Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
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 PubChem ID
CID: 49765871
SID: 103022204
Canonical SMILES
FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1
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Compound Formula C22H23F3N4
Compound Structure
Protein Name
 Protein Info 
Metabotropic glutamate receptor 2
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
>
Neurotransmitter receptor (family C GPCR)
>
Metabotropic glutamate receptor
Uniprot ID
Q14416
Gene Name
GRM2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  3
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
2
EC50 = 270 nM
   TI
   LI
   LO
   TS
3
IC50 = 15 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  6
1
EC50 = 4.8 nM
   TI
   LI
   LO
   TS
2
EC50 = 23.6 nM
   TI
   LI
   LO
   TS
3
EC50 = 27 nM
   TI
   LI
   LO
   TS
4
EC50 = 46.4 nM
   TI
   LI
   LO
   TS
5
EC50 = 385 nM
   TI
   LI
   LO
   TS
6
EC50 > 10000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 147 nM
2 Ki = 15 nM