Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)ethynyl)-7-hydroxy-1H-benzo[b][1,4]diazepin-2(3H)-one
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 PubChem ID
CID: 9845873
SID: 14807836
Canonical SMILES
Oc1cc2N=C(CC(=O)Nc2cc1C#Cc1ccc(F)cc1)c1cccc(c1)-n1ccnc1
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Compound Formula C26H17FN4O2
Compound Structure
Protein Name
 Protein Info 
Metabotropic glutamate receptor 2
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
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Small molecule receptor (family C GPCR)
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Neurotransmitter receptor (family C GPCR)
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Metabotropic glutamate receptor
Uniprot ID
P31421
Gene Name
GRM2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  3
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
2
IC50 = 24 nM
   TI
   LI
   LO
   TS
3
IC50 = 26 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 26 nM