Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-(cyclopropylmethyl)-7-[4-(2,6-dimethylpyridin-3-yl)oxy-3-fluorophenyl]-8-methyl-[1,2,4]triazolo[4,3-a]pyridine
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 PubChem ID
CID: 66786131
Canonical SMILES
Cc1ccc(Oc2ccc(cc2F)-c2ccn3c(CC4CC4)nnc3c2C)c(C)n1
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Compound Formula C24H23FN4O
Compound Structure
Protein Name
 Protein Info 
Metabotropic glutamate receptor 2
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
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Small molecule receptor (family C GPCR)
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Neurotransmitter receptor (family C GPCR)
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Metabotropic glutamate receptor
Uniprot ID
Q14416
Gene Name
GRM2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  3
1
EC50 = 77.62 nM
   TI
   LI
   LO
   TS
2
Kd = 10 nM
   TI
   LI
   LO
   TS
3
Ki = 21.88 nM
   TI
   LI
   LO
   TS