| Compound ID |
Compound Name |
Compound Formula |
|
CP0076675
|
(1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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|
C8H11NO4
|
2
|
| 1 |
EC50 = 18.3 nM
|
|
|
| 2 |
Ki = 23.4 nM
|
|
|
|
CP0428983
|
(+/-)-2-Amino-6-fluoro-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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|
C8H10FNO5
|
2
|
| 1 |
EC50 = 21 nM
|
|
|
| 2 |
EC50 > 100000 nM
|
|
|
|
CP0399772
|
2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cyclopropanecarboxylic acid
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|
C20H19NO5
|
2
|
| 1 |
EC50 = 50.3 nM
|
|
|
| 2 |
Ki = 3.72 nM
|
|
|
|
CP0373675
|
(1S,2R,3R,5R,6S)-2-amino-3-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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|
C8H10FNO4
|
2
|
| 1 |
EC50 = 4490 nM
|
|
|
| 2 |
EC50 > 100000 nM
|
|
|
|
CP0492666
|
(1S,2S,3R,5R,6S)-2-amino-3-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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|
C8H10FNO4
|
2
|
| 1 |
EC50 = 17100 nM
|
|
|
| 2 |
EC50 > 100000 nM
|
|
|
|
CP0384897
|
(+/-)-2-Amino-3,3-difluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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|
C8H9F2NO4
|
2
|
| 1 |
EC50 = 36200 nM
|
|
|
| 2 |
EC50 > 100000 nM
|
|
|
|
CP0406282
|
(+/-)-2-Amino-6-methyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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|
C9H13NO4
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0140442
|
(+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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|
C8H10FNO4
|
2
|
| 1 |
EC50 > 100000 nM
|
|
|
| 2 |
Ki = 47.7 nM
|
|
|
|
CP0374563
|
(+)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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|
C8H8FNO5
|
2
|
| 1 |
EC50 > 100000 nM
|
|
|
| 2 |
Ki = 3.3 nM
|
|
|
|
CP0409272
|
(+)-2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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|
C8H10FNO4
|
2
|
| 1 |
EC50 > 100000 nM
|
|
|
| 2 |
Ki = 22.5 nM
|
|
|
|
CP0211752
|
(1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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|
C15H14Cl2FNO5
|
3
|
| 1 |
EC50 > 100000 nM
|
|
|
| 2 |
IC50 = 20 nM
|
|
|
| 3 |
Ki = 2.38 nM
|
|
|
|
CP0377729
|
(1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl)cyclopropanecarboxylic acid
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|
C20H19NO5
|
3
|
| 1 |
EC50 > 100000 nM
|
|
|
| 2 |
IC50 = 23.2 nM
|
|
|
| 3 |
Ki = 3.13 nM
|
|
|
|
CP0391913
|
(1R,2R,3R,5R,6R)-2-Amino-3-benzhydryloxy-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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|
C21H20FNO5
|
3
|
| 1 |
EC50 > 100000 nM
|
|
|
| 2 |
IC50 = 24.4 nM
|
|
|
| 3 |
Ki = 2.58 nM
|
|
|
|
CP0392388
|
(1R,2R,3R,5R,6R)-2-Amino-3-(3,4-difluoro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
|
C15H14F3NO5
|
3
|
| 1 |
EC50 > 100000 nM
|
|
|
| 2 |
IC50 = 40.8 nM
|
|
|
| 3 |
Ki = 2.27 nM
|
|
|
|
CP0406578
|
(1R,2R,3R,5R,6R)-2-Amino-3-(4-chloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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|
C15H15ClFNO5
|
3
|
| 1 |
EC50 > 100000 nM
|
|
|
| 2 |
IC50 = 29.1 nM
|
|
|
| 3 |
Ki = 3.17 nM
|
|
|
|
CP0497432
|
(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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|
C8H10FNO5
|
3
|
| 1 |
EC50 > 100000 nM
|
|
|
| 2 |
IC50 = 476 nM
|
|
|
| 3 |
Ki = 32.9 nM
|
|
|
|
CP0231490
|
7,8-dichloro-4-(3-(2-methylpyridin-4-yl)phenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
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|
C21H15Cl2N3O
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0101907
|
7-methyl-4-(3-(pyridin-3-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
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|
C22H16F3N3O
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0202837
|
4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
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|
C24H20F3N3O
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 < 10 nM
|
|
|
|
CP0237661
|
8-chloro-4-(3-(pyridin-4-yl)phenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
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|
C20H14ClN3O
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0053384
|
7-methyl-4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C23H18F3N3O
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 13 nM
|
|
|
|
CP0297209
|
4-(3-(2-ethyl-6-methylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C25H22F3N3O
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0336097
|
4-(3-(2-cyclopropyl-6-methylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
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|
C26H22F3N3O
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0218960
|
4-(3-(2-benzylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
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|
C29H22F3N3O
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0295951
|
4-(3-(2-ethylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
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|
C24H20F3N3O
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0336098
|
4-(3-(2-(methoxymethyl)-6-methylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C25H22F3N3O2
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0337808
|
7-methyl-4-(3-(6-methylpyridin-3-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C23H18F3N3O
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0530818
|
8-[2-(4-fluorophenyl)ethynyl]-4-[3-(triazol-1-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
|
C25H16FN5O
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0053390
|
4-(3-(2-cyclopropylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C25H20F3N3O
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0295952
|
4-(3-(2-(methoxymethyl)pyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C24H20F3N3O2
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0101910
|
4-(3-(2-cyclopentylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
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|
C27H24F3N3O
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0237659
|
4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7,8-bis(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
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|
C24H17F6N3O
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0232347
|
7-ethoxy-4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
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|
C24H20F3N3O2
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0338876
|
7-ethoxy-4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
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|
C23H18F3N3O2
|
2
|
| 1 |
IC50 = 8 nM
|
|
|
| 2 |
IC50 = 10 nM
|
|
|
|
CP0371812
|
8-[2-(4-fluorophenyl)ethynyl]-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
|
C26H17FN4O
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0036327
|
7-methyl-4-(3-(3-methylisoxazol-5-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
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|
C21H16F3N3O2
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0052924
|
4-(3-(6-methoxypyridin-3-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C23H18F3N3O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0053392
|
4-(3-(6-isopropylpyridin-3-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C25H22F3N3O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0101909
|
4-(3-(2-isopropylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C25H22F3N3O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0059417
|
8-(2-fluorophenyl)-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
|
C24H17FN4O
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0101908
|
7-methyl-4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C22H16F3N3O
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0101912
|
4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)ethynyl)-7-hydroxy-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C26H17FN4O2
|
3
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 24 nM
|
|
|
| 3 |
IC50 = 26 nM
|
|
|
|
CP0162027
|
4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C23H16FN5O
|
4
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 16 nM
|
|
|
| 3 |
IC50 = 22 nM
|
|
|
| 4 |
IC50 = 27 nM
|
|
|
|
CP0472153
|
4-(3-imidazol-1-ylphenyl)-8-(2-phenylethynyl)-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
|
C26H18N4O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0335052
|
4-(3-(2-(2-hydroxypropan-2-yl)pyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C25H22F3N3O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0295953
|
4-(3-(2-(hydroxymethyl)-6-methylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C24H20F3N3O2
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0038458
|
4-(3-(2-methoxypyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C23H18F3N3O2
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0283397
|
7-methyl-4-(3-(pyrazin-2-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C21H15F3N4O
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0079531
|
(E)-3-(4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
|
C24H15N3O
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 = 34 nM
|
|
|
|
CP0510824
|
(E)-3-(8-(cyanomethoxy)-4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
|
C26H16N4O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0371810
|
2-[[4-(3-imidazol-1-ylphenyl)-2-oxo-8-(2-phenylethynyl)-1,3-dihydro-1,5-benzodiazepin-7-yl]oxy]acetonitrile
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|
C28H19N5O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0161929
|
4-(3-(6-ethylpyridin-3-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C24H20F3N3O
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0297211
|
4-(3-(2-(hydroxymethyl)pyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C23H18F3N3O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0368814
|
4-(3-(7-methyl-2-oxo-8-(trifluoromethyl)-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl)phenyl)picolinonitrile
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|
C23H15F3N4O
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0059416
|
4-(3-(1H-imidazol-1-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C20H15F3N4O
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0311023
|
8-[2-(4-fluorophenyl)ethynyl]-7-hydroxy-4-[3-(triazol-1-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
|
C25H16FN5O2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0472152
|
8-[2-(2-fluorophenyl)ethynyl]-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
|
C26H17FN4O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0039555
|
4-(3-(6-cyclopropylpyridin-3-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C25H20F3N3O
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0499045
|
(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(naphthalen-2-ylmethoxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
|
C19H18FNO5
|
2
|
| 1 |
IC50 = 22.7 nM
|
|
|
| 2 |
Ki = 2.53 nM
|
|
|
|
CP0438863
|
4-(3-imidazol-1-ylphenyl)-7-(2-methoxyethoxy)-8-(2-phenylethynyl)-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
|
C29H24N4O3
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0373237
|
(E)-N-tert-butyl-2-(4-(3-cyanophenyl)-2-oxo-8-(2-phenylethynyl)-2,3-dihydro-1H-benzo[b][1,4]diazepin-7-yloxy)acetamide
Show/Hide
|
C30H26N4O3
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0373238
|
(E)-4-phenyl-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C23H16N2O
|
1
|
| 1 |
IC50 = 26 nM
|
|
|
|
CP0237670
|
4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C21H14F3N3O
|
2
|
| 1 |
IC50 = 26 nM
|
|
|
| 2 |
IC50 = 101 nM
|
|
|
|
CP0510825
|
(E)-3-(8-(2-methoxyethoxy)-4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
|
C27H21N3O3
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0511442
|
(E)-3-(7-(2-(2-fluorophenyl)ethynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
|
C24H14FN3O
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0295955
|
4-(3-(2,2'-bipyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C22H16F3N3O
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0467707
|
(E)-3-(4-oxo-7-(2-(thiophen-2-yl)ethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
|
C22H13N3OS
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0510826
|
(E)-3-(7-(2-(4-fluorophenyl)ethynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
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C24H14FN3O
|
1
|
| 1 |
IC50 = 34 nM
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CP0205609
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8-(2-fluorophenyl)-7-hydroxy-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
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C24H17FN4O2
|
1
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| 1 |
IC50 = 35 nM
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CP0511612
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7-(dimethylamino)-8-(2-phenylethynyl)-4-[3-(triazol-1-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
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C27H22N6O
|
1
|
| 1 |
IC50 = 36 nM
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CP0295954
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4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
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C22H16F3N3O
|
1
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| 1 |
IC50 = 36 nM
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CP0349551
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4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
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C19H14F3N5O
|
1
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| 1 |
IC50 = 39 nM
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CP0392972
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(E)-3-(4-oxo-7-(2-phenylethynyl)-8-thiomorpholino-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
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C28H22N4OS
|
1
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| 1 |
IC50 = 40 nM
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CP0472150
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8-[2-(4-fluorophenyl)ethynyl]-7-(2-hydroxyethoxy)-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
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C28H21FN4O3
|
1
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| 1 |
IC50 = 46 nM
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CP0336099
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7-methyl-4-(3-(6-(pyrimidin-5-yl)pyridin-3-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
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C21H15F3N4O
|
1
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| 1 |
IC50 = 48 nM
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CP0332809
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7-methyl-4-(3-(pyrimidin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
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C21H15F3N4O
|
1
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| 1 |
IC50 = 50 nM
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CP0521578
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(E)-3-(8-(dimethylamino)-4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
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C26H20N4O
|
1
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| 1 |
IC50 = 60 nM
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CP0541780
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(E)-3-(4-oxo-7-(2-p-tolylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
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C25H17N3O
|
1
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| 1 |
IC50 = 64 nM
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CP0536199
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7-(2-hydroxyethoxy)-4-(3-imidazol-1-ylphenyl)-8-(2-phenylethynyl)-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
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C28H22N4O3
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1
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| 1 |
IC50 = 64 nM
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CP0510827
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(E)-3-(7-(2-(4-methoxyphenyl)ethynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
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C25H17N3O2
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1
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| 1 |
IC50 = 68 nM
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CP0516505
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8-[2-(4-fluorophenyl)ethynyl]-4-[3-(tetrazol-1-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
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C24H15FN6O
|
1
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| 1 |
IC50 = 72 nM
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CP0237672
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7-methyl-4-(3-(pyridazin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
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C21H15F3N4O
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1
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| 1 |
IC50 = 72 nM
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CP0161928
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4-(3-(1H-1,2,4-triazol-1-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
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C19H14F3N5O
|
1
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| 1 |
IC50 = 75 nM
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CP0521579
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(E)-3-(7-(2-(2-chlorophenyl)ethynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
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C24H14ClN3O
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1
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| 1 |
IC50 = 76 nM
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CP0522335
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(E)-4-(3-chlorophenyl)-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
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C23H15ClN2O
|
1
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| 1 |
IC50 = 80 nM
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CP0501786
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(E)-3-(8-(4-methoxypiperidin-1-yl)-4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
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C30H26N4O2
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1
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| 1 |
IC50 = 82 nM
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CP0501785
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(E)-3-(8-methoxy-4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
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C25H17N3O2
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1
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| 1 |
IC50 = 92 nM
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CP0371811
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8-[2-(4-fluorophenyl)ethynyl]-4-[3-(1,2,4-triazol-1-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
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C25H16FN5O
|
1
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| 1 |
IC50 = 98 nM
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CP0472151
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8-[2-(4-fluorophenyl)ethynyl]-4-[3-(4-methylimidazol-1-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
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C27H19FN4O
|
1
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| 1 |
IC50 = 98 nM
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CP0293651
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1-[(Z)-2-Cycloheptyloxy-2-(2,6-dichloro-phenyl)-vinyl]-1H-[1,2,4]triazole
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C17H19Cl2N3O
|
2
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| 1 |
IC50 = 110 nM
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| 2 |
IC50 = 500 nM
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CP0491988
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(1R,2R,3R,5R,6R)-2-Amino-3-benzyloxy-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H16FNO5
|
2
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| 1 |
IC50 = 131 nM
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| 2 |
Ki = 7.14 nM
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CP0438862
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8-[2-(4-fluorophenyl)ethynyl]-7-[2-hydroxyethyl(methyl)amino]-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
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C29H24FN5O2
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1
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| 1 |
IC50 = 140 nM
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CP0505614
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(E)-4-(3-iodophenyl)-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
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C23H15IN2O
|
1
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| 1 |
IC50 = 154 nM
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CP0501787
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3-[8-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-4-oxo-7-phenylethynyl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl]-benzonitrile
Show/Hide
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C28H22N4O3S
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1
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| 1 |
IC50 = 160 nM
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CP0237671
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4-(3-(6-aminopyridin-3-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
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C22H17F3N4O
|
1
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| 1 |
IC50 = 160 nM
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CP0394010
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4-[3-(2,4-dimethylimidazol-1-yl)phenyl]-8-(2-phenylethynyl)-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
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C28H22N4O
|
1
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| 1 |
IC50 = 170 nM
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CP0243343
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4-(3-(1-methyl-1H-pyrazol-5-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
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C20H15F3N4O
|
1
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| 1 |
IC50 = 190 nM
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CP0491986
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(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-methoxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C9H12FNO5
|
2
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| 1 |
IC50 = 229 nM
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| 2 |
Ki = 39.2 nM
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CP0438892
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8-(2-phenylethynyl)-4-(3-(trifluoromethyl)phenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
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C24H15F3N2O
|
1
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| 1 |
IC50 = 268 nM
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CP0467706
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(E)-3-(8-(4-methylpiperazin-1-yl)-4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
|
C29H25N5O
|
1
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| 1 |
IC50 = 278 nM
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CP0484073
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8-(4-fluorophenyl)-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
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C24H17FN4O
|
1
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| 1 |
IC50 = 299 nM
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CP0438890
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(E)-3-(4-oxo-7-(2-(thiazol-2-yl)ethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
|
C21H12N4OS
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1
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| 1 |
IC50 = 300 nM
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CP0405277
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(E)-3-(4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzamide
Show/Hide
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C24H17N3O2
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1
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| 1 |
IC50 = 358 nM
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CP0500554
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(E)-4-(3-(morpholine-4-carbonyl)phenyl)-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C28H23N3O3
|
1
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| 1 |
IC50 = 360 nM
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CP0522333
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(E)-3-(8-morpholino-4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
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C28H22N4O2
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1
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| 1 |
IC50 = 378 nM
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CP0530817
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8-[2-(4-fluorophenyl)ethynyl]-7-hydroxy-4-[3-[5-(hydroxymethyl)triazol-1-yl]phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
|
C26H18FN5O3
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1
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| 1 |
IC50 = 378 nM
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CP0511441
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(E)-3-(7-(3-methylbut-3-en-1-ynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
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C21H15N3O
|
1
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| 1 |
IC50 = 400 nM
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CP0438888
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3-[4-oxo-8-(1-oxo-1lambda4-thiomorpholin-4-yl)-7-phenylethynyl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl]-benzonitrile
Show/Hide
|
C28H22N4O2S
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1
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| 1 |
IC50 = 446 nM
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CP0432271
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1-[(Z)-2-Cycloheptyloxy-2-(2,4-dichloro-phenyl)-vinyl]-1H-[1,2,4]triazole
Show/Hide
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C17H19Cl2N3O
|
1
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| 1 |
IC50 = 470 nM
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CP0392973
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(E)-3-(7-(2-(2,4-difluorophenyl)ethynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
|
C24H13F2N3O
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1
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| 1 |
IC50 = 480 nM
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CP0395350
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1-[(Z)-2-Cyclohexyloxy-2-(2,6-dichloro-phenyl)-vinyl]-1H-[1,2,4]triazole
Show/Hide
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C16H17Cl2N3O
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1
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| 1 |
IC50 = 580 nM
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CP0496578
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(E)-2-(4-(3-cyanophenyl)-2-oxo-8-(2-phenylethynyl)-2,3-dihydro-1H-benzo[b][1,4]diazepin-7-yloxy)acetic acid
Show/Hide
|
C26H17N3O4
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1
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| 1 |
IC50 = 600 nM
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CP0394009
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4-[3-(1-methylimidazol-2-yl)phenyl]-8-(2-phenylethynyl)-1,3-dihydro-1,5-benzodiazepin-2-one
Show/Hide
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C27H20N4O
|
1
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| 1 |
IC50 = 730 nM
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CP0505613
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(E)-3-(4-oxo-7-(2-(pyridin-2-yl)ethynyl)-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
|
C23H14N4O
|
1
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| 1 |
IC50 = 870 nM
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CP0522336
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(E)-4-(3-methoxyphenyl)-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
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C24H18N2O2
|
1
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| 1 |
IC50 = 962 nM
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CP0525023
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(E)-4-(3-(1-methylpiperazine-4-carbonyl)phenyl)-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C29H26N4O2
|
1
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| 1 |
IC50 = 1040 nM
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CP0524539
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1-[(Z)-2-Cyclohexyloxy-2-(2,4-dichloro-phenyl)-vinyl]-1H-[1,2,4]triazole
Show/Hide
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C16H17Cl2N3O
|
1
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| 1 |
IC50 = 1050 nM
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CP0428732
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1-[(Z)-2-Cyclooctyloxy-2-(2,4-dichloro-phenyl)-vinyl]-1H-[1,2,4]triazole
Show/Hide
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C18H21Cl2N3O
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1
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| 1 |
IC50 = 1210 nM
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CP0414866
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1-[(Z)-2-Cycloheptyloxy-2-(4-trifluoromethyl-phenyl)-vinyl]-1H-[1,2,4]triazole
Show/Hide
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C18H20F3N3O
|
1
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| 1 |
IC50 = 1380 nM
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CP0510828
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(E)-8-methyl-4-(3-(trifluoromethyl)phenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
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C17H13F3N2O
|
1
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| 1 |
IC50 = 1530 nM
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CP0448963
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1-[(Z)-2-Benzyloxy-2-(2,6-dichloro-phenyl)-vinyl]-1H-[1,2,4]triazole
Show/Hide
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C17H13Cl2N3O
|
1
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| 1 |
IC50 = 2000 nM
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CP0501784
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(E)-2-(4-(3-cyanophenyl)-2-oxo-8-(2-phenylethynyl)-2,3-dihydro-1H-benzo[b][1,4]diazepin-7-yloxy)acetamide
Show/Hide
|
C26H18N4O3
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1
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| 1 |
IC50 = 2400 nM
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CP0509448
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1-[(Z)-2-Cyclopentyloxy-2-(2,4-dichloro-phenyl)-vinyl]-1H-[1,2,4]triazole
Show/Hide
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C15H15Cl2N3O
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1
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| 1 |
IC50 = 2550 nM
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CP0504842
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1-[(Z)-2-Benzyloxy-2-(2,4-dichloro-phenyl)-vinyl]-1H-tetrazole
Show/Hide
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C16H12Cl2N4O
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1
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| 1 |
IC50 = 2680 nM
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CP0438891
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(E)-4-(3-chlorophenyl)-8-methyl-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C16H13ClN2O
|
1
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| 1 |
IC50 = 2820 nM
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CP0501808
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(E)-3-(7-methyl-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
|
C17H13N3O
|
1
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| 1 |
IC50 = 2900 nM
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CP0375990
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2-[(Z)-2-Butoxy-2-(4-chloro-phenyl)-vinyl]-2H-tetrazole
Show/Hide
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C13H15ClN4O
|
1
|
| 1 |
IC50 = 3160 nM
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CP0496893
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1-[(Z)-2-(2,4-Dichloro-phenyl)-2-isopropoxy-vinyl]-1H-[1,2,4]triazole
Show/Hide
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C13H13Cl2N3O
|
2
|
| 1 |
IC50 = 6000 nM
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| 2 |
IC50 = 11500 nM
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CP0295902
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8-methyl-4-phenyl-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C16H14N2O
|
1
|
| 1 |
IC50 = 6400 nM
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CP0500553
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(E)-4-(3-methoxyphenyl)-8-methyl-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C17H16N2O2
|
1
|
| 1 |
IC50 = 6580 nM
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CP0522334
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(E)-3-(7-(3-hydroxy-3-methylbut-1-ynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile
Show/Hide
|
C21H17N3O2
|
1
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| 1 |
IC50 = 26000 nM
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CP0406519
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1-[2-(2,6-dichloro-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-6-yl]-ethanone
Show/Hide
|
C25H25Cl2N3O3S
|
2
|
| 1 |
IC50 = 30000 nM
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|
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| 2 |
Ki = 7000 nM
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CP0501079
|
1-[(Z)-2-(2,4-Difluoro-phenyl)-2-isopropoxy-vinyl]-1H-[1,2,4]triazole
Show/Hide
|
C13H13F2N3O
|
1
|
| 1 |
IC50 = 75000 nM
|
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CP0504186
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1-[(Z)-2-(2,4-Dimethoxy-phenyl)-2-isopropoxy-vinyl]-1H-[1,2,4]triazole
Show/Hide
|
C15H19N3O3
|
1
|
| 1 |
IC50 > 100000 nM
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CP0469288
|
(1R,2R,3R,5R,6R)-2-Amino-3-(3-carboxy-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
|
C16H16FNO7
|
1
|
| 1 |
Ki = 1.06 nM
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CP0429935
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(1R,2R,3R,5R,6R)-2-Amino-3-[(R)-1-(3,4-dichloro-phenyl)-ethoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
|
C16H16Cl2FNO5
|
1
|
| 1 |
Ki = 1.45 nM
|
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CP0392054
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(1R,2R,3R,5R,6R)-2-Amino-3-[(R)-1-(3,4-dichloro-phenyl)-butoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
|
C18H20Cl2FNO5
|
1
|
| 1 |
Ki = 1.48 nM
|
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CP0502825
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(1R,2R,3R,5R,6R)-2-Amino-3-[(R)-1-(3,4-dichloro-phenyl)-propoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C17H18Cl2FNO5
|
1
|
| 1 |
Ki = 1.61 nM
|
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CP0436519
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(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-((S)-1-naphthalen-2-yl-ethoxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C20H20FNO5
|
1
|
| 1 |
Ki = 1.79 nM
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CP0500540
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(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-((R)-1-naphthalen-2-yl-ethoxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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C20H20FNO5
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1
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| 1 |
Ki = 2.01 nM
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CP0405838
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(1R,2R,3R,5R,6R)-2-Amino-3-[bis-(3,4-dichloro-phenyl)-methoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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C21H16Cl4FNO5
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1
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| 1 |
Ki = 2.61 nM
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CP0406579
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(1R,2R,3R,5R,6R)-2-Amino-3-(3-cyano-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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C16H15FN2O5
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1
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| 1 |
Ki = 2.94 nM
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CP0497422
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(1R,2R,3R,5R,6R)-2-Amino-3-[(S)-1-(3,4-dichloro-phenyl)-butoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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C18H20Cl2FNO5
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1
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| 1 |
Ki = 3.05 nM
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CP0492972
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(1R,2R,3R,5R,6R)-2-Amino-3-[(S)-1-(3,4-dichloro-phenyl)-propoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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C17H18Cl2FNO5
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1
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| 1 |
Ki = 3.12 nM
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CP0491991
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(1R,2R,3R,5R,6R)-2-Amino-3-(3-chloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H15ClFNO5
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1
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| 1 |
Ki = 3.28 nM
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CP0506238
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(1R,2R,3R,5R,6R)-2-Amino-3-(3-chloro-4-fluoro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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C15H14ClF2NO5
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1
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| 1 |
Ki = 3.57 nM
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CP0496872
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(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3,4,5-trichloro-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H13Cl3FNO5
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1
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| 1 |
Ki = 3.67 nM
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CP0497433
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(1R,2R,3R,5R,6R)-2-Amino-3-[bis-(4-chloro-phenyl)-methoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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C21H18Cl2FNO5
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1
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| 1 |
Ki = 3.75 nM
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CP0440314
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(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-pentafluorophenylmethoxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H11F6NO5
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1
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| 1 |
Ki = 3.77 nM
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CP0497434
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(1R,2R,3R,5R,6R)-2-Amino-3-[bis-(4-fluoro-phenyl)-methoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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C21H18F3NO5
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1
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| 1 |
Ki = 3.79 nM
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CP0500805
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(1R,2R,3R,5R,6R)-2-Amino-3-(2,4-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H14Cl2FNO5
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1
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| 1 |
Ki = 3.89 nM
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CP0550894
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(1R,2R,3R,5R,6R)-2-Amino-3-(4-chloro-3-fluoro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H14ClF2NO5
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1
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| 1 |
Ki = 4.02 nM
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CP0491993
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(1R,2R,3R,5R,6R)-2-Amino-3-(biphenyl-2-ylmethoxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C21H20FNO5
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1
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| 1 |
Ki = 4.07 nM
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CP0374731
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(1R,2R,3R,5R,6R)-2-Amino-3-(2,3-difluoro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H14F3NO5
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1
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| 1 |
Ki = 4.25 nM
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CP0485762
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(1R,2R,3R,5R,6R)-2-Amino-3-(2,6-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H14Cl2FNO5
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1
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| 1 |
Ki = 4.3 nM
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CP0497294
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(1R,2R,3R,5R,6R)-2-Amino-3-(2,3-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H14Cl2FNO5
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1
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| 1 |
Ki = 4.35 nM
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CP0541498
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(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3-methyl-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C16H18FNO5
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1
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| 1 |
Ki = 4.53 nM
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CP0445907
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(1R,2R,3R,5R,6R)-2-Amino-3-(2,4-difluoro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H14F3NO5
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1
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| 1 |
Ki = 4.71 nM
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CP0485010
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(1R,2R,3R,5R,6R)-2-Amino-3-(3-bromo-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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C15H15BrFNO5
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1
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| 1 |
Ki = 4.71 nM
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CP0541488
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(1R,2R,3R,5R,6R)-2-Amino-3-(2-chloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H15ClFNO5
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1
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| 1 |
Ki = 4.99 nM
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CP0394652
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(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-propoxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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C11H16FNO5
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1
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| 1 |
Ki = 5.17 nM
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CP0379235
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(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(naphthalen-1-ylmethoxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C19H18FNO5
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1
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| 1 |
Ki = 5.36 nM
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CP0491990
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(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(4-fluoro-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H15F2NO5
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1
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| 1 |
Ki = 5.55 nM
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CP0521126
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(1R,2R,3R,5R,6R)-2-Amino-3-(3,5-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H14Cl2FNO5
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1
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| 1 |
Ki = 5.61 nM
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CP0511387
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(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3-trifluoromethyl-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C16H15F4NO5
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1
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| 1 |
Ki = 5.72 nM
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CP0491946
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(1R,2R,3R,5R,6R)-2-Amino-3-[(S)-1-(3,4-dichloro-phenyl)-ethoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C16H16Cl2FNO5
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1
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| 1 |
Ki = 5.81 nM
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CP0469289
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(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3-methoxy-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C16H18FNO6
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1
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| 1 |
Ki = 5.92 nM
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CP0435564
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(1R,2R,3R,5R,6R)-2-Amino-3-sec-butoxy-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C12H18FNO5
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1
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| 1 |
Ki = 6.68 nM
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CP0403586
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(1R,2R,3R,5R,6R)-2-Amino-3-(2,6-difluoro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H14F3NO5
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1
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| 1 |
Ki = 7.02 nM
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CP0491987
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(1R,2R,3R,5R,6R)-3-Allyloxy-2-amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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C11H14FNO5
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1
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| 1 |
Ki = 7.07 nM
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CP0374514
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(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3-phenoxy-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C21H20FNO6
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1
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| 1 |
Ki = 7.15 nM
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CP0494599
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(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3-nitro-benzyloxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H15FN2O7
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1
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| 1 |
Ki = 7.87 nM
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CP0543248
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(1R,2R,3R,5R,6R)-2-Amino-3-cyclopentyloxy-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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C13H18FNO5
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1
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| 1 |
Ki = 8.57 nM
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CP0502898
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(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(thiophen-2-ylmethoxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C13H14FNO5S
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1
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| 1 |
Ki = 8.79 nM
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CP0440234
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(1R,2R,3R,5R,6R)-2-Amino-3-(biphenyl-3-ylmethoxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C21H20FNO5
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1
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| 1 |
Ki = 9.34 nM
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CP0497452
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(1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3-phenyl-propoxy)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C17H20FNO5
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1
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| 1 |
Ki = 9.83 nM
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CP0437051
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(1R,2R,3R,5R,6R)-2-Amino-3-(2,5-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H14Cl2FNO5
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1
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| 1 |
Ki = 11.8 nM
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CP0509748
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(1R,2R,3R,5R,6R)-2-Amino-3-(3,5-difluoro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H14F3NO5
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1
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| 1 |
Ki = 12.4 nM
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CP0445908
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(1R,2R,3R,5R,6R)-2-Amino-3-(2,5-difluoro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H14F3NO5
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1
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| 1 |
Ki = 14.4 nM
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CP0499951
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(1R,2R,3R,5R,6R)-2-Amino-3-(3-amino-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H17FN2O5
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1
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| 1 |
Ki = 15.4 nM
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CP0432785
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(1R,2R,3S,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H14Cl2FNO5
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1
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| 1 |
Ki = 17.1 nM
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CP0497251
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(1R,2R,3S,5R,6R)-2-Amino-3-[bis-(4-chloro-phenyl)-methoxy]-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C21H18Cl2FNO5
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1
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| 1 |
Ki = 20.2 nM
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CP0485011
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(1R,2R,3R,5R,6R)-2-Amino-3-(biphenyl-4-ylmethoxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C21H20FNO5
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1
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| 1 |
Ki = 25.6 nM
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CP0433546
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(1R,2S,4R,5R)-2-Amino-6-(R)-fluoro-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C8H10FNO5
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1
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| 1 |
Ki = 105 nM
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CP0497250
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(1R,2R,3S,5R,6R)-2-Amino-6-fluoro-3-methoxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C9H12FNO5
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1
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| 1 |
Ki = 190 nM
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CP0448141
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2-(2,4-Dichloro-phenyl)-5-(2-methoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester
Show/Hide
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C25H25Cl2N3O3S
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1
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| 1 |
Ki = 1000 nM
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CP0535343
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2-(2,6-Dichloro-phenyl)-7-ethyl-5-(2-methoxy-phenyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester
Show/Hide
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C26H27Cl2N3O3S
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1
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| 1 |
Ki = 1000 nM
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CP0516104
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2-(2,6-Dichloro-phenyl)-5-(2-methoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester
Show/Hide
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C25H25Cl2N3O3S
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1
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| 1 |
Ki = 1500 nM
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CP0462808
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2-(2,6-Dichloro-phenyl)-5-(3-methoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester
Show/Hide
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C25H25Cl2N3O3S
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1
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| 1 |
Ki = 2000 nM
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CP0466563
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2-(2,6-Dichloro-phenyl)-5-(2-isopropoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester
Show/Hide
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C27H29Cl2N3O3S
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1
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| 1 |
Ki = 2000 nM
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CP0535617
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5-(2-Chloro-phenyl)-2-(2,6-dichloro-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester
Show/Hide
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C24H22Cl3N3O2S
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1
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| 1 |
Ki = 2000 nM
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CP0380437
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2-(2,6-Dichloro-phenyl)-5-(2-methoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 3-dimethylamino-propyl ester
Show/Hide
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C26H27Cl2N3O3S
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1
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| 1 |
Ki = 2400 nM
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CP0526091
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2-(2,6-Dichloro-phenyl)-5-(2-ethoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester
Show/Hide
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C26H27Cl2N3O3S
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1
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| 1 |
Ki = 3000 nM
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CP0559676
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2-(2,6-Dichloro-phenyl)-5-(2-fluoro-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester
Show/Hide
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C24H22Cl2FN3O2S
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1
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| 1 |
Ki = 3200 nM
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CP0451223
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2-(2,6-Dichloro-phenyl)-7-isopropyl-5-(2-methoxy-phenyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester
Show/Hide
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C27H29Cl2N3O3S
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1
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| 1 |
Ki = 4000 nM
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CP0460067
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2-(4-Chloro-phenyl)-5-(2-methoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester
Show/Hide
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C25H26ClN3O3S
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1
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| 1 |
Ki = 4000 nM
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CP0498119
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2-(2,6-Dichloro-phenyl)-5-(2-methoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester
Show/Hide
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C23H20Cl2N2O3S
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1
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| 1 |
Ki = 4000 nM
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CP0408490
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2-(2,6-Dichloro-phenyl)-7-methyl-5-o-tolyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester
Show/Hide
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C25H25Cl2N3O2S
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1
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| 1 |
Ki = 8000 nM
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CP0480629
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7-Benzoyl-2-(2,6-dichloro-phenyl)-5-(2-methoxy-phenyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid 2-dimethylamino-ethyl ester
Show/Hide
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C31H27Cl2N3O4S
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1
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| 1 |
Ki > 10000 nM
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CP0515290
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2-(2,6-Dichloro-phenyl)-5-(2-methoxy-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid (2-dimethylamino-ethyl)-amide
Show/Hide
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C25H26Cl2N4O2S
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1
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| 1 |
Ki > 10000 nM
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CP0485761
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(1S,2S,3S,5S,6S)-2-Amino-3-(3,4-dichloro-benzyloxy)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Show/Hide
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C15H14Cl2FNO5
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1
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| 1 |
Ki > 10000 nM
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