
C31H33FN6O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0572595
|
8-[[4-(3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-7-(3-hydroxynaphthalen-1-yl)pyrido[4,3-d]pyrimidin-2-yl]oxymethyl]-2,5,6,7-tetrahydro-1H-pyrrolizin-3-one
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C31H31FN6O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
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CP0579155
|
4-[4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-2-[2-(dimethylamino)ethoxy]-8-fluoropyrido[4,3-d]pyrimidin-7-yl]naphthalen-2-ol
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|
C27H29FN6O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0349547
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1-[4-[7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
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C30H36N6O3
|
1
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| 1 |
IC50 > 16000 nM
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