General Information of the Compound
Compound ID
CP0571949
Compound Name
4-[4-[(1S,5R)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[2-(1-methylimidazol-2-yl)ethoxy]pyrido[4,3-d]pyrimidin-7-yl]naphthalen-2-ol
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Structure
Formula
C29H28FN7O2
Molecular Weight
525.588
Canonical SMILES
Cn1ccnc1CCOc1nc(N2C[C@@H]3CC[C@H](C2)N3)c2cnc(c(F)c2n1)-c1cc(O)cc2ccccc12
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InChI
InChI=1S/C29H28FN7O2/c1-36-10-9-31-24(36)8-11-39-29-34-27-23(28(35-29)37-15-18-6-7-19(16-37)33-18)14-32-26(25(27)30)22-13-20(38)12-17-4-2-3-5-21(17)22/h2-5,9-10,12-14,18-19,33,38H,6-8,11,15-16H2,1H3/t18-,19+
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InChIKey
GMDCEYKQKRSCLT-KDURUIRLSA-N
Physicochemical Property
logP
3.9853
Rotatable Bonds
6
Heavy Atom Count
39
Polar Areas
101.22
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156117342
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03462, GTPase KRas
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000275 AGS Homo sapiens (Human)  1
1
IC50 = 3500 nM
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