| Compound ID |
Compound Name |
Compound Formula |
|
CP0470531
|
CHEMBL4063313
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|
C26H28ClF3N4O
|
4
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| 1 |
EC50 = 1.122 nM
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| 2 |
EC50 = 11.22 nM
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| 3 |
Kd = 1.5 nM
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| 4 |
Ki = 0.8913 nM
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CP0417655
|
7-[3-chloro-4-(2,6-dimethylpyridin-3-yl)oxyphenyl]-3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
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|
C24H20ClF3N4O
|
3
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| 1 |
EC50 = 2.884 nM
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| 2 |
Kd = 7.3 nM
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| 3 |
Ki = 1.514 nM
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CP0070721
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3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
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|
C22H23F3N4
|
6
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| 1 |
EC50 = 4.8 nM
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| 2 |
EC50 = 23.6 nM
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| 3 |
EC50 = 27 nM
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| 4 |
EC50 = 46.4 nM
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| 5 |
EC50 = 385 nM
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| 6 |
EC50 > 10000 nM
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CP0460444
|
4-[3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]-2-fluoro-N-[(6-methoxypyridin-3-yl)methyl]aniline
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|
C24H21F4N5O
|
3
|
| 1 |
EC50 = 5.888 nM
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| 2 |
Kd = 2.9 nM
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| 3 |
Ki = 2.042 nM
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CP0417647
|
2-chloro-N-cyclopropyl-4-[3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]aniline
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|
C20H18ClF3N4
|
3
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| 1 |
EC50 = 7.762 nM
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| 2 |
Kd = 1.2 nM
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| 3 |
Ki = 2.239 nM
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CP0417654
|
3-(cyclopropylmethyl)-7-[4-(2,6-dimethylpyridin-3-yl)oxy-3-fluorophenyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
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|
C24H20F4N4O
|
3
|
| 1 |
EC50 = 8.71 nM
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| 2 |
Kd = 2.5 nM
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| 3 |
Ki = 2.57 nM
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CP0417698
|
4-[2-chloro-4-[3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]anilino]cyclohexan-1-ol
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|
C23H24ClF3N4O
|
3
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| 1 |
EC50 = 9.333 nM
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| 2 |
Kd = 3 nM
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| 3 |
Ki = 2.188 nM
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CP0308328
|
8-chloro-7-[3-chloro-4-(2,6-dimethylpyridin-3-yl)oxyphenyl]-3-(cyclopropylmethyl)-[1,2,4]triazolo[4,3-a]pyridine
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|
C23H20Cl2N4O
|
3
|
| 1 |
EC50 = 12.3 nM
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| 2 |
Kd = 1 nM
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| 3 |
Ki = 6.026 nM
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CP0460459
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4-[3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]-N-[(6-methoxypyridin-3-yl)methyl]aniline
Show/Hide
|
C24H22F3N5O
|
3
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| 1 |
EC50 = 15.14 nM
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| 2 |
Kd = 2 nM
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| 3 |
Ki = 3.162 nM
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CP0392159
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7-[3-chloro-4-(2,6-dimethylpyridin-3-yl)oxyphenyl]-3-(cyclopropylmethyl)-8-methyl-[1,2,4]triazolo[4,3-a]pyridine
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|
C24H23ClN4O
|
3
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| 1 |
EC50 = 17.38 nM
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| 2 |
Kd = 17.4 nM
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| 3 |
Ki = 14.79 nM
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CP0417700
|
2-chloro-4-[3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]-N-propan-2-ylaniline
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|
C20H20ClF3N4
|
3
|
| 1 |
EC50 = 17.38 nM
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| 2 |
Kd = 3.4 nM
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| 3 |
Ki = 3.89 nM
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CP0417697
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N-[2-chloro-4-[3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]phenyl]oxan-4-amine
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|
C22H22ClF3N4O
|
3
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| 1 |
EC50 = 18.62 nM
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| 2 |
Kd = 3.8 nM
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| 3 |
Ki = 5.012 nM
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CP0446996
|
3-(cyclopropylmethyl)-7-[4-(2-cyclopropylpyridin-4-yl)oxy-3-fluorophenyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
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|
C25H20F4N4O
|
3
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| 1 |
EC50 = 18.62 nM
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| 2 |
Kd = 8.6 nM
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| 3 |
Ki = 3.631 nM
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CP0417652
|
4-[2-chloro-4-[3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]phenoxy]cyclohexan-1-ol
Show/Hide
|
C23H23ClF3N3O2
|
3
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| 1 |
EC50 = 25.12 nM
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| 2 |
Kd = 3 nM
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| 3 |
Ki = 1.905 nM
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CP0411614
|
3-(cyclopropylmethyl)-7-[4-(2,6-dimethylpyridin-3-yl)oxy-3-fluorophenyl]-8-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridine
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|
C26H27FN4O
|
3
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| 1 |
EC50 = 28.18 nM
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| 2 |
Kd = 10.7 nM
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| 3 |
Ki = 25.12 nM
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CP0417650
|
2-chloro-4-[8-chloro-3-(cyclopropylmethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]-N-cyclopropylaniline
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|
C19H18Cl2N4
|
3
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| 1 |
EC50 = 29.51 nM
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| 2 |
Kd = 6.1 nM
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| 3 |
Ki = 6.761 nM
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CP0417694
|
8-chloro-7-[4-(2,6-dimethylpyridin-3-yl)oxy-3-fluorophenyl]-3-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridine
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|
C21H15ClF4N4O
|
3
|
| 1 |
EC50 = 29.51 nM
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| 2 |
Kd = 3.3 nM
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| 3 |
Ki = 7.943 nM
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CP0468734
|
7-[4-(2,6-dimethylpyridin-3-yl)oxy-3-fluorophenyl]-3-(ethoxymethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
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|
C23H20F4N4O2
|
3
|
| 1 |
EC50 = 29.51 nM
|
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| 2 |
Kd = 2.1 nM
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| 3 |
Ki = 11.75 nM
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CP0468720
|
N-cyclopropyl-4-[3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]-2-fluoroaniline
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|
C20H18F4N4
|
3
|
| 1 |
EC50 = 30.2 nM
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| 2 |
Kd = 1.1 nM
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| 3 |
Ki = 3.631 nM
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CP0510379
|
4-[2-chloro-4-[8-chloro-3-(cyclopropylmethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]anilino]cyclohexan-1-ol
Show/Hide
|
C22H24Cl2N4O
|
3
|
| 1 |
EC50 = 33.11 nM
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| 2 |
Kd = 12.7 nM
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| 3 |
Ki = 3.02 nM
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CP0331590
|
7-[3-chloro-4-(oxan-4-yloxy)phenyl]-3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
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|
C22H21ClF3N3O2
|
4
|
| 1 |
EC50 = 38.02 nM
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| 2 |
EC50 = 89.13 nM
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| 3 |
Kd = 12.3 nM
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| 4 |
Ki = 5.248 nM
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CP0417701
|
3-(cyclopropylmethyl)-7-[3-fluoro-4-[(6-methoxypyridin-3-yl)methoxy]phenyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C24H20F4N4O2
|
3
|
| 1 |
EC50 = 40.74 nM
|
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| 2 |
Kd = 16 nM
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| 3 |
Ki = 11.75 nM
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CP0481071
|
8-chloro-3-(cyclopropylmethyl)-7-[4-(2,6-dimethylpyridin-3-yl)oxy-3-fluorophenyl]-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C23H20ClFN4O
|
3
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| 1 |
EC50 = 40.74 nM
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| 2 |
Kd = 15.3 nM
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| 3 |
Ki = 1.95 nM
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CP0417706
|
4-[2-chloro-4-[8-chloro-3-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]anilino]cyclohexan-1-ol
Show/Hide
|
C20H19Cl2F3N4O
|
3
|
| 1 |
EC50 = 41.69 nM
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| 2 |
Kd = 10.8 nM
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| 3 |
Ki = 6.026 nM
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CP0461796
|
4-[2-chloro-4-[3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]anilino]cyclohexan-1-ol
Show/Hide
|
C23H24ClF3N4O
|
3
|
| 1 |
EC50 = 41.69 nM
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| 2 |
Kd = 10.3 nM
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| 3 |
Ki = 9.333 nM
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CP0046845
|
3-(cyclopropylmethyl)-7-[[4-(2,4-difluorophenyl)piperazin-1-yl]methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H22F5N5
|
5
|
| 1 |
EC50 = 45.7 nM
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| 2 |
EC50 = 977 nM
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| 3 |
EC50 = 1410 nM
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| 4 |
EC50 = 2340 nM
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| 5 |
EC50 = 6610 nM
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CP0463331
|
3-(cyclopropylmethyl)-7-[3-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
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|
C23H18F4N4O
|
3
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| 1 |
EC50 = 56.23 nM
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| 2 |
Kd = 9.2 nM
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| 3 |
Ki = 7.079 nM
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CP0417705
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3-(cyclopropylmethyl)-7-[4-[(6-methoxypyridin-3-yl)methoxy]phenyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C24H21F3N4O2
|
3
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| 1 |
EC50 = 57.54 nM
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| 2 |
Kd = 8.7 nM
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| 3 |
Ki = 8.71 nM
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CP0227909
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4-[8-chloro-3-(cyclopropylmethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]-N-cyclopropyl-2-fluoroaniline
Show/Hide
|
C19H18ClFN4
|
3
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| 1 |
EC50 = 63.1 nM
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| 2 |
Kd = 12.7 nM
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| 3 |
Ki = 10.23 nM
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CP0475294
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3-(cyclopropylmethyl)-7-[4-(2,6-dimethylpyridin-4-yl)oxy-3-fluorophenyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C24H20F4N4O
|
3
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| 1 |
EC50 = 64.57 nM
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| 2 |
Kd = 11.5 nM
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| 3 |
Ki = 10 nM
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CP0054727
|
1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)pyridin-2-one
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|
C20H25ClN2O
|
7
|
| 1 |
EC50 = 65 nM
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| 2 |
EC50 = 77 nM
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| 3 |
EC50 = 265 nM
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| 4 |
EC50 = 1350 nM
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| 5 |
EC50 = 1630 nM
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| 6 |
EC50 = 2000 nM
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| 7 |
EC50 = 2570 nM
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CP0461792
|
8-chloro-7-[4-(2,6-dimethylpyridin-3-yl)oxy-3-fluorophenyl]-3-(ethoxymethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H20ClFN4O2
|
3
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| 1 |
EC50 = 74.13 nM
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| 2 |
Kd = 25.2 nM
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| 3 |
Ki = 6.457 nM
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CP0488970
|
3-(cyclopropylmethyl)-7-[4-(2,6-dimethylpyridin-3-yl)oxy-3-fluorophenyl]-8-methyl-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C24H23FN4O
|
3
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| 1 |
EC50 = 77.62 nM
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| 2 |
Kd = 10 nM
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| 3 |
Ki = 21.88 nM
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CP0417653
|
1-(cyclopropylmethyl)-2-oxo-4-(4-phenylpiperidin-1-yl)pyridine-3-carbonitrile
Show/Hide
|
C21H23N3O
|
3
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| 1 |
EC50 = 79.43 nM
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| 2 |
Kd = 51 nM
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| 3 |
Ki = 26.3 nM
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CP0417699
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8-chloro-3-(cyclopropylmethyl)-7-[4-(2-cyclopropylpyridin-4-yl)oxy-3-fluorophenyl]-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C24H20ClFN4O
|
3
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| 1 |
EC50 = 87.1 nM
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| 2 |
Kd = 42.7 nM
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| 3 |
Ki = 53.7 nM
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CP0440056
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3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yloxy)methyl)-biphenyl-4-carboxylic acid
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|
C30H30O4
|
3
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| 1 |
EC50 = 93.33 nM
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| 2 |
Kd = 190 nM
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| 3 |
Ki = 60.26 nM
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CP0510380
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4-[3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]-2-fluoro-N-propan-2-ylaniline
Show/Hide
|
C20H20F4N4
|
3
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| 1 |
EC50 = 93.33 nM
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| 2 |
Kd = 2.2 nM
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| 3 |
Ki = 8.913 nM
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CP0460449
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4-[2-chloro-4-[8-chloro-3-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]phenoxy]cyclohexan-1-ol
Show/Hide
|
C20H18Cl2F3N3O2
|
3
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| 1 |
EC50 = 97.72 nM
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| 2 |
Kd = 8.1 nM
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| 3 |
Ki = 32.36 nM
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CP0463332
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8-chloro-3-(cyclopropylmethyl)-7-[4-(2-ethylpyridin-4-yl)oxy-3-fluorophenyl]-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C23H20ClFN4O
|
3
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| 1 |
EC50 = 100 nM
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| 2 |
Kd = 23.3 nM
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| 3 |
Ki = 18.62 nM
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CP0481063
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N-[[4-[[3-hydroxy-4-(2-methylpropanoyl)-2-(trifluoromethyl)phenoxy]methyl]phenyl]methyl]-1-methylimidazole-4-carboxamide
Show/Hide
|
C24H24F3N3O4
|
3
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| 1 |
EC50 = 107.15 nM
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| 2 |
Kd = 100 nM
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| 3 |
Ki = 79.43 nM
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CP0417696
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N-[2-chloro-4-[8-chloro-3-(cyclopropylmethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]phenyl]oxan-4-amine
Show/Hide
|
C21H22Cl2N4O
|
3
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| 1 |
EC50 = 147.91 nM
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| 2 |
Kd = 19.5 nM
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| 3 |
Ki = 38.9 nM
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CP0461793
|
4-[8-chloro-3-(cyclopropylmethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]-N-[(6-methoxypyridin-3-yl)methyl]aniline
Show/Hide
|
C23H22ClN5O
|
3
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| 1 |
EC50 = 151.36 nM
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| 2 |
Kd = 15.6 nM
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| 3 |
Ki = 7.413 nM
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CP0468718
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4-[2-chloro-4-[8-chloro-3-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]phenoxy]cyclohexan-1-ol
Show/Hide
|
C20H18Cl2F3N3O2
|
3
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| 1 |
EC50 = 158.49 nM
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| 2 |
Kd = 16.6 nM
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| 3 |
Ki = 11.48 nM
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CP0417646
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4-[8-chloro-3-(cyclopropylmethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]-2-fluoro-N-propan-2-ylaniline
Show/Hide
|
C19H20ClFN4
|
3
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| 1 |
EC50 = 223.87 nM
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| 2 |
Kd = 20.3 nM
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| 3 |
Ki = 61.66 nM
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CP0417695
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8-chloro-7-[3-chloro-4-(oxan-4-yloxy)phenyl]-3-(cyclopropylmethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C21H21Cl2N3O2
|
3
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| 1 |
EC50 = 223.87 nM
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| 2 |
Kd = 28.1 nM
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| 3 |
Ki = 22.91 nM
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CP0411615
|
8-chloro-3-(cyclopropylmethyl)-7-[3-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H18ClFN4O
|
3
|
| 1 |
EC50 = 251.19 nM
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| 2 |
Kd = 37.6 nM
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| 3 |
Ki = 63.1 nM
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CP0158029
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7-methyl-5-[3-(piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl]-2-[[4-(trifluoromethoxy)phenyl]methyl]-3H-isoindol-1-one
Show/Hide
|
C24H24F3N5O3
|
3
|
| 1 |
EC50 = 562.34 nM
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| 2 |
Kd = 600 nM
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| 3 |
Ki = 371.54 nM
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CP0488980
|
N-[[2-chloro-4-[3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]phenyl]methyl]oxan-4-amine
Show/Hide
|
C23H24ClF3N4O
|
3
|
| 1 |
EC50 = 630.96 nM
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| 2 |
Kd = 54 nM
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| 3 |
Ki = 61.66 nM
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