| Compound ID |
Compound Name |
Compound Formula |
|
CP0379593
|
(2S)-2-[[[4-[2-(2-hydroxypropan-2-yl)-5-methylbenzimidazol-1-yl]cyclohexyl]amino]methyl]-2,3-dihydro-1H-indene-5-carbonitrile
Show/Hide
|
C28H34N4O
|
2
|
| 1 |
EC50 = 20 nM
|
|
|
| 2 |
IC50 = 8.7 nM
|
|
|
|
CP0469459
|
N-[(5-chloro-2,3-dihydro-1H-inden-2-yl)methyl]-4-(2,5-dimethylbenzimidazol-1-yl)cyclohexan-1-amine
Show/Hide
|
C25H30ClN3
|
2
|
| 1 |
EC50 = 20 nM
|
|
|
| 2 |
IC50 = 57 nM
|
|
|
|
CP0406881
|
(2S)-2-[[[4-[5-chloro-2-(2-hydroxypropan-2-yl)benzimidazol-1-yl]cyclohexyl]amino]methyl]-2,3-dihydro-1H-indene-5-carbonitrile
Show/Hide
|
C27H31ClN4O
|
2
|
| 1 |
EC50 = 25 nM
|
|
|
| 2 |
IC50 = 3 nM
|
|
|
|
CP0433929
|
(2S)-2-[[[4-(5-fluoro-2-methylbenzimidazol-1-yl)cyclohexyl]amino]methyl]-2,3-dihydro-1H-indene-5-carbonitrile
Show/Hide
|
C25H27FN4
|
2
|
| 1 |
EC50 = 27 nM
|
|
|
| 2 |
IC50 = 3 nM
|
|
|
|
CP0381080
|
(2R)-2-[[[4-[5-chloro-2-(2-hydroxypropan-2-yl)benzimidazol-1-yl]cyclohexyl]amino]methyl]-2,3-dihydro-1H-indene-5-carbonitrile
Show/Hide
|
C27H31ClN4O
|
2
|
| 1 |
EC50 = 30 nM
|
|
|
| 2 |
IC50 = 5.9 nM
|
|
|
|
CP0395612
|
(2S)-2-[[[4-(2,5-dimethylbenzimidazol-1-yl)cyclohexyl]amino]methyl]-2,3-dihydro-1H-indene-5-carbonitrile
Show/Hide
|
C26H30N4
|
2
|
| 1 |
EC50 = 30 nM
|
|
|
| 2 |
IC50 = 13 nM
|
|
|
|
CP0406880
|
2-[5-chloro-1-[4-[(5-chloro-2,3-dihydro-1H-inden-2-yl)methylamino]cyclohexyl]benzimidazol-2-yl]propan-2-ol
Show/Hide
|
C26H31Cl2N3O
|
2
|
| 1 |
EC50 = 30 nM
|
|
|
| 2 |
IC50 = 32 nM
|
|
|
|
CP0411653
|
2-[1-[4-[(5-fluoro-2,3-dihydro-1H-inden-2-yl)methylamino]cyclohexyl]-5-methylbenzimidazol-2-yl]propan-2-ol
Show/Hide
|
C27H34FN3O
|
2
|
| 1 |
EC50 = 30 nM
|
|
|
| 2 |
IC50 = 67 nM
|
|
|
|
CP0403911
|
2-[5-chloro-1-[4-(2,3-dihydro-1H-inden-2-ylmethylamino)cyclohexyl]benzimidazol-2-yl]propan-2-ol
Show/Hide
|
C26H32ClN3O
|
2
|
| 1 |
EC50 = 40 nM
|
|
|
| 2 |
IC50 = 40 nM
|
|
|
|
CP0456110
|
1-[4-[(5-chloro-2,3-dihydro-1H-inden-2-yl)methylamino]cyclohexyl]-2-methylbenzimidazole-5-carbonitrile
Show/Hide
|
C25H27ClN4
|
2
|
| 1 |
EC50 = 53 nM
|
|
|
| 2 |
IC50 = 76 nM
|
|
|
|
CP0407426
|
2-[1-[4-[[(2S)-5-bromo-2,3-dihydro-1H-inden-2-yl]methylamino]cyclohexyl]-5-chlorobenzimidazol-2-yl]propan-2-ol
Show/Hide
|
C26H31BrClN3O
|
2
|
| 1 |
EC50 = 60 nM
|
|
|
| 2 |
IC50 = 21 nM
|
|
|
|
CP0454086
|
N-[[(2S)-5-bromo-2,3-dihydro-1H-inden-2-yl]methyl]-4-(2,5-dimethylbenzimidazol-1-yl)cyclohexan-1-amine
Show/Hide
|
C25H30BrN3
|
2
|
| 1 |
EC50 = 70 nM
|
|
|
| 2 |
IC50 = 50 nM
|
|
|
|
CP0456109
|
2-[5-chloro-1-[4-[[5-(trifluoromethyl)-2,3-dihydro-1H-inden-2-yl]methylamino]cyclohexyl]benzimidazol-2-yl]propan-2-ol
Show/Hide
|
C27H31ClF3N3O
|
2
|
| 1 |
EC50 = 480 nM
|
|
|
| 2 |
IC50 = 230 nM
|
|
|
|
CP0493095
|
N-[3-[1-[4-[1-(4-fluorophenyl)benzimidazol-2-yl]butyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H33FN4O
|
2
|
| 1 |
IC50 = 0.6 nM
|
|
|
| 2 |
IC50 = 3 nM
|
|
|
|
CP0485076
|
(E)-N-{2-[(2-Hydroxy-ethyl)-methyl-amino]-4-methyl-quinolin-6-yl}-3-(4-trifluoromethoxy-phenyl)-acrylamide
Show/Hide
|
C23H22F3N3O3
|
3
|
| 1 |
IC50 = 0.9 nM
|
|
|
| 2 |
IC50 = 5.2 nM
|
|
|
| 3 |
IC50 = 41 nM
|
|
|
|
CP0859264
|
N-(3-(1-(4-((1-(4-fluorophenyl)-1H-benzo[d]imidazol-2-yl)methyl)benzyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
|
C34H33FN4O
|
1
|
| 1 |
IC50 = 0.9 nM
|
|
|
|
CP0446450
|
N-(4-methyl-2-piperidin-1-ylquinolin-6-yl)-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C24H24F3N3O3
|
3
|
| 1 |
IC50 = 0.92 nM
|
|
|
| 2 |
IC50 = 19 nM
|
|
|
| 3 |
IC50 = 97 nM
|
|
|
|
CP0494661
|
N-[4-methyl-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C28H31F3N4O3
|
3
|
| 1 |
IC50 = 1.5 nM
|
|
|
| 2 |
IC50 = 7.1 nM
|
|
|
| 3 |
IC50 = 7.5 nM
|
|
|
|
CP0510365
|
N-[2-(4-aminopiperidin-1-yl)-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C24H25F3N4O3
|
3
|
| 1 |
IC50 = 1.5 nM
|
|
|
| 2 |
IC50 = 3.5 nM
|
|
|
| 3 |
IC50 = 14 nM
|
|
|
|
CP0446449
|
N-(4-methyl-2-morpholin-4-ylquinolin-6-yl)-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C23H22F3N3O4
|
4
|
| 1 |
IC50 = 1.6 nM
|
|
|
| 2 |
IC50 = 12 nM
|
|
|
| 3 |
IC50 = 50 nM
|
|
|
| 4 |
IC50 = 82 nM
|
|
|
|
CP0391621
|
N-[2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C24H23F3N4O3
|
3
|
| 1 |
IC50 = 1.9 nM
|
|
|
| 2 |
IC50 = 9.7 nM
|
|
|
| 3 |
IC50 = 16 nM
|
|
|
|
CP0417050
|
N-[3-[1-[3-[[1-(4-fluorophenyl)benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C29H32FN5O
|
2
|
| 1 |
IC50 = 2 nM
|
|
|
| 2 |
IC50 = 18 nM
|
|
|
|
CP0378081
|
2-(2,4-Dichloro-phenoxy)-N-{2-[(2-hydroxy-ethyl)-methyl-amino]-4-methyl-quinolin-6-yl}-acetamide
Show/Hide
|
C21H21Cl2N3O3
|
3
|
| 1 |
IC50 = 2.1 nM
|
|
|
| 2 |
IC50 = 11 nM
|
|
|
| 3 |
IC50 = 43 nM
|
|
|
|
CP0302898
|
N-[4-methyl-2-(4-methylpiperazin-1-yl)quinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C24H25F3N4O3
|
4
|
| 1 |
IC50 = 2.3 nM
|
|
|
| 2 |
IC50 = 25 nM
|
|
|
| 3 |
IC50 = 29 nM
|
|
|
| 4 |
IC50 = 50 nM
|
|
|
|
CP0378082
|
Acetic acid 2-({6-[2-(3,4-dichloro-phenoxy)-acetylamino]-4-methyl-quinolin-2-yl}-methyl-amino)-ethyl ester
Show/Hide
|
C23H23Cl2N3O4
|
3
|
| 1 |
IC50 = 2.3 nM
|
|
|
| 2 |
IC50 = 14 nM
|
|
|
| 3 |
IC50 = 29 nM
|
|
|
|
CP0446393
|
(E)-N-[2-(4-Ethyl-piperazin-1-yl)-4-methyl-quinolin-6-yl]-3-(4-trifluoromethoxy-phenyl)-acrylamide
Show/Hide
|
C26H27F3N4O2
|
2
|
| 1 |
IC50 = 2.3 nM
|
|
|
| 2 |
IC50 = 16 nM
|
|
|
|
CP0170592
|
4-(4-fluorobenzyloxy)-1-(4-((propylamino)methyl)phenethyl)pyridin-2(1H)-one
Show/Hide
|
C24H27FN2O2
|
2
|
| 1 |
IC50 = 2.6 nM
|
|
|
| 2 |
IC50 = 20 nM
|
|
|
|
CP0514460
|
2-aminobenzimidazole-based compound, 25
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|
C22H21FN6O
|
1
|
| 1 |
IC50 = 2.7 nM
|
|
|
|
CP0391850
|
N-[2-[3-(dimethylamino)propylamino]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C24H27F3N4O3
|
3
|
| 1 |
IC50 = 2.7 nM
|
|
|
| 2 |
IC50 = 3.8 nM
|
|
|
| 3 |
IC50 = 16 nM
|
|
|
|
CP0466898
|
(E)-N-[2-(2-Dimethylamino-ethylamino)-4-methyl-quinolin-6-yl]-3-(4-trifluoromethoxy-phenyl)-acrylamide
Show/Hide
|
C24H25F3N4O2
|
3
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 13 nM
|
|
|
| 3 |
IC50 = 42 nM
|
|
|
|
CP0513696
|
N-cyclopropyl-1-[4-methyl-6-[[2-[4-(trifluoromethoxy)phenoxy]acetyl]amino]quinazolin-2-yl]piperidine-4-carboxamide
Show/Hide
|
C27H28F3N5O4
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 9 nM
|
|
|
|
CP0511706
|
2-aminobenzimidazole-based compound, 20
Show/Hide
|
C24H22F3N5O
|
1
|
| 1 |
IC50 = 3.1 nM
|
|
|
|
CP0535087
|
1-(4-((dipropylamino)methyl)phenethyl)-4-(4-fluorobenzyloxy)pyridin-2(1H)-one
Show/Hide
|
C27H33FN2O2
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0491220
|
4-(4-fluorobenzyloxy)-1-(4-((methyl(propyl)amino)methyl)phenethyl)pyridin-2(1H)-one
Show/Hide
|
C25H29FN2O2
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0535230
|
1-(4-((cyclopentyl(propyl)amino)methyl)phenethyl)-4-(4-fluorobenzyloxy)pyridin-2(1H)-one
Show/Hide
|
C29H35FN2O2
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0387611
|
2-aminobenzimidazole-based compound, 12
Show/Hide
|
C23H25F3N4O
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 22 nM
|
|
|
|
CP0378080
|
(E)-N-(4-Methyl-2-piperazin-1-yl-quinolin-6-yl)-3-(4-trifluoromethoxy-phenyl)-acrylamide
Show/Hide
|
C24H23F3N4O2
|
3
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 65 nM
|
|
|
| 3 |
IC50 = 88 nM
|
|
|
|
CP0452953
|
N-[3-[1-[4,4-difluoro-4-[1-(4-fluorophenyl)benzimidazol-2-yl]butyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H31F3N4O
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 37 nM
|
|
|
|
CP0261399
|
N-[4-methyl-2-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]quinazolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C27H28F3N5O4
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 19 nM
|
|
|
|
CP0425661
|
2-(4-chlorophenoxy)-N-[4-methyl-2-[4-(propan-2-ylcarbamoylamino)piperidin-1-yl]quinazolin-6-yl]acetamide
Show/Hide
|
C26H31ClN6O3
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 7 nM
|
|
|
|
CP0433353
|
(E)-N-[2-[4-(1,1-dioxo-1,2-thiazolidin-2-yl)piperidin-1-yl]-4-methylquinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
|
C27H28F3N5O4S
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 16 nM
|
|
|
|
CP0456423
|
(E)-N-[2-(2-Dimethylamino-1-methyl-ethylamino)-4-methyl-quinolin-6-yl]-3-(4-trifluoromethoxy-phenyl)-acrylamide
Show/Hide
|
C25H27F3N4O2
|
3
|
| 1 |
IC50 = 4.3 nM
|
|
|
| 2 |
IC50 = 22 nM
|
|
|
| 3 |
IC50 = 98 nM
|
|
|
|
CP0491219
|
1-(4-((ethyl(propyl)amino)methyl)phenethyl)-4-(4-fluorobenzyloxy)pyridin-2(1H)-one
Show/Hide
|
C26H31FN2O2
|
1
|
| 1 |
IC50 = 4.4 nM
|
|
|
|
CP0419122
|
4-(4-fluorobenzyloxy)-1-(4-((isobutyl(propyl)amino)methyl)phenethyl)pyridin-2(1H)-one
Show/Hide
|
C28H35FN2O2
|
1
|
| 1 |
IC50 = 4.9 nM
|
|
|
|
CP0378079
|
2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-piperazin-1-yl-quinolin-6-yl)-acetamide
Show/Hide
|
C22H22Cl2N4O2
|
3
|
| 1 |
IC50 = 5 nM
|
|
|
| 2 |
IC50 = 16 nM
|
|
|
| 3 |
IC50 = 74 nM
|
|
|
|
CP0502758
|
4-(4-fluorobenzyloxy)-1-(4-(pyrrolidin-1-ylmethyl)phenethyl)pyridin-2(1H)-one
Show/Hide
|
C25H27FN2O2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0502759
|
4-(4-fluorobenzyloxy)-1-(4-((isopropyl(propyl)amino)methyl)phenethyl)pyridin-2(1H)-one
Show/Hide
|
C27H33FN2O2
|
1
|
| 1 |
IC50 = 5.2 nM
|
|
|
|
CP0535060
|
4-(4-fluorobenzyloxy)-1-(4-(((2-methoxyethyl)(propyl)amino)methyl)phenethyl)pyridin-2(1H)-one
Show/Hide
|
C27H33FN2O3
|
1
|
| 1 |
IC50 = 5.4 nM
|
|
|
|
CP0514459
|
2-aminobenzimidazole-based compound, 22
Show/Hide
|
C23H22FN5O
|
1
|
| 1 |
IC50 = 5.5 nM
|
|
|
|
CP0508149
|
2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-morpholin-4-yl-quinolin-6-yl)-acetamide
Show/Hide
|
C22H21Cl2N3O3
|
3
|
| 1 |
IC50 = 5.5 nM
|
|
|
| 2 |
IC50 = 15.4 nM
|
|
|
| 3 |
IC50 = 59 nM
|
|
|
|
CP0379612
|
4-(4-fluorobenzyloxy)-1-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyridin-2(1H)-one
Show/Hide
|
C24H25FN2O3
|
1
|
| 1 |
IC50 = 5.6 nM
|
|
|
|
CP0418023
|
2-aminobenzimidazole-based compound, 8
Show/Hide
|
C21H23F3N4O
|
2
|
| 1 |
IC50 = 5.9 nM
|
|
|
| 2 |
IC50 = 21 nM
|
|
|
|
CP0466897
|
2-(2,4-Dichloro-phenoxy)-N-{2-[(2-dimethylamino-ethyl)-methyl-amino]-4-methyl-quinolin-6-yl}-acetamide
Show/Hide
|
C23H26Cl2N4O2
|
3
|
| 1 |
IC50 = 5.9 nM
|
|
|
| 2 |
IC50 = 9.4 nM
|
|
|
| 3 |
IC50 = 66 nM
|
|
|
|
CP0419121
|
1-(4-((diethylamino)methyl)phenethyl)-4-(4-fluorobenzyloxy)pyridin-2(1H)-one
Show/Hide
|
C25H29FN2O2
|
1
|
| 1 |
IC50 = 5.9 nM
|
|
|
|
CP0235384
|
N-[4-methyl-2-(4-morpholin-4-ylpiperidin-1-yl)quinazolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C27H30F3N5O4
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 16 nM
|
|
|
|
CP0400077
|
(E)-N-[2-[4-[(2-hydroxyacetyl)amino]piperidin-1-yl]-4-methylquinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
|
C26H26F3N5O4
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 26 nM
|
|
|
|
CP0409389
|
2-(2,4-Dichloro-phenoxy)-N-{4-methyl-2-[methyl-(2-methylamino-ethyl)-amino]-quinolin-6-yl}-acetamide
Show/Hide
|
C22H24Cl2N4O2
|
3
|
| 1 |
IC50 = 6.1 nM
|
|
|
| 2 |
IC50 = 6.9 nM
|
|
|
| 3 |
IC50 = 28 nM
|
|
|
|
CP0485074
|
(E)-N-(2-[1,4]Diazepan-1-yl-4-methyl-quinolin-6-yl)-3-(4-trifluoromethoxy-phenyl)-acrylamide
Show/Hide
|
C25H25F3N4O2
|
3
|
| 1 |
IC50 = 6.1 nM
|
|
|
| 2 |
IC50 = 23 nM
|
|
|
| 3 |
IC50 = 65 nM
|
|
|
|
CP0391852
|
2-(2,4-Dichloro-phenoxy)-N-[4-methyl-2-(4-methyl-piperazin-1-yl)-quinolin-6-yl]-acetamide
Show/Hide
|
C23H24Cl2N4O2
|
3
|
| 1 |
IC50 = 6.4 nM
|
|
|
| 2 |
IC50 = 24 nM
|
|
|
| 3 |
IC50 = 89 nM
|
|
|
|
CP0422078
|
2-aminobenzimidazole-based compound, 13
Show/Hide
|
C24H27F3N4O
|
2
|
| 1 |
IC50 = 6.7 nM
|
|
|
| 2 |
IC50 = 27 nM
|
|
|
|
CP0130796
|
4-(4-fluorobenzyloxy)-1-(2-(5-((propylamino)methyl)pyridin-2-yl)ethyl)pyridin-2(1H)-one
Show/Hide
|
C23H26FN3O2
|
2
|
| 1 |
IC50 = 7 nM
|
|
|
| 2 |
IC50 = 27 nM
|
|
|
|
CP0513877
|
N-[4-methyl-2-[4-(oxan-4-yl)piperazin-1-yl]quinazolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C27H30F3N5O4
|
2
|
| 1 |
IC50 = 7 nM
|
|
|
| 2 |
IC50 = 31 nM
|
|
|
|
CP0497198
|
N-[3-[1-[3-[[1-[(4-chlorophenyl)methyl]benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H34ClN5O
|
2
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
IC50 = 65 nM
|
|
|
|
CP0898831
|
N-(3-(1-(4-(1-(4-fluorophenyl)-1H-benzo[d]imidazol-2-yloxy)benzyl)piperidin-4-yl)phenyl)acetamide
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C33H31FN4O2
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1
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| 1 |
IC50 = 8 nM
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CP0485075
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N-[2-[(1-ethylpyrrolidin-2-yl)methylamino]-4-methylquinolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
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C26H29F3N4O3
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3
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| 1 |
IC50 = 8.7 nM
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| 2 |
IC50 = 21 nM
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| 3 |
IC50 = 109 nM
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CP0533263
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2-aminobenzimidazole-based compound, 21
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C23H23N5O
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1
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| 1 |
IC50 = 8.8 nM
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CP0405587
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6-(1-(4-(1-(4-fluorophenyl)-1H-benzo[d]imidazol-2-yl)butyl)piperidin-4-yl)indolin-2-one
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C30H31FN4O
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1
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| 1 |
IC50 = 9 nM
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CP0536566
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1-[4-methyl-6-[[2-[4-(trifluoromethoxy)phenoxy]acetyl]amino]quinazolin-2-yl]-N-propan-2-ylpiperidine-4-carboxamide
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C27H30F3N5O4
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2
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| 1 |
IC50 = 9 nM
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| 2 |
IC50 = 17 nM
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CP0493094
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N-[3-[1-[3-[[1-(4-fluorophenyl)benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]cyclopropanecarboxamide
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C31H34FN5O
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2
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| 1 |
IC50 = 10 nM
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| 2 |
IC50 = 96 nM
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CP0474628
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N-[2-[4-(cyclopropanecarbonyl)piperidin-1-yl]-4-methylquinazolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
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C27H27F3N4O4
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2
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| 1 |
IC50 = 10 nM
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| 2 |
IC50 = 14 nM
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CP0408857
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(E)-N-[4-methyl-2-(4-morpholin-4-ylpiperidin-1-yl)quinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
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C28H30F3N5O3
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2
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| 1 |
IC50 = 10 nM
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| 2 |
IC50 = 13 nM
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CP0859262
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N-(3-(1-(2-cyano-4-((1-(4-fluorophenyl)-1H-benzo[d]imidazol-2-yl)methyl)benzyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
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C35H32FN5O
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1
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| 1 |
IC50 = 10 nM
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CP0506494
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4-(4-fluorobenzyloxy)-1-(2-(6-((propylamino)methyl)pyridin-3-yl)ethyl)pyridin-2(1H)-one
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C23H26FN3O2
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1
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| 1 |
IC50 = 11 nM
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CP0535088
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4-(4-fluorobenzyloxy)-1-(4-(((2-fluoroethyl)(propyl)amino)methyl)phenethyl)pyridin-2(1H)-one
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C26H30F2N2O2
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1
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| 1 |
IC50 = 11 nM
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CP0398652
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N-[3-[1-[3-[[1-(4-chlorophenyl)benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
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C29H32ClN5O
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2
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| 1 |
IC50 = 11 nM
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| 2 |
IC50 = 49 nM
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CP0433355
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(E)-N-[4-methyl-2-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]quinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
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C28H28F3N5O3
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2
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| 1 |
IC50 = 11 nM
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| 2 |
IC50 = 12 nM
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CP0859263
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N-(3-(1-(4-(1-(4-fluorophenyl)-1H-benzo[d]imidazole-2-carbonyl)benzyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
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C34H31FN4O2
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1
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| 1 |
IC50 = 11 nM
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CP0898829
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N-(3-(1-((6-(1-(4-fluorophenyl)-1H-benzo[d]imidazole-2-carbonyl)pyridin-3-yl)methyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
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C33H30FN5O2
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1
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| 1 |
IC50 = 11 nM
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CP0498219
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2-aminobenzimidazole-based compound, 9
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C19H19F3N4O
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1
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| 1 |
IC50 = 12 nM
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CP0849411
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N-(3-(1-(4-(1-(4-fluorophenyl)-1H-imidazo[4,5-c]pyridine-2-carbonyl)benzyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
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C33H30FN5O2
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1
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| 1 |
IC50 = 12 nM
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CP0398651
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N-[3-[1-[4-[1-(4-fluorophenyl)benzimidazol-2-yl]-4-oxobutyl]piperidin-4-yl]phenyl]acetamide
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C30H31FN4O2
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2
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| 1 |
IC50 = 13 nM
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| 2 |
IC50 = 112 nM
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CP0858976
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(E)-N-(4-methyl-2-(4-(3-oxomorpholino)piperidin-1-yl)quinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)acrylamide
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C28H28F3N5O4
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2
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| 1 |
IC50 = 13 nM
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| 2 |
IC50 = 30 nM
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CP0163170
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4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
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C25H26N4O2
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2
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| 1 |
IC50 = 14 nM
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| 2 |
Ki = 2.6 nM
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CP0397927
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(E)-3-(4-chlorophenyl)-N-[2-[4-(methanesulfonamido)piperidin-1-yl]-4-methylquinazolin-6-yl]prop-2-enamide
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C24H26ClN5O3S
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2
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| 1 |
IC50 = 14 nM
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| 2 |
IC50 = 31 nM
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CP0433354
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(E)-N-[2-[4-[(2-methoxyacetyl)amino]piperidin-1-yl]-4-methylquinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
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C27H28F3N5O4
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2
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| 1 |
IC50 = 14 nM
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| 2 |
IC50 = 32 nM
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CP0859266
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N-(3-(1-(4-(3-(4-fluorophenyl)-3H-imidazo[4,5-b]pyridine-2-carbonyl)benzyl)piperidin-4-yl)phenyl)acetamide
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C33H30FN5O2
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1
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| 1 |
IC50 = 14 nM
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CP0496184
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2-aminobenzimidazole-based compound, 24
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C22H21FN6O
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1
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| 1 |
IC50 = 15 nM
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CP0398653
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N-[3-[1-[3-[[1-(4-fluorophenyl)benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]-2-methylpropanamide
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C31H36FN5O
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2
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| 1 |
IC50 = 15 nM
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| 2 |
IC50 = 183 nM
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CP0444334
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1-[6-[[2-(4-chlorophenoxy)acetyl]amino]-4-methylquinazolin-2-yl]-N-propan-2-ylpiperidine-4-carboxamide
Show/Hide
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C26H30ClN5O3
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2
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| 1 |
IC50 = 15 nM
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| 2 |
IC50 = 25 nM
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CP0474625
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N-[1-[6-[[2-(4-chlorophenoxy)acetyl]amino]-4-methylquinazolin-2-yl]piperidin-4-yl]-2-methylpropanamide
Show/Hide
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C26H30ClN5O3
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2
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| 1 |
IC50 = 15 nM
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| 2 |
IC50 = 54 nM
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CP0397922
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(E)-N-[4-methyl-2-[4-(2-oxopiperidin-1-yl)piperidin-1-yl]quinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
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C29H30F3N5O3
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2
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| 1 |
IC50 = 15 nM
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| 2 |
IC50 = 51 nM
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CP0914693
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N-(3-(1-(4-(4,6-difluoro-1-(4-fluorophenyl)-1H-benzo[d]imidazole-2-carbonyl)benzyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
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C34H29F3N4O2
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1
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| 1 |
IC50 = 15 nM
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CP0034944
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(E)-N-{2-[(2-Dimethylamino-ethyl)-methyl-amino]-4-methyl-quinolin-6-yl}-3-(4-trifluoromethoxy-phenyl)-acrylamide
Show/Hide
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C25H27F3N4O2
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2
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| 1 |
IC50 = 16 nM
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| 2 |
IC50 = 19 nM
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CP0409388
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(E)-N-[2-(4-Ethyl-piperazin-1-yl)-4-methyl-quinolin-6-yl]-3-(4-methoxy-phenyl)-acrylamide
Show/Hide
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C26H30N4O2
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1
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| 1 |
IC50 = 16 nM
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CP0397921
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(E)-3-(4-chlorophenyl)-N-[4-methyl-2-(4-morpholin-4-ylpiperidin-1-yl)quinazolin-6-yl]prop-2-enamide
Show/Hide
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C27H30ClN5O2
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2
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| 1 |
IC50 = 16 nM
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| 2 |
IC50 = 17 nM
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CP0482026
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(E)-3-(4-chlorophenyl)-N-[2-(4-cyclopropyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]prop-2-enamide
Show/Hide
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C26H27ClN4O2
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2
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| 1 |
IC50 = 16 nM
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| 2 |
IC50 = 149 nM
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CP0517543
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N,N-dimethyl-1-[4-methyl-6-[[2-[4-(trifluoromethoxy)phenoxy]acetyl]amino]quinazolin-2-yl]piperidine-4-carboxamide
Show/Hide
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C26H28F3N5O4
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2
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| 1 |
IC50 = 18 nM
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| 2 |
IC50 = 47 nM
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CP0408863
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(E)-N-[2-[4-(5,5-dimethyl-2-oxo-1,3-oxazolidin-3-yl)piperidin-1-yl]-4-methylquinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
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C29H30F3N5O4
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2
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| 1 |
IC50 = 18 nM
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| 2 |
IC50 = 68 nM
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CP0504088
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2-aminobenzimidazole-based compound, 10
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C20H21F3N4O
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1
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| 1 |
IC50 = 19 nM
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CP0400117
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(E)-3-(4-chlorophenyl)-N-[2-[4-[(2-methoxyacetyl)amino]piperidin-1-yl]-4-methylquinazolin-6-yl]prop-2-enamide
Show/Hide
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C26H28ClN5O3
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2
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| 1 |
IC50 = 19 nM
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| 2 |
IC50 = 45 nM
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CP0391847
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(E)-N-{2-[(2-Dimethylamino-ethyl)-methyl-amino]-quinolin-6-yl}-3-p-tolyl-acrylamide
Show/Hide
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C24H28N4O
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2
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| 1 |
IC50 = 20 nM
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| 2 |
IC50 = 804 nM
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CP0343076
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2-(4-chlorophenoxy)-N-[4-methyl-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-6-yl]acetamide
Show/Hide
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C26H30ClN5O2
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2
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| 1 |
IC50 = 20 nM
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| 2 |
IC50 = 81 nM
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CP0426690
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N-cyclopropyl-4-[[4-methyl-6-[[(E)-3-[4-(trifluoromethoxy)phenyl]prop-2-enoyl]amino]quinazolin-2-yl]amino]butanamide
Show/Hide
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C26H26F3N5O3
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2
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| 1 |
IC50 = 20 nM
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| 2 |
IC50 = 35 nM
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CP0389848
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(E)-3-(4-chlorophenyl)-N-[4-methyl-2-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]quinazolin-6-yl]prop-2-enamide
Show/Hide
|
C27H28ClN5O2
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2
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| 1 |
IC50 = 20 nM
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| 2 |
IC50 = 74 nM
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CP0036884
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1-[(3R,4R)-1-[[(2S)-5-bromo-2,3-dihydro-1H-inden-2-yl]methyl]-3-methoxypiperidin-4-yl]-2,5-dimethylbenzimidazole
Show/Hide
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C25H30BrN3O
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1
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| 1 |
IC50 = 20 nM
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CP0493088
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N-[3-[1-[3-[(1-phenylbenzimidazol-2-yl)amino]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
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C29H33N5O
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2
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| 1 |
IC50 = 21 nM
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| 2 |
IC50 = 153 nM
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CP0408866
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(E)-N-[4-methyl-2-[4-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl]quinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
|
C28H29F3N6O3
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1
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| 1 |
IC50 = 21 nM
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CP0469223
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2-(4-Chloro-phenoxy)-N-[2-(4-ethyl-piperazin-1-yl)-4-methyl-quinolin-6-yl]-acetamide
Show/Hide
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C24H27ClN4O2
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1
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| 1 |
IC50 = 22 nM
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CP0493090
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N-[3-[1-[3-[[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
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C30H34FN5O
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2
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| 1 |
IC50 = 22 nM
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| 2 |
IC50 = 45 nM
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CP0408683
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N-[2-(4-aminopiperidin-1-yl)-4-methylquinazolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
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C23H24F3N5O3
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2
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| 1 |
IC50 = 22 nM
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| 2 |
IC50 = 80 nM
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CP0914694
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N-(3-(1-(4-(1-(4-fluorophenyl)-4,5-dimethyl-1H-imidazole-2-carbonyl)benzyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
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C32H33FN4O2
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1
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| 1 |
IC50 = 22 nM
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CP0504089
|
2-aminobenzimidazole-based compound, 16
Show/Hide
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C24H28F3N5O
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1
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| 1 |
IC50 = 23 nM
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CP0454387
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2-(4-chlorophenyl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)furo[3,2-c]pyridin-4(5H)-one
Show/Hide
|
C26H23ClN4O2
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2
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| 1 |
IC50 = 23 nM
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| 2 |
Ki = 5.2 nM
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CP0462628
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1-[4-methyl-6-[[2-[4-(trifluoromethoxy)phenoxy]acetyl]amino]quinazolin-2-yl]piperidine-4-carboxamide
Show/Hide
|
C24H24F3N5O4
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2
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| 1 |
IC50 = 23 nM
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| 2 |
IC50 = 32 nM
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CP0400074
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N-[2-[[4-methyl-6-[[(E)-3-[4-(trifluoromethoxy)phenyl]prop-2-enoyl]amino]quinazolin-2-yl]amino]ethyl]cyclopropanecarboxamide
Show/Hide
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C25H24F3N5O3
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2
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| 1 |
IC50 = 23 nM
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| 2 |
IC50 = 61 nM
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CP0450930
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2-aminobenzimidazole-based compound, 11
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C21H21F3N4O
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1
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| 1 |
IC50 = 24 nM
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CP0487854
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N-[3-[1-[3-[[1-(4-cyanophenyl)benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
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C30H32N6O
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2
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| 1 |
IC50 = 24 nM
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| 2 |
IC50 = 71 nM
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CP0400106
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(E)-3-(4-chlorophenyl)-N-[2-[4-hydroxy-4-(2-oxopropyl)piperidin-1-yl]-4-methylquinazolin-6-yl]prop-2-enamide
Show/Hide
|
C26H27ClN4O3
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2
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| 1 |
IC50 = 24 nM
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| 2 |
IC50 = 150 nM
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CP0389847
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N-[3-[[4-methyl-6-[[(E)-3-[4-(trifluoromethoxy)phenyl]prop-2-enoyl]amino]quinazolin-2-yl]amino]propyl]cyclopropanecarboxamide
Show/Hide
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C26H26F3N5O3
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2
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| 1 |
IC50 = 26 nM
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| 2 |
IC50 = 63 nM
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CP0482024
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(E)-N-[2-[4-(1,1-dioxo-1,2,5-thiadiazolidin-2-yl)piperidin-1-yl]-4-methylquinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
|
C26H27F3N6O4S
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2
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| 1 |
IC50 = 26 nM
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| 2 |
IC50 = 145 nM
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CP0422079
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2-aminobenzimidazole-based compound, 14
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C22H23F3N4O2
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1
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| 1 |
IC50 = 27 nM
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CP0207449
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N-[2-(4-cyclobutyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C27H29F3N4O4
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2
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| 1 |
IC50 = 27 nM
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| 2 |
IC50 = 79 nM
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CP0400105
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(E)-3-(4-chlorophenyl)-N-[2-[4-[(2-hydroxyacetyl)amino]piperidin-1-yl]-4-methylquinazolin-6-yl]prop-2-enamide
Show/Hide
|
C25H26ClN5O3
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2
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| 1 |
IC50 = 27 nM
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| 2 |
IC50 = 41 nM
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CP0916472
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N-(3-(1-((5-(1-(4-fluorophenyl)-1H-benzo[d]imidazole-2-carbonyl)pyridin-2-yl)methyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
|
C33H30FN5O2
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1
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| 1 |
IC50 = 27 nM
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CP0378078
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(E)-N-[2-(4-Ethyl-piperazin-1-ylmethyl)-quinolin-6-yl]-3-(4-trifluoromethoxy-phenyl)-acrylamide
Show/Hide
|
C25H25F3N4O2
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2
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| 1 |
IC50 = 29 nM
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| 2 |
IC50 = 346 nM
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CP0521739
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(E)-N-(2-{[(2-Dimethylamino-ethyl)-methyl-amino]-methyl}-quinolin-6-yl)-3-(4-trifluoromethoxy-phenyl)-acrylamide
Show/Hide
|
C24H25F3N4O2
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2
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| 1 |
IC50 = 29 nM
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| 2 |
IC50 = 174 nM
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CP0531183
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4-(4-fluorobenzyloxy)-1-(3-(2-(pyrrolidin-1-yl)ethoxy)benzyl)pyridin-2(1H)-one
Show/Hide
|
C25H27FN2O3
|
1
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| 1 |
IC50 = 29 nM
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CP0493093
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N-[3-[1-[3-[[1-[(3-chlorophenyl)methyl]benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H34ClN5O
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1
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| 1 |
IC50 = 29 nM
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CP0491049
|
2-aminobenzimidazole-based compound, 15
Show/Hide
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C24H26F3N5O2
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1
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| 1 |
IC50 = 30 nM
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CP0502757
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4-(4-fluorobenzyloxy)-1-(3-(3-(pyrrolidin-1-yl)propoxy)benzyl)pyridin-2(1H)-one
Show/Hide
|
C26H29FN2O3
|
1
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| 1 |
IC50 = 30 nM
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CP0410799
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N-[2-[4-(cyclopropanecarbonyl)piperazin-1-yl]-4-methylquinazolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C26H26F3N5O4
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2
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| 1 |
IC50 = 30 nM
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| 2 |
IC50 = 49 nM
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CP0400107
|
(E)-N-[2-(3-hydroxypropylamino)-4-methylquinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
|
C22H21F3N4O3
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
IC50 = 36 nM
|
|
|
|
CP0526170
|
N-[4-methyl-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C27H30F3N5O3
|
2
|
| 1 |
IC50 = 31 nM
|
|
|
| 2 |
IC50 = 120 nM
|
|
|
|
CP0380958
|
(E)-N-[2-[4-(dimethylsulfamoylamino)piperidin-1-yl]-4-methylquinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
|
C26H29F3N6O4S
|
2
|
| 1 |
IC50 = 31 nM
|
|
|
| 2 |
IC50 = 105 nM
|
|
|
|
CP0389849
|
(E)-N-[4-methyl-2-[4-(2-oxo-1,3-oxazolidin-3-yl)piperidin-1-yl]quinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
|
C27H26F3N5O4
|
2
|
| 1 |
IC50 = 31 nM
|
|
|
| 2 |
IC50 = 41 nM
|
|
|
|
CP0858978
|
(E)-N-(4-methyl-2-(4-(2-oxoimidazolidin-1-yl)piperidin-1-yl)quinazolin-6-yl)-3-(4-(trifluoromethoxy)phenyl)acrylamide
Show/Hide
|
C27H27F3N6O3
|
2
|
| 1 |
IC50 = 31 nM
|
|
|
| 2 |
IC50 = 66 nM
|
|
|
|
CP0389846
|
(E)-N-[2-[3-(methanesulfonamido)propylamino]-4-methylquinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
|
C23H24F3N5O4S
|
2
|
| 1 |
IC50 = 32 nM
|
|
|
| 2 |
IC50 = 54 nM
|
|
|
|
CP0410756
|
N-[2-(4-cyclopropyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C26H27F3N4O4
|
2
|
| 1 |
IC50 = 33 nM
|
|
|
| 2 |
IC50 = 101 nM
|
|
|
|
CP0474587
|
N-[4-methyl-2-[4-(2-methylpropanoyl)piperazin-1-yl]quinazolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C26H28F3N5O4
|
2
|
| 1 |
IC50 = 33 nM
|
|
|
| 2 |
IC50 = 36 nM
|
|
|
|
CP0531184
|
4-(4-fluorobenzyloxy)-1-(4-((propylamino)methyl)benzyloxy)pyridin-2(1H)-one
Show/Hide
|
C23H25FN2O3
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0397928
|
(E)-3-(4-chlorophenyl)-N-[2-[4-(methanesulfonamido)piperidin-1-yl]-4-methylquinazolin-6-yl]but-2-enamide
Show/Hide
|
C25H28ClN5O3S
|
2
|
| 1 |
IC50 = 34 nM
|
|
|
| 2 |
IC50 = 112 nM
|
|
|
|
CP0426691
|
(E)-N-[2-[4-[(2-methoxyacetyl)-methylamino]piperidin-1-yl]-4-methylquinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
|
C28H30F3N5O4
|
2
|
| 1 |
IC50 = 34 nM
|
|
|
| 2 |
IC50 = 45 nM
|
|
|
|
CP0898830
|
N-(3-(1-(4-(1-(4-chlorophenyl)-1H-benzo[d]imidazole-2-carbonyl)benzyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
|
C34H31ClN4O2
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0417122
|
N-[3-[1-[3-[[1-(4-methylphenyl)benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H35N5O
|
2
|
| 1 |
IC50 = 35 nM
|
|
|
| 2 |
IC50 = 85 nM
|
|
|
|
CP0519002
|
N-[3-[1-[3-[[1-[[4-(trifluoromethoxy)phenyl]methyl]benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C31H34F3N5O2
|
2
|
| 1 |
IC50 = 35 nM
|
|
|
| 2 |
IC50 = 85 nM
|
|
|
|
CP0408861
|
(E)-N-[2-[4-(2,5-dioxopyrrolidin-1-yl)piperidin-1-yl]-4-methylquinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
|
C28H26F3N5O4
|
2
|
| 1 |
IC50 = 35 nM
|
|
|
| 2 |
IC50 = 94 nM
|
|
|
|
CP0417123
|
N-[3-[1-[3-[[1-[(4-cyanophenyl)methyl]benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C31H34N6O
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0400104
|
(E)-N-[4-methyl-2-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]quinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]but-2-enamide
Show/Hide
|
C29H30F3N5O3
|
2
|
| 1 |
IC50 = 39 nM
|
|
|
| 2 |
IC50 = 69 nM
|
|
|
|
CP0397913
|
(E)-N-[2-(4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
|
C24H23F3N4O3
|
2
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
IC50 = 62 nM
|
|
|
|
CP0506555
|
2-aminobenzimidazole-based compound, 19
Show/Hide
|
C20H22F3N5O
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0408859
|
(E)-3-(4-chlorophenyl)-N-[4-methyl-2-[4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]quinazolin-6-yl]but-2-enamide
Show/Hide
|
C28H30ClN5O2
|
2
|
| 1 |
IC50 = 43 nM
|
|
|
| 2 |
IC50 = 81 nM
|
|
|
|
CP0508146
|
(E)-N-[4-methyl-2-(4-methylpiperazin-1-yl)quinolin-6-yl]-3-(4-methylphenyl)prop-2-enamide
Show/Hide
|
C25H28N4O
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0405585
|
N-[3-[1-[3-[[1-(3-chlorophenyl)benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C29H32ClN5O
|
2
|
| 1 |
IC50 = 45 nM
|
|
|
| 2 |
IC50 = 110 nM
|
|
|
|
CP0425655
|
2-(4-chlorophenoxy)-N-[4-methyl-2-[4-(oxan-4-yl)piperazin-1-yl]quinazolin-6-yl]acetamide
Show/Hide
|
C26H30ClN5O3
|
2
|
| 1 |
IC50 = 45 nM
|
|
|
| 2 |
IC50 = 115 nM
|
|
|
|
CP0408743
|
N-[2-[4-(cyclobutanecarbonyl)piperazin-1-yl]-4-methylquinazolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C27H28F3N5O4
|
2
|
| 1 |
IC50 = 45 nM
|
|
|
| 2 |
IC50 = 84 nM
|
|
|
|
CP0400076
|
N-[1-[6-[[(E)-3-(4-chlorophenyl)prop-2-enoyl]amino]-4-methylquinazolin-2-yl]piperidin-4-yl]cyclopropanecarboxamide
Show/Hide
|
C27H28ClN5O2
|
2
|
| 1 |
IC50 = 45 nM
|
|
|
| 2 |
IC50 = 225 nM
|
|
|
|
CP0881803
|
N-(3-(1-(2-fluoro-4-(1-(4-fluorophenyl)-1H-benzo[d]imidazole-2-carbonyl)benzyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
|
C34H30F2N4O2
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0446395
|
(E)-N-[2-(4-Ethyl-piperazin-1-ylmethyl)-3-methyl-quinolin-6-yl]-3-(4-trifluoromethoxy-phenyl)-acrylamide
Show/Hide
|
C26H27F3N4O2
|
2
|
| 1 |
IC50 = 50 nM
|
|
|
| 2 |
IC50 = 476 nM
|
|
|
|
CP0417121
|
N-[3-[1-[3-[[1-[(3-methoxyphenyl)methyl]benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C31H37N5O2
|
2
|
| 1 |
IC50 = 54 nM
|
|
|
| 2 |
IC50 = 180 nM
|
|
|
|
CP0463142
|
(E)-3-(4-chlorophenyl)-N-[2-(4-cyclobutyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]prop-2-enamide
Show/Hide
|
C27H29ClN4O2
|
2
|
| 1 |
IC50 = 54 nM
|
|
|
| 2 |
IC50 = 206 nM
|
|
|
|
CP0474626
|
N-[2-[4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl]-4-methylquinazolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C29H26F4N4O4
|
2
|
| 1 |
IC50 = 55 nM
|
|
|
| 2 |
IC50 = 150 nM
|
|
|
|
CP0857737
|
N-(3-(1-(4-(1-(tetrahydro-2H-pyran-4-yl)-1H-benzo[d]imidazole-2-carbonyl)benzyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
|
C33H36N4O3
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0497476
|
(E)-3-(4-Methoxy-phenyl)-N-(4-methyl-2-morpholin-4-yl-quinolin-6-yl)-acrylamide
Show/Hide
|
C24H25N3O3
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0408867
|
(E)-N-[2-[4-[(2-hydroxyacetyl)-methylamino]piperidin-1-yl]-4-methylquinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
|
C27H28F3N5O4
|
2
|
| 1 |
IC50 = 56 nM
|
|
|
| 2 |
IC50 = 91 nM
|
|
|
|
CP0389845
|
(E)-3-(4-chlorophenyl)-N-[2-[cyclopentyl(methyl)amino]-4-methylquinazolin-6-yl]prop-2-enamide
Show/Hide
|
C24H25ClN4O
|
2
|
| 1 |
IC50 = 57 nM
|
|
|
| 2 |
IC50 = 399 nM
|
|
|
|
CP0104797
|
2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piperazin-1-yl)-quinolin-6-yl]-acetamide
Show/Hide
|
C23H25ClN4O2
|
1
|
| 1 |
IC50 = 58 nM
|
|
|
|
CP0410763
|
N-[2-(4-ethyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C25H27F3N4O4
|
2
|
| 1 |
IC50 = 59 nM
|
|
|
| 2 |
IC50 = 116 nM
|
|
|
|
CP0426940
|
N-[2-[4-(5-fluoropyridin-2-yl)-4-hydroxypiperidin-1-yl]-4-methylquinazolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C28H25F4N5O4
|
2
|
| 1 |
IC50 = 59 nM
|
|
|
| 2 |
IC50 = 213 nM
|
|
|
|
CP0408855
|
(E)-N-[2-(4-cyclopropyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]-3-(4-methoxyphenyl)prop-2-enamide
Show/Hide
|
C27H30N4O3
|
2
|
| 1 |
IC50 = 59 nM
|
|
|
| 2 |
IC50 = 116 nM
|
|
|
|
CP0397916
|
(E)-N-[2-(4-cyclopropyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]-3-[4-(difluoromethyl)phenyl]prop-2-enamide
Show/Hide
|
C27H28F2N4O2
|
2
|
| 1 |
IC50 = 62 nM
|
|
|
| 2 |
IC50 = 122 nM
|
|
|
|
CP0380965
|
(E)-N-[2-(4-cyclopropyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]-3-[4-(difluoromethoxy)phenyl]prop-2-enamide
Show/Hide
|
C27H28F2N4O3
|
2
|
| 1 |
IC50 = 63 nM
|
|
|
| 2 |
IC50 = 201 nM
|
|
|
|
CP0406848
|
5-chloro-N-[4-(2,5-dimethylbenzimidazol-1-yl)cyclohexyl]-2,3-dihydro-1H-inden-2-amine
Show/Hide
|
C24H28ClN3
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0475643
|
N-[2-(4-hydroxy-4-phenylpiperidin-1-yl)-4-methylquinazolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C29H27F3N4O4
|
2
|
| 1 |
IC50 = 67 nM
|
|
|
| 2 |
IC50 = 354 nM
|
|
|
|
CP0417120
|
N-[3-[1-[3-[[1-(4-methoxyphenyl)benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H35N5O2
|
2
|
| 1 |
IC50 = 68 nM
|
|
|
| 2 |
IC50 = 110 nM
|
|
|
|
CP0389843
|
(E)-3-(4-chlorophenyl)-N-[2-(4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]prop-2-enamide
Show/Hide
|
C23H23ClN4O2
|
2
|
| 1 |
IC50 = 73 nM
|
|
|
| 2 |
IC50 = 107 nM
|
|
|
|
CP0397915
|
(E)-N-[2-(4-cyclopropyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
|
C27H27F3N4O3
|
2
|
| 1 |
IC50 = 74 nM
|
|
|
| 2 |
IC50 = 208 nM
|
|
|
|
CP0446445
|
2-(2,4-Dichloro-phenoxy)-N-(4-methyl-2-piperidin-1-yl-quinolin-6-yl)-acetamide
Show/Hide
|
C23H23Cl2N3O2
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0400079
|
(E)-N-[2-(4-cyclopropyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]-3-[4-(trifluoromethyl)phenyl]prop-2-enamide
Show/Hide
|
C27H27F3N4O2
|
2
|
| 1 |
IC50 = 83 nM
|
|
|
| 2 |
IC50 = 232 nM
|
|
|
|
CP0192469
|
2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-ethoxy)-4-methyl-quinolin-6-yl]-acetamide
Show/Hide
|
C22H23Cl2N3O3
|
3
|
| 1 |
IC50 = 85 nM
|
|
|
| 2 |
IC50 = 180 nM
|
|
|
| 3 |
IC50 = 1480 nM
|
|
|
|
CP0400081
|
(E)-3-(4-chlorophenyl)-N-[2-(4-hydroxy-4-phenylpiperidin-1-yl)-4-methylquinazolin-6-yl]prop-2-enamide
Show/Hide
|
C29H27ClN4O2
|
2
|
| 1 |
IC50 = 86 nM
|
|
|
| 2 |
IC50 = 1095 nM
|
|
|
|
CP0487902
|
N-[3-[4-[3-(ethylamino)phenyl]piperidin-1-yl]propyl]-1-(4-fluorophenyl)benzimidazol-2-amine
Show/Hide
|
C29H34FN5
|
2
|
| 1 |
IC50 = 87 nM
|
|
|
| 2 |
IC50 = 970 nM
|
|
|
|
CP0471626
|
N-[3-[1-[3-[1-(4-fluorophenyl)benzimidazol-2-yl]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C29H31FN4O
|
2
|
| 1 |
IC50 = 88 nM
|
|
|
| 2 |
IC50 = 280 nM
|
|
|
|
CP0504052
|
N-[3-[1-[3-[[1-[[3-(trifluoromethoxy)phenyl]methyl]benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C31H34F3N5O2
|
2
|
| 1 |
IC50 = 88 nM
|
|
|
| 2 |
IC50 = 110 nM
|
|
|
|
CP0408856
|
(E)-3-(4-chlorophenyl)-N-[2-(4-hydroxy-4-propan-2-ylpiperidin-1-yl)-4-methylquinazolin-6-yl]prop-2-enamide
Show/Hide
|
C26H29ClN4O2
|
2
|
| 1 |
IC50 = 89 nM
|
|
|
| 2 |
IC50 = 171 nM
|
|
|
|
CP0410798
|
2-(4-chlorophenoxy)-N-[4-methyl-2-[4-(2-methylpropanoyl)piperazin-1-yl]quinazolin-6-yl]acetamide
Show/Hide
|
C25H28ClN5O3
|
2
|
| 1 |
IC50 = 91 nM
|
|
|
| 2 |
IC50 = 225 nM
|
|
|
|
CP0566679
|
(E)-3-(4-chlorophenyl)-N-[2-(4-hydroxy-4-propylpiperidin-1-yl)-4-methylquinazolin-6-yl]prop-2-enamide
Show/Hide
|
C26H29ClN4O2
|
2
|
| 1 |
IC50 = 91 nM
|
|
|
| 2 |
IC50 = 245 nM
|
|
|
|
CP0471617
|
N-[3-[1-[3-[[1-[[3-(trifluoromethyl)phenyl]methyl]benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C31H34F3N5O
|
2
|
| 1 |
IC50 = 93 nM
|
|
|
| 2 |
IC50 = 150 nM
|
|
|
|
CP0515925
|
(E)-N-[2-(4-Ethyl-piperazin-1-yl)-4-methyl-quinolin-6-yl]-3-(4-isopropoxy-phenyl)-acrylamide
Show/Hide
|
C28H34N4O2
|
1
|
| 1 |
IC50 = 95 nM
|
|
|
|
CP0410764
|
2-(4-chlorophenoxy)-N-[2-(4-cyclopentylpiperazin-1-yl)-4-methylquinazolin-6-yl]acetamide
Show/Hide
|
C26H30ClN5O2
|
2
|
| 1 |
IC50 = 96 nM
|
|
|
| 2 |
IC50 = 150 nM
|
|
|
|
CP0508152
|
(E)-N-[2-((3S,5R)-3,5-Dimethyl-piperazin-1-yl)-4-methyl-quinolin-6-yl]-3-(4-trifluoromethoxy-phenyl)-acrylamide
Show/Hide
|
C26H27F3N4O2
|
3
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
IC50 = 409 nM
|
|
|
| 3 |
IC50 = 1160 nM
|
|
|
|
CP0408691
|
N-[2-[4-(3-fluorophenyl)-4-hydroxypiperidin-1-yl]-4-methylquinazolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
Show/Hide
|
C29H26F4N4O4
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
IC50 = 635 nM
|
|
|
|
CP0487858
|
1-(4-fluorophenyl)-2-(4-(4-(2-methyl-1H-benzo[d]imidazol-6-yl)piperidin-1-yl)butyl)-1H-benzo[d]imidazole
Show/Hide
|
C30H32FN5
|
1
|
| 1 |
IC50 = 106 nM
|
|
|
|
CP0430757
|
(E)-N-[2-(4-cyclopropyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]-3-(4-methylphenyl)prop-2-enamide
Show/Hide
|
C27H30N4O2
|
2
|
| 1 |
IC50 = 107 nM
|
|
|
| 2 |
IC50 = 344 nM
|
|
|
|
CP0487855
|
3-(1-(3-(1-(4-chlorophenyl)-1H-benzo[d]imidazol-2-ylamino)propyl)piperidin-4-yl)phenol
Show/Hide
|
C27H29ClN4O
|
2
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
IC50 = 1435 nM
|
|
|
|
CP0485037
|
(E)-N-(2-{[(2-Dimethylamino-ethyl)-methyl-amino]-methyl}-3-methyl-quinolin-6-yl)-3-(4-trifluoromethoxy-phenyl)-acrylamide
Show/Hide
|
C25H27F3N4O2
|
2
|
| 1 |
IC50 = 111 nM
|
|
|
| 2 |
IC50 = 1050 nM
|
|
|
|
CP0487857
|
N-[3-[4-[3-[[1-(4-chlorophenyl)benzimidazol-2-yl]amino]propyl]piperazin-1-yl]phenyl]acetamide
Show/Hide
|
C28H31ClN6O
|
2
|
| 1 |
IC50 = 112 nM
|
|
|
| 2 |
IC50 = 648 nM
|
|
|
|
CP0342335
|
4-Butyl-N-[2-(4-ethyl-piperazin-1-yl)-4-methyl-quinolin-6-yl]-benzamide
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C27H34N4O
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1
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| 1 |
IC50 = 114 nM
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CP0385676
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2-(4-chlorophenoxy)-N-[2-[4-(cyclohexanecarbonyl)piperazin-1-yl]-4-methylquinazolin-6-yl]acetamide
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C28H32ClN5O3
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2
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| 1 |
IC50 = 116 nM
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| 2 |
IC50 = 1035 nM
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CP0387612
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2-aminobenzimidazole-based compound, 17
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C25H29F3N4O
|
1
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| 1 |
IC50 = 135 nM
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CP0857738
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N-(3-(1-(4-(1-isopropyl-1H-benzo[d]imidazole-2-carbonyl)benzyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
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C31H34N4O2
|
1
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| 1 |
IC50 = 138 nM
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CP0493092
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N-[3-[1-[3-[[1-[(3-cyanophenyl)methyl]benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
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C31H34N6O
|
1
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| 1 |
IC50 = 140 nM
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CP0474627
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2-(4-chlorophenoxy)-N-[4-methyl-2-[4-(3-methylbutanoyl)piperazin-1-yl]quinazolin-6-yl]acetamide
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C26H30ClN5O3
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2
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| 1 |
IC50 = 141 nM
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| 2 |
IC50 = 160 nM
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CP0408872
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(E)-N-[2-[2-(methanesulfonamido)ethylamino]-4-methylquinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
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C22H22F3N5O4S
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2
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| 1 |
IC50 = 142 nM
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| 2 |
IC50 = 169 nM
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CP0513878
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2-(4-chlorophenoxy)-N-[2-[4-(cyclopropanecarbonyl)piperazin-1-yl]-4-methylquinazolin-6-yl]acetamide
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C25H26ClN5O3
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2
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| 1 |
IC50 = 146 nM
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| 2 |
IC50 = 251 nM
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CP0425657
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2-(4-chlorophenoxy)-N-[2-(4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]acetamide
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C22H23ClN4O3
|
2
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| 1 |
IC50 = 150 nM
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| 2 |
IC50 = 163 nM
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CP0517545
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N-[2-(4-aminopiperidin-1-yl)-4-methylquinazolin-6-yl]-2-(4-chlorophenoxy)acetamide
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C22H24ClN5O2
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2
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| 1 |
IC50 = 150 nM
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| 2 |
IC50 = 610 nM
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CP0947853
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N-(3-(1-(1-(4-(1-(4-fluorophenyl)-1H-benzo[d]imidazole-2-carbonyl)phenyl)ethyl)piperidin-4-yl)phenyl)acetamide
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C35H33FN4O2
|
1
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| 1 |
IC50 = 150 nM
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CP0446447
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(E)-N-(2-{[(2-Dimethylamino-ethyl)-methyl-amino]-methyl}-4-ethyl-quinolin-6-yl)-3-(4-trifluoromethoxy-phenyl)-acrylamide
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C26H29F3N4O2
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2
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| 1 |
IC50 = 151 nM
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| 2 |
IC50 = 241 nM
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CP0408842
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N-[2-(4-cyclohexyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]-2-[4-(trifluoromethoxy)phenoxy]acetamide
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C29H33F3N4O4
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2
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| 1 |
IC50 = 156 nM
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| 2 |
IC50 = 327 nM
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CP0485038
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(E)-N-[2-(2-Dimethylamino-ethoxy)-4-methyl-quinolin-6-yl]-3-(4-trifluoromethoxy-phenyl)-acrylamide
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C24H24F3N3O3
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2
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| 1 |
IC50 = 158 nM
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| 2 |
IC50 = 416 nM
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CP0425656
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2-(4-chlorophenoxy)-N-[2-[4-(cyclobutanecarbonyl)piperazin-1-yl]-4-methylquinazolin-6-yl]acetamide
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C26H28ClN5O3
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2
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| 1 |
IC50 = 158 nM
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| 2 |
IC50 = 325 nM
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CP0397926
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(E)-N-[4-methyl-2-[4-(5-methyl-1,1-dioxo-1,2,5-thiadiazolidin-2-yl)piperidin-1-yl]quinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
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C27H29F3N6O4S
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2
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| 1 |
IC50 = 170 nM
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| 2 |
IC50 = 280 nM
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CP0857736
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N-(3-(1-(4-(1-(4-cyanophenyl)-1H-benzo[d]imidazole-2-carbonyl)benzyl)piperidin-4-yl)phenyl)acetamide
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C35H31N5O2
|
1
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| 1 |
IC50 = 172 nM
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CP0426983
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2-(4-chlorophenoxy)-N-(4-methyl-2-piperidin-1-ylquinazolin-6-yl)acetamide
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C22H23ClN4O2
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2
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| 1 |
IC50 = 180 nM
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| 2 |
IC50 = 305 nM
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CP0426985
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2-(4-chlorophenoxy)-N-[2-(4-methoxypiperidin-1-yl)-4-methylquinazolin-6-yl]acetamide
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C23H25ClN4O3
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2
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| 1 |
IC50 = 181 nM
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| 2 |
IC50 = 213 nM
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CP0397918
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(E)-3-(4-chlorophenyl)-N-[2-(2-hydroxyethylamino)-4-methylquinazolin-6-yl]prop-2-enamide
Show/Hide
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C20H19ClN4O2
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2
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| 1 |
IC50 = 182 nM
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| 2 |
IC50 = 555 nM
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CP0925608
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N-(3-(1-(2-chloro-4-(1-(4-fluorophenyl)-1H-benzo[d]imidazole-2-carbonyl)benzyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
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C34H30ClFN4O2
|
1
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| 1 |
IC50 = 184 nM
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CP0463141
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(E)-N-[2-(4-cyclopropyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]but-2-enamide
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C28H29F3N4O3
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2
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| 1 |
IC50 = 196 nM
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| 2 |
IC50 = 354 nM
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CP0474654
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2-(4-chlorophenoxy)-N-[2-(4-ethyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]acetamide
Show/Hide
|
C24H27ClN4O3
|
2
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| 1 |
IC50 = 208 nM
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| 2 |
IC50 = 384 nM
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CP0517544
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2-(4-chlorophenoxy)-N-[2-[4-(2-methoxyacetyl)piperazin-1-yl]-4-methylquinazolin-6-yl]acetamide
Show/Hide
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C24H26ClN5O4
|
2
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| 1 |
IC50 = 215 nM
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| 2 |
IC50 = 295 nM
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CP0425654
|
2-(4-chlorophenoxy)-N-[4-methyl-2-(4-methylpiperazin-1-yl)quinazolin-6-yl]acetamide
Show/Hide
|
C22H24ClN5O2
|
2
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| 1 |
IC50 = 220 nM
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| 2 |
IC50 = 3800 nM
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CP0400082
|
(E)-3-(4-chlorophenyl)-N-[2-[4-hydroxy-4-(2-hydroxyethyl)piperidin-1-yl]-4-methylquinazolin-6-yl]prop-2-enamide
Show/Hide
|
C25H27ClN4O3
|
2
|
| 1 |
IC50 = 220 nM
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| 2 |
IC50 = 230 nM
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CP0400073
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(E)-3-(4-chlorophenyl)-N-[2-[4-hydroxy-4-(2-methoxyethyl)piperidin-1-yl]-4-methylquinazolin-6-yl]prop-2-enamide
Show/Hide
|
C26H29ClN4O3
|
2
|
| 1 |
IC50 = 220 nM
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| 2 |
IC50 = 245 nM
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CP0378077
|
N-(4-fluorophenyl)-N'-[4-methyl-2-(4-methylpiperazin-1-yl)quinolin-6-yl]butanediamide
Show/Hide
|
C25H28FN5O2
|
1
|
| 1 |
IC50 = 224 nM
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CP0380964
|
(E)-3-(4-chlorophenyl)-N-[2-(4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]but-2-enamide
Show/Hide
|
C24H25ClN4O2
|
2
|
| 1 |
IC50 = 227 nM
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| 2 |
IC50 = 670 nM
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CP0501347
|
(1R,3S)-N-[[(2S)-5-bromo-2,3-dihydro-1H-inden-2-yl]methyl]-3-(2,5-dimethylbenzimidazol-1-yl)cyclopentan-1-amine
Show/Hide
|
C24H28BrN3
|
1
|
| 1 |
IC50 = 230 nM
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CP0426938
|
2-(4-chlorophenoxy)-N-[2-(4-hydroxy-4-methylpiperidin-1-yl)-4-methylquinazolin-6-yl]acetamide
Show/Hide
|
C23H25ClN4O3
|
2
|
| 1 |
IC50 = 237 nM
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| 2 |
IC50 = 827 nM
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CP0408742
|
2-(4-chlorophenoxy)-N-[2-[4-(2,2-dimethylpropyl)piperazin-1-yl]-4-methylquinazolin-6-yl]acetamide
Show/Hide
|
C26H32ClN5O2
|
2
|
| 1 |
IC50 = 246 nM
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| 2 |
IC50 = 782 nM
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CP0409387
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N-[2-(4-ethylpiperazin-1-yl)-4-methylquinolin-6-yl]-3-(4-methoxyphenyl)propanamide
Show/Hide
|
C26H32N4O2
|
1
|
| 1 |
IC50 = 251 nM
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CP0397920
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(E)-N-[2-[3-hydroxypropyl(propan-2-yl)amino]-4-methylquinazolin-6-yl]-3-[4-(trifluoromethoxy)phenyl]prop-2-enamide
Show/Hide
|
C25H27F3N4O3
|
2
|
| 1 |
IC50 = 255 nM
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| 2 |
IC50 = 290 nM
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CP0537606
|
(E)-3-(4-chlorophenyl)-N-[2-(4-ethyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]prop-2-enamide
Show/Hide
|
C25H27ClN4O2
|
2
|
| 1 |
IC50 = 255 nM
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| 2 |
IC50 = 270 nM
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CP0343075
|
2-(4-chlorophenoxy)-N-[4-methyl-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-6-yl]propanamide
Show/Hide
|
C27H32ClN5O2
|
2
|
| 1 |
IC50 = 258 nM
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| 2 |
IC50 = 401 nM
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CP0497197
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1-(4-chlorophenyl)-N-(3-(4-(3-fluorophenyl)piperidin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine
Show/Hide
|
C27H28ClFN4
|
2
|
| 1 |
IC50 = 261 nM
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| 2 |
IC50 = 6320 nM
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CP0487859
|
N-[3-[1-[3-[[1-(4-methylsulfonylphenyl)benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H35N5O3S
|
2
|
| 1 |
IC50 = 269 nM
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| 2 |
IC50 = 798 nM
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CP0474586
|
2-(4-chlorophenoxy)-N-[2-(4-cyclopropylpiperazin-1-yl)-4-methylquinazolin-6-yl]acetamide
Show/Hide
|
C24H26ClN5O2
|
2
|
| 1 |
IC50 = 270 nM
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| 2 |
IC50 = 350 nM
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CP0884559
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N-(3-(1-(4-(1-cyclopropyl-1H-benzo[d]imidazole-2-carbonyl)benzyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
|
C31H32N4O2
|
1
|
| 1 |
IC50 = 271 nM
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CP0859265
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N-(3-(1-(4-(1-methyl-1H-benzo[d]imidazole-2-carbonyl)benzyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
|
C29H30N4O2
|
1
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| 1 |
IC50 = 289 nM
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CP0494659
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(E)-N-[2-(4-Ethyl-piperazin-1-ylmethyl)-4-methyl-quinolin-6-yl]-N-methyl-3-(4-trifluoromethoxy-phenyl)-acrylamide
Show/Hide
|
C26H29F3N4O2
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2
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| 1 |
IC50 = 302 nM
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| 2 |
IC50 = 1086 nM
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CP0527483
|
2-(4-chlorophenoxy)-N-[2-[4-(cyclopentanecarbonyl)piperazin-1-yl]-4-methylquinazolin-6-yl]acetamide
Show/Hide
|
C27H30ClN5O3
|
2
|
| 1 |
IC50 = 305 nM
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| 2 |
IC50 = 350 nM
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CP0493091
|
N-[3-[1-[3-[[1-[(4-tert-butylphenyl)methyl]benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C34H43N5O
|
2
|
| 1 |
IC50 = 320 nM
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| 2 |
IC50 = 600 nM
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CP0497475
|
N'-(3-chloro-4-fluorophenyl)-N-[2-(4-ethylpiperazin-1-yl)-4-methylquinolin-6-yl]butanediamide
Show/Hide
|
C26H29ClFN5O2
|
1
|
| 1 |
IC50 = 327 nM
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CP0493096
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N-[3-[1-[2-[1-(4-fluorophenyl)benzimidazol-2-yl]ethyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C28H29FN4O
|
2
|
| 1 |
IC50 = 336 nM
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| 2 |
IC50 = 1467 nM
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CP0400078
|
(E)-3-(4-chlorophenyl)-N-[2-(4-cyclopropyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]but-2-enamide
Show/Hide
|
C27H29ClN4O2
|
2
|
| 1 |
IC50 = 340 nM
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| 2 |
IC50 = 532 nM
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CP0407020
|
N-(2,3-dihydro-1H-inden-2-ylmethyl)-4-(2,5-dimethylbenzimidazol-1-yl)cyclohexan-1-amine
Show/Hide
|
C25H31N3
|
1
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| 1 |
IC50 = 340 nM
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CP0395613
|
(2S)-2-[[[4-[2-(2-hydroxypropan-2-yl)-5-methylbenzimidazol-1-yl]cyclohexyl]amino]methyl]-2,3-dihydro-1H-indene-5-carbonitrile
Show/Hide
|
C28H34N4O
|
1
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| 1 |
IC50 = 360 nM
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CP0450931
|
aminonaphthyridine-based compound, 36
Show/Hide
|
C22H23F3N4O
|
1
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| 1 |
IC50 = 365 nM
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CP0387613
|
aminonaphthyridine-based compound, 31
Show/Hide
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C22H23F3N4O
|
1
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| 1 |
IC50 = 375 nM
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CP0496464
|
2-aminobenzimidazole-based compound, 18
Show/Hide
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C21H21F3N4O2
|
1
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| 1 |
IC50 = 428 nM
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CP0543697
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(E)-3-[4-(3-Methyl-butoxy)-phenyl]-N-[4-methyl-2-(4-methyl-piperazin-1-yl)-quinolin-6-yl]-acrylamide
Show/Hide
|
C29H36N4O2
|
1
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| 1 |
IC50 = 438 nM
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CP0515776
|
1-[2-(4-Ethyl-piperazin-1-yl)-4-methyl-quinolin-6-yl]-3-(4-methoxy-benzyl)-urea
Show/Hide
|
C25H31N5O2
|
1
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| 1 |
IC50 = 442 nM
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CP0456112
|
(1S,3S)-N-[[(2S)-5-bromo-2,3-dihydro-1H-inden-2-yl]methyl]-3-(2,5-dimethylbenzimidazol-1-yl)cyclopentan-1-amine
Show/Hide
|
C24H28BrN3
|
1
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| 1 |
IC50 = 470 nM
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CP0507562
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1-(4-chlorophenyl)-N-(3-(4-(3-(trifluoromethoxy)phenyl)piperidin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine
Show/Hide
|
C28H28ClF3N4O
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2
|
| 1 |
IC50 = 528 nM
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| 2 |
IC50 = 7579 nM
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CP0456111
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4-(2,5-dimethylbenzimidazol-1-yl)-N-[[5-(trifluoromethyl)-2,3-dihydro-1H-inden-2-yl]methyl]cyclohexan-1-amine
Show/Hide
|
C26H30F3N3
|
1
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| 1 |
IC50 = 560 nM
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CP0471627
|
ethyl 4-[1-[4-[1-(4-fluorophenyl)benzimidazol-2-yl]butyl]piperidin-4-yl]-2-hydroxybenzoate
Show/Hide
|
C31H34FN3O3
|
1
|
| 1 |
IC50 = 566 nM
|
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CP0389844
|
(E)-N-[2-(4-cyclopropyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]-3-(2,4-dichlorophenyl)prop-2-enamide
Show/Hide
|
C26H26Cl2N4O2
|
2
|
| 1 |
IC50 = 575 nM
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| 2 |
IC50 = 620 nM
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CP0475642
|
4-hydroxy-1-[4-methyl-6-[[2-[4-(trifluoromethoxy)phenoxy]acetyl]amino]quinazolin-2-yl]piperidine-4-carboxamide
Show/Hide
|
C24H24F3N5O5
|
1
|
| 1 |
IC50 = 636 nM
|
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CP0417124
|
N-[3-[4-[3-[[1-(4-fluorophenyl)benzimidazol-2-yl]amino]propyl]piperazin-1-yl]phenyl]acetamide
Show/Hide
|
C28H31FN6O
|
2
|
| 1 |
IC50 = 646 nM
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|
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| 2 |
IC50 = 3002 nM
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CP0880712
|
N-(3-(1-(2-cyano-4-(1-(4-fluorophenyl)-1H-benzo[d]imidazole-2-carbonyl)benzyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
|
C35H30FN5O2
|
1
|
| 1 |
IC50 = 651 nM
|
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CP0519006
|
N-[2-[4-(3-acetamidophenyl)piperidin-1-yl]ethyl]-1-(4-fluorophenyl)benzimidazole-2-carboxamide
Show/Hide
|
C29H30FN5O2
|
2
|
| 1 |
IC50 = 678 nM
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|
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| 2 |
IC50 = 973 nM
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CP0474585
|
2-(4-chlorophenoxy)-N-[2-(4-ethylpiperazin-1-yl)-4-methylquinazolin-6-yl]acetamide
Show/Hide
|
C23H26ClN5O2
|
1
|
| 1 |
IC50 = 690 nM
|
|
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CP0463143
|
(E)-3-(4-chlorophenyl)-N-[2-[cyclopentyl(2-hydroxyethyl)amino]-4-methylquinazolin-6-yl]prop-2-enamide
Show/Hide
|
C25H27ClN4O2
|
2
|
| 1 |
IC50 = 850 nM
|
|
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| 2 |
IC50 = 4125 nM
|
|
|
|
CP0506013
|
2-aminobenzimidazole-based compound, 23
Show/Hide
|
C23H22FN5O
|
1
|
| 1 |
IC50 = 900 nM
|
|
|
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CP0857735
|
N-(3-(1-(4-(1-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-2-carbonyl)benzyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
|
C35H31F3N4O2
|
1
|
| 1 |
IC50 = 1004 nM
|
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CP0469458
|
2-[1-[4-[(5-fluoro-2,3-dihydro-1H-inden-2-yl)methylamino]cyclohexyl]-5-methylbenzimidazol-2-yl]propan-2-ol
Show/Hide
|
C27H34FN3O
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
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CP0504055
|
N-[3-[1-[4-[1-(4-fluorophenyl)benzimidazol-2-yl]butanoyl]piperidin-4-yl]phenyl]acetamide
Show/Hide
|
C30H31FN4O2
|
2
|
| 1 |
IC50 = 1450 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
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CP0461244
|
(E)-N-[2-(4-cyclopropyl-4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]-3-(4-pyrrolidin-1-ylphenyl)prop-2-enamide
Show/Hide
|
C30H35N5O2
|
2
|
| 1 |
IC50 = 1450 nM
|
|
|
| 2 |
IC50 = 1800 nM
|
|
|
|
CP0519005
|
N-[3-[1-[3-[[1-(4-chlorophenyl)benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]-N-methylacetamide
Show/Hide
|
C30H34ClN5O
|
2
|
| 1 |
IC50 = 1620 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0559662
|
(E)-3-(3-Chloro-phenyl)-N-[4-methyl-2-(4-methyl-piperazin-1-yl)-quinolin-6-yl]-acrylamide
Show/Hide
|
C24H25ClN4O
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0494449
|
5-chloro-N-[4-(2,5-dimethylbenzimidazol-1-yl)cyclohexyl]-2,3-dihydro-1H-inden-2-amine
Show/Hide
|
C24H28ClN3
|
1
|
| 1 |
IC50 = 2610 nM
|
|
|
|
CP0243999
|
5-Chloro-N-[2-(4-ethyl-piperazin-1-yl)-4-methyl-quinolin-6-yl]-2-methoxy-benzamide
Show/Hide
|
C24H27ClN4O2
|
1
|
| 1 |
IC50 = 2630 nM
|
|
|
|
CP0947420
|
N-(3-(1-(4-(1-(4-fluorophenyl)-1H-benzo[d]imidazole-2-carbonyl)-2-(trifluoromethyl)benzyl)piperidin-4-yl)phenyl)acetamide
Show/Hide
|
C35H30F4N4O2
|
1
|
| 1 |
IC50 = 3250 nM
|
|
|
|
CP0446448
|
(E)-N-(3,4-Difluoro-benzyl)-N-{2-[(2-dimethylamino-ethyl)-methyl-amino]-4-methyl-quinolin-6-yl}-3-(4-trifluoromethoxy-phenyl)-acrylamide
Show/Hide
|
C32H31F5N4O2
|
2
|
| 1 |
IC50 = 5360 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0525980
|
N-[2-(4-benzoylpiperazin-1-yl)-4-methylquinazolin-6-yl]-2-(4-chlorophenoxy)acetamide
Show/Hide
|
C28H26ClN5O3
|
2
|
| 1 |
IC50 = 7300 nM
|
|
|
| 2 |
IC50 > 10000 nM
|
|
|
|
CP0475644
|
2-(4-chlorophenoxy)-N-[4-methyl-2-(4-methylsulfonylpiperazin-1-yl)quinazolin-6-yl]acetamide
Show/Hide
|
C22H24ClN5O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0475645
|
2-(4-chlorophenoxy)-2-methyl-N-[4-methyl-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-6-yl]propanamide
Show/Hide
|
C28H34ClN5O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0548286
|
2-(4-chlorophenoxy)-N-[2-(4-hydroxypiperidin-1-yl)-4-methylquinazolin-6-yl]-2-methylpropanamide
Show/Hide
|
C24H27ClN4O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0515924
|
2-Thiophen-2-yl-quinoline-4-carboxylic acid [2-(4-ethyl-piperazin-1-yl)-4-methyl-quinolin-6-yl]-amide
Show/Hide
|
C30H29N5OS
|
1
|
| 1 |
IC50 = 24800 nM
|
|
|
|
CP0400855
|
aminobenzothiazole-based compound, 39
Show/Hide
|
C21H22F3N3OS
|
1
|
| 1 |
IC50 > 750 nM
|
|
|
|
CP0419120
|
4-(4-fluorobenzyloxy)-1-(4-(pyrrolidin-1-yl)phenethyl)pyridin-2(1H)-one
Show/Hide
|
C24H25FN2O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0500051
|
4-(4-fluorobenzyloxy)-1-(4-(pyrrolidin-1-ylmethyl)phenyl)pyridin-2(1H)-one
Show/Hide
|
C23H23FN2O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0535229
|
4-(4-fluorobenzyloxy)-1-(3-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyridin-2(1H)-one
Show/Hide
|
C24H25FN2O3
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0785079
|
1-(5-(4-cyanophenyl)bicyclo[3.1.0]hexan-2-yl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)-1-(3-(4-methylpiperazin-1-yl)propyl)urea
Show/Hide
|
C29H33F4N5O
|
1
|
| 1 |
Ki = 1.2 nM
|
|
|
|
CP0446890
|
1-(5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)-4-(4-(methylthio)phenyl)pyridin-2(1H)-one
Show/Hide
|
C24H23N3OS
|
1
|
| 1 |
Ki = 2.4 nM
|
|
|
|
CP0514488
|
4-(4-methoxyphenyl)-1-(5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C24H23N3O2
|
1
|
| 1 |
Ki = 2.6 nM
|
|
|
|
CP0528709
|
4-(4-chlorophenyl)-1-(5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C23H20ClN3O
|
1
|
| 1 |
Ki = 2.7 nM
|
|
|
|
CP0124792
|
6-(4-chlorophenyl)-3-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)thieno[3,2-d]pyrimidin-4(3H)-one
Show/Hide
|
C25H24ClN3O3S
|
1
|
| 1 |
Ki = 2.8 nM
|
|
|
|
CP0504564
|
4-(2-chloro-4-methoxyphenyl)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C25H25ClN4O2
|
1
|
| 1 |
Ki = 2.8 nM
|
|
|
|
CP0479138
|
(R)-4-(benzyloxy)-1-(1-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C26H28N4O3
|
1
|
| 1 |
Ki = 3.1 nM
|
|
|
|
CP0124791
|
4-(2,4-dichlorophenyl)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C24H22Cl2N4O
|
1
|
| 1 |
Ki = 3.4 nM
|
|
|
|
CP0531359
|
4-(benzyloxy)-1-(2-(2-hydroxyethyl)-5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C26H27N3O3
|
1
|
| 1 |
Ki = 3.6 nM
|
|
|
|
CP0231904
|
4-(benzyloxy)-1-(2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C23H21N3O2
|
1
|
| 1 |
Ki = 3.8 nM
|
|
|
|
CP0521421
|
4-(2-methyl-4-(trifluoromethoxy)phenyl)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C26H25F3N4O2
|
1
|
| 1 |
Ki = 3.9 nM
|
|
|
|
CP0454525
|
1-(5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)-4-(4-(trifluoromethyl)phenyl)pyridin-2(1H)-one
Show/Hide
|
C24H20F3N3O
|
1
|
| 1 |
Ki = 4.2 nM
|
|
|
|
CP0521982
|
4-(4-chlorobenzyloxy)-1-(5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C24H22ClN3O2
|
1
|
| 1 |
Ki = 4.2 nM
|
|
|
|
CP0533441
|
2-(4-chloro-2-fluorophenyl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)furo[3,2-c]pyridin-4(5H)-one
Show/Hide
|
C26H22ClFN4O2
|
1
|
| 1 |
Ki = 4.2 nM
|
|
|
|
CP0231903
|
4-(benzyloxy)-1-(2,5-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C25H25N3O2
|
1
|
| 1 |
Ki = 4.5 nM
|
|
|
|
CP0556432
|
US8637501, 64
Show/Hide
|
C25H29ClN4O
|
1
|
| 1 |
Ki = 4.6 nM
|
|
|
|
CP0159424
|
(S)-4-(benzyloxy)-1-(1-(2-(3-hydroxypyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C25H26N4O3
|
1
|
| 1 |
Ki = 4.7 nM
|
|
|
|
CP0447605
|
4-(benzyloxy)-1-(1-(2-(dimethylamino)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C23H24N4O2
|
1
|
| 1 |
Ki = 4.7 nM
|
|
|
|
CP0524430
|
US8637501, 21
Show/Hide
|
C25H25N3O2
|
1
|
| 1 |
Ki = 4.7 nM
|
|
|
|
CP0561064
|
US8637501, 23
Show/Hide
|
C24H21F3N4O
|
1
|
| 1 |
Ki = 4.7 nM
|
|
|
|
CP0960022
|
US8993765, 10
Show/Hide
|
C23H19F3N4O
|
1
|
| 1 |
Ki = 4.7 nM
|
|
|
|
CP0159425
|
4-(benzyloxy)-1-(9-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C24H23N3O2
|
1
|
| 1 |
Ki = 4.9 nM
|
|
|
|
CP0556422
|
US8637501, 32
Show/Hide
|
C25H25N3OS
|
1
|
| 1 |
Ki = 4.9 nM
|
|
|
|
CP0036759
|
1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)-4-(4-(trifluoromethyl)phenyl)pyridin-2(1H)-one
Show/Hide
|
C25H23F3N4O
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0450759
|
US8637501, 63
Show/Hide
|
C24H23ClN4O2
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0492523
|
US8637501, 29
Show/Hide
|
C26H27N3O2
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0492524
|
US8637501, 30
Show/Hide
|
C27H29N3O2
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0231906
|
4-(benzyloxy)-1-(2,9-dimethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C25H25N3O2
|
1
|
| 1 |
Ki = 5.2 nM
|
|
|
|
CP0500116
|
US8637501, 27
Show/Hide
|
C24H21F3N4O
|
1
|
| 1 |
Ki = 5.3 nM
|
|
|
|
CP0435487
|
4-(4-chlorophenyl)-1-(2,9-dimethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C24H22ClN3O
|
1
|
| 1 |
Ki = 5.6 nM
|
|
|
|
CP0493812
|
4-(2-chloro-4-(trifluoromethyl)phenyl)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C25H22ClF3N4O
|
1
|
| 1 |
Ki = 5.8 nM
|
|
|
|
CP0443844
|
US8637501, 35
Show/Hide
|
C24H23N3O2
|
1
|
| 1 |
Ki = 5.8 nM
|
|
|
|
CP0561071
|
US8637501, 113
Show/Hide
|
C24H23ClN4O2
|
1
|
| 1 |
Ki = 5.9 nM
|
|
|
|
CP0574879
|
US9073925, 3
Show/Hide
|
C27H27N3O2
|
1
|
| 1 |
Ki = 5.9 nM
|
|
|
|
CP0524435
|
US8637501, 103
Show/Hide
|
C25H24FN3O2
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0553852
|
US8637501, 7
Show/Hide
|
C24H23N3O2
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0470287
|
US8618299, 24
Show/Hide
|
C26H25N3O2
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0506079
|
2-(4-fluorophenyl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)furo[3,2-c]pyridin-4(5H)-one
Show/Hide
|
C26H23FN4O2
|
1
|
| 1 |
Ki = 6.1 nM
|
|
|
|
CP0516763
|
US8637501, 26
Show/Hide
|
C25H22F3N3O
|
1
|
| 1 |
Ki = 6.1 nM
|
|
|
|
CP0492532
|
US8637501, 90
Show/Hide
|
C24H24N4O2
|
1
|
| 1 |
Ki = 6.4 nM
|
|
|
|
CP0516761
|
US8637501, 24
Show/Hide
|
C25H23F3N4O2
|
1
|
| 1 |
Ki = 6.4 nM
|
|
|
|
CP0500340
|
US9073925, 2
Show/Hide
|
C26H25N3O2
|
1
|
| 1 |
Ki = 6.4 nM
|
|
|
|
CP0528711
|
1-(5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)-4-(4-(trifluoromethyl)benzyloxy)pyridin-2(1H)-one
Show/Hide
|
C25H22F3N3O2
|
1
|
| 1 |
Ki = 6.7 nM
|
|
|
|
CP0384774
|
US8637501, 87
Show/Hide
|
C26H28N4O2
|
1
|
| 1 |
Ki = 6.9 nM
|
|
|
|
CP0502295
|
4-(4-chloro-2-methoxyphenyl)-1-(5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C24H22ClN3O2
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0468402
|
US8618299, 16
Show/Hide
|
C26H25N3O2
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0544759
|
US8618299, 36
Show/Hide
|
C27H25F3N4O
|
1
|
| 1 |
Ki = 7 nM
|
|
|
|
CP0400434
|
US8637501, 4
Show/Hide
|
C24H21F3N4O
|
1
|
| 1 |
Ki = 7.1 nM
|
|
|
|
CP0960019
|
US8993765, 2
Show/Hide
|
C23H22N4O2
|
1
|
| 1 |
Ki = 7.1 nM
|
|
|
|
CP0504546
|
4-(2,4-dichlorophenyl)-1-(5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C23H19Cl2N3O
|
1
|
| 1 |
Ki = 7.2 nM
|
|
|
|
CP0443845
|
US8637501, 40
Show/Hide
|
C24H23FN4O2
|
1
|
| 1 |
Ki = 7.2 nM
|
|
|
|
CP0542021
|
US8637501, 17
Show/Hide
|
C27H29N3O2
|
1
|
| 1 |
Ki = 7.2 nM
|
|
|
|
CP0492531
|
US8637501, 66
Show/Hide
|
C25H23F2N3O2
|
1
|
| 1 |
Ki = 7.3 nM
|
|
|
|
CP0529293
|
US8637501, 57
Show/Hide
|
C25H24FN3O2
|
1
|
| 1 |
Ki = 7.3 nM
|
|
|
|
CP0551371
|
US8637501, 50
Show/Hide
|
C24H23ClN4O2
|
1
|
| 1 |
Ki = 7.4 nM
|
|
|
|
CP0529295
|
US8637501, 72
Show/Hide
|
C28H29FN4O2
|
1
|
| 1 |
Ki = 7.5 nM
|
|
|
|
CP0437524
|
4-(4-chlorobenzyloxy)-1-(2,9-dimethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C25H24ClN3O2
|
1
|
| 1 |
Ki = 7.6 nM
|
|
|
|
CP0479127
|
4-(4-methoxy-2-methylphenyl)-1-(5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C25H25N3O2
|
1
|
| 1 |
Ki = 7.6 nM
|
|
|
|
CP0524436
|
US8637501, 105
Show/Hide
|
C25H24ClN3O2
|
1
|
| 1 |
Ki = 7.6 nM
|
|
|
|
CP0435488
|
1-(2,5-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)-4-(4-fluorophenyl)pyridin-2(1H)-one
Show/Hide
|
C24H22FN3O
|
1
|
| 1 |
Ki = 7.8 nM
|
|
|
|
CP0492528
|
US8637501, 52
Show/Hide
|
C25H23F2N3O2
|
1
|
| 1 |
Ki = 7.8 nM
|
|
|
|
CP0492533
|
US8637501, 95
Show/Hide
|
C24H21F3N4O
|
1
|
| 1 |
Ki = 7.8 nM
|
|
|
|
CP0563382
|
US8618299, 11
Show/Hide
|
C27H27N3O2
|
1
|
| 1 |
Ki = 8.1 nM
|
|
|
|
CP0524434
|
US8637501, 68
Show/Hide
|
C25H23ClFN3O2
|
1
|
| 1 |
Ki = 8.2 nM
|
|
|
|
CP0927510
|
US8993765, 16
Show/Hide
|
C23H20F2N4O2
|
1
|
| 1 |
Ki = 8.3 nM
|
|
|
|
CP0550965
|
US8618299, 30
Show/Hide
|
C26H23F3N4O
|
1
|
| 1 |
Ki = 8.3 nM
|
|
|
|
CP0528708
|
1-(9-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-7-yl)-4-(4-(methylthio)phenyl)pyridin-2(1H)-one
Show/Hide
|
C24H23N3OS
|
1
|
| 1 |
Ki = 8.4 nM
|
|
|
|
CP0541833
|
US8618299, 21
Show/Hide
|
C27H27FN4O2
|
1
|
| 1 |
Ki = 8.4 nM
|
|
|
|
CP0400442
|
US8637501, 71
Show/Hide
|
C26H25F3N4O2
|
1
|
| 1 |
Ki = 8.5 nM
|
|
|
|
CP0463152
|
US8618299, 29
Show/Hide
|
C27H27N3O2
|
1
|
| 1 |
Ki = 8.5 nM
|
|
|
|
CP0550966
|
US8618299, 39
Show/Hide
|
C26H22F3N3O
|
1
|
| 1 |
Ki = 8.5 nM
|
|
|
|
CP0503770
|
US8637501, 88
Show/Hide
|
C25H26N4O2
|
1
|
| 1 |
Ki = 8.7 nM
|
|
|
|
CP0529294
|
US8637501, 70
Show/Hide
|
C25H25FN4O2
|
1
|
| 1 |
Ki = 8.8 nM
|
|
|
|
CP0503761
|
US8637501, 43
Show/Hide
|
C25H25N3O2
|
1
|
| 1 |
Ki = 8.9 nM
|
|
|
|
CP0561070
|
US8637501, 112
Show/Hide
|
C24H23FN4O2
|
1
|
| 1 |
Ki = 8.9 nM
|
|
|
|
CP0555083
|
US8637501, 96
Show/Hide
|
C24H22ClFN4O2
|
1
|
| 1 |
Ki = 9.2 nM
|
|
|
|
CP0502634
|
(S)-4-(benzyloxy)-1-(1-(2-(3-methoxypyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C26H28N4O3
|
1
|
| 1 |
Ki = 9.4 nM
|
|
|
|
CP0384773
|
US8637501, 73
Show/Hide
|
C26H27FN4O2
|
1
|
| 1 |
Ki = 9.4 nM
|
|
|
|
CP0516765
|
US8637501, 31
Show/Hide
|
C28H31N3O2
|
1
|
| 1 |
Ki = 9.4 nM
|
|
|
|
CP0384780
|
US8637501, 109
Show/Hide
|
C24H23ClN4O2
|
1
|
| 1 |
Ki = 9.6 nM
|
|
|
|
CP0500115
|
US8637501, 14
Show/Hide
|
C27H29N3O2
|
1
|
| 1 |
Ki = 9.6 nM
|
|
|
|
CP0528722
|
2-phenyl-5-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)furo[3,2-c]pyridin-4(5H)-one
Show/Hide
|
C26H24N4O2
|
1
|
| 1 |
Ki = 9.7 nM
|
|
|
|
CP0555093
|
US8637501, 107
Show/Hide
|
C25H26N4O
|
1
|
| 1 |
Ki = 9.7 nM
|
|
|
|
CP0472585
|
US8618299, 12
Show/Hide
|
C26H25FN4O2
|
1
|
| 1 |
Ki = 9.7 nM
|
|
|
|
CP0529301
|
US8629158, 26
Show/Hide
|
C27H27N3O2
|
1
|
| 1 |
Ki = 9.7 nM
|
|
|
|
CP0531771
|
US8637501, 76
Show/Hide
|
C27H33FN4O
|
1
|
| 1 |
Ki = 9.8 nM
|
|
|
|
CP0561069
|
US8637501, 101
Show/Hide
|
C25H26N4O
|
1
|
| 1 |
Ki = 9.9 nM
|
|
|
|
CP0400440
|
US8637501, 41
Show/Hide
|
C25H22F3N3O
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0529296
|
US8637501, 74
Show/Hide
|
C26H31FN4O
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0561068
|
US8637501, 100
Show/Hide
|
C25H24ClN3O2
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0560824
|
US8618299, 47
Show/Hide
|
C26H24ClFN4O2
|
1
|
| 1 |
Ki = 10 nM
|
|
|
|
CP0400433
|
US8637501, 3
Show/Hide
|
C24H21F3N4O
|
1
|
| 1 |
Ki = 10.1 nM
|
|
|
|
CP0553853
|
US8637501, 13
Show/Hide
|
C23H21FN4O2
|
1
|
| 1 |
Ki = 10.3 nM
|
|
|
|
CP0400437
|
US8637501, 15
Show/Hide
|
C28H31N3O2
|
1
|
| 1 |
Ki = 10.4 nM
|
|
|
|
CP0531769
|
US8637501, 34
Show/Hide
|
C25H26N4O2
|
1
|
| 1 |
Ki = 10.6 nM
|
|
|
|
CP0561065
|
US8637501, 28
Show/Hide
|
C23H20F3N5O
|
1
|
| 1 |
Ki = 10.9 nM
|
|
|
|
CP0502119
|
4-(naphthalen-2-yl)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C28H26N4O
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0435486
|
1-(9-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-7-yl)-4-(4-(trifluoromethyl)phenyl)pyridin-2(1H)-one
Show/Hide
|
C24H20F3N3O
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0454389
|
4-(4-chlorophenyl)-1-(9-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C23H20ClN3O
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0450761
|
US8637501, 94
Show/Hide
|
C24H22F2N4O2
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0503764
|
US8637501, 65
Show/Hide
|
C25H23Cl2N3O2
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0503766
|
US8637501, 77
Show/Hide
|
C24H24N4O2
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0503769
|
US8637501, 85
Show/Hide
|
C23H22ClN5O2
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0555303
|
US8637501, 84
Show/Hide
|
C24H22ClFN4O2
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0551636
|
US8618299, 19
Show/Hide
|
C26H25FN4O2
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0574880
|
US9073925, 7
Show/Hide
|
C27H25F3N4O2
|
1
|
| 1 |
Ki = 11 nM
|
|
|
|
CP0447607
|
(R)-4-(benzyloxy)-1-(1-(2-(2-(methoxymethyl)pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C27H30N4O3
|
1
|
| 1 |
Ki = 11.2 nM
|
|
|
|
CP0503760
|
US8637501, 12
Show/Hide
|
C24H20F3N3O
|
1
|
| 1 |
Ki = 11.4 nM
|
|
|
|
CP0503762
|
US8637501, 44
Show/Hide
|
C26H27N3O2
|
1
|
| 1 |
Ki = 11.6 nM
|
|
|
|
CP0450840
|
US8637501, 18
Show/Hide
|
C25H25N3O2
|
1
|
| 1 |
Ki = 11.8 nM
|
|
|
|
CP0492522
|
US8637501, 5
Show/Hide
|
C25H23F3N4O2
|
1
|
| 1 |
Ki = 11.8 nM
|
|
|
|
CP0454155
|
(S)-4-(benzyloxy)-1-(1-(pyrrolidin-2-ylmethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C24H24N4O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0400441
|
US8637501, 69
Show/Hide
|
C24H22F3N5O
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0443674
|
US8637501, 55
Show/Hide
|
C25H23ClFN3O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0555094
|
US8637501, 110
Show/Hide
|
C24H23FN4O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0470290
|
US8618299, 44
Show/Hide
|
C26H26N4O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0521031
|
US8618299, 28
Show/Hide
|
C26H23F2N3O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0544758
|
US8618299, 17
Show/Hide
|
C27H27N3O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0561530
|
US8618299, 18
Show/Hide
|
C27H25F3N4O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0565719
|
US8618299, 26
Show/Hide
|
C26H22F3N3O
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0443675
|
US8629158, 28
Show/Hide
|
C29H31N3O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0450215
|
US8629158, 38
Show/Hide
|
C26H23F3N4O2
|
1
|
| 1 |
Ki = 12 nM
|
|
|
|
CP0555079
|
US8637501, 36
Show/Hide
|
C23H19F3N4O
|
1
|
| 1 |
Ki = 12.2 nM
|
|
|
|
CP0447606
|
4-(benzyloxy)-1-(1-(3-(dimethylamino)propyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C24H26N4O2
|
1
|
| 1 |
Ki = 12.6 nM
|
|
|
|
CP0521423
|
4-(1-methyl-1H-indol-2-yl)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C27H27N5O
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0400445
|
US8637501, 98
Show/Hide
|
C26H31FN4O
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0450762
|
US8637501, 97
Show/Hide
|
C25H29FN4O
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0520551
|
US8637501, 53
Show/Hide
|
C25H29ClN4O
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0556425
|
US8637501, 83
Show/Hide
|
C24H22F2N4O2
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0541832
|
US8618299, 20
Show/Hide
|
C27H28N4O2
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0424095
|
US8637501, 10
Show/Hide
|
C23H22FN5O2
|
1
|
| 1 |
Ki = 13.4 nM
|
|
|
|
CP0424096
|
US8637501, 16
Show/Hide
|
C27H29FN4O2
|
1
|
| 1 |
Ki = 13.7 nM
|
|
|
|
CP0454524
|
4-(4-methoxy-2-methylphenyl)-1-(9-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C25H25N3O2
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0493470
|
4-(4-methoxyphenyl)-1-(9-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C24H23N3O2
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0528707
|
4-(2,4-dichlorophenyl)-1-(2,9-dimethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C24H21Cl2N3O
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0479095
|
2-(2,4-dichlorophenyl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)furo[3,2-c]pyridin-4(5H)-one
Show/Hide
|
C26H22Cl2N4O2
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0556424
|
US8637501, 75
Show/Hide
|
C29H35FN4O
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0521018
|
US8618299, 40
Show/Hide
|
C25H23FN4O2
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0521030
|
US8618299, 25
Show/Hide
|
C25H23FN4O2
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0544760
|
US8618299, 41
Show/Hide
|
C25H21F3N4O
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0488331
|
US8629158, 47
Show/Hide
|
C25H22ClFN4O2
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0503794
|
US8637501, 2
Show/Hide
|
C23H20F3N5O
|
1
|
| 1 |
Ki = 14.4 nM
|
|
|
|
CP0561063
|
US8637501, 19
Show/Hide
|
C24H23FN4O2
|
1
|
| 1 |
Ki = 14.8 nM
|
|
|
|
CP0527183
|
4-(4-chlorophenyl)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C24H23ClN4O
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0528710
|
1-(5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)-4-phenylpyridin-2(1H)-one
Show/Hide
|
C23H21N3O
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0400443
|
US8637501, 89
Show/Hide
|
C23H20F3N5O
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0888229
|
US8993765, 4
Show/Hide
|
C22H20FN5O2
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0949629
|
US8993765, 6
Show/Hide
|
C22H18F3N5O
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0564521
|
US8618299, 49
Show/Hide
|
C26H23F3N4O
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0423822
|
US9073925, 10
Show/Hide
|
C26H23F3N4O
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0559686
|
US9073925, 9
Show/Hide
|
C26H24F2N4O2
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0505350
|
4-(2-fluoro-4-(trifluoromethyl)phenyl)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C25H22F4N4O
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0561067
|
US8637501, 86
Show/Hide
|
C28H30N4O2
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0521032
|
US8618299, 46
Show/Hide
|
C26H24F2N4O2
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0565721
|
US8618299, 50
Show/Hide
|
C26H26N4O2
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0529698
|
4-(4-chloro-2-methoxyphenyl)-1-(9-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C24H22ClN3O2
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0531770
|
US8637501, 49
Show/Hide
|
C24H21F3N4O
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0555304
|
US8637501, 99
Show/Hide
|
C27H33FN4O
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0954728
|
US8993765, 15
Show/Hide
|
C23H20Cl2N4O2
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0437577
|
US8618299, 52
Show/Hide
|
C26H23F3N4O
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0488328
|
US8629158, 23
Show/Hide
|
C25H24N4O2
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0488329
|
US8629158, 33
Show/Hide
|
C26H30N4O
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0526446
|
1-(1-(2-(2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)ethyl)-1H-indazol-5-yl)-4-(benzyloxy)pyridin-2(1H)-one
Show/Hide
|
C26H26N4O3
|
1
|
| 1 |
Ki = 17.3 nM
|
|
|
|
CP0521289
|
US8637501, 33
Show/Hide
|
C24H24N4O
|
1
|
| 1 |
Ki = 17.5 nM
|
|
|
|
CP0492527
|
US8637501, 42
Show/Hide
|
C26H27FN4O2
|
1
|
| 1 |
Ki = 17.8 nM
|
|
|
|
CP0400447
|
US8637501, 106
Show/Hide
|
C24H22F2N4O2
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0416075
|
4-(4-chloro-2-methoxyphenyl)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C25H25ClN4O2
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0959375
|
US8993765, 27
Show/Hide
|
C25H26N4O2
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0544761
|
US8618299, 42
Show/Hide
|
C26H23ClFN3O2
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0564520
|
US8618299, 23
Show/Hide
|
C28H30N4O2
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0450216
|
US8629158, 50
Show/Hide
|
C25H21F3N4O
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0437571
|
US8618299, 8
Show/Hide
|
C27H27ClN4O2
|
1
|
| 1 |
Ki = 20 nM
|
|
|
|
CP0450757
|
US8637501, 60
Show/Hide
|
C24H22F3N5O2
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0969965
|
US8993765, 22
Show/Hide
|
C22H20N4O2
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0549272
|
US8618299, 45
Show/Hide
|
C25H24FN5O2
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0560823
|
US8618299, 22
Show/Hide
|
C28H29N3O2
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0575951
|
US8629158, 39
Show/Hide
|
C25H24N4O2
|
1
|
| 1 |
Ki = 21 nM
|
|
|
|
CP0450763
|
US8637501, 102
Show/Hide
|
C24H22F2N4O2
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0503765
|
US8637501, 67
Show/Hide
|
C24H22Cl2N4O2
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0460124
|
US8618299, 31
Show/Hide
|
C27H28N4O2
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0269961
|
4-(benzyloxy)-1-(1-((4,5-dihydro-1H-imidazol-2-yl)methyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C23H21N5O2
|
1
|
| 1 |
Ki = 22.6 nM
|
|
|
|
CP0565700
|
US8629158, 10
Show/Hide
|
C24H19F3N4O
|
1
|
| 1 |
Ki = 22.7 nM
|
|
|
|
CP0527184
|
1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)-4-(4-(trifluoromethoxy)phenyl)pyridin-2(1H)-one
Show/Hide
|
C25H23F3N4O2
|
1
|
| 1 |
Ki = 23 nM
|
|
|
|
CP0899566
|
US8993765, 26
Show/Hide
|
C22H17F3N4O
|
1
|
| 1 |
Ki = 23 nM
|
|
|
|
CP0559685
|
US9073925, 5
Show/Hide
|
C25H22F3N5O
|
1
|
| 1 |
Ki = 23 nM
|
|
|
|
CP0505349
|
1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)-4-para-tolylpyridin-2(1H)-one
Show/Hide
|
C25H26N4O
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0524432
|
US8637501, 51
Show/Hide
|
C25H23Cl2N3O2
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0517951
|
US8618299, 32
Show/Hide
|
C27H25F3N4O2
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0517952
|
US8618299, 34
Show/Hide
|
C28H27F3N4O2
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0521989
|
4-(benzyloxy)-1-(1-(2-(piperazin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C25H27N5O2
|
1
|
| 1 |
Ki = 24.3 nM
|
|
|
|
CP0494172
|
US8629158, 3
Show/Hide
|
C24H20F3N5O
|
1
|
| 1 |
Ki = 24.4 nM
|
|
|
|
CP0521422
|
4-(benzo[b]thiophen-2-yl)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C26H24N4OS
|
1
|
| 1 |
Ki = 25 nM
|
|
|
|
CP0502294
|
1-(2,9-dimethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-7-yl)-4-(4-(trifluoromethyl)benzyloxy)pyridin-2(1H)-one
Show/Hide
|
C26H24F3N3O2
|
1
|
| 1 |
Ki = 25 nM
|
|
|
|
CP0535907
|
US8993765, 14
Show/Hide
|
C23H22FN5O2
|
1
|
| 1 |
Ki = 25 nM
|
|
|
|
CP0542009
|
US8629158, 22
Show/Hide
|
C24H22N4O2
|
1
|
| 1 |
Ki = 25 nM
|
|
|
|
CP0467570
|
US9073925, 11
Show/Hide
|
C25H24FN5O2
|
1
|
| 1 |
Ki = 25 nM
|
|
|
|
CP0516942
|
US8629158, 9
Show/Hide
|
C24H21FN4O2
|
1
|
| 1 |
Ki = 25.3 nM
|
|
|
|
CP0504566
|
4-(1-methyl-1H-indol-5-yl)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C27H27N5O
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0400444
|
US8637501, 93
Show/Hide
|
C24H22Cl2N4O2
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0503763
|
US8637501, 45
Show/Hide
|
C25H26N4O2
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0550967
|
US8618299, 54
Show/Hide
|
C26H24ClFN4O2
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0551637
|
US8618299, 43
Show/Hide
|
C26H25FN4O2
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0450764
|
US8629158, 45
Show/Hide
|
C25H22F2N4O2
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0555317
|
US8637501, 56
Show/Hide
|
C24H22Cl2N4O2
|
1
|
| 1 |
Ki = 27 nM
|
|
|
|
CP0443676
|
US8629158, 42
Show/Hide
|
C26H26N4O2
|
1
|
| 1 |
Ki = 27 nM
|
|
|
|
CP0454378
|
2-(2-chlorophenyl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)furo[3,2-c]pyridin-4(5H)-one
Show/Hide
|
C26H23ClN4O2
|
1
|
| 1 |
Ki = 28 nM
|
|
|
|
CP0488332
|
US8629158, 48
Show/Hide
|
C25H22Cl2N4O2
|
1
|
| 1 |
Ki = 28 nM
|
|
|
|
CP0503767
|
US8637501, 78
Show/Hide
|
C23H20F3N5O
|
1
|
| 1 |
Ki = 29 nM
|
|
|
|
CP0517860
|
US9073925, 8
Show/Hide
|
C26H26N4O2
|
1
|
| 1 |
Ki = 29 nM
|
|
|
|
CP0556431
|
US8637501, 37
Show/Hide
|
C22H18F3N5O
|
1
|
| 1 |
Ki = 29.2 nM
|
|
|
|
CP0959348
|
US8993765, 23
Show/Hide
|
C21H18FN5O2
|
1
|
| 1 |
Ki = 30 nM
|
|
|
|
CP0454156
|
4-(benzyloxy)-1-(1-((1-methyl-4,5-dihydro-1H-imidazol-2-yl)methyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C24H23N5O2
|
1
|
| 1 |
Ki = 30.4 nM
|
|
|
|
CP0470291
|
US8618299, 55
Show/Hide
|
C26H24F2N4O2
|
1
|
| 1 |
Ki = 31 nM
|
|
|
|
CP0472587
|
US8618299, 33
Show/Hide
|
C28H30N4O2
|
1
|
| 1 |
Ki = 31 nM
|
|
|
|
CP0546598
|
US8618299, 5
Show/Hide
|
C28H29N3O2
|
1
|
| 1 |
Ki = 31 nM
|
|
|
|
CP0504614
|
4-(benzyloxy)-1-(1-(((4R)-4-hydroxypyrrolidin-2-yl)methyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C24H24N4O3
|
1
|
| 1 |
Ki = 33 nM
|
|
|
|
CP0531772
|
US8637501, 81
Show/Hide
|
C23H22FN5O2
|
1
|
| 1 |
Ki = 33 nM
|
|
|
|
CP0899426
|
US8993765, 8
Show/Hide
|
C22H18F3N5O
|
1
|
| 1 |
Ki = 33 nM
|
|
|
|
CP0521019
|
US8618299, 53
Show/Hide
|
C25H22F3N5O
|
1
|
| 1 |
Ki = 33 nM
|
|
|
|
CP0550964
|
US8618299, 27
Show/Hide
|
C25H21F3N4O
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0549281
|
US8618299, 51
Show/Hide
|
C25H24FN5O2
|
1
|
| 1 |
Ki = 37 nM
|
|
|
|
CP0454154
|
4-(benzyloxy)-1-(1-(3-(dimethylamino)-2-hydroxypropyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C24H26N4O3
|
1
|
| 1 |
Ki = 37.7 nM
|
|
|
|
CP0475473
|
2-(3-chlorophenyl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)furo[3,2-c]pyridin-4(5H)-one
Show/Hide
|
C26H23ClN4O2
|
1
|
| 1 |
Ki = 38 nM
|
|
|
|
CP0400452
|
US8629158, 43
Show/Hide
|
C24H22FN5O2
|
1
|
| 1 |
Ki = 38 nM
|
|
|
|
CP0536931
|
US8637501, 25
Show/Hide
|
C23H20F3N5O
|
1
|
| 1 |
Ki = 42.3 nM
|
|
|
|
CP0454157
|
4-(benzyloxy)-1-(1-(2-morpholinoethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C25H26N4O3
|
1
|
| 1 |
Ki = 43.4 nM
|
|
|
|
CP0524433
|
US8637501, 59
Show/Hide
|
C24H29N5O
|
1
|
| 1 |
Ki = 44 nM
|
|
|
|
CP0555095
|
US8637501, 114
Show/Hide
|
C23H21F2N5O2
|
1
|
| 1 |
Ki = 44 nM
|
|
|
|
CP0559684
|
US9073925, 4
Show/Hide
|
C26H25FN4O2
|
1
|
| 1 |
Ki = 44 nM
|
|
|
|
CP0517933
|
US8618299, 7
Show/Hide
|
C27H27FN4O2
|
1
|
| 1 |
Ki = 45 nM
|
|
|
|
CP0500117
|
US8637501, 46
Show/Hide
|
C26H23F3N4O2
|
1
|
| 1 |
Ki = 47 nM
|
|
|
|
CP0959373
|
US8993765, 3
Show/Hide
|
C23H27N5O
|
1
|
| 1 |
Ki = 47 nM
|
|
|
|
CP0517935
|
US8618299, 48
Show/Hide
|
C25H22F3N5O
|
1
|
| 1 |
Ki = 47 nM
|
|
|
|
CP0572429
|
US8618299,10
Show/Hide
|
C29H31N3O2
|
1
|
| 1 |
Ki = 47 nM
|
|
|
|
CP0505321
|
2-(4-chloro-2-methoxyphenyl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)furo[3,2-c]pyridin-4(5H)-one
Show/Hide
|
C27H25ClN4O3
|
1
|
| 1 |
Ki = 48 nM
|
|
|
|
CP0503795
|
US8637501, 11
Show/Hide
|
C24H24N4O
|
1
|
| 1 |
Ki = 49 nM
|
|
|
|
CP0500120
|
US8637501, 82
Show/Hide
|
C22H21FN6O2
|
1
|
| 1 |
Ki = 53 nM
|
|
|
|
CP0492530
|
US8637501, 61
Show/Hide
|
C26H25FN4O3
|
1
|
| 1 |
Ki = 57 nM
|
|
|
|
CP0516240
|
US8993765, 12
Show/Hide
|
C24H28FN5O
|
1
|
| 1 |
Ki = 58 nM
|
|
|
|
CP0514492
|
2-(pyridin-2-yl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)furo[3,2-c]pyridin-4(5H)-one
Show/Hide
|
C25H23N5O2
|
1
|
| 1 |
Ki = 59 nM
|
|
|
|
CP0563383
|
US8618299, 13
Show/Hide
|
C26H26N4O
|
1
|
| 1 |
Ki = 59 nM
|
|
|
|
CP0529302
|
US8629158, 35
Show/Hide
|
C25H24N4O
|
1
|
| 1 |
Ki = 59 nM
|
|
|
|
CP0450758
|
US8637501, 62
Show/Hide
|
C26H23F3N4O2
|
1
|
| 1 |
Ki = 60 nM
|
|
|
|
CP0500118
|
US8637501, 48
Show/Hide
|
C26H25FN4O3
|
1
|
| 1 |
Ki = 60 nM
|
|
|
|
CP0556389
|
US8637501, 108
Show/Hide
|
C23H20F3N5O
|
1
|
| 1 |
Ki = 60 nM
|
|
|
|
CP0502118
|
4-(4-chloro-2-fluorophenyl)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C24H22ClFN4O
|
1
|
| 1 |
Ki = 62 nM
|
|
|
|
CP0961911
|
US8993765, 18
Show/Hide
|
C22H20N4O2
|
1
|
| 1 |
Ki = 62 nM
|
|
|
|
CP0568493
|
US8629158, 7
Show/Hide
|
C24H20F3N5O
|
1
|
| 1 |
Ki = 68.1 nM
|
|
|
|
CP0503768
|
US8637501, 80
Show/Hide
|
C23H20F3N5O
|
1
|
| 1 |
Ki = 69 nM
|
|
|
|
CP0492534
|
US8637501, 111
Show/Hide
|
C23H21F2N5O2
|
1
|
| 1 |
Ki = 71 nM
|
|
|
|
CP0954580
|
US8993765, 7
Show/Hide
|
C23H20F3N5O2
|
1
|
| 1 |
Ki = 71 nM
|
|
|
|
CP0960024
|
US8993765, 11
Show/Hide
|
C25H24N4O3
|
1
|
| 1 |
Ki = 71 nM
|
|
|
|
CP0555316
|
US8637501, 47
Show/Hide
|
C24H22F3N5O2
|
1
|
| 1 |
Ki = 74 nM
|
|
|
|
CP0575950
|
US8629158, 29
Show/Hide
|
C27H25FN4O3
|
1
|
| 1 |
Ki = 75 nM
|
|
|
|
CP0544757
|
US8618299, 15
Show/Hide
|
C26H26N4O
|
1
|
| 1 |
Ki = 76 nM
|
|
|
|
CP0899427
|
US8993765, 9
Show/Hide
|
C24H20F3N5O2
|
1
|
| 1 |
Ki = 78 nM
|
|
|
|
CP0559764
|
US8993765, 29
Show/Hide
|
C26H26N4O3
|
1
|
| 1 |
Ki = 81 nM
|
|
|
|
CP0899565
|
US8993765, 21
Show/Hide
|
C25H26N4O2
|
1
|
| 1 |
Ki = 94 nM
|
|
|
|
CP0550067
|
US8629158, 30
Show/Hide
|
C27H25N3O3
|
1
|
| 1 |
Ki = 97 nM
|
|
|
|
CP0504565
|
4-(2-fluoro-4-methoxyphenyl)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C25H25FN4O2
|
1
|
| 1 |
Ki = 99 nM
|
|
|
|
CP0488330
|
US8629158, 46
Show/Hide
|
C25H28ClN5O
|
1
|
| 1 |
Ki = 99 nM
|
|
|
|
CP0492526
|
US8637501, 38
Show/Hide
|
C25H23N3O3
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0516242
|
US8993765, 28
Show/Hide
|
C23H20N4O3
|
1
|
| 1 |
Ki = 103 nM
|
|
|
|
CP0960020
|
US8993765, 5
Show/Hide
|
C21H17F3N6O
|
1
|
| 1 |
Ki = 105 nM
|
|
|
|
CP0400453
|
US8629158, 44
Show/Hide
|
C24H20F3N5O
|
1
|
| 1 |
Ki = 110 nM
|
|
|
|
CP0500119
|
US8637501, 54
Show/Hide
|
C26H25N3O3
|
1
|
| 1 |
Ki = 112 nM
|
|
|
|
CP0463153
|
US8618299, 56
Show/Hide
|
C25H23F2N5O2
|
1
|
| 1 |
Ki = 121 nM
|
|
|
|
CP0423821
|
US9073925, 6
Show/Hide
|
C26H23F3N4O
|
1
|
| 1 |
Ki = 123 nM
|
|
|
|
CP0528706
|
4-(5-chloropyridin-2-yl)-1-(9-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-7-yl)pyridin-2(1H)-one
Show/Hide
|
C22H19ClN4O
|
1
|
| 1 |
Ki = 128 nM
|
|
|
|
CP0443705
|
US8637501, 6
Show/Hide
|
C23H20F3N5O
|
1
|
| 1 |
Ki = 131 nM
|
|
|
|
CP0575949
|
US8629158, 27
Show/Hide
|
C28H27N3O3
|
1
|
| 1 |
Ki = 131 nM
|
|
|
|
CP0555319
|
US8637501, 8
Show/Hide
|
C22H18F3N5O
|
1
|
| 1 |
Ki = 148 nM
|
|
|
|
CP0555092
|
US8637501, 104
Show/Hide
|
C24H21FN4O3
|
1
|
| 1 |
Ki = 149 nM
|
|
|
|
CP0544732
|
US8618299, 14
Show/Hide
|
C26H23F3N4O
|
1
|
| 1 |
Ki = 153 nM
|
|
|
|
CP0492529
|
US8637501, 58
Show/Hide
|
C23H20F3N5O
|
1
|
| 1 |
Ki = 163 nM
|
|
|
|
CP0528712
|
1-(2-acetyl-5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-7-yl)-4-(benzyloxy)pyridin-2(1H)-one
Show/Hide
|
C26H25N3O3
|
1
|
| 1 |
Ki = 168 nM
|
|
|
|
CP0565720
|
US8618299, 35
Show/Hide
|
C27H28N4O
|
1
|
| 1 |
Ki = 193 nM
|
|
|
|
CP0561066
|
US8637501, 79
Show/Hide
|
C22H19F3N6O
|
1
|
| 1 |
Ki = 235 nM
|
|
|
|
CP0555315
|
US8637501, 20
Show/Hide
|
C24H21F3N4O
|
1
|
| 1 |
Ki = 242 nM
|
|
|
|
CP0504567
|
4-(5-chloropyridin-2-yl)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C23H22ClN5O
|
1
|
| 1 |
Ki = 272 nM
|
|
|
|
CP0502117
|
4-(4-fluorophenyl)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
Show/Hide
|
C24H23FN4O
|
1
|
| 1 |
Ki = 275 nM
|
|
|
|
CP0550962
|
US8618299, 6
Show/Hide
|
C27H25F3N4O
|
1
|
| 1 |
Ki = 481 nM
|
|
|
|
CP0505348
|
1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)-4-ortho-tolylpyridin-2(1H)-one
Show/Hide
|
C25H26N4O
|
1
|
| 1 |
Ki = 539 nM
|
|
|
|
CP0950958
|
US8993765, 24
Show/Hide
|
C21H16F3N5O
|
1
|
| 1 |
Ki = 616 nM
|
|
|
|
CP0502293
|
1-(2,9-dimethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-7-yl)-4-(5-fluoropyridin-2-yl)pyridin-2(1H)-one
Show/Hide
|
C23H21FN4O
|
1
|
| 1 |
Ki = 708 nM
|
|
|
|
CP0400435
|
US8637501, 9
Show/Hide
|
C23H19F3N4O
|
1
|
| 1 |
Ki = 1371 nM
|
|
|
|
CP0479130
|
2-(pyrimidin-2-yl)-5-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)furo[3,2-c]pyridin-4(5H)-one
Show/Hide
|
C24H22N6O2
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1
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| 1 |
Ki = 1679 nM
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CP0437576
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US8618299, 9
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C26H25ClN4O
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1
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| 1 |
Ki = 1750 nM
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CP0959374
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US8993765, 25
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C22H18F3N5O2
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1
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| 1 |
Ki = 3323 nM
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CP0502116
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1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)-4-meta-tolylpyridin-2(1H)-one
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C25H26N4O
|
1
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| 1 |
Ki > 1000 nM
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CP0535696
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4-phenyl-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one
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C24H24N4O
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1
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| 1 |
Ki > 1000 nM
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CP0479128
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4-(benzyloxy)-1-(1-butyl-1H-indazol-5-yl)pyridin-2(1H)-one
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C23H23N3O2
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1
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| 1 |
Ki > 5000 nM
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