Protein Information

General Information of the Protein

Protein ID	PT01491
Protein Name	Metabotropic glutamate receptor 2
Gene Name	GRM2
Secondarily Gene Name	Gprc1b Mglur2
Sequence	MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL Show/Hide
Organism	Rattus norvegicus, Rat
Protein Classification	Membrane receptor > Family C G protein-coupled receptor > Small molecule receptor (family C GPCR) > Neurotransmitter receptor (family C GPCR) > Metabotropic glutamate receptor
Function	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Show/Hide
Uniprot ID	P31421
Ensembl ID	ENSG00000164082
Subcellular Location	Cell membrane Synapse Cell projection Dendrite

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0076675 Compound Info	(1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C8H11NO4	2
1	EC50 = 18.3 nM Bioactivity Info	TI LI LO TS
2	Ki = 23.4 nM Bioactivity Info	TI LI LO TS
CP0428983 Compound Info	(+/-)-2-Amino-6-fluoro-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C8H10FNO5	2
1	EC50 = 21 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0399772 Compound Info	2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cyclopropanecarboxylic acid Show/Hide	C20H19NO5	2
1	EC50 = 50.3 nM Bioactivity Info	TI LI LO TS
2	Ki = 3.72 nM Bioactivity Info	TI LI LO TS
CP0373675 Compound Info	(1S,2R,3R,5R,6S)-2-amino-3-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C8H10FNO4	2
1	EC50 = 4490 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0492666 Compound Info	(1S,2S,3R,5R,6S)-2-amino-3-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C8H10FNO4	2
1	EC50 = 17100 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0384897 Compound Info	(+/-)-2-Amino-3,3-difluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C8H9F2NO4	2
1	EC50 = 36200 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0406282 Compound Info	(+/-)-2-Amino-6-methyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C9H13NO4	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0140442 Compound Info	(+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C8H10FNO4	2
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
2	Ki = 47.7 nM Bioactivity Info	TI LI LO TS
CP0374563 Compound Info	(+)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C8H8FNO5	2
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
2	Ki = 3.3 nM Bioactivity Info	TI LI LO TS
CP0409272 Compound Info	(+)-2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C8H10FNO4	2
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
2	Ki = 22.5 nM Bioactivity Info	TI LI LO TS
CP0211752 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H14Cl2FNO5	3
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 20 nM Bioactivity Info	TI LI LO TS
3	Ki = 2.38 nM Bioactivity Info	TI LI LO TS
CP0377729 Compound Info	(1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl)cyclopropanecarboxylic acid Show/Hide	C20H19NO5	3
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 23.2 nM Bioactivity Info	TI LI LO TS
3	Ki = 3.13 nM Bioactivity Info	TI LI LO TS
CP0391913 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-benzhydryloxy-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C21H20FNO5	3
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 24.4 nM Bioactivity Info	TI LI LO TS
3	Ki = 2.58 nM Bioactivity Info	TI LI LO TS
CP0392388 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(3,4-difluoro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H14F3NO5	3
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 40.8 nM Bioactivity Info	TI LI LO TS
3	Ki = 2.27 nM Bioactivity Info	TI LI LO TS
CP0406578 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(4-chloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H15ClFNO5	3
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 29.1 nM Bioactivity Info	TI LI LO TS
3	Ki = 3.17 nM Bioactivity Info	TI LI LO TS
CP0497432 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C8H10FNO5	3
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 476 nM Bioactivity Info	TI LI LO TS
3	Ki = 32.9 nM Bioactivity Info	TI LI LO TS
CP0231490 Compound Info	7,8-dichloro-4-(3-(2-methylpyridin-4-yl)phenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C21H15Cl2N3O	1
1	IC50 = 2 nM Bioactivity Info	TI LI LO TS
CP0101907 Compound Info	7-methyl-4-(3-(pyridin-3-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C22H16F3N3O	1
1	IC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0202837 Compound Info	4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C24H20F3N3O	2
1	IC50 = 3 nM Bioactivity Info	TI LI LO TS
2	IC50 < 10 nM Bioactivity Info	TI LI LO TS
CP0237661 Compound Info	8-chloro-4-(3-(pyridin-4-yl)phenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C20H14ClN3O	1
1	IC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0053384 Compound Info	7-methyl-4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C23H18F3N3O	2
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
2	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0297209 Compound Info	4-(3-(2-ethyl-6-methylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C25H22F3N3O	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0336097 Compound Info	4-(3-(2-cyclopropyl-6-methylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C26H22F3N3O	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0218960 Compound Info	4-(3-(2-benzylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C29H22F3N3O	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0295951 Compound Info	4-(3-(2-ethylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C24H20F3N3O	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0336098 Compound Info	4-(3-(2-(methoxymethyl)-6-methylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C25H22F3N3O2	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0337808 Compound Info	7-methyl-4-(3-(6-methylpyridin-3-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C23H18F3N3O	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0530818 Compound Info	8-[2-(4-fluorophenyl)ethynyl]-4-[3-(triazol-1-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C25H16FN5O	1
1	IC50 = 6 nM Bioactivity Info	TI LI LO TS
CP0053390 Compound Info	4-(3-(2-cyclopropylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C25H20F3N3O	1
1	IC50 = 6 nM Bioactivity Info	TI LI LO TS
CP0295952 Compound Info	4-(3-(2-(methoxymethyl)pyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C24H20F3N3O2	1
1	IC50 = 6 nM Bioactivity Info	TI LI LO TS
CP0101910 Compound Info	4-(3-(2-cyclopentylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C27H24F3N3O	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0237659 Compound Info	4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7,8-bis(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C24H17F6N3O	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0232347 Compound Info	7-ethoxy-4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C24H20F3N3O2	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0338876 Compound Info	7-ethoxy-4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C23H18F3N3O2	2
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
2	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0371812 Compound Info	8-[2-(4-fluorophenyl)ethynyl]-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C26H17FN4O	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0036327 Compound Info	7-methyl-4-(3-(3-methylisoxazol-5-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C21H16F3N3O2	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0052924 Compound Info	4-(3-(6-methoxypyridin-3-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C23H18F3N3O2	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0053392 Compound Info	4-(3-(6-isopropylpyridin-3-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C25H22F3N3O	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0101909 Compound Info	4-(3-(2-isopropylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C25H22F3N3O	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0059417 Compound Info	8-(2-fluorophenyl)-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C24H17FN4O	1
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0101908 Compound Info	7-methyl-4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C22H16F3N3O	1
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0101912 Compound Info	4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)ethynyl)-7-hydroxy-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C26H17FN4O2	3
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
2	IC50 = 24 nM Bioactivity Info	TI LI LO TS
3	IC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0162027 Compound Info	4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C23H16FN5O	4
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
2	IC50 = 16 nM Bioactivity Info	TI LI LO TS
3	IC50 = 22 nM Bioactivity Info	TI LI LO TS
4	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0472153 Compound Info	4-(3-imidazol-1-ylphenyl)-8-(2-phenylethynyl)-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C26H18N4O	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0335052 Compound Info	4-(3-(2-(2-hydroxypropan-2-yl)pyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C25H22F3N3O2	1
1	IC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0295953 Compound Info	4-(3-(2-(hydroxymethyl)-6-methylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C24H20F3N3O2	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0038458 Compound Info	4-(3-(2-methoxypyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C23H18F3N3O2	1
1	IC50 = 16 nM Bioactivity Info	TI LI LO TS
CP0283397 Compound Info	7-methyl-4-(3-(pyrazin-2-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C21H15F3N4O	1
1	IC50 = 16 nM Bioactivity Info	TI LI LO TS
CP0079531 Compound Info	(E)-3-(4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C24H15N3O	2
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
2	IC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0510824 Compound Info	(E)-3-(8-(cyanomethoxy)-4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C26H16N4O2	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0371810 Compound Info	2-[[4-(3-imidazol-1-ylphenyl)-2-oxo-8-(2-phenylethynyl)-1,3-dihydro-1,5-benzodiazepin-7-yl]oxy]acetonitrile Show/Hide	C28H19N5O2	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0161929 Compound Info	4-(3-(6-ethylpyridin-3-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C24H20F3N3O	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0297211 Compound Info	4-(3-(2-(hydroxymethyl)pyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C23H18F3N3O2	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0368814 Compound Info	4-(3-(7-methyl-2-oxo-8-(trifluoromethyl)-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl)phenyl)picolinonitrile Show/Hide	C23H15F3N4O	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0059416 Compound Info	4-(3-(1H-imidazol-1-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C20H15F3N4O	1
1	IC50 = 19 nM Bioactivity Info	TI LI LO TS
CP0311023 Compound Info	8-[2-(4-fluorophenyl)ethynyl]-7-hydroxy-4-[3-(triazol-1-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C25H16FN5O2	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0472152 Compound Info	8-[2-(2-fluorophenyl)ethynyl]-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C26H17FN4O	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0039555 Compound Info	4-(3-(6-cyclopropylpyridin-3-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C25H20F3N3O	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0499045 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(naphthalen-2-ylmethoxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C19H18FNO5	2
1	IC50 = 22.7 nM Bioactivity Info	TI LI LO TS
2	Ki = 2.53 nM Bioactivity Info	TI LI LO TS
CP0438863 Compound Info	4-(3-imidazol-1-ylphenyl)-7-(2-methoxyethoxy)-8-(2-phenylethynyl)-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C29H24N4O3	1
1	IC50 = 23 nM Bioactivity Info	TI LI LO TS
CP0373237 Compound Info	(E)-N-tert-butyl-2-(4-(3-cyanophenyl)-2-oxo-8-(2-phenylethynyl)-2,3-dihydro-1H-benzo[b][1,4]diazepin-7-yloxy)acetamide Show/Hide	C30H26N4O3	1
1	IC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0373238 Compound Info	(E)-4-phenyl-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C23H16N2O	1
1	IC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0237670 Compound Info	4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C21H14F3N3O	2
1	IC50 = 26 nM Bioactivity Info	TI LI LO TS
2	IC50 = 101 nM Bioactivity Info	TI LI LO TS
CP0510825 Compound Info	(E)-3-(8-(2-methoxyethoxy)-4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C27H21N3O3	1
1	IC50 = 28 nM Bioactivity Info	TI LI LO TS
CP0511442 Compound Info	(E)-3-(7-(2-(2-fluorophenyl)ethynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C24H14FN3O	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0295955 Compound Info	4-(3-(2,2'-bipyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C22H16F3N3O	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0467707 Compound Info	(E)-3-(4-oxo-7-(2-(thiophen-2-yl)ethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C22H13N3OS	1
1	IC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0510826 Compound Info	(E)-3-(7-(2-(4-fluorophenyl)ethynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C24H14FN3O	1
1	IC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0205609 Compound Info	8-(2-fluorophenyl)-7-hydroxy-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C24H17FN4O2	1
1	IC50 = 35 nM Bioactivity Info	TI LI LO TS
CP0511612 Compound Info	7-(dimethylamino)-8-(2-phenylethynyl)-4-[3-(triazol-1-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C27H22N6O	1
1	IC50 = 36 nM Bioactivity Info	TI LI LO TS
CP0295954 Compound Info	4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C22H16F3N3O	1
1	IC50 = 36 nM Bioactivity Info	TI LI LO TS
CP0349551 Compound Info	4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C19H14F3N5O	1
1	IC50 = 39 nM Bioactivity Info	TI LI LO TS
CP0392972 Compound Info	(E)-3-(4-oxo-7-(2-phenylethynyl)-8-thiomorpholino-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C28H22N4OS	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0472150 Compound Info	8-[2-(4-fluorophenyl)ethynyl]-7-(2-hydroxyethoxy)-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C28H21FN4O3	1
1	IC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0336099 Compound Info	7-methyl-4-(3-(6-(pyrimidin-5-yl)pyridin-3-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C21H15F3N4O	1
1	IC50 = 48 nM Bioactivity Info	TI LI LO TS
CP0332809 Compound Info	7-methyl-4-(3-(pyrimidin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C21H15F3N4O	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0521578 Compound Info	(E)-3-(8-(dimethylamino)-4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C26H20N4O	1
1	IC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0541780 Compound Info	(E)-3-(4-oxo-7-(2-p-tolylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C25H17N3O	1
1	IC50 = 64 nM Bioactivity Info	TI LI LO TS
CP0536199 Compound Info	7-(2-hydroxyethoxy)-4-(3-imidazol-1-ylphenyl)-8-(2-phenylethynyl)-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C28H22N4O3	1
1	IC50 = 64 nM Bioactivity Info	TI LI LO TS
CP0510827 Compound Info	(E)-3-(7-(2-(4-methoxyphenyl)ethynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C25H17N3O2	1
1	IC50 = 68 nM Bioactivity Info	TI LI LO TS
CP0516505 Compound Info	8-[2-(4-fluorophenyl)ethynyl]-4-[3-(tetrazol-1-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C24H15FN6O	1
1	IC50 = 72 nM Bioactivity Info	TI LI LO TS
CP0237672 Compound Info	7-methyl-4-(3-(pyridazin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C21H15F3N4O	1
1	IC50 = 72 nM Bioactivity Info	TI LI LO TS
CP0161928 Compound Info	4-(3-(1H-1,2,4-triazol-1-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C19H14F3N5O	1
1	IC50 = 75 nM Bioactivity Info	TI LI LO TS
CP0521579 Compound Info	(E)-3-(7-(2-(2-chlorophenyl)ethynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C24H14ClN3O	1
1	IC50 = 76 nM Bioactivity Info	TI LI LO TS
CP0522335 Compound Info	(E)-4-(3-chlorophenyl)-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C23H15ClN2O	1
1	IC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0501786 Compound Info	(E)-3-(8-(4-methoxypiperidin-1-yl)-4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C30H26N4O2	1
1	IC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0501785 Compound Info	(E)-3-(8-methoxy-4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C25H17N3O2	1
1	IC50 = 92 nM Bioactivity Info	TI LI LO TS
CP0371811 Compound Info	8-[2-(4-fluorophenyl)ethynyl]-4-[3-(1,2,4-triazol-1-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C25H16FN5O	1
1	IC50 = 98 nM Bioactivity Info	TI LI LO TS
CP0472151 Compound Info	8-[2-(4-fluorophenyl)ethynyl]-4-[3-(4-methylimidazol-1-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C27H19FN4O	1
1	IC50 = 98 nM Bioactivity Info	TI LI LO TS
CP0293651 Compound Info	1-[(Z)-2-Cycloheptyloxy-2-(2,6-dichloro-phenyl)-vinyl]-1H-[1,2,4]triazole Show/Hide	C17H19Cl2N3O	2
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
2	IC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0491988 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-benzyloxy-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H16FNO5	2
1	IC50 = 131 nM Bioactivity Info	TI LI LO TS
2	Ki = 7.14 nM Bioactivity Info	TI LI LO TS
CP0438862 Compound Info	8-[2-(4-fluorophenyl)ethynyl]-7-[2-hydroxyethyl(methyl)amino]-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C29H24FN5O2	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0505614 Compound Info	(E)-4-(3-iodophenyl)-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C23H15IN2O	1
1	IC50 = 154 nM Bioactivity Info	TI LI LO TS
CP0501787 Compound Info	3-[8-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-4-oxo-7-phenylethynyl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl]-benzonitrile Show/Hide	C28H22N4O3S	1
1	IC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0237671 Compound Info	4-(3-(6-aminopyridin-3-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C22H17F3N4O	1
1	IC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0394010 Compound Info	4-[3-(2,4-dimethylimidazol-1-yl)phenyl]-8-(2-phenylethynyl)-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C28H22N4O	1
1	IC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0243343 Compound Info	4-(3-(1-methyl-1H-pyrazol-5-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C20H15F3N4O	1
1	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0491986 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-methoxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C9H12FNO5	2
1	IC50 = 229 nM Bioactivity Info	TI LI LO TS
2	Ki = 39.2 nM Bioactivity Info	TI LI LO TS
CP0438892 Compound Info	8-(2-phenylethynyl)-4-(3-(trifluoromethyl)phenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C24H15F3N2O	1
1	IC50 = 268 nM Bioactivity Info	TI LI LO TS
CP0467706 Compound Info	(E)-3-(8-(4-methylpiperazin-1-yl)-4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C29H25N5O	1
1	IC50 = 278 nM Bioactivity Info	TI LI LO TS
CP0484073 Compound Info	8-(4-fluorophenyl)-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C24H17FN4O	1
1	IC50 = 299 nM Bioactivity Info	TI LI LO TS
CP0438890 Compound Info	(E)-3-(4-oxo-7-(2-(thiazol-2-yl)ethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C21H12N4OS	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0405277 Compound Info	(E)-3-(4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzamide Show/Hide	C24H17N3O2	1
1	IC50 = 358 nM Bioactivity Info	TI LI LO TS
CP0500554 Compound Info	(E)-4-(3-(morpholine-4-carbonyl)phenyl)-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C28H23N3O3	1
1	IC50 = 360 nM Bioactivity Info	TI LI LO TS
CP0522333 Compound Info	(E)-3-(8-morpholino-4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C28H22N4O2	1
1	IC50 = 378 nM Bioactivity Info	TI LI LO TS
CP0530817 Compound Info	8-[2-(4-fluorophenyl)ethynyl]-7-hydroxy-4-[3-[5-(hydroxymethyl)triazol-1-yl]phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C26H18FN5O3	1
1	IC50 = 378 nM Bioactivity Info	TI LI LO TS
CP0511441 Compound Info	(E)-3-(7-(3-methylbut-3-en-1-ynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C21H15N3O	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0438888 Compound Info	3-[4-oxo-8-(1-oxo-1lambda4-thiomorpholin-4-yl)-7-phenylethynyl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl]-benzonitrile Show/Hide	C28H22N4O2S	1
1	IC50 = 446 nM Bioactivity Info	TI LI LO TS
CP0432271 Compound Info	1-[(Z)-2-Cycloheptyloxy-2-(2,4-dichloro-phenyl)-vinyl]-1H-[1,2,4]triazole Show/Hide	C17H19Cl2N3O	1
1	IC50 = 470 nM Bioactivity Info	TI LI LO TS
CP0392973 Compound Info	(E)-3-(7-(2-(2,4-difluorophenyl)ethynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C24H13F2N3O	1
1	IC50 = 480 nM Bioactivity Info	TI LI LO TS
CP0395350 Compound Info	1-[(Z)-2-Cyclohexyloxy-2-(2,6-dichloro-phenyl)-vinyl]-1H-[1,2,4]triazole Show/Hide	C16H17Cl2N3O	1
1	IC50 = 580 nM Bioactivity Info	TI LI LO TS
CP0496578 Compound Info	(E)-2-(4-(3-cyanophenyl)-2-oxo-8-(2-phenylethynyl)-2,3-dihydro-1H-benzo[b][1,4]diazepin-7-yloxy)acetic acid Show/Hide	C26H17N3O4	1
1	IC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0394009 Compound Info	4-[3-(1-methylimidazol-2-yl)phenyl]-8-(2-phenylethynyl)-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C27H20N4O	1
1	IC50 = 730 nM Bioactivity Info	TI LI LO TS
CP0505613 Compound Info	(E)-3-(4-oxo-7-(2-(pyridin-2-yl)ethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C23H14N4O	1
1	IC50 = 870 nM Bioactivity Info	TI LI LO TS
CP0522336 Compound Info	(E)-4-(3-methoxyphenyl)-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C24H18N2O2	1
1	IC50 = 962 nM Bioactivity Info	TI LI LO TS
CP0525023 Compound Info	(E)-4-(3-(1-methylpiperazine-4-carbonyl)phenyl)-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C29H26N4O2	1
1	IC50 = 1040 nM Bioactivity Info	TI LI LO TS
CP0524539 Compound Info	1-[(Z)-2-Cyclohexyloxy-2-(2,4-dichloro-phenyl)-vinyl]-1H-[1,2,4]triazole Show/Hide	C16H17Cl2N3O	1
1	IC50 = 1050 nM Bioactivity Info	TI LI LO TS
CP0428732 Compound Info	1-[(Z)-2-Cyclooctyloxy-2-(2,4-dichloro-phenyl)-vinyl]-1H-[1,2,4]triazole Show/Hide	C18H21Cl2N3O	1
1	IC50 = 1210 nM Bioactivity Info	TI LI LO TS
CP0414866 Compound Info	1-[(Z)-2-Cycloheptyloxy-2-(4-trifluoromethyl-phenyl)-vinyl]-1H-[1,2,4]triazole Show/Hide	C18H20F3N3O	1
1	IC50 = 1380 nM Bioactivity Info	TI LI LO TS
CP0510828 Compound Info	(E)-8-methyl-4-(3-(trifluoromethyl)phenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C17H13F3N2O	1
1	IC50 = 1530 nM Bioactivity Info	TI LI LO TS
CP0448963 Compound Info	1-[(Z)-2-Benzyloxy-2-(2,6-dichloro-phenyl)-vinyl]-1H-[1,2,4]triazole Show/Hide	C17H13Cl2N3O	1
1	IC50 = 2000 nM Bioactivity Info	TI LI LO TS
CP0501784 Compound Info	(E)-2-(4-(3-cyanophenyl)-2-oxo-8-(2-phenylethynyl)-2,3-dihydro-1H-benzo[b][1,4]diazepin-7-yloxy)acetamide Show/Hide	C26H18N4O3	1
1	IC50 = 2400 nM Bioactivity Info	TI LI LO TS
CP0509448 Compound Info	1-[(Z)-2-Cyclopentyloxy-2-(2,4-dichloro-phenyl)-vinyl]-1H-[1,2,4]triazole Show/Hide	C15H15Cl2N3O	1
1	IC50 = 2550 nM Bioactivity Info	TI LI LO TS
CP0504842 Compound Info	1-[(Z)-2-Benzyloxy-2-(2,4-dichloro-phenyl)-vinyl]-1H-tetrazole Show/Hide	C16H12Cl2N4O	1
1	IC50 = 2680 nM Bioactivity Info	TI LI LO TS
CP0438891 Compound Info	(E)-4-(3-chlorophenyl)-8-methyl-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C16H13ClN2O	1
1	IC50 = 2820 nM Bioactivity Info	TI LI LO TS
CP0501808 Compound Info	(E)-3-(7-methyl-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C17H13N3O	1
1	IC50 = 2900 nM Bioactivity Info	TI LI LO TS
CP0375990 Compound Info	2-[(Z)-2-Butoxy-2-(4-chloro-phenyl)-vinyl]-2H-tetrazole Show/Hide	C13H15ClN4O	1
1	IC50 = 3160 nM Bioactivity Info	TI LI LO TS
CP0496893 Compound Info	1-[(Z)-2-(2,4-Dichloro-phenyl)-2-isopropoxy-vinyl]-1H-[1,2,4]triazole Show/Hide	C13H13Cl2N3O	2
1	IC50 = 6000 nM Bioactivity Info	TI LI LO TS
2	IC50 = 11500 nM Bioactivity Info	TI LI LO TS
CP0295902 Compound Info	8-methyl-4-phenyl-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C16H14N2O	1
1	IC50 = 6400 nM Bioactivity Info	TI LI LO TS
CP0500553 Compound Info	(E)-4-(3-methoxyphenyl)-8-methyl-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C17H16N2O2	1
1	IC50 = 6580 nM Bioactivity Info	TI LI LO TS
CP0522334 Compound Info	(E)-3-(7-(3-hydroxy-3-methylbut-1-ynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C21H17N3O2	1
1	IC50 = 26000 nM Bioactivity Info	TI LI LO TS
CP0406519 Compound Info	1-[2-(2,6-dichloro-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-6-yl]-ethanone Show/Hide	C25H25Cl2N3O3S	2
1	IC50 = 30000 nM Bioactivity Info	TI LI LO TS
2	Ki = 7000 nM Bioactivity Info	TI LI LO TS
CP0501079 Compound Info	1-[(Z)-2-(2,4-Difluoro-phenyl)-2-isopropoxy-vinyl]-1H-[1,2,4]triazole Show/Hide	C13H13F2N3O	1
1	IC50 = 75000 nM Bioactivity Info	TI LI LO TS
CP0504186 Compound Info	1-[(Z)-2-(2,4-Dimethoxy-phenyl)-2-isopropoxy-vinyl]-1H-[1,2,4]triazole Show/Hide	C15H19N3O3	1
1	IC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0469288 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(3-carboxy-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C16H16FNO7	1
1	Ki = 1.06 nM Bioactivity Info	TI LI LO TS
CP0429935 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-[(R)-1-(3,4-dichloro-phenyl)-ethoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C16H16Cl2FNO5	1
1	Ki = 1.45 nM Bioactivity Info	TI LI LO TS
CP0392054 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-[(R)-1-(3,4-dichloro-phenyl)-butoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C18H20Cl2FNO5	1
1	Ki = 1.48 nM Bioactivity Info	TI LI LO TS
CP0502825 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-[(R)-1-(3,4-dichloro-phenyl)-propoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C17H18Cl2FNO5	1
1	Ki = 1.61 nM Bioactivity Info	TI LI LO TS
CP0436519 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-((S)-1-naphthalen-2-yl-ethoxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C20H20FNO5	1
1	Ki = 1.79 nM Bioactivity Info	TI LI LO TS
CP0500540 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-((R)-1-naphthalen-2-yl-ethoxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C20H20FNO5	1
1	Ki = 2.01 nM Bioactivity Info	TI LI LO TS
CP0405838 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-[bis-(3,4-dichloro-phenyl)-methoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C21H16Cl4FNO5	1
1	Ki = 2.61 nM Bioactivity Info	TI LI LO TS
CP0406579 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(3-cyano-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C16H15FN2O5	1
1	Ki = 2.94 nM Bioactivity Info	TI LI LO TS
CP0497422 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-[(S)-1-(3,4-dichloro-phenyl)-butoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C18H20Cl2FNO5	1
1	Ki = 3.05 nM Bioactivity Info	TI LI LO TS
CP0492972 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-[(S)-1-(3,4-dichloro-phenyl)-propoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C17H18Cl2FNO5	1
1	Ki = 3.12 nM Bioactivity Info	TI LI LO TS
CP0491991 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(3-chloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H15ClFNO5	1
1	Ki = 3.28 nM Bioactivity Info	TI LI LO TS
CP0506238 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(3-chloro-4-fluoro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H14ClF2NO5	1
1	Ki = 3.57 nM Bioactivity Info	TI LI LO TS
CP0496872 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3,4,5-trichloro-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H13Cl3FNO5	1
1	Ki = 3.67 nM Bioactivity Info	TI LI LO TS
CP0497433 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-[bis-(4-chloro-phenyl)-methoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C21H18Cl2FNO5	1
1	Ki = 3.75 nM Bioactivity Info	TI LI LO TS
CP0440314 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-pentafluorophenylmethoxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H11F6NO5	1
1	Ki = 3.77 nM Bioactivity Info	TI LI LO TS
CP0497434 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-[bis-(4-fluoro-phenyl)-methoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C21H18F3NO5	1
1	Ki = 3.79 nM Bioactivity Info	TI LI LO TS
CP0500805 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(2,4-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H14Cl2FNO5	1
1	Ki = 3.89 nM Bioactivity Info	TI LI LO TS
CP0550894 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(4-chloro-3-fluoro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H14ClF2NO5	1
1	Ki = 4.02 nM Bioactivity Info	TI LI LO TS
CP0491993 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(biphenyl-2-ylmethoxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C21H20FNO5	1
1	Ki = 4.07 nM Bioactivity Info	TI LI LO TS
CP0374731 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(2,3-difluoro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H14F3NO5	1
1	Ki = 4.25 nM Bioactivity Info	TI LI LO TS
CP0485762 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(2,6-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H14Cl2FNO5	1
1	Ki = 4.3 nM Bioactivity Info	TI LI LO TS
CP0497294 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(2,3-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H14Cl2FNO5	1
1	Ki = 4.35 nM Bioactivity Info	TI LI LO TS
CP0541498 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3-methyl-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C16H18FNO5	1
1	Ki = 4.53 nM Bioactivity Info	TI LI LO TS
CP0445907 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(2,4-difluoro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H14F3NO5	1
1	Ki = 4.71 nM Bioactivity Info	TI LI LO TS
CP0485010 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(3-bromo-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H15BrFNO5	1
1	Ki = 4.71 nM Bioactivity Info	TI LI LO TS
CP0541488 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(2-chloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H15ClFNO5	1
1	Ki = 4.99 nM Bioactivity Info	TI LI LO TS
CP0394652 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-propoxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C11H16FNO5	1
1	Ki = 5.17 nM Bioactivity Info	TI LI LO TS
CP0379235 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(naphthalen-1-ylmethoxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C19H18FNO5	1
1	Ki = 5.36 nM Bioactivity Info	TI LI LO TS
CP0491990 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(4-fluoro-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H15F2NO5	1
1	Ki = 5.55 nM Bioactivity Info	TI LI LO TS
CP0521126 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(3,5-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H14Cl2FNO5	1
1	Ki = 5.61 nM Bioactivity Info	TI LI LO TS
CP0511387 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3-trifluoromethyl-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C16H15F4NO5	1
1	Ki = 5.72 nM Bioactivity Info	TI LI LO TS
CP0491946 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-[(S)-1-(3,4-dichloro-phenyl)-ethoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C16H16Cl2FNO5	1
1	Ki = 5.81 nM Bioactivity Info	TI LI LO TS
CP0469289 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3-methoxy-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C16H18FNO6	1
1	Ki = 5.92 nM Bioactivity Info	TI LI LO TS
CP0435564 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-sec-butoxy-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C12H18FNO5	1
1	Ki = 6.68 nM Bioactivity Info	TI LI LO TS
CP0403586 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(2,6-difluoro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H14F3NO5	1
1	Ki = 7.02 nM Bioactivity Info	TI LI LO TS
CP0491987 Compound Info	(1R,2R,3R,5R,6R)-3-Allyloxy-2-amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C11H14FNO5	1
1	Ki = 7.07 nM Bioactivity Info	TI LI LO TS
CP0374514 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3-phenoxy-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C21H20FNO6	1
1	Ki = 7.15 nM Bioactivity Info	TI LI LO TS
CP0494599 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3-nitro-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H15FN2O7	1
1	Ki = 7.87 nM Bioactivity Info	TI LI LO TS
CP0543248 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-cyclopentyloxy-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C13H18FNO5	1
1	Ki = 8.57 nM Bioactivity Info	TI LI LO TS
CP0502898 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(thiophen-2-ylmethoxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C13H14FNO5S	1
1	Ki = 8.79 nM Bioactivity Info	TI LI LO TS
CP0440234 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(biphenyl-3-ylmethoxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C21H20FNO5	1
1	Ki = 9.34 nM Bioactivity Info	TI LI LO TS
CP0497452 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3-phenyl-propoxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C17H20FNO5	1
1	Ki = 9.83 nM Bioactivity Info	TI LI LO TS
CP0437051 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(2,5-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H14Cl2FNO5	1
1	Ki = 11.8 nM Bioactivity Info	TI LI LO TS
CP0509748 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(3,5-difluoro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H14F3NO5	1
1	Ki = 12.4 nM Bioactivity Info	TI LI LO TS
CP0445908 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(2,5-difluoro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H14F3NO5	1
1	Ki = 14.4 nM Bioactivity Info	TI LI LO TS
CP0499951 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(3-amino-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H17FN2O5	1
1	Ki = 15.4 nM Bioactivity Info	TI LI LO TS
CP0432785 Compound Info	(1R,2R,3S,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H14Cl2FNO5	1
1	Ki = 17.1 nM Bioactivity Info	TI LI LO TS
CP0497251 Compound Info	(1R,2R,3S,5R,6R)-2-Amino-3-[bis-(4-chloro-phenyl)-methoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C21H18Cl2FNO5	1
1	Ki = 20.2 nM Bioactivity Info	TI LI LO TS
CP0485011 Compound Info	(1R,2R,3R,5R,6R)-2-Amino-3-(biphenyl-4-ylmethoxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C21H20FNO5	1
1	Ki = 25.6 nM Bioactivity Info	TI LI LO TS
CP0433546 Compound Info	(1R,2S,4R,5R)-2-Amino-6-(R)-fluoro-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C8H10FNO5	1
1	Ki = 105 nM Bioactivity Info	TI LI LO TS
CP0497250 Compound Info	(1R,2R,3S,5R,6R)-2-Amino-6-fluoro-3-methoxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C9H12FNO5	1
1	Ki = 190 nM Bioactivity Info	TI LI LO TS
CP0448141 Compound Info	2-(2,4-Dichloro-phenyl)-5-(2-methoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester Show/Hide	C25H25Cl2N3O3S	1
1	Ki = 1000 nM Bioactivity Info	TI LI LO TS
CP0535343 Compound Info	2-(2,6-Dichloro-phenyl)-7-ethyl-5-(2-methoxy-phenyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester Show/Hide	C26H27Cl2N3O3S	1
1	Ki = 1000 nM Bioactivity Info	TI LI LO TS
CP0516104 Compound Info	2-(2,6-Dichloro-phenyl)-5-(2-methoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester Show/Hide	C25H25Cl2N3O3S	1
1	Ki = 1500 nM Bioactivity Info	TI LI LO TS
CP0462808 Compound Info	2-(2,6-Dichloro-phenyl)-5-(3-methoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester Show/Hide	C25H25Cl2N3O3S	1
1	Ki = 2000 nM Bioactivity Info	TI LI LO TS
CP0466563 Compound Info	2-(2,6-Dichloro-phenyl)-5-(2-isopropoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester Show/Hide	C27H29Cl2N3O3S	1
1	Ki = 2000 nM Bioactivity Info	TI LI LO TS
CP0535617 Compound Info	5-(2-Chloro-phenyl)-2-(2,6-dichloro-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester Show/Hide	C24H22Cl3N3O2S	1
1	Ki = 2000 nM Bioactivity Info	TI LI LO TS
CP0380437 Compound Info	2-(2,6-Dichloro-phenyl)-5-(2-methoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 3-dimethylamino-propyl ester Show/Hide	C26H27Cl2N3O3S	1
1	Ki = 2400 nM Bioactivity Info	TI LI LO TS
CP0526091 Compound Info	2-(2,6-Dichloro-phenyl)-5-(2-ethoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester Show/Hide	C26H27Cl2N3O3S	1
1	Ki = 3000 nM Bioactivity Info	TI LI LO TS
CP0559676 Compound Info	2-(2,6-Dichloro-phenyl)-5-(2-fluoro-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester Show/Hide	C24H22Cl2FN3O2S	1
1	Ki = 3200 nM Bioactivity Info	TI LI LO TS
CP0451223 Compound Info	2-(2,6-Dichloro-phenyl)-7-isopropyl-5-(2-methoxy-phenyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester Show/Hide	C27H29Cl2N3O3S	1
1	Ki = 4000 nM Bioactivity Info	TI LI LO TS
CP0460067 Compound Info	2-(4-Chloro-phenyl)-5-(2-methoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester Show/Hide	C25H26ClN3O3S	1
1	Ki = 4000 nM Bioactivity Info	TI LI LO TS
CP0498119 Compound Info	2-(2,6-Dichloro-phenyl)-5-(2-methoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester Show/Hide	C23H20Cl2N2O3S	1
1	Ki = 4000 nM Bioactivity Info	TI LI LO TS
CP0408490 Compound Info	2-(2,6-Dichloro-phenyl)-7-methyl-5-o-tolyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester Show/Hide	C25H25Cl2N3O2S	1
1	Ki = 8000 nM Bioactivity Info	TI LI LO TS
CP0480629 Compound Info	7-Benzoyl-2-(2,6-dichloro-phenyl)-5-(2-methoxy-phenyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester Show/Hide	C31H27Cl2N3O4S	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0515290 Compound Info	2-(2,6-Dichloro-phenyl)-5-(2-methoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid (2-dimethylamino-ethyl)-amide Show/Hide	C25H26Cl2N4O2S	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0485761 Compound Info	(1S,2S,3S,5S,6S)-2-Amino-3-(3,4-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid Show/Hide	C15H14Cl2FNO5	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000460 , Flp-In-T-REx-293

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000050 , HEK293-A

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0091883 Compound Info	(1R,2R)-3-((S)-Amino-carboxy-methyl)-cyclopropane-1,2-dicarboxylic acid Show/Hide	C7H9NO6	1
1	EC50 = 350 nM
CP0002355 Compound Info	(2S)-2-aminopentanedioic acid Show/Hide	C5H9NO4	2
1	EC50 = 4000 nM
2	EC50 = 16090 nM
CP0101907 Compound Info	7-methyl-4-(3-(pyridin-3-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C22H16F3N3O	1
1	IC50 = 2 nM
CP0202837 Compound Info	4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C24H20F3N3O	1
1	IC50 = 2 nM
CP0297209 Compound Info	4-(3-(2-ethyl-6-methylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C25H22F3N3O	1
1	IC50 = 2 nM
CP0336097 Compound Info	4-(3-(2-cyclopropyl-6-methylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C26H22F3N3O	1
1	IC50 = 2 nM
CP0053384 Compound Info	7-methyl-4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C23H18F3N3O	1
1	IC50 = 4 nM
CP0101908 Compound Info	7-methyl-4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C22H16F3N3O	1
1	IC50 = 4 nM
CP0101909 Compound Info	4-(3-(2-isopropylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C25H22F3N3O	1
1	IC50 = 4 nM
CP0231490 Compound Info	7,8-dichloro-4-(3-(2-methylpyridin-4-yl)phenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C21H15Cl2N3O	1
1	IC50 = 4 nM
CP0338876 Compound Info	7-ethoxy-4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C23H18F3N3O2	1
1	IC50 = 4 nM
CP0036327 Compound Info	7-methyl-4-(3-(3-methylisoxazol-5-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C21H16F3N3O2	1
1	IC50 = 5 nM
CP0052924 Compound Info	4-(3-(6-methoxypyridin-3-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C23H18F3N3O2	1
1	IC50 = 5 nM
CP0039555 Compound Info	4-(3-(6-cyclopropylpyridin-3-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C25H20F3N3O	1
1	IC50 = 6 nM
CP0232347 Compound Info	7-ethoxy-4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C24H20F3N3O2	1
1	IC50 = 6 nM
CP0332809 Compound Info	7-methyl-4-(3-(pyrimidin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C21H15F3N4O	1
1	IC50 = 6 nM
CP0237659 Compound Info	4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7,8-bis(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C24H17F6N3O	1
1	IC50 = 7 nM
CP0161928 Compound Info	4-(3-(1H-1,2,4-triazol-1-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C19H14F3N5O	1
1	IC50 = 8 nM
CP0237661 Compound Info	8-chloro-4-(3-(pyridin-4-yl)phenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C20H14ClN3O	1
1	IC50 = 8 nM
CP0295951 Compound Info	4-(3-(2-ethylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C24H20F3N3O	1
1	IC50 = 8 nM
CP0336098 Compound Info	4-(3-(2-(methoxymethyl)-6-methylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C25H22F3N3O2	1
1	IC50 = 8 nM
CP0349551 Compound Info	4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C19H14F3N5O	1
1	IC50 = 9 nM
CP0161929 Compound Info	4-(3-(6-ethylpyridin-3-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C24H20F3N3O	1
1	IC50 = 9 nM
CP0053390 Compound Info	4-(3-(2-cyclopropylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C25H20F3N3O	1
1	IC50 = 10 nM
CP0053392 Compound Info	4-(3-(6-isopropylpyridin-3-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C25H22F3N3O	1
1	IC50 = 10 nM
CP0101910 Compound Info	4-(3-(2-cyclopentylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C27H24F3N3O	1
1	IC50 = 10 nM
CP0237670 Compound Info	4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C21H14F3N3O	1
1	IC50 = 10 nM
CP0059416 Compound Info	4-(3-(1H-imidazol-1-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C20H15F3N4O	1
1	IC50 = 12 nM
CP0059417 Compound Info	8-(2-fluorophenyl)-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C24H17FN4O	1
1	IC50 = 12 nM
CP0162027 Compound Info	4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C23H16FN5O	2
1	IC50 = 12 nM
2	IC50 = 16 nM
CP0368814 Compound Info	4-(3-(7-methyl-2-oxo-8-(trifluoromethyl)-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl)phenyl)picolinonitrile Show/Hide	C23H15F3N4O	1
1	IC50 = 12 nM
CP0038458 Compound Info	4-(3-(2-methoxypyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C23H18F3N3O2	1
1	IC50 = 13 nM
CP0295952 Compound Info	4-(3-(2-(methoxymethyl)pyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C24H20F3N3O2	1
1	IC50 = 13 nM
CP0297211 Compound Info	4-(3-(2-(hydroxymethyl)pyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C23H18F3N3O2	1
1	IC50 = 13 nM
CP0337808 Compound Info	7-methyl-4-(3-(6-methylpyridin-3-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C23H18F3N3O	1
1	IC50 = 13 nM
CP0237671 Compound Info	4-(3-(6-aminopyridin-3-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C22H17F3N4O	1
1	IC50 = 14 nM
CP0295953 Compound Info	4-(3-(2-(hydroxymethyl)-6-methylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C24H20F3N3O2	1
1	IC50 = 14 nM
CP0218960 Compound Info	4-(3-(2-benzylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C29H22F3N3O	1
1	IC50 = 16 nM
CP0484073 Compound Info	8-(4-fluorophenyl)-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C24H17FN4O	1
1	IC50 = 17 nM
CP0237672 Compound Info	7-methyl-4-(3-(pyridazin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C21H15F3N4O	1
1	IC50 = 18 nM
CP0295954 Compound Info	4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C22H16F3N3O	1
1	IC50 = 18 nM
CP0283397 Compound Info	7-methyl-4-(3-(pyrazin-2-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C21H15F3N4O	1
1	IC50 = 20 nM
CP0205609 Compound Info	8-(2-fluorophenyl)-7-hydroxy-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one Show/Hide	C24H17FN4O2	1
1	IC50 = 22 nM
CP0336099 Compound Info	7-methyl-4-(3-(6-(pyrimidin-5-yl)pyridin-3-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C21H15F3N4O	1
1	IC50 = 23 nM
CP0101912 Compound Info	4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)ethynyl)-7-hydroxy-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C26H17FN4O2	1
1	IC50 = 26 nM
CP0295955 Compound Info	4-(3-(2,2'-bipyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C22H16F3N3O	1
1	IC50 = 26 nM
CP0079531 Compound Info	(E)-3-(4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile Show/Hide	C24H15N3O	1
1	IC50 = 34 nM
CP0243343 Compound Info	4-(3-(1-methyl-1H-pyrazol-5-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C20H15F3N4O	1
1	IC50 = 39 nM
CP0335052 Compound Info	4-(3-(2-(2-hydroxypropan-2-yl)pyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C25H22F3N3O2	1
1	IC50 = 40 nM
CP0295902 Compound Info	8-methyl-4-phenyl-1H-benzo[b][1,4]diazepin-2(3H)-one Show/Hide	C16H14N2O	1
1	IC50 = 6400 nM

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han