| Compound ID |
Compound Name |
Compound Formula |
|
CP0038086
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-methoxybut-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C22H21F2N3O3
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0038397
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(3-methoxyprop-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C21H19F2N3O3
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0292223
|
(5S)-2-amino-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methyl-5-(5-propanoylthiophen-3-yl)imidazol-4-one
Show/Hide
|
C22H19FN4O2S
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0270731
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(6-hydroxyhex-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C23H23F2N3O3
|
1
|
| 1 |
EC50 = 20 nM
|
|
|
|
CP0346196
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-hydroxybut-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C21H19F2N3O3
|
1
|
| 1 |
EC50 = 20 nM
|
|
|
|
CP0270732
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C22H17F3N4O2
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0067158
|
(R)-2-amino-4-(4-(difluoromethoxy)-3-methylphenyl)-4-(4-fluoro-3-(3-methoxyprop-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C22H20F3N3O3
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0126705
|
(R)-2-amino-4-(3-(2,2-difluoroethoxy)-4-fluorophenyl)-4-(4-(difluoromethoxy)-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C20H18F5N3O3
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0304524
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-fluoro-3-(3-methoxyprop-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C21H18F3N3O3
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0140858
|
2-amino-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methyl-5-(5-propanoylthiophen-3-yl)imidazol-4-one
Show/Hide
|
C22H19FN4O2S
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0120921
|
(R,E)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-fluorobut-1-enyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C21H20F3N3O2
|
1
|
| 1 |
EC50 = 40 nM
|
|
|
|
CP0294324
|
(R,E)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-methoxybut-1-enyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C22H23F2N3O3
|
1
|
| 1 |
EC50 = 40 nM
|
|
|
|
CP0294348
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-fluoro-3-(3-fluoropropoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C20H19F4N3O3
|
1
|
| 1 |
EC50 = 40 nM
|
|
|
|
CP0298926
|
(R,E)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(3-methoxyprop-1-enyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C21H21F2N3O3
|
1
|
| 1 |
EC50 = 40 nM
|
|
|
|
CP0270841
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-(3-(3-methylbut-1-ynyl)phenyl)-1H-imidazol-5(4H)-one
Show/Hide
|
C22H21F2N3O2
|
1
|
| 1 |
EC50 = 50 nM
|
|
|
|
CP0298927
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(3,3-difluoropropoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C20H19F4N3O3
|
1
|
| 1 |
EC50 = 50 nM
|
|
|
|
CP0038393
|
(R)-2-amino-4-(3-(4,4-difluorobut-3-enyloxy)phenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C21H19F4N3O3
|
1
|
| 1 |
EC50 = 60 nM
|
|
|
|
CP0067139
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(6-fluorohex-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C23H22F3N3O2
|
1
|
| 1 |
EC50 = 70 nM
|
|
|
|
CP0099659
|
(R)-2-amino-4-(3-(cyclopropylethynyl)-4-fluorophenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C22H18F3N3O2
|
1
|
| 1 |
EC50 = 70 nM
|
|
|
|
CP0270681
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-(3-(prop-1-ynyl)phenyl)-1H-imidazol-5(4H)-one
Show/Hide
|
C20H17F2N3O2
|
1
|
| 1 |
EC50 = 70 nM
|
|
|
|
CP0270730
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-((R)-3-hydroxybut-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C21H19F2N3O3
|
1
|
| 1 |
EC50 = 70 nM
|
|
|
|
CP0342261
|
(R)-2-amino-4-(3-(cyclopropylmethoxy)phenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C21H21F2N3O3
|
1
|
| 1 |
EC50 = 70 nM
|
|
|
|
CP0296543
|
2-amino-3-methyl-5-(5-propanoylthiophen-3-yl)-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one
Show/Hide
|
C21H19N5O2S
|
1
|
| 1 |
EC50 = 70 nM
|
|
|
|
CP0039560
|
(8R)-8-(3-Pyrimidin-5-ylphenyl)-8-[4-(trifluoromethoxy)phenyl]-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
|
C23H19F3N6O
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
|
CP0038388
|
(R)-2-amino-4-(3-(but-1-ynyl)phenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C21H19F2N3O2
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
|
CP0039696
|
(8R)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trifluoromethoxy)phenyl]-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
|
C24H19F4N5O
|
1
|
| 1 |
EC50 = 90 nM
|
|
|
|
CP0038382
|
(R)-4-(3-(2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl)phenyl)butanenitrile
Show/Hide
|
C21H20F2N4O2
|
1
|
| 1 |
EC50 = 90 nM
|
|
|
|
CP0070206
|
(R)-2-amino-4-(3-(cyclopropylethynyl)-4-fluorophenyl)-4-(4-(difluoromethoxy)-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C23H20F3N3O2
|
1
|
| 1 |
EC50 = 90 nM
|
|
|
|
CP0120922
|
(R,E)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(5-hydroxypent-1-enyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C22H23F2N3O3
|
1
|
| 1 |
EC50 = 90 nM
|
|
|
|
CP0038391
|
(R)-2-amino-4-(3-(cyclopropylethynyl)phenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C22H19F2N3O2
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0043523
|
(R,E)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(5-methoxypent-1-enyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C23H25F2N3O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0043536
|
(R)-2-amino-4-(3-(2,2-difluoroethoxy)phenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C19H17F4N3O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0288118
|
(R)-2-amino-4-(3-(2,2-difluoroethoxy)-4-fluorophenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C19H16F5N3O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0304532
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-fluorobutanoyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C21H20F3N3O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0342655
|
(R)-2-amino-4-(3-butylphenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C21H23F2N3O2
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0342656
|
(R,E)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-hydroxybut-1-enyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C21H21F2N3O3
|
1
|
| 1 |
EC50 = 100 nM
|
|
|
|
CP0288133
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-(3-propylphenyl)-1H-imidazol-5(4H)-one
Show/Hide
|
C20H21F2N3O2
|
1
|
| 1 |
EC50 = 110 nM
|
|
|
|
CP0185856
|
2-amino-5-[1-(3,3-dimethylbutyl)pyrazol-4-yl]-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methylimidazol-4-one
Show/Hide
|
C24H27FN6O
|
1
|
| 1 |
EC50 = 110 nM
|
|
|
|
CP0294336
|
(R,E)-2-amino-4-(3-(4,4-difluorobut-1-enyl)phenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C21H19F4N3O2
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0342657
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(4-fluorobut-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C21H18F3N3O2
|
1
|
| 1 |
EC50 = 130 nM
|
|
|
|
CP0288296
|
(R)-2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-4-(4-methoxyphenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C22H19FN4O2
|
1
|
| 1 |
EC50 = 140 nM
|
|
|
|
CP0255961
|
2-amino-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methyl-5-[1-(2-methylpropyl)pyrazol-4-yl]imidazol-4-one
Show/Hide
|
C22H23FN6O
|
1
|
| 1 |
EC50 = 140 nM
|
|
|
|
CP0043519
|
(S)-2-amino-4-(4-(difluoromethoxy)-3-methylphenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one
Show/Hide
|
C18H17F2N3O2
|
1
|
| 1 |
EC50 = 150 nM
|
|
|
|
CP0294329
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-fluoro-3-(4-fluorobutoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C21H21F4N3O3
|
1
|
| 1 |
EC50 = 150 nM
|
|
|
|
CP0291978
|
2-amino-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methyl-5-thiophen-3-ylimidazol-4-one
Show/Hide
|
C19H15FN4OS
|
1
|
| 1 |
EC50 = 150 nM
|
|
|
|
CP0061078
|
(S)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one
Show/Hide
|
C17H15F2N3O2
|
1
|
| 1 |
EC50 = 160 nM
|
|
|
|
CP0240568
|
2-amino-5-[1-(2-ethylbutyl)pyrazol-4-yl]-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methylimidazol-4-one
Show/Hide
|
C24H27FN6O
|
1
|
| 1 |
EC50 = 160 nM
|
|
|
|
CP0263481
|
2-amino-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methyl-5-[1-(3-methylbutyl)pyrazol-4-yl]imidazol-4-one
Show/Hide
|
C23H25FN6O
|
1
|
| 1 |
EC50 = 160 nM
|
|
|
|
CP0129105
|
8-(3-(pyrimidin-5-yl)phenyl)-8-(4-(trifluoromethoxy)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
|
C23H19F3N6O
|
1
|
| 1 |
EC50 = 190 nM
|
|
|
|
CP0228018
|
8-(3-(2-fluoropyridin-3-yl)phenyl)-8-(4-(trifluoromethoxy)phenyl)-4,8-dihydro-3H-imidazo[5,1-c][1,2,4]oxadiazin-6-amine
Show/Hide
|
C23H17F4N5O2
|
1
|
| 1 |
EC50 = 200 nM
|
|
|
|
CP0152153
|
2-amino-5-[4-fluoro-3-(2-fluoropyridin-3-yl)phenyl]-3-methyl-5-thiophen-3-ylimidazol-4-one
Show/Hide
|
C19H14F2N4OS
|
1
|
| 1 |
EC50 = 200 nM
|
|
|
|
CP0505839
|
2-amino-5-(1-butylpyrazol-4-yl)-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methylimidazol-4-one
Show/Hide
|
C22H23FN6O
|
1
|
| 1 |
EC50 = 200 nM
|
|
|
|
CP0043548
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-(3-(pent-1-ynyl)phenyl)-1H-imidazol-5(4H)-one
Show/Hide
|
C22H21F2N3O2
|
1
|
| 1 |
EC50 = 220 nM
|
|
|
|
CP0099657
|
(R,E)-2-amino-4-(3-(2-cyclopropyl-1-fluorovinyl)phenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C22H20F3N3O2
|
1
|
| 1 |
EC50 = 220 nM
|
|
|
|
CP0295369
|
2-amino-5-[3-(5-methoxypyridin-3-yl)phenyl]-3-methyl-5-thiophen-3-ylimidazol-4-one
Show/Hide
|
C20H18N4O2S
|
1
|
| 1 |
EC50 = 220 nM
|
|
|
|
CP0191641
|
2-amino-5-(5-ethyl-2-methylthiophen-3-yl)-3-methyl-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one
Show/Hide
|
C21H21N5OS
|
1
|
| 1 |
EC50 = 230 nM
|
|
|
|
CP0227760
|
7-(3-(2-fluoropyridin-3-yl)phenyl)-7-(4-(trifluoromethoxy)phenyl)-3,7-dihydro-2H-imidazo[1,5-a]imidazol-5-amine
Show/Hide
|
C23H17F4N5O
|
1
|
| 1 |
EC50 = 250 nM
|
|
|
|
CP0090653
|
(5S)-2-amino-5-(1-ethylpyrazol-4-yl)-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methylimidazol-4-one
Show/Hide
|
C20H19FN6O
|
1
|
| 1 |
EC50 = 260 nM
|
|
|
|
CP0038384
|
(4R)-2-amino-4-(3-(1,4-difluorobutyl)phenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C21H21F4N3O2
|
1
|
| 1 |
EC50 = 270 nM
|
|
|
|
CP0346191
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-(3-(4,4,4-trifluorobutyl)phenyl)-1H-imidazol-5(4H)-one
Show/Hide
|
C21H20F5N3O2
|
1
|
| 1 |
EC50 = 270 nM
|
|
|
|
CP0265716
|
9-(3-(2-fluoropyridin-3-yl)phenyl)-9-(4-(trifluoromethoxy)phenyl)-3,4,5,9-tetrahydro-2H-imidazo[1,5-a][1,3]diazepin-7-amine
Show/Hide
|
C25H21F4N5O
|
1
|
| 1 |
EC50 = 300 nM
|
|
|
|
CP0696991
|
rac-8-(3-(2-fluoropyridin-3-yl)phenyl)-8-(4-(trifluoromethoxy)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
|
C24H19F4N5O
|
1
|
| 1 |
EC50 = 300 nM
|
|
|
|
CP0038392
|
(R)-2-amino-4-(3-(4,4-difluorobut-3-enyloxy)-4-fluorophenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C21H18F5N3O3
|
1
|
| 1 |
EC50 = 300 nM
|
|
|
|
CP0342658
|
(R)-2-amino-4-(3-(difluoromethoxy)phenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C18H15F4N3O3
|
1
|
| 1 |
EC50 = 300 nM
|
|
|
|
CP0090739
|
2-amino-5-[1-(2-cyclohexylethyl)pyrazol-4-yl]-3-methyl-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one
Show/Hide
|
C25H29N7O
|
1
|
| 1 |
EC50 = 300 nM
|
|
|
|
CP0310689
|
2-amino-5-[1-(3,3-dimethylbutyl)pyrazol-4-yl]-3-methyl-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one
Show/Hide
|
C23H27N7O
|
1
|
| 1 |
EC50 = 300 nM
|
|
|
|
CP0288297
|
(R)-2-amino-4-(4-(2-fluoroethoxy)phenyl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C23H20F2N4O2
|
1
|
| 1 |
EC50 = 320 nM
|
|
|
|
CP0294326
|
(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-(3-fluoroprop-1-ynyl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C20H16F3N3O2
|
1
|
| 1 |
EC50 = 330 nM
|
|
|
|
CP0191642
|
2-amino-5-(5-chlorothiophen-3-yl)-3-methyl-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one
Show/Hide
|
C18H14ClN5OS
|
1
|
| 1 |
EC50 = 340 nM
|
|
|
|
CP0291173
|
(R,E)-2-amino-4-(3-(2-cyclopropylvinyl)phenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
|
C22H21F2N3O2
|
1
|
| 1 |
EC50 = 350 nM
|
|
|
|
CP0120919
|
(R)-2-amino-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methyl-4-(4-(trifluoromethoxy)phenyl)-1H-imidazol-5(4H)-one
Show/Hide
|
C22H16F4N4O2
|
1
|
| 1 |
EC50 = 370 nM
|
|
|
|
CP0191622
|
2-amino-5-(5-ethylthiophen-3-yl)-3-methyl-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one
Show/Hide
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C20H19N5OS
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1
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| 1 |
EC50 = 370 nM
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CP0272177
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2-amino-5-(4-fluoro-3-pyridin-3-ylphenyl)-3-methyl-5-thiophen-3-ylimidazol-4-one
Show/Hide
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C19H15FN4OS
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1
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| 1 |
EC50 = 370 nM
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CP0067155
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(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(4-fluoro-3-(2-fluoroethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
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C19H17F4N3O3
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1
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| 1 |
EC50 = 400 nM
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CP0159439
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(4R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-(3-(2-methylbutyl)phenyl)-1H-imidazol-5(4H)-one
Show/Hide
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C22H25F2N3O2
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1
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| 1 |
EC50 = 410 nM
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CP0263524
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2-amino-5-(1-cyclopentylpyrazol-4-yl)-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methylimidazol-4-one
Show/Hide
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C23H23FN6O
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1
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| 1 |
EC50 = 410 nM
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CP0198923
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2-amino-3-methyl-5-(3-pyridin-3-ylphenyl)-5-thiophen-3-ylimidazol-4-one
Show/Hide
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C19H16N4OS
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1
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| 1 |
EC50 = 420 nM
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CP0272115
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2-amino-5-(1-ethylpyrazol-4-yl)-5-[4-fluoro-3-(2-fluoropyridin-3-yl)phenyl]-3-methylimidazol-4-one
Show/Hide
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C20H18F2N6O
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1
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| 1 |
EC50 = 420 nM
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CP0206002
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(5S)-2-amino-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methyl-5-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]imidazol-4-one
Show/Hide
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C20H16F4N6O
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1
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| 1 |
EC50 = 430 nM
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CP0191643
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2-amino-3-methyl-5-(3-pyrazin-2-ylphenyl)-5-thiophen-3-ylimidazol-4-one
Show/Hide
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C18H15N5OS
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1
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| 1 |
EC50 = 450 nM
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CP0310424
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2-amino-3-methyl-5-(3-pyrimidin-5-ylphenyl)-5-thiophen-3-ylimidazol-4-one
Show/Hide
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C18H15N5OS
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1
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| 1 |
EC50 = 470 nM
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CP0733922
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rac-2-amino-4-(1-ethyl-1H-pyrazol-4-yl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
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C20H19FN6O
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1
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| 1 |
EC50 = 490 nM
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CP0141911
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2-amino-3-methyl-5-[1-(3-methylbutyl)pyrazol-4-yl]-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one
Show/Hide
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C22H25N7O
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1
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| 1 |
EC50 = 500 nM
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CP0271644
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2-amino-5-[4-fluoro-3-(2-fluoropyridin-3-yl)phenyl]-3-methyl-5-(1-propan-2-ylpyrazol-4-yl)imidazol-4-one
Show/Hide
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C21H20F2N6O
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1
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| 1 |
EC50 = 500 nM
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CP0298923
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(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-(3-pentylphenyl)-1H-imidazol-5(4H)-one
Show/Hide
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C22H25F2N3O2
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1
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| 1 |
EC50 = 530 nM
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CP0295366
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2-amino-3-methyl-5-(5-methylthiophen-3-yl)-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one
Show/Hide
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C19H17N5OS
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1
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| 1 |
EC50 = 550 nM
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CP0331726
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2-amino-5-(1-ethylpyrazol-4-yl)-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3-methylimidazol-4-one
Show/Hide
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C19H18FN7O
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1
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| 1 |
EC50 = 600 nM
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CP0090737
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2-amino-5-(1-butylpyrazol-4-yl)-3-methyl-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one
Show/Hide
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C21H23N7O
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1
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| 1 |
EC50 = 700 nM
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CP0185924
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2-amino-3-methyl-5-[1-(2-methylpropyl)pyrazol-4-yl]-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one
Show/Hide
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C21H23N7O
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1
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| 1 |
EC50 = 800 nM
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CP0288298
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(S)-2-amino-1-methyl-4-phenyl-4-(4-(trifluoromethoxy)phenyl)-1H-imidazol-5(4H)-one
Show/Hide
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C17H14F3N3O2
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1
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| 1 |
EC50 = 810 nM
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CP0039550
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10-(3-(2-fluoropyridin-3-yl)phenyl)-10-(4-(trifluoromethoxy)phenyl)-2,3,4,5,6,10-hexahydroimidazo[1,5-a][1,3]diazocin-8-amine
Show/Hide
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C26H23F4N5O
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1
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| 1 |
EC50 = 900 nM
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CP0143890
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2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3-methyl-5-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]imidazol-4-one
Show/Hide
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C19H15F4N7O
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1
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| 1 |
EC50 = 900 nM
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CP0039691
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8-(3-(2-cyclopropylethyl)phenyl)-8-(4-(trifluoromethoxy)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
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C24H25F3N4O
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1
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| 1 |
EC50 = 950 nM
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CP0038379
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(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-ethylphenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
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C19H19F2N3O2
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1
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| 1 |
EC50 = 1120 nM
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CP0205940
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2-amino-5-[1-(2-fluoroethyl)pyrazol-4-yl]-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methylimidazol-4-one
Show/Hide
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C20H18F2N6O
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1
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| 1 |
EC50 = 1170 nM
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CP0294330
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(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-(3-(3,3,3-trifluoropropoxy)phenyl)-1H-imidazol-5(4H)-one
Show/Hide
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C20H18F5N3O3
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1
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| 1 |
EC50 = 1200 nM
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CP0215798
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2-amino-3-methyl-5-(2-methylthiophen-3-yl)-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one
Show/Hide
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C19H17N5OS
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1
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| 1 |
EC50 = 1310 nM
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CP0039553
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8-(4-methoxyphenyl)-8-(3-(pyrimidin-5-yl)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
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C23H22N6O
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1
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| 1 |
EC50 = 1400 nM
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CP0039562
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7-(3-(2-fluoropyridin-3-yl)phenyl)-2,2-dimethyl-7-(4-(trifluoromethoxy)phenyl)-3,7-dihydro-2H-imidazo[1,5-a]imidazol-5-amine
Show/Hide
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C25H21F4N5O
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1
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| 1 |
EC50 = 1500 nM
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CP0281967
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2-amino-5-(1-cyclopentylpyrazol-4-yl)-3-methyl-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one
Show/Hide
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C22H23N7O
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1
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| 1 |
EC50 = 1500 nM
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CP0275438
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8-(3-bromophenyl)-8-(4-(trifluoromethoxy)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
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C19H16BrF3N4O
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1
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| 1 |
EC50 = 1600 nM
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CP0090734
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2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-3-methyl-5-(1-propan-2-ylpyrazol-4-yl)imidazol-4-one
Show/Hide
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C20H20FN7O
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1
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| 1 |
EC50 = 1600 nM
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CP0277419
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8-(3-(2-fluoropyridin-3-yl)phenyl)-8-(4-methoxyphenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
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C24H22FN5O
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1
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| 1 |
EC50 = 1630 nM
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CP0185750
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2-amino-5-(1-ethylpyrazol-4-yl)-3-methyl-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one
Show/Hide
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C19H19N7O
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1
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| 1 |
EC50 = 1700 nM
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CP0227679
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8-(3-propylphenyl)-8-(4-(trifluoromethoxy)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
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C22H23F3N4O
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1
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| 1 |
EC50 = 2100 nM
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CP0292066
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2-amino-5-(2-chloro-5-methylthiophen-3-yl)-3-methyl-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one
Show/Hide
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C19H16ClN5OS
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1
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| 1 |
EC50 = 2230 nM
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CP0291172
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(S)-2-amino-4-(4-(2-fluoroethoxy)phenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one
Show/Hide
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C18H18FN3O2
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1
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| 1 |
EC50 = 2450 nM
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CP0294936
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(8S)-8-(3-Pyrimidin-5-ylphenyl)-8-[4-(trifluoromethoxy)phenyl]-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
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C23H19F3N6O
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1
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| 1 |
EC50 = 2560 nM
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CP0203199
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(5R)-2-amino-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methyl-5-(5-propanoylthiophen-3-yl)imidazol-4-one
Show/Hide
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C22H19FN4O2S
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1
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| 1 |
EC50 = 2900 nM
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CP0094524
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8-(3-tert-butylphenyl)-8-phenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
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C22H26N4
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1
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| 1 |
EC50 = 3000 nM
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CP0038387
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(R)-2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-ethynylphenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
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C19H15F2N3O2
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1
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| 1 |
EC50 = 3140 nM
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CP0270729
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(R)-2-amino-4-(3-(cyclohexylethynyl)phenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
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C25H25F2N3O2
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1
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| 1 |
EC50 = 4320 nM
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CP0185922
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2-amino-3-methyl-5-(1-methylpyrazol-4-yl)-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one
Show/Hide
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C18H17N7O
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1
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| 1 |
EC50 = 4400 nM
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CP0039556
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8-(3-(4-fluorobenzyl)phenyl)-8-phenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
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C25H23FN4
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1
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| 1 |
EC50 = 4600 nM
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CP0039558
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8-(3-benzylphenyl)-8-phenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
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C25H24N4
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1
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| 1 |
EC50 = 5100 nM
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CP0039689
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8-(3-(4-methoxybenzyl)phenyl)-8-phenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
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C26H26N4O
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1
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| 1 |
EC50 = 5100 nM
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CP0182168
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(8S)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trifluoromethoxy)phenyl]-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
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C24H19F4N5O
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1
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| 1 |
EC50 = 5100 nM
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CP0275437
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8-phenyl-8-(3-(trifluoromethyl)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
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C19H17F3N4
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1
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| 1 |
EC50 = 5100 nM
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CP0298924
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(R,Z)-2-amino-4-(3-(2-cyclopropyl-1-fluorovinyl)phenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one
Show/Hide
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C22H20F3N3O2
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1
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| 1 |
EC50 = 5370 nM
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CP0090773
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8,8-diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
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C18H18N4
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1
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| 1 |
EC50 = 16000 nM
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CP0228016
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8-(3-methoxyphenyl)-8-phenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Show/Hide
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C19H20N4O
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1
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| 1 |
EC50 = 20900 nM
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CP0073803
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(5R)-2-amino-5-(1-ethylpyrazol-4-yl)-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methylimidazol-4-one
Show/Hide
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C20H19FN6O
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1
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| 1 |
EC50 > 2500 nM
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CP0876278
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(2R,3S)-3-{[(7-Ethyl-1-methyl-2,2-dioxido-3,4-dihydro-1H-[1,2,5]thiadiazepino[3,4,5-hi]indol-9-yl)carbonyl]amino}-2-hydroxy-4-phenyl-N-{[3-(trifluoromethyl)phenyl]methyl}-1-butanaminium formate
Show/Hide
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C33H37F3N4O6S
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1
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| 1 |
IC50 = 2 nM
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CP0230205
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3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]benzamide
Show/Hide
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C31H37F3N4O4S
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1
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| 1 |
IC50 = 3 nM
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CP0935596
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(2R,3S)-3-({[3-(1,1-Dioxidotetrahydro-2H-1,2-thiazin-2-yl)-5-(ethylamino)phenyl]carbonyl}amino)-2-hydroxy-4-phenyl-N-{[3-(trifluoromethyl)phenyl]methyl}-1-butanaminium formate
Show/Hide
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C32H39F3N4O6S
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1
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| 1 |
IC50 = 3 nM
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CP0074357
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US8846658, 118
Show/Hide
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C17H14BrF3N4O2
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1
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| 1 |
IC50 = 3 nM
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CP0553635
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N-[3-[(3R)-5-amino-6,6-bis(fluoromethyl)-3-methyl-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
Show/Hide
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C21H20F3N5O2
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1
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| 1 |
IC50 = 3 nM
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CP0170144
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3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-2-fluoro-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]benzamide
Show/Hide
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C31H36F4N4O4S
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1
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| 1 |
IC50 = 4 nM
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CP0455072
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3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-2-fluoro-N-[(2S,3R)-3-hydroxy-4-{[(3-methoxyphenyl)methyl]amino}-1-phenylbutan-2-yl]benzamide
Show/Hide
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C31H39FN4O5S
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1
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| 1 |
IC50 = 4 nM
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CP0073849
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US8846658, 33
Show/Hide
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C17H16BrFN4O2
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1
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| 1 |
IC50 = 4 nM
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CP0359951
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N-[3-[(6R)-8-amino-6-(difluoromethyl)-4-oxa-7-azaspiro[2.5]oct-7-en-6-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
Show/Hide
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C21H18F3N5O2
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1
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| 1 |
IC50 = 4 nM
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CP0396647
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N-[3-[(3R,6R)-5-amino-6-methoxy-3,6-dimethyl-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
Show/Hide
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C21H22FN5O3
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1
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| 1 |
IC50 = 4 nM
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CP0454076
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3-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]-5-propylbenzamide
Show/Hide
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C32H38F3N3O4S
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1
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| 1 |
IC50 = 5 nM
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CP0457705
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3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethoxy)phenyl]methyl}amino)butan-2-yl]benzamide
Show/Hide
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C31H37F3N4O5S
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1
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| 1 |
IC50 = 5 nM
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CP0457720
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3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethoxy)phenyl]methyl}amino)butan-2-yl]benzamide
Show/Hide
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C31H36F3N3O6S
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1
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| 1 |
IC50 = 5 nM
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CP0464299
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N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-{[(3-methoxyphenyl)methyl]amino}butan-2-yl]-3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)benzamide
Show/Hide
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C31H38F2N4O5S
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1
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| 1 |
IC50 = 5 nM
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CP0943195
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N-((2R,3S)-3-{[(7-Ethyl-1-methyl-2,2-dioxido-3,4-dihydro-1H-[1,2,5]thiadiazepino[3,4,5-hi]indol-9-yl)carbonyl]amino}-2-hydroxy-4-phenylbutyl)cyclohexanaminium formate
Show/Hide
|
C31H42N4O6S
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1
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| 1 |
IC50 = 5 nM
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CP0246618
|
US8846658, 78
Show/Hide
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C18H16BrF3N4O2
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1
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| 1 |
IC50 = 5 nM
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CP0454070
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3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]benzamide
Show/Hide
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C31H36F3N3O5S
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1
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| 1 |
IC50 = 6 nM
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CP0455071
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3-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(2S,3R)-4-{[(1-ethyl-1H-pyrazol-4-yl)methyl]amino}-3-hydroxy-1-phenylbutan-2-yl]-5-(ethylamino)-2-fluorobenzamide
Show/Hide
|
C29H39FN6O4S
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1
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| 1 |
IC50 = 6 nM
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CP0246617
|
US8846658, 144
Show/Hide
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C19H16F3N5O2
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1
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| 1 |
IC50 = 7 nM
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CP0454075
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3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-{[(3-methoxyphenyl)methyl]amino}-1-phenylbutan-2-yl]benzamide
Show/Hide
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C31H40N4O5S
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1
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| 1 |
IC50 = 8 nM
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CP0327614
|
US8846658, 42
Show/Hide
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C17H14BrF3N4O2
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1
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| 1 |
IC50 = 8 nM
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CP0935597
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N-((2R,3S)-3-{[(7-Ethyl-1-methyl-2,2-dioxido-3,4-dihydro-1H-[1,2,5]thiadiazepino[3,4,5-hi]indol-9-yl)carbonyl]amino}-2-hydroxy-4-phenylbutyl)-2,6-dimethyl-2-heptanaminium formate
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C34H50N4O6S
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1
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| 1 |
IC50 = 9 nM
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CP0086391
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N-[3-[(3R)-5-amino-3-(difluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]-4,5-difluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
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C19H15F4N5O2
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1
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| 1 |
IC50 = 9 nM
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CP0284803
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2'-amino-2,2,3'-trimethyl-6-(5-prop-1-ynylpyridin-3-yl)spiro[3H-chromene-4,5'-imidazole]-4'-one
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C22H22N4O2
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1
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| 1 |
IC50 = 10 nM
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CP0178201
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(1R,3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(2R)-1,1,1-trifluoro-3-methoxypropan-2-yl]oxyphenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1-oxothian-4-ol
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C27H36F4N2O4S
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1
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| 1 |
IC50 = 10 nM
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CP0489349
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3-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]-5-(propan-2-ylamino)benzamide
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C32H39F3N4O4S
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1
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| 1 |
IC50 = 11 nM
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CP0486635
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(1R,4aR,10R,10aR)-2'-amino-8-(2-fluoropyridin-3-yl)-1,3'-dimethylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
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C21H21FN4O3
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1
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| 1 |
IC50 = 11 nM
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CP0254781
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US8846658, 77
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C18H16BrF3N4O2
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1
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| 1 |
IC50 = 11 nM
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CP0327525
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N-[3-[(3R)-5-amino-3-(difluoromethyl)-1,9-dioxa-4-azaspiro[5.5]undec-4-en-3-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
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C23H22F3N5O3
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1
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| 1 |
IC50 = 11 nM
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CP0138372
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3-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(2S,3R)-4-{[(1-ethyl-1H-pyrazol-4-yl)methyl]amino}-3-hydroxy-1-phenylbutan-2-yl]-5-(ethylamino)benzamide
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C29H40N6O4S
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1
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| 1 |
IC50 = 12 nM
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CP0703546
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[2H]-(1R,3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(1R)-2,2,2-trifluoro-1-(methoxymethyl)ethoxy]phenyl]methyl]-5-[[(3-tert-butylphenyl)-dideuterio-methyl]amino]-1-oxido-tetrahydrothiopyran-1-ium-4-ol
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C27H36F4N2O4S
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1
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| 1 |
IC50 = 12 nM
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CP0246620
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N-[3-[(3R)-5-amino-3,6,6-tris(fluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
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C21H19F4N5O2
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1
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| 1 |
IC50 = 13 nM
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CP0554343
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(1R,3S,4S,5R)-3-[[4-amino-3-fluoro-5-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)phenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1-oxothian-4-ol
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C26H31F7N2O3S
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1
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| 1 |
IC50 = 14 nM
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CP0876280
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(2R,3S)-3-{[(7-Ethyl-1-methyl-2,2-dioxido-3,4-dihydro-1H-[1,2,5]thiadiazepino[3,4,5-hi]indol-9-yl)carbonyl]amino}-2-hydroxy-N-methyl-4-phenyl-1-butanaminium formate
Show/Hide
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C26H34N4O6S
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1
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| 1 |
IC50 = 15 nM
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CP0475872
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N-[3-[(3R)-5-amino-3-(difluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]phenyl]-5-bromopyridine-2-carboxamide
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C17H15BrF2N4O2
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1
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| 1 |
IC50 = 15 nM
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CP0443447
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(4aS,10R,10aS)-2'-amino-8-(2-fluoropyridin-3-yl)-3'-methylspiro[1,3,4,4a,5,10a-hexahydrobenzo[g]isochromene-10,5'-imidazole]-4'-one
Show/Hide
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C21H21FN4O2
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1
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| 1 |
IC50 = 16 nM
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CP0327522
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US8846658, 3
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C17H17BrN4O2
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1
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| 1 |
IC50 = 17 nM
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CP0262731
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3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-[(6-methoxy-2,3-dihydro-1H-inden-1-yl)amino]-1-phenylbutan-2-yl]benzamide
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C33H42N4O5S
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1
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| 1 |
IC50 = 18 nM
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CP0302146
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3-[(8R)-2'-amino-1',6,6-trimethyl-5'-oxospiro[5,7-dihydronaphthalene-8,4'-imidazole]-2-yl]benzonitrile
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C22H22N4O
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1
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| 1 |
IC50 = 18 nM
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CP0302147
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(4R)-2'-amino-6-(5-chloropyridin-3-yl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
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C19H19ClN4O2
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1
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| 1 |
IC50 = 19 nM
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CP0040694
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BMCL193669 Compound 18
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C27H34N4O4S
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1
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| 1 |
IC50 = 20 nM
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CP0281307
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(1R,3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(2R)-1,1,1-trifluoro-3-hydroxypropan-2-yl]oxyphenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1-oxothian-4-ol
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C26H34F4N2O4S
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1
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| 1 |
IC50 = 21 nM
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CP0315956
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3'-[(1-acetylpiperidin-4-yl)methyl]-2'-amino-6-(3-chlorophenyl)-2,2-dimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
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C27H31ClN4O3
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1
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| 1 |
IC50 = 22 nM
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CP0368699
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2'-amino-6-(5-chloropyridin-3-yl)-2,2,3'-trimethylspiro[3H-thiochromene-4,5'-imidazole]-4'-one
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C19H19ClN4OS
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1
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| 1 |
IC50 = 22 nM
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CP0368700
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2'-amino-6-(3-chloro-5-fluorophenyl)-2,2,3'-trimethylspiro[3H-thiochromene-4,5'-imidazole]-4'-one
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C20H19ClFN3OS
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1
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| 1 |
IC50 = 23 nM
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CP0924955
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rac-3-(2-Amino-1,3',3'-trimethyl-5-oxo-1,3',4',5-tetrahydro-2'Hspiro[imidazole-4,1'-naphthalene]-7'-yl)benzonitrile
Show/Hide
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C22H22N4O
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1
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| 1 |
IC50 = 23 nM
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CP0443207
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(4aS,10R,10aS)-2'-amino-8-[3-(difluoromethoxy)phenyl]-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C22H21F2N3O4
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1
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| 1 |
IC50 = 23 nM
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CP0284891
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2'-amino-6-(3-chloro-5-fluorophenyl)-2,2,3'-trimethylspiro[1,3-dihydronaphthalene-4,5'-imidazole]-4'-one
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C21H21ClFN3O
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1
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| 1 |
IC50 = 24 nM
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CP0315958
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2'-amino-6-(3-chlorophenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
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C20H20ClN3O2
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1
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| 1 |
IC50 = 24 nM
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CP0388199
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5-[(4aS,10R,10aS)-2'-amino-1'-methyl-5'-oxospiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-imidazole]-8-yl]pyridine-3-carbonitrile
Show/Hide
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C21H19N5O3
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1
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| 1 |
IC50 = 24 nM
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CP0549047
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(4aS,10R,10aS)-2'-amino-8-(2-fluoropyridin-3-yl)-3',10a-dimethylspiro[1,3,4,4a-tetrahydropyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
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C21H21FN4O3
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1
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| 1 |
IC50 = 24 nM
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CP0359952
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N-[3-[(1R,4R,5S)-2-amino-4-methyl-6,8-dioxa-3-azabicyclo[3.2.1]oct-2-en-4-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
Show/Hide
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C20H18FN5O3
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1
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| 1 |
IC50 = 25 nM
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CP0244459
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(1R,3S,4S,5R)-3-[(4-amino-3-fluoro-5-methoxyphenyl)methyl]-5-[(3-tert-butylphenyl)methylamino]-1-oxothian-4-ol
Show/Hide
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C24H33FN2O3S
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1
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| 1 |
IC50 = 26 nM
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CP0246619
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N-[3-[(3R)-5-amino-3-(difluoromethyl)-6,6-dimethyl-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-bromopyridine-2-carboxamide
Show/Hide
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C19H18BrF3N4O2
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1
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| 1 |
IC50 = 26 nM
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CP0486634
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(4aS,10R,10aS)-2'-amino-8-(5-chloropyridin-3-yl)-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C20H19ClN4O3
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1
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| 1 |
IC50 = 27 nM
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CP0560838
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N-[3-[(3R,6S)-5-amino-6-methoxy-3,6-dimethyl-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
Show/Hide
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C21H22FN5O3
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1
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| 1 |
IC50 = 27 nM
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CP0065927
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2'-amino-6-[3-(difluoromethoxy)phenyl]-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
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C21H21F2N3O3
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1
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| 1 |
IC50 = 28 nM
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CP0449442
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2'-amino-6-(3,5-dichlorophenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
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C20H19Cl2N3O2
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1
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| 1 |
IC50 = 28 nM
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CP0388198
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(4aS,10R,10aS)-2'-amino-8-(3-methoxyphenyl)-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C22H23N3O4
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1
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| 1 |
IC50 = 28 nM
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CP0473436
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(4aS,10R,10aS)-2'-amino-8-(5-methoxypyridin-3-yl)-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C21H22N4O4
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1
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| 1 |
IC50 = 28 nM
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CP0388204
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3-[(4aS,10R,10aS)-2'-amino-1',10a-dimethyl-5'-oxospiro[1,3,4,4a-tetrahydropyrano[4,3-b]chromene-10,4'-imidazole]-8-yl]benzonitrile
Show/Hide
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C23H22N4O3
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1
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| 1 |
IC50 = 29 nM
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CP0876279
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N-[(2R,3S)-3-({[3-(1,1-Dioxidotetrahydro-2H-1,2-thiazin-2-yl)-5-ethylamino)phenyl]carbonyl}amino)-2-hydroxy-4-phenylbutyl]cyclohexanaminiumformate
Show/Hide
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C30H44N4O6S
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1
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| 1 |
IC50 = 30 nM
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CP0284890
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2'-amino-6-(5-chloropyridin-3-yl)-2,2,3'-trimethylspiro[1,3-dihydronaphthalene-4,5'-imidazole]-4'-one
Show/Hide
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C20H21ClN4O
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1
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| 1 |
IC50 = 30 nM
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CP0315955
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(4R)-2'-amino-6-(2-fluoropyridin-3-yl)-2,2,3'-trimethylspiro[1,3-dihydronaphthalene-4,5'-imidazole]-4'-one
Show/Hide
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C20H21FN4O
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1
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| 1 |
IC50 = 30 nM
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CP0745138
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[2H]-(1R,3S,4S,5R)-3-{4-Amino-3-fluoro-5-[2,2,2-trifluoro-1-((R)-methoxymethyl)-ethoxy]-benzyl}-5-(3-isopropyl-benzylamino)-1-oxo-tetrahydro-thiopyran-4-ol
Show/Hide
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C26H34F4N2O4S
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1
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| 1 |
IC50 = 31 nM
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CP0174600
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(4aS,10R,10aS)-2'-amino-8-(3-chloro-5-fluorophenyl)-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C21H19ClFN3O3
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1
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| 1 |
IC50 = 31 nM
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CP0178200
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(1R,3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(2R)-1,1,1-trifluoro-3-methoxypropan-2-yl]oxyphenyl]methyl]-5-[[(1R)-1-(3-tert-butylphenyl)ethyl]amino]-1-oxothian-4-ol
Show/Hide
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C28H38F4N2O4S
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1
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| 1 |
IC50 = 32 nM
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CP0359953
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US8846658, 66
Show/Hide
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C19H18BrF3N4O2
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1
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| 1 |
IC50 = 32 nM
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CP0432699
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(4aS,10R,10aS)-2'-amino-8-(5-fluoropyridin-3-yl)-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C20H19FN4O3
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1
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| 1 |
IC50 = 33 nM
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CP0443206
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(4aS,10R,10aS)-2'-amino-3',10a-dimethyl-8-pyrimidin-5-ylspiro[1,3,4,4a-tetrahydropyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C20H21N5O3
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1
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| 1 |
IC50 = 33 nM
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CP0486753
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N-[(2S,3R)-4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-3-hydroxy-1-phenylbutan-2-yl]-3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)benzamide
Show/Hide
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C32H40N4O4S
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1
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| 1 |
IC50 = 34 nM
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CP0897223
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N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide;formic acid
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C32H38N4O6S
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1
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| 1 |
IC50 = 34 nM
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CP0703986
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rac-2'-Amino-6-(5-chloropyridin-3-yl)-1',2,2-trimethylspiro-[chroman-4,4'-imidazol]-5'(1'H)-one
Show/Hide
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C19H19ClN4O2
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1
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| 1 |
IC50 = 34 nM
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CP0065929
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2'-amino-6-(5-chloro-2-fluorophenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
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C20H19ClFN3O2
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1
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| 1 |
IC50 = 36 nM
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CP0053444
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(1R,3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(2R)-1,1,1-trifluoro-3-methoxypropan-2-yl]oxyphenyl]methyl]-5-[(5-tert-butyl-2-fluorophenyl)methylamino]-1-oxothian-4-ol
Show/Hide
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C27H35F5N2O4S
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1
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| 1 |
IC50 = 38 nM
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CP0145337
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1-N-[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-methyl-1-(propan-2-ylcarbamoyl)propyl]carbamoyl}heptan-4-yl]-5-(N-methylmethanesulfonamido)-3-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
Show/Hide
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C36H55N5O7S
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1
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| 1 |
IC50 = 39 nM
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CP0449566
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2'-amino-6-(3-chloro-5-fluorophenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
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C20H19ClFN3O2
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1
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| 1 |
IC50 = 39 nM
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CP0388197
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(4aS,10R,10aS)-2'-amino-3'-methyl-8-pyrimidin-5-ylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C19H19N5O3
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1
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| 1 |
IC50 = 39 nM
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CP0454079
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3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-1-(furan-2-yl)-3-hydroxy-4-{[(3-methoxyphenyl)methyl]amino}butan-2-yl]benzamide
Show/Hide
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C29H38N4O6S
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1
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| 1 |
IC50 = 40 nM
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CP0240340
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2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-5-yloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-3-yloxy)ethanol
Show/Hide
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C28H24ClN5O3
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1
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| 1 |
IC50 = 40 nM
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CP0112434
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N-[4-[[(3S,4S,5R)-5-[(3-tert-butylphenyl)methylamino]-4-hydroxy-1,1-dioxothian-3-yl]methyl]-2-ethyl-6-fluorophenyl]-2-(dimethylamino)acetamide
Show/Hide
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C29H42FN3O4S
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1
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| 1 |
IC50 = 40 nM
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CP0101060
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(1R,3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(2R)-1,1,1-trifluoro-3-methoxypropan-2-yl]oxyphenyl]methyl]-1-oxo-5-[(3-propan-2-ylphenyl)methylamino]thian-4-ol
Show/Hide
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C26H34F4N2O4S
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1
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| 1 |
IC50 = 44 nM
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CP0070640
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(3S,14R,16S)-16-((R)-1-hydroxy-2-(3-isopropylbenzylamino)ethyl)-3,4,14-trimethyl-1,4-diazacyclohexadecane-2,5-dione
Show/Hide
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C29H49N3O3
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1
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| 1 |
IC50 = 45 nM
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CP0333398
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3-(2'-amino-1',2,2-trimethyl-5'-oxospiro[3H-thiochromene-4,4'-imidazole]-6-yl)benzonitrile
Show/Hide
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C21H20N4OS
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1
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| 1 |
IC50 = 47 nM
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CP0333396
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(4R)-2'-amino-2,2,3'-trimethyl-6-pyrimidin-5-ylspiro[1,3-dihydronaphthalene-4,5'-imidazole]-4'-one
Show/Hide
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C19H21N5O
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1
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| 1 |
IC50 = 48 nM
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CP0455080
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3-(1,1-dioxo-1,2-thiazolidin-2-yl)-5-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]benzamide
Show/Hide
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C30H34F3N3O5S
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1
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| 1 |
IC50 = 50 nM
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CP0360722
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(3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(2R)-1,1,1-trifluoro-3-methoxypropan-2-yl]oxyphenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
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C27H36F4N2O5S
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1
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| 1 |
IC50 = 50 nM
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CP0388072
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(4aS,10R,10aS)-8-(3-chloro-5-fluorophenyl)-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
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C21H20ClFN2O3
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1
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| 1 |
IC50 = 54 nM
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CP0109039
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(3S,4S,5R)-3-[[4-amino-3-fluoro-5-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)phenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C26H31F7N2O4S
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1
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| 1 |
IC50 = 55 nM
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CP0323332
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2'-amino-6-(2-fluoro-5-methoxyphenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
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C21H22FN3O3
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1
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| 1 |
IC50 = 60 nM
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CP0795276
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rac-2-Amino-7'-(2-fluoropyridin-3-yl)-1,3',3'-trimethyl-3',4'-dihydro-2'H-spiro[imidazole-4,1'-naphthalen]-5(1H)-one
Show/Hide
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C20H21FN4O
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1
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| 1 |
IC50 = 60 nM
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CP0473437
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(4aS,10R,10aS)-8-(5-chloropyridin-3-yl)-7-fluoro-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
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C20H19ClFN3O3
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1
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| 1 |
IC50 = 60 nM
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CP0449511
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2'-amino-6-(3-fluoro-5-methoxyphenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
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C21H22FN3O3
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1
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| 1 |
IC50 = 61 nM
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CP0443205
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(4aS,10R,10aS)-2'-amino-8-[3-(difluoromethoxy)phenyl]-7-fluoro-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C22H20F3N3O4
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1
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| 1 |
IC50 = 61 nM
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CP0178202
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(1R,3S,4S,5R)-3-[[4-amino-3-fluoro-5-(2,2,2-trifluoroethoxy)phenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1-oxothian-4-ol
Show/Hide
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C25H32F4N2O3S
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1
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| 1 |
IC50 = 62 nM
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CP0284894
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2'-amino-2,2,3'-trimethyl-6-[5-(trifluoromethyl)pyridin-3-yl]spiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
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C20H19F3N4O2
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1
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| 1 |
IC50 = 63 nM
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CP0388203
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(4aS,10R,10aS)-2'-amino-7-fluoro-8-(2-fluoropyridin-3-yl)-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
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C20H18F2N4O3
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1
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| 1 |
IC50 = 66 nM
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CP0302151
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2'-amino-6-(3-methoxyphenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
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C21H23N3O3
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1
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| 1 |
IC50 = 68 nM
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CP0443448
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(4R)-2'-amino-6-(3-methoxyphenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
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C21H23N3O3
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1
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| 1 |
IC50 = 68 nM
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CP0876281
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N-[(2R,3S)-3-({[3-(1,1-Dioxidotetrahydro-2H-1,2-thiazin-2-yl)-5-(ethylamino)phenyl]carbonyl}amino)-2-hydroxy-4-phenylbutyl]-2,6-dimethyl-2-heptanaminium formate
Show/Hide
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C34H54N4O6S
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1
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| 1 |
IC50 = 69 nM
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CP0475873
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N-[3-[5-amino-3-(difluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]-2,4-difluorophenyl]-5-bromopyridine-2-carboxamide
Show/Hide
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C17H13BrF4N4O2
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1
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| 1 |
IC50 = 69 nM
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CP0274741
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2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-5-yloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-3-ylamino)ethanol
Show/Hide
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C28H25ClN6O2
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1
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| 1 |
IC50 = 70 nM
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CP0259786
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2'-amino-6-(3-ethoxyphenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
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C22H25N3O3
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1
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| 1 |
IC50 = 70 nM
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CP0529539
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(4aS,10R,10aS)-7-fluoro-8-(2-fluoropyridin-3-yl)-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
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C20H19F2N3O3
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1
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| 1 |
IC50 = 71 nM
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CP0317586
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(3S,4S,5R)-3-[[4-amino-3-(2,2-difluoroethoxy)-5-fluorophenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C25H33F3N2O4S
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1
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| 1 |
IC50 = 72 nM
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CP0368707
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2'-amino-2,2,3'-trimethyl-6-[3-(trifluoromethyl)phenyl]spiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
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C21H20F3N3O2
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1
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| 1 |
IC50 = 74 nM
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CP0069442
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(1R,3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(2R)-1,1,1-trifluoro-3-methoxypropan-2-yl]oxyphenyl]methyl]-1-oxo-5-[(3-propan-2-yloxyphenyl)methylamino]thian-4-ol
Show/Hide
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C26H34F4N2O5S
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1
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| 1 |
IC50 = 75 nM
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CP0069645
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1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-(N-methylmethanesulfonamido)-3-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
Show/Hide
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C31H38N4O5S
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1
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| 1 |
IC50 = 78 nM
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CP0112430
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(3R,4S,5S)-3-[(3-tert-butylphenyl)methylamino]-5-[(7-fluorospiro[1,2-dihydroindole-3,1'-cyclobutane]-5-yl)methyl]-1,1-dioxothian-4-ol
Show/Hide
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C28H37FN2O3S
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1
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| 1 |
IC50 = 80 nM
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CP0259787
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3-(2'-amino-1',2,2-trimethyl-5'-oxospiro[3H-chromene-4,4'-imidazole]-6-yl)benzonitrile
Show/Hide
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C21H20N4O2
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1
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| 1 |
IC50 = 94 nM
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CP0368704
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2'-amino-6-(3-fluorophenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
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C20H20FN3O2
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1
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| 1 |
IC50 = 99 nM
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CP0315887
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6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-5-yloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
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C26H20ClN5O
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1
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| 1 |
IC50 = 100 nM
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CP0165968
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(3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(2R)-1,1,1-trifluoropropan-2-yl]oxyphenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C26H34F4N2O4S
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1
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| 1 |
IC50 = 105 nM
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CP0046914
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2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-3-yloxy)ethanol
Show/Hide
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C29H32ClN3O3
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1
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| 1 |
IC50 = 110 nM
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CP0368702
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2'-amino-2,2,3'-trimethyl-6-pyridin-3-ylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
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C19H20N4O2
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1
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| 1 |
IC50 = 113 nM
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CP0246593
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(3S,4S,5R)-3-[(4-amino-3-propoxyphenyl)methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C26H38N2O4S
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1
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| 1 |
IC50 = 115 nM
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CP0175034
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(3S,4S,5R)-3-[[4-amino-3-fluoro-5-(2,2,2-trifluoroethoxy)phenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C25H32F4N2O4S
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1
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| 1 |
IC50 = 116 nM
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CP0188431
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(3S,4S,5R)-3-[[4-amino-3-fluoro-5-(oxetan-3-yloxy)phenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C26H35FN2O5S
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1
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| 1 |
IC50 = 118 nM
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CP0454078
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BMCL181022 Compound 12
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C30H38N4O4S
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1
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| 1 |
IC50 = 120 nM
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CP0894683
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N-[(2R,3S)-3-({[3-(1,1-Dioxidotetrahydro-2H-1,2-thiazin-2-yl)-5-(ethylamino)phenyl]carbonyl}amino)-2-hydroxy-4-phenylbutyl]cyclopropanaminiumformate
Show/Hide
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C27H38N4O6S
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1
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| 1 |
IC50 = 120 nM
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CP0897224
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(2R,3S)-3-({[3-(1,1-Dioxidotetrahydro-2H-1,2-thiazin-2-yl)-5-(ethylamino)phenyl]carbonyl}amino)-2-hydroxy-4-phenyl-N-(phenylmethyl)-1-butanaminium formate
Show/Hide
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C31H40N4O6S
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1
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| 1 |
IC50 = 120 nM
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CP0388071
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(1R,4aR,10R,10aR)-8-(2-fluoropyridin-3-yl)-1-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-thiazole]-2'-amine
Show/Hide
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C20H20FN3O2S
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1
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| 1 |
IC50 = 120 nM
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CP0065924
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2'-amino-6-(3-chlorophenyl)-3'-(2-methoxyethyl)-2,2-dimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
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C22H24ClN3O3
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1
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| 1 |
IC50 = 123 nM
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CP0210726
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(1R,3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(2R)-1,1,1-trifluoro-3-methoxypropan-2-yl]oxyphenyl]methyl]-5-[[1-(2,2-dimethylpropyl)pyrazol-4-yl]methylamino]-1-oxothian-4-ol
Show/Hide
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C25H36F4N4O4S
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1
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| 1 |
IC50 = 124 nM
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CP0112460
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(3S,4S,5R)-3-[[4-amino-3-[(2R)-3-ethoxy-1,1,1-trifluoropropan-2-yl]oxy-5-fluorophenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C28H38F4N2O5S
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1
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| 1 |
IC50 = 126 nM
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CP0101056
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(1R,3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(2R)-1,1,1-trifluoro-3-methoxypropan-2-yl]oxyphenyl]methyl]-5-[[3-(2-hydroxypropan-2-yl)phenyl]methylamino]-1-oxothian-4-ol
Show/Hide
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C26H34F4N2O5S
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1
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| 1 |
IC50 = 126 nM
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CP0127644
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(3S,4S,5R)-3-[[4-amino-3-fluoro-5-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)phenyl]methyl]-5-[(3,3-dimethyl-1H-2-benzofuran-5-yl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C26H29F7N2O5S
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1
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| 1 |
IC50 = 130 nM
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CP0206649
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2'-amino-6-(2-fluoropyridin-3-yl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
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C19H19FN4O2
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1
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| 1 |
IC50 = 130 nM
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CP0165967
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(3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(2R)-1,1,1-trifluoro-3-(2-methoxyethoxy)propan-2-yl]oxyphenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C29H40F4N2O6S
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1
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| 1 |
IC50 = 131 nM
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CP0101059
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(1R,3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(2R)-1,1,1-trifluoro-3-methoxypropan-2-yl]oxyphenyl]methyl]-5-[[3-(1-hydroxy-2-methylpropan-2-yl)phenyl]methylamino]-1-oxothian-4-ol
Show/Hide
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C27H36F4N2O5S
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1
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| 1 |
IC50 = 134 nM
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CP0368698
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2'-amino-2,2,3'-trimethyl-6-pyrimidin-5-ylspiro[3H-thiochromene-4,5'-imidazole]-4'-one
Show/Hide
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C18H19N5OS
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1
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| 1 |
IC50 = 135 nM
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CP0795275
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rac-2-Amino-1,3',3'-trimethyl-7'-(pyrimidin-5-yl)-3',4'-dihydro-2'H-spiro[imidazole-4,1'-naphthalen]-5(1H)-one
Show/Hide
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C19H21N5O
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1
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| 1 |
IC50 = 138 nM
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CP0880740
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(2R,3S)-3-({[3-(1,1-Dioxidotetrahydro-2H-1,2-thiazin-2-yl)-5-(ethylamino)phenyl]carbonyl}amino)-2-hydroxy-N-methyl-4-phenyl-1-butanaminium chloride
Show/Hide
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C24H35ClN4O4S
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1
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| 1 |
IC50 = 140 nM
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CP0284892
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2'-amino-6-(5-fluoropyridin-3-yl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
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C19H19FN4O2
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1
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| 1 |
IC50 = 145 nM
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CP0188433
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(3S,4S,5R)-3-[(4-amino-3-ethoxy-5-fluorophenyl)methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C25H35FN2O4S
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1
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| 1 |
IC50 = 150 nM
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CP0304034
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2'-amino-2,2,3'-trimethyl-6-pyrimidin-5-ylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
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C18H19N5O2
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1
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| 1 |
IC50 = 151 nM
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CP0489362
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3-(2-cyanophenyl)-5-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]benzamide
Show/Hide
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C34H32F3N3O3
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1
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| 1 |
IC50 = 160 nM
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CP0294456
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2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-3-ylamino)ethanol
Show/Hide
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C29H33ClN4O2
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1
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| 1 |
IC50 = 170 nM
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CP0125076
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(3S,4S,5R)-3-[[4-amino-3-fluoro-5-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)phenyl]methyl]-5-[[3-(2-hydroxypropan-2-yl)phenyl]methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C25H29F7N2O5S
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1
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| 1 |
IC50 = 170 nM
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CP0420920
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(4aS,10R,10aS)-8-(5-chloropyridin-3-yl)-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
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C20H20ClN3O3
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1
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| 1 |
IC50 = 190 nM
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CP0207854
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(3S,4S,5R)-3-[[4-amino-3-fluoro-5-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)phenyl]methyl]-5-[[3-(1-hydroxy-2-methylpropan-2-yl)phenyl]methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C26H31F7N2O5S
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1
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| 1 |
IC50 = 210 nM
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CP0175032
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(3S,4S,5R)-3-[(4-amino-3-cyclobutyloxy-5-fluorophenyl)methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C27H37FN2O4S
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1
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| 1 |
IC50 = 215 nM
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CP0046947
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3-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-3-ylamino)propan-1-ol
Show/Hide
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C30H35ClN4O2
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1
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| 1 |
IC50 = 220 nM
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CP0432700
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(4aS,10R,10aS)-8-(2-fluoropyridin-3-yl)-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
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C20H20FN3O3
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1
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| 1 |
IC50 = 220 nM
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CP0553854
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(4aR,10R,10aR)-8-(5-chloropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-thiazole]-2'-amine
Show/Hide
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C19H18ClN3O2S
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1
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| 1 |
IC50 = 220 nM
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CP0175033
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(3S,4S,5R)-3-[[4-amino-3-fluoro-5-(2-fluoroethoxy)phenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C25H34F2N2O4S
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1
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| 1 |
IC50 = 225 nM
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CP0368701
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N-(2'-amino-1',2,2-trimethyl-5'-oxospiro[3H-chromene-4,4'-imidazole]-6-yl)-5-methylfuran-2-carboxamide
Show/Hide
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C20H22N4O4
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1
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| 1 |
IC50 = 230 nM
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CP0388202
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(1R,4aR,10R,10aR)-8-(2-fluoropyridin-3-yl)-1-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
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C20H20FN3O3
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1
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| 1 |
IC50 = 230 nM
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CP0147514
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(3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]phenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C26H34F4N2O4S
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1
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| 1 |
IC50 = 240 nM
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CP0511437
|
3-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]-5-(2-methyl-5-oxocyclopent-1-en-1-yl)benzamide
Show/Hide
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C33H35F3N2O4
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1
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| 1 |
IC50 = 250 nM
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CP0175028
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(3S,4S,5R)-3-[(4-amino-3-bromophenyl)methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C23H31BrN2O3S
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1
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| 1 |
IC50 = 250 nM
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CP0368697
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2'-amino-6-(3-chlorophenyl)-3'-ethyl-2,2-dimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
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C21H22ClN3O2
|
1
|
| 1 |
IC50 = 260 nM
|
|
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CP0065926
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2'-amino-6-cyclohexyl-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
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C20H27N3O2
|
1
|
| 1 |
IC50 = 278 nM
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|
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CP0464298
|
3-(2-acetylphenyl)-5-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]benzamide
Show/Hide
|
C35H35F3N2O4
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
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CP0293106
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6-((2-(2-chlorophenyl)-5-(4-(thiophen-2-yloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
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C26H20ClN3OS
|
1
|
| 1 |
IC50 = 290 nM
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|
|
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CP0112432
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N-[4-[[(3S,4S,5R)-5-[(3-tert-butylphenyl)methylamino]-4-hydroxy-1,1-dioxothian-3-yl]methyl]-2-fluorophenyl]-2-(dimethylamino)acetamide
Show/Hide
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C27H38FN3O4S
|
1
|
| 1 |
IC50 = 300 nM
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|
|
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CP0493839
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3-[(4aS,10R,10aS)-2'-amino-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-8-yl]benzonitrile
Show/Hide
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C22H21N3O3
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
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CP0536082
|
US8846658, 81
Show/Hide
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C17H13BrF4N4O2
|
1
|
| 1 |
IC50 = 300 nM
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|
|
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CP0112452
|
(3S,4S,5R)-3-[[4-amino-3-(2,2,2-trifluoroethoxy)phenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C25H33F3N2O4S
|
1
|
| 1 |
IC50 = 310 nM
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|
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CP0563239
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N-[3-[5-amino-3-(trifluoromethyl)-2,6-dihydro-1,4-oxazin-3-yl]phenyl]-5-chloropyridine-2-carboxamide
Show/Hide
|
C17H14ClF3N4O2
|
1
|
| 1 |
IC50 = 324 nM
|
|
|
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CP0143647
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(1S,3S,4S,5R)-3-[[4-amino-3-fluoro-5-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)phenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1-oxothian-4-ol
Show/Hide
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C26H31F7N2O3S
|
1
|
| 1 |
IC50 = 330 nM
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|
|
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CP0443204
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(4aR,10R,10aR)-8-(2-fluoropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-thiazole]-2'-amine
Show/Hide
|
C19H18FN3O2S
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
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CP0368706
|
2'-amino-2,2,3'-trimethyl-6-(3-methylsulfanylphenyl)spiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C21H23N3O2S
|
1
|
| 1 |
IC50 = 344 nM
|
|
|
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CP0291294
|
(3S,4S,5R)-3-[[4-amino-3-[(2S)-3-ethoxy-1,1,1-trifluoropropan-2-yl]oxy-5-fluorophenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
|
C28H38F4N2O5S
|
1
|
| 1 |
IC50 = 346 nM
|
|
|
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CP0409545
|
(3S,4S,5R)-3-[[4-amino-3-fluoro-5-(1H-pyrazol-5-yl)phenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
|
C26H33FN4O3S
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
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CP0112435
|
(3S,4S,5R)-3-[[4-amino-3-fluoro-5-(3,3,3-trifluoropropyl)phenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
|
C26H34F4N2O3S
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
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CP0125119
|
(3S,4S,5R)-3-[[4-amino-3-fluoro-5-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)phenyl]methyl]-5-[(4-tert-butylpyridin-2-yl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
|
C25H30F7N3O4S
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
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CP0501733
|
3-ethoxy-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trifluoromethyl)phenyl]methyl}amino)butan-2-yl]-5-(2-oxopyrrolidin-1-yl)benzamide
Show/Hide
|
C31H34F3N3O4
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0207857
|
(3S,4S,5R)-3-[[4-amino-3-fluoro-5-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)phenyl]methyl]-5-[[1-(2,2-dimethylpropyl)pyrazol-4-yl]methylamino]-1,1-dioxothian-4-ol
Show/Hide
|
C24H31F7N4O4S
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
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CP0246594
|
(3S,4S,5R)-3-[[4-amino-3-fluoro-5-(2-methoxyethoxy)phenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
|
C26H37FN2O5S
|
1
|
| 1 |
IC50 = 382 nM
|
|
|
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CP0108632
|
(1R,3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(2R)-1,1,1-trifluoro-3-methoxypropan-2-yl]oxyphenyl]methyl]-1-oxo-5-[[3-(trifluoromethoxy)phenyl]methylamino]thian-4-ol
Show/Hide
|
C24H27F7N2O5S
|
1
|
| 1 |
IC50 = 382 nM
|
|
|
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CP0046916
|
6-((2-(2-chlorophenyl)-5-(4-(pyridazin-3-yloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
|
C26H20ClN5O
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0330889
|
6-((2-(2-chlorophenyl)-5-(4-(pyridin-3-yloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
|
C27H21ClN4O
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0246567
|
(3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(2S)-3,3,3-trifluoro-2-methoxypropyl]phenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
|
C27H36F4N2O4S
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
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CP0228587
|
4-(4-(1-((6-aminopyridin-2-yl)methyl)-5-(2-chlorophenyl)-1H-pyrrol-2-yl)phenoxy)butanenitrile
Show/Hide
|
C26H23ClN4O
|
1
|
| 1 |
IC50 = 420 nM
|
|
|
|
CP0420917
|
(4aS,10R,10aS)-4a-methyl-8-pyrimidin-5-ylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C19H20N4O3
|
1
|
| 1 |
IC50 = 420 nM
|
|
|
|
CP0108631
|
(1R,3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(2R)-1,1,1-trifluoro-3-methoxypropan-2-yl]oxyphenyl]methyl]-5-[(4-tert-butylpyridin-2-yl)methylamino]-1-oxothian-4-ol
Show/Hide
|
C26H35F4N3O4S
|
1
|
| 1 |
IC50 = 422 nM
|
|
|
|
CP0236940
|
(3S,4S,5R)-3-[(4-amino-3-fluoro-5-propoxyphenyl)methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
|
C26H37FN2O4S
|
1
|
| 1 |
IC50 = 424 nM
|
|
|
|
CP0066921
|
2'-amino-2,2,3'-trimethyl-6-(2-methylpropoxy)spiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C18H25N3O3
|
1
|
| 1 |
IC50 = 431 nM
|
|
|
|
CP0388201
|
(4aR,10R,10aR)-8-(5-chloropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C19H18ClN3O3
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0112457
|
(3S,4S,5R)-3-[(4-amino-3-fluoro-5-propan-2-yloxyphenyl)methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
|
C26H37FN2O4S
|
1
|
| 1 |
IC50 = 443 nM
|
|
|
|
CP0175030
|
(3S,4S,5R)-3-[(4-amino-3-bromo-5-fluorophenyl)methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
|
C23H30BrFN2O3S
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0302152
|
2'-amino-2,2,3'-trimethyl-6-phenylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C20H21N3O2
|
1
|
| 1 |
IC50 = 455 nM
|
|
|
|
CP0228588
|
6-((2-(2-chlorophenyl)-5-(4-(pyrazin-2-yloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
|
C26H20ClN5O
|
1
|
| 1 |
IC50 = 460 nM
|
|
|
|
CP0125074
|
(3S,4S,5R)-3-[[4-amino-3-fluoro-5-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)phenyl]methyl]-5-[[5-(2,2-dimethylpropyl)-1,2-oxazol-3-yl]methylamino]-1,1-dioxothian-4-ol
Show/Hide
|
C24H30F7N3O5S
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0529538
|
(4aR,10S,10aR)-2'-amino-8-(2-fluoropyridin-3-yl)-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
|
C20H19FN4O3
|
1
|
| 1 |
IC50 = 490 nM
|
|
|
|
CP0334972
|
2'-amino-2,2,3'-trimethyl-6-(1,2-thiazol-5-yl)spiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C17H18N4O2S
|
1
|
| 1 |
IC50 = 501 nM
|
|
|
|
CP0420916
|
(4aS,10R,10aS)-8-(5-fluoropyridin-3-yl)-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C20H20FN3O3
|
1
|
| 1 |
IC50 = 530 nM
|
|
|
|
CP0075443
|
6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
|
C27H28ClN3O
|
1
|
| 1 |
IC50 = 550 nM
|
|
|
|
CP0259405
|
(3S,4S,5R)-3-[(4-amino-3-fluoro-5-propylphenyl)methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
|
C26H37FN2O3S
|
1
|
| 1 |
IC50 = 550 nM
|
|
|
|
CP0314145
|
N-[4-[[(3S,4S,5R)-5-[(3-tert-butylphenyl)methylamino]-4-hydroxy-1,1-dioxothian-3-yl]methyl]-2-ethyl-6-fluorophenyl]acetamide
Show/Hide
|
C27H37FN2O4S
|
1
|
| 1 |
IC50 = 560 nM
|
|
|
|
CP0188428
|
(3S,4S,5R)-3-[(4-amino-3-cyclopropyl-5-fluorophenyl)methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
|
C26H35FN2O3S
|
1
|
| 1 |
IC50 = 580 nM
|
|
|
|
CP0128706
|
6-((2-(2-chlorophenyl)-5-(4-(pyridin-4-yloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
|
C27H21ClN4O
|
1
|
| 1 |
IC50 = 590 nM
|
|
|
|
CP0316186
|
4-[1-[(6-aminopyridin-2-yl)methyl]-5-phenylpyrrol-2-yl]-N-prop-2-enylbenzamide
Show/Hide
|
C26H24N4O
|
1
|
| 1 |
IC50 = 590 nM
|
|
|
|
CP0065925
|
2'-amino-6-(3-chlorophenyl)-2,2-dimethyl-3'-(2,2,2-trifluoroethyl)spiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
|
C21H19ClF3N3O2
|
1
|
| 1 |
IC50 = 604 nM
|
|
|
|
CP0341927
|
(3S,4S,5R)-3-[(4-amino-3-fluorophenyl)methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
|
C23H31FN2O3S
|
1
|
| 1 |
IC50 = 630 nM
|
|
|
|
CP0114822
|
N-[3-[(3R)-5-amino-3-(difluoromethyl)-6,6-bis(fluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
Show/Hide
|
C21H18F5N5O2
|
1
|
| 1 |
IC50 = 663 nM
|
|
|
|
CP0458938
|
(4aS,10R,10aS)-2'-amino-8-bromo-3'-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
Show/Hide
|
C15H16BrN3O3
|
1
|
| 1 |
IC50 = 670 nM
|
|
|
|
CP0284889
|
2'-amino-2,2,3'-trimethyl-6-pyrimidin-5-ylspiro[3H-naphthalene-4,5'-imidazole]-1,4'-dione
Show/Hide
|
C19H19N5O2
|
1
|
| 1 |
IC50 = 703 nM
|
|
|
|
CP0112428
|
(3R,4S,5S)-3-[(3-tert-butylphenyl)methylamino]-5-[(3-ethyl-1H-indol-5-yl)methyl]-1,1-dioxothian-4-ol
Show/Hide
|
C27H36N2O3S
|
1
|
| 1 |
IC50 = 740 nM
|
|
|
|
CP0388070
|
(4aS,10R,10aS)-8-(5-chloropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C19H18ClN3O3
|
1
|
| 1 |
IC50 = 760 nM
|
|
|
|
CP0133094
|
(1R,3S,4S,5R)-3-[[4-amino-3-fluoro-5-[(2R)-1,1,1-trifluoro-3-methoxypropan-2-yl]oxyphenyl]methyl]-5-[[5-(2,2-dimethylpropyl)-1,2-oxazol-3-yl]methylamino]-1-oxothian-4-ol
Show/Hide
|
C25H35F4N3O5S
|
1
|
| 1 |
IC50 = 764 nM
|
|
|
|
CP0385841
|
6-(5-chloropyridin-3-yl)-2,2-dimethylspiro[1,3-dihydronaphthalene-4,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C19H20ClN3O
|
1
|
| 1 |
IC50 = 789 nM
|
|
|
|
CP0315886
|
6-((2-(2-chlorophenyl)-5-(4-(pyridin-2-yloxy)phenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
|
C27H21ClN4O
|
1
|
| 1 |
IC50 = 810 nM
|
|
|
|
CP0443203
|
(4aR,10R,10aR)-8-(2-fluoropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C19H18FN3O3
|
1
|
| 1 |
IC50 = 830 nM
|
|
|
|
CP0330890
|
6-((2-(2-chlorophenyl)-5-(4-phenoxyphenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
|
C28H22ClN3O
|
1
|
| 1 |
IC50 = 850 nM
|
|
|
|
CP0125077
|
(3S,4S,5R)-3-[[4-amino-3-fluoro-5-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)phenyl]methyl]-1,1-dioxo-5-[[3-(trifluoromethoxy)phenyl]methylamino]thian-4-ol
Show/Hide
|
C23H22F10N2O5S
|
1
|
| 1 |
IC50 = 950 nM
|
|
|
|
CP0294457
|
N-[4-[1-[(6-aminopyridin-2-yl)methyl]-5-(2-chlorophenyl)pyrrol-2-yl]phenyl]pyrimidin-5-amine
Show/Hide
|
C26H21ClN6
|
1
|
| 1 |
IC50 = 980 nM
|
|
|
|
CP0165966
|
(3S,4S,5R)-3-[[4-amino-3-fluoro-5-(3,3,3-trifluoropropoxy)phenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
|
C26H34F4N2O4S
|
1
|
| 1 |
IC50 = 1030 nM
|
|
|
|
CP0444116
|
(4aR,10R,10aR)-8-(2-fluoropyridin-3-yl)-10a-methylspiro[1,3,4,4a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C20H20FN3O3
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0175029
|
(3S,4S,5R)-3-[[4-amino-3-(trifluoromethoxy)phenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
|
C24H31F3N2O4S
|
1
|
| 1 |
IC50 = 1120 nM
|
|
|
|
CP0294458
|
6-((2-(2-chlorophenyl)-5-(4-propoxyphenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
Show/Hide
|
C25H24ClN3O
|
1
|
| 1 |
IC50 = 1150 nM
|
|
|
|
CP0546849
|
N-[3-[(3R,6S)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]phenyl]-5-bromopyridine-2-carboxamide
Show/Hide
|
C19H18BrF3N4O2
|
1
|
| 1 |
IC50 = 1161 nM
|
|
|
|
CP0075440
|
4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyrrol-2-yl)-N-cyclopropylbenzamide
Show/Hide
|
C26H24N4O
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0174599
|
(4aS,10R,10aS)-8-(2-fluoropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C19H18FN3O3
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0108633
|
(1R,3S,4S,5R)-3-[(4-amino-3-fluoro-5-hydroxyphenyl)methyl]-5-[(3-tert-butylphenyl)methylamino]-1-oxothian-4-ol
Show/Hide
|
C23H31FN2O3S
|
1
|
| 1 |
IC50 = 1340 nM
|
|
|
|
CP0065923
|
(4R)-2,2-dimethyl-6-pyrimidin-5-ylspiro[1,3-dihydronaphthalene-4,4'-5H-1,3-oxazole]-2'-amine
Show/Hide
|
C18H20N4O
|
1
|
| 1 |
IC50 = 1348 nM
|
|
|
|
CP0112423
|
(3S,4S,5R)-3-[(6-aminopyridin-3-yl)methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
|
C22H31N3O3S
|
1
|
| 1 |
IC50 = 1360 nM
|
|
|
|
CP0246569
|
(3S,4S,5R)-3-[[4-amino-3-fluoro-5-(furan-2-yl)phenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
Show/Hide
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C27H33FN2O4S
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1
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| 1 |
IC50 = 1380 nM
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CP0112455
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(3S,4S,5R)-3-[(4-amino-3-fluoro-5-hydroxyphenyl)methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
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C23H31FN2O4S
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1
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| 1 |
IC50 = 1413 nM
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CP0334971
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2'-amino-4,4-difluoro-3,3,3'-trimethyl-7-pyrimidin-5-ylspiro[2H-naphthalene-1,5'-imidazole]-4'-one
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C19H19F2N5O
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1
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| 1 |
IC50 = 1493 nM
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CP0274742
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6-((2-(4-butoxyphenyl)-5-(2-chlorophenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
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C26H26ClN3O
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1
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| 1 |
IC50 = 1650 nM
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CP0112424
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(3R,4S,5S)-3-[(3-tert-butylphenyl)methylamino]-5-(1H-indazol-5-ylmethyl)-1,1-dioxothian-4-ol
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C24H31N3O3S
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1
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| 1 |
IC50 = 1650 nM
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CP0302150
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2'-amino-6-(2-methoxyphenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
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C21H23N3O3
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1
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| 1 |
IC50 = 1701 nM
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CP0317584
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(3S,4S,5R)-3-[(4-amino-3-ethyl-5-fluorophenyl)methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
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C25H35FN2O3S
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1
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| 1 |
IC50 = 1770 nM
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CP0316187
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4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyrrol-2-yl)-N-isopropylbenzamide
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C26H26N4O
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1
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| 1 |
IC50 = 1780 nM
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CP0339798
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1-N-[(2,5-dimethyl-1,3-oxazol-4-yl)methyl]-3-N-[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-methyl-1-(propan-2-ylcarbamoyl)propyl]carbamoyl}heptan-4-yl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide
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C34H54N6O8S
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1
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| 1 |
IC50 = 1800 nM
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CP0368695
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6-(2-fluoropyridin-3-yl)-2,2-dimethylspiro[1,3-dihydronaphthalene-4,4'-5H-1,3-oxazole]-2'-amine
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C19H20FN3O
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1
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| 1 |
IC50 = 1908 nM
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CP0368696
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6-(5-chloropyridin-3-yl)-2,2-dimethylspiro[1,3-dihydronaphthalene-4,4'-5H-1,3-thiazole]-2'-amine
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C19H20ClN3S
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1
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| 1 |
IC50 = 1994 nM
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CP0174453
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(4aR,10R,10aR)-8-pyrimidin-5-ylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
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C18H18N4O3
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1
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| 1 |
IC50 = 2000 nM
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CP0147512
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(3R,4S,5S)-3-[(3-tert-butylphenyl)methylamino]-5-(1H-indol-5-ylmethyl)-1,1-dioxothian-4-ol
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C25H32N2O3S
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1
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| 1 |
IC50 = 2010 nM
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CP0301277
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(3R,4S,5S)-3-[(3-tert-butylphenyl)methylamino]-1,1-dioxo-5-[[3-(2,2,2-trifluoroethyl)-1H-indol-5-yl]methyl]thian-4-ol
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C27H33F3N2O3S
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1
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| 1 |
IC50 = 2060 nM
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CP0095372
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4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyrrol-2-yl)-N-ethylbenzamide
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C25H24N4O
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1
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| 1 |
IC50 = 2250 nM
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CP0246592
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(3S,4S,5R)-3-[[4-amino-3-fluoro-5-(furan-3-yl)phenyl]methyl]-5-[(3-tert-butylphenyl)methylamino]-1,1-dioxothian-4-ol
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C27H33FN2O4S
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1
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| 1 |
IC50 = 2350 nM
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CP0315957
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2'-amino-2,2,3'-trimethyl-6-pyridin-2-ylspiro[3H-chromene-4,5'-imidazole]-4'-one
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C19H20N4O2
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1
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| 1 |
IC50 = 2363 nM
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CP0150366
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6-((2-(2-chlorophenyl)-5-(4-methoxyphenyl)-1H-pyrrol-1-yl)methyl)pyridin-2-amine
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C23H20ClN3O
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1
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| 1 |
IC50 = 2450 nM
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CP0421425
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(4aS,10R,10aS)-8-pyrimidin-5-ylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
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C18H18N4O3
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1
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| 1 |
IC50 = 2500 nM
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CP0464295
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3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-{[(3-methoxyphenyl)methyl]amino}-1-(1H-pyrazol-1-yl)butan-2-yl]benzamide
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C28H38N6O5S
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1
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| 1 |
IC50 = 2690 nM
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CP0065928
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2'-amino-2,2,3'-trimethyl-6-(3-propan-2-yloxyphenyl)spiro[3H-chromene-4,5'-imidazole]-4'-one
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C23H27N3O3
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1
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| 1 |
IC50 = 2864 nM
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CP0075441
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4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyrrol-2-yl)-N-butylbenzamide
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C27H28N4O
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1
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| 1 |
IC50 = 3000 nM
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CP0095418
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4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyrrol-2-yl)-N-propylbenzamide
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C26H26N4O
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1
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| 1 |
IC50 = 3000 nM
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CP0075438
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4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyrrol-2-yl)-N-cyclobutylbenzamide
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C27H26N4O
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1
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| 1 |
IC50 = 3400 nM
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CP0112426
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(3R,4S,5S)-3-[(3-tert-butylphenyl)methylamino]-1,1-dioxo-5-[(3-propyl-2H-indazol-5-yl)methyl]thian-4-ol
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C27H37N3O3S
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1
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| 1 |
IC50 = 3520 nM
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CP0165964
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(3R,4S,5S)-3-[(3-tert-butylphenyl)methylamino]-1,1-dioxo-5-[(4',4',7-trifluorospiro[1,2-dihydroindole-3,1'-cyclohexane]-5-yl)methyl]thian-4-ol
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C30H39F3N2O3S
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1
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| 1 |
IC50 = 3530 nM
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CP0202574
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1-N-[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-methyl-1-(propan-2-ylcarbamoyl)propyl]carbamoyl}heptan-4-yl]-5-(N-methylmethanesulfonamido)-3-N-propylbenzene-1,3-dicarboxamide
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C31H53N5O7S
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1
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| 1 |
IC50 = 3600 nM
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CP0112449
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(3R,4S,5S)-3-[(3-tert-butylphenyl)methylamino]-1,1-dioxo-5-[(3-propoxyphenyl)methyl]thian-4-ol
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C26H37NO4S
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1
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| 1 |
IC50 = 4450 nM
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CP0781787
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rac-3,3-Dimethyl-7-(pyrimidin-5-yl)-3,4-dihydro-2H,5'H-spiro-[naphthalene-1,4'-oxazol]-2'-amine
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C18H20N4O
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1
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| 1 |
IC50 = 4892 nM
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CP0246566
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(3S,4S,5R)-3-[(4-amino-3-bromo-5-fluorophenyl)methyl]-5-[[3-(1,1-difluoroethyl)phenyl]methylamino]-1,1-dioxothian-4-ol
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C21H24BrF3N2O3S
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1
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| 1 |
IC50 = 4980 nM
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CP0075448
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6-((2,5-diphenyl-1H-pyrrol-1-yl)methyl)pyridin-2-amine
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C22H19N3
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1
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| 1 |
IC50 = 5200 nM
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CP0162525
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1-N-benzyl-3-N-[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-methyl-1-(propan-2-ylcarbamoyl)propyl]carbamoyl}heptan-4-yl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide
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C35H53N5O7S
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1
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| 1 |
IC50 = 5600 nM
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CP0385840
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6-(5-chloropyridin-3-yl)-2,2-dimethylspiro[1,3-dihydronaphthalene-4,4'-5,6-dihydro-1,3-thiazine]-2'-amine
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C20H22ClN3S
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1
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| 1 |
IC50 = 5738 nM
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CP0890931
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3-(1,1-dioxo-1lambda*6*-[1,2]thiazinan-2-yl)-5-ethylamino-N-[(1S,2R)-2-hydroxy-1-isopropyl-3-(3-methoxy-benzylamino)-propyl]-benzamide
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C27H40N4O5S
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1
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| 1 |
IC50 = 5750 nM
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CP0304033
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6-(5-fluoropyridin-3-yl)-2,2-dimethylspiro[1,3-dihydronaphthalene-4,4'-5H-1,3-oxazole]-2'-amine
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C19H20FN3O
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1
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| 1 |
IC50 = 5840 nM
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CP0115121
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2'-amino-2,2,3'-trimethyl-6-pyridin-4-ylspiro[3H-chromene-4,5'-imidazole]-4'-one
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C19H20N4O2
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1
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| 1 |
IC50 = 6270 nM
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CP0302149
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2'-amino-6-(4-methoxyphenyl)-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
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C21H23N3O3
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1
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| 1 |
IC50 = 7197 nM
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CP0147513
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(3R,4S,5S)-3-[(3-tert-butylphenyl)methylamino]-5-[[3-(2,2-difluoroethyl)-1H-indol-5-yl]methyl]-1,1-dioxothian-4-ol
Show/Hide
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C27H34F2N2O3S
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1
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| 1 |
IC50 = 7420 nM
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CP0368703
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2'-amino-2,2,3'-trimethyl-6-piperidin-1-ylspiro[3H-chromene-4,5'-imidazole]-4'-one
Show/Hide
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C19H26N4O2
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1
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| 1 |
IC50 = 8661 nM
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CP0052085
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macrocyclic peptidomimetic, 3h
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C26H49N3O4
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1
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| 1 |
IC50 = 8700 nM
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CP0138139
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NVP-ARV99
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C24H45N3O4
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1
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| 1 |
IC50 > 10000 nM
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CP0151964
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macrocyclic peptidomimetic, 3d
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C25H47N3O4
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1
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| 1 |
IC50 > 10000 nM
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CP0151966
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hydroxyethylene tripeptide inhibitor, 1
Show/Hide
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C25H49N3O4S
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1
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| 1 |
IC50 > 10000 nM
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CP0296844
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1-N-[1-(2,5-dimethyl-1,3-oxazol-4-yl)ethyl]-3-N-[(1R,3S,4S)-3-hydroxy-1,6-dimethyl-1-{[(1S)-2-methyl-1-(propan-2-ylcarbamoyl)propyl]carbamoyl}heptan-4-yl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide
Show/Hide
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C35H56N6O8S
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1
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| 1 |
IC50 = 10300 nM
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CP0070639
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(3S,14R,16S)-16-((R)-1-hydroxy-2-((S)-6-isopropyl-2,2-dimethylchroman-4-ylamino)ethyl)-3,4,14-trimethyl-1,4-diazacyclohexadecane-2,5-dione
Show/Hide
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C33H55N3O4
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1
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| 1 |
IC50 = 24000 nM
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CP0449122
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2'-amino-6-(5-chloropyridin-3-yl)-2,2,3'-trimethylspiro[1,3-dihydronaphthalene-4,6'-5H-pyrimidine]-4'-one
Show/Hide
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C21H23ClN4O
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1
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| 1 |
IC50 = 32863 nM
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CP0186635
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2'-amino-6-bromo-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
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C14H16BrN3O2
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1
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| 1 |
IC50 = 36830 nM
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