Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[4-[7-(3-hydroxynaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl]prop-2-en-1-one
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 PubChem ID
CID: 132163222
Canonical SMILES
CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN(CC1)C(=O)C=C)c1cc(O)cc2ccccc12
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Compound Formula C30H36N6O3
Compound Structure
Protein Name
 Protein Info 
GTPase KRas
Protein Classification
Enzyme
>
Hydrolase
Uniprot ID
P01116
Gene Name
KRAS
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000275 AGS
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 > 16000 nM
   TI
   LI
   LO
   TS
CL000207 MIA PaCa-2
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
CL000268 NCI-H358
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 70 nM
   TI
   LI
   LO
   TS
2
IC50 = 142 nM
   TI
   LI
   LO
   TS
CL000189 RKO
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 > 16000 nM
   TI
   LI
   LO
   TS