Brief Information of the Compound and Protein
Compound Name
N-[[2-chloro-4-[3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]phenyl]methyl]oxan-4-amine
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PubChem ID
CID: 68109379
Canonical SMILES
FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)-c1ccc(CNC2CCOCC2)c(Cl)c1
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Compound Formula C23H24ClF3N4O
Compound Structure
Protein Name
Metabotropic glutamate receptor 2
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
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Small molecule receptor (family C GPCR)
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Neurotransmitter receptor (family C GPCR)
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Metabotropic glutamate receptor
Uniprot ID
Q14416
Gene Name
GRM2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  3
1
EC50 = 630.96 nM
   TI
   LI
   LO
   TS
2
Kd = 54 nM
   TI
   LI
   LO
   TS
3
Ki = 61.66 nM
   TI
   LI
   LO
   TS