Brief Information of the Compound and Protein
Compound Name
 Compound Info 
rac-3-(2-Amino-1,3',3'-trimethyl-5-oxo-1,3',4',5-tetrahydro-2'Hspiro[imidazole-4,1'-naphthalene]-7'-yl)benzonitrile
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 PubChem ID
CID: 53493350
SID: 126721001
Canonical SMILES
CN1C(=O)C2(CC(C)(C)Cc3ccc(-c4cccc(C#N)c4)cc32)N=C1N
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Compound Formula C22H22N4O
Compound Structure
Protein Name
 Protein Info 
Beta-secretase 1
Protein Classification
Enzyme
>
Protease
>
Aspartic protease
>
Aspartic protease AA clan
>
Aspartic protease A1A subfamily
Uniprot ID
P56817
Gene Name
BACE1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 23 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 17 nM
   TI
   LI
   LO
   TS