Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(1R,4aR,10R,10aR)-2'-amino-8-(2-fluoropyridin-3-yl)-1,3'-dimethylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,5'-imidazole]-4'-one
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 PubChem ID
CID: 76318242
Canonical SMILES
C[C@H]1OCC[C@H]2Oc3ccc(cc3[C@]3(N=C(N)N(C)C3=O)[C@H]12)-c1cccnc1F
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Compound Formula C21H21FN4O3
Compound Structure
Protein Name
 Protein Info 
Beta-secretase 1
Protein Classification
Enzyme
>
Protease
>
Aspartic protease
>
Aspartic protease AA clan
>
Aspartic protease A1A subfamily
Uniprot ID
P56817
Gene Name
BACE1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS