Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)pyridin-2-one
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 PubChem ID
CID: 25195461
SID: 57305022
Canonical SMILES
CCCCn1ccc(N2CCC(CC2)c2ccccc2)c(Cl)c1=O
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Compound Formula C20H25ClN2O
Compound Structure
Protein Name
 Protein Info 
Metabotropic glutamate receptor 2
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
>
Neurotransmitter receptor (family C GPCR)
>
Metabotropic glutamate receptor
Uniprot ID
Q14416
Gene Name
GRM2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
EC50 = 147 nM
   TI
   LI
   LO
   TS
2
IC50 = 68 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  7
1
EC50 = 65 nM
   TI
   LI
   LO
   TS
2
EC50 = 77 nM
   TI
   LI
   LO
   TS
3
EC50 = 265 nM
   TI
   LI
   LO
   TS
4
EC50 = 1350 nM
   TI
   LI
   LO
   TS
5
EC50 = 1630 nM
   TI
   LI
   LO
   TS
6
EC50 = 2000 nM
   TI
   LI
   LO
   TS
7
EC50 = 2570 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 180 nM