Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-(cyclopropylmethyl)-7-[[4-(2,4-difluorophenyl)piperazin-1-yl]methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
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 PubChem ID
CID: 49822116
SID: 103804591
Canonical SMILES
Fc1ccc(N2CCN(Cc3ccn4c(CC5CC5)nnc4c3C(F)(F)F)CC2)c(F)c1
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Compound Formula C22H22F5N5
Compound Structure
Protein Name
 Protein Info 
Metabotropic glutamate receptor 2
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
>
Neurotransmitter receptor (family C GPCR)
>
Metabotropic glutamate receptor
Uniprot ID
Q14416
Gene Name
GRM2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
EC50 = 78 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  5
1
EC50 = 45.7 nM
   TI
   LI
   LO
   TS
2
EC50 = 977 nM
   TI
   LI
   LO
   TS
3
EC50 = 1410 nM
   TI
   LI
   LO
   TS
4
EC50 = 2340 nM
   TI
   LI
   LO
   TS
5
EC50 = 6610 nM
   TI
   LI
   LO
   TS
CL000460 Flp-In-T-REx-293
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 82 nM
   TI
   LI
   LO
   TS
2
EC50 = 166 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 150 nM