Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2'-amino-6-(5-chloropyridin-3-yl)-2,2,3'-trimethylspiro[3H-thiochromene-4,5'-imidazole]-4'-one
    Show/Hide
 PubChem ID
CID: 71624686
Canonical SMILES
CN1C(N)=NC2(CC(C)(C)Sc3ccc(cc23)-c2cncc(Cl)c2)C1=O
    Show/Hide
Compound Formula C19H19ClN4OS
Compound Structure
Protein Name
 Protein Info 
Beta-secretase 1
Protein Classification
Enzyme
>
Protease
>
Aspartic protease
>
Aspartic protease AA clan
>
Aspartic protease A1A subfamily
Uniprot ID
P56817
Gene Name
BACE1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 25 nM
   TI
   LI
   LO
   TS