| Compound ID |
Compound Name |
Compound Formula |
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CP0404503
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(3S)-N-[(2R)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(4-iodophenyl)-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
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C36H42IN9O4
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3
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| 1 |
Activity = 0.3 nM
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| 2 |
Kd = 0.7943 nM
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|
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| 3 |
Ki = 0.79 nM
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CP0374300
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(3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(4H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide
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C50H69N15O9
|
1
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| 1 |
EC50 = 0.11 nM
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CP0458781
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-1-[(3R)-3-hydroxypyrrolidin-1-yl]-2-methylpropan-1-one
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C37H48ClF2N3O3
|
2
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| 1 |
EC50 = 0.25 nM
|
|
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| 2 |
IC50 = 0.53 nM
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CP0411217
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(3S,11S,14S,17S,20R,23S)-3-[[(2S)-2-acetamidohexanoyl]amino]-20-benzyl-17-[3-(diaminomethylideneamino)propyl]-14-(1H-indol-3-ylmethyl)-2,5,13,16,19,22-hexaoxo-1,6,12,15,18,21-hexazabicyclo[21.3.0]hexacosane-11-carboxamide
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C49H69N13O9
|
1
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| 1 |
EC50 = 0.34 nM
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CP0373322
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-1-[(3S)-3-hydroxypyrrolidin-1-yl]-2-methylpropan-1-one
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C37H48ClF2N3O3
|
2
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| 1 |
EC50 = 0.37 nM
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| 2 |
IC50 = 0.89 nM
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CP0397988
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-2-methyl-1-morpholin-4-ylpropan-1-one
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C37H48ClF2N3O3
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2
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| 1 |
EC50 = 0.38 nM
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| 2 |
IC50 = 0.85 nM
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CP0375196
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1-(azetidin-1-yl)-2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-2-methylpropan-1-one
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C36H46ClF2N3O2
|
2
|
| 1 |
EC50 = 0.59 nM
|
|
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| 2 |
IC50 = 1.1 nM
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CP0383644
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(S)-(6-chloro-5-methyl-3-(2-morpholinopropan-2-yl)-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl)methanone
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C36H46ClF2N3O4
|
2
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| 1 |
EC50 = 0.6 nM
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| 2 |
IC50 = 1 nM
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CP0436625
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-1-[(3R)-3-methoxypyrrolidin-1-yl]-2-methylpropan-1-one
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C38H50ClF2N3O3
|
2
|
| 1 |
EC50 = 0.69 nM
|
|
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| 2 |
IC50 = 1.4 nM
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CP0436185
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-2-methyl-1-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]propan-1-one
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|
C38H48ClF2N3O3
|
2
|
| 1 |
EC50 = 0.76 nM
|
|
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| 2 |
IC50 = 1.6 nM
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CP0383645
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(S)-(6-chloro-3-(2-((S)-3-hydroxypyrrolidin-1-yl)propan-2-yl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl)methanone
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|
C36H46ClF2N3O4
|
2
|
| 1 |
EC50 = 0.8 nM
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|
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| 2 |
IC50 = 1.4 nM
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CP0436634
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-N-cyclopropyl-2-methylpropanamide
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C36H46ClF2N3O2
|
2
|
| 1 |
EC50 = 0.8 nM
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| 2 |
IC50 = 2.2 nM
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CP0376062
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-N,N,2-trimethylpropanamide
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C35H46ClF2N3O2
|
2
|
| 1 |
EC50 = 0.87 nM
|
|
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| 2 |
IC50 = 0.71 nM
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CP0458785
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-N,2-dimethylpropanamide
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|
C34H44ClF2N3O2
|
2
|
| 1 |
EC50 = 0.91 nM
|
|
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| 2 |
IC50 = 2.6 nM
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CP0397987
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-2-methylpropan-1-one
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|
C37H47ClF3N3O2
|
2
|
| 1 |
EC50 = 0.98 nM
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|
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| 2 |
IC50 = 1.4 nM
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CP0458787
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-2-methyl-1-pyrrolidin-1-ylpropan-1-one
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|
C37H48ClF2N3O2
|
2
|
| 1 |
EC50 = 1 nM
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|
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| 2 |
IC50 = 1.8 nM
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CP0398561
|
2-((S)-1'-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)-6-chloro-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
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|
C32H38ClF2N3O2
|
2
|
| 1 |
EC50 = 1.1 nM
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|
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| 2 |
IC50 = 0.9 nM
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CP0373321
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-1-[(3R)-3-fluoropyrrolidin-1-yl]-2-methylpropan-1-one
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|
C37H47ClF3N3O2
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2
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| 1 |
EC50 = 1.1 nM
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|
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| 2 |
IC50 = 1.6 nM
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CP0502886
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-N-(2-fluoroethyl)-2-methylpropanamide
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C35H45ClF3N3O2
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2
|
| 1 |
EC50 = 1.1 nM
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| 2 |
IC50 = 2.6 nM
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CP0458782
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-1-[(3S)-3-methoxypyrrolidin-1-yl]-2-methylpropan-1-one
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|
C38H50ClF2N3O3
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2
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| 1 |
EC50 = 1.2 nM
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| 2 |
IC50 = 2.3 nM
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CP0501239
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-N-(2-hydroxyethyl)-2-methylpropanamide
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|
C35H46ClF2N3O3
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2
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| 1 |
EC50 = 1.3 nM
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| 2 |
IC50 = 2.6 nM
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CP0375193
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-N-ethyl-2-methylpropanamide
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|
C35H46ClF2N3O2
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2
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| 1 |
EC50 = 1.4 nM
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| 2 |
IC50 = 3.1 nM
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CP0501574
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(S)-(6-chloro-3-(2-(dimethylamino)propan-2-yl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl)methanone
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|
C34H44ClF2N3O3
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2
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| 1 |
EC50 = 1.5 nM
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| 2 |
IC50 = 2.4 nM
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CP0373323
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-N-ethyl-N,2-dimethylpropanamide
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|
C36H48ClF2N3O2
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2
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| 1 |
EC50 = 1.6 nM
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| 2 |
IC50 = 2.1 nM
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CP0458340
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-N,N-diethyl-2-methylpropanamide
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C37H50ClF2N3O2
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2
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| 1 |
EC50 = 1.7 nM
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| 2 |
IC50 = 2.6 nM
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CP0045108
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(4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid
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|
C77H109N21O19S
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4
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| 1 |
EC50 = 1.9 nM
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| 2 |
EC50 = 2.2 nM
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| 3 |
IC50 = 19 nM
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| 4 |
Ki = 21 nM
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CP0436184
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-N-(1-hydroxy-2-methylpropan-2-yl)-2-methylpropanamide
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|
C37H50ClF2N3O3
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2
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| 1 |
EC50 = 1.9 nM
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| 2 |
IC50 = 3.9 nM
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CP0083436
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N-[(1S)-1-[2-[1-[(3S,4R)-4-(4-bromo-2-fluorophenyl)-1-tert-butylpyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
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|
C31H40BrClFN3O2
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2
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| 1 |
EC50 = 2.1 nM
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| 2 |
IC50 = 4 nM
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CP0375191
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N-[2-[(1R)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]propan-2-yl]-N-methylacetamide
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|
C35H46ClF2N3O2
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2
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| 1 |
EC50 = 2.1 nM
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| 2 |
IC50 = 8.5 nM
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CP0474889
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-2-methyl-N-(oxan-4-yl)propanamide
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C38H50ClF2N3O3
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2
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| 1 |
EC50 = 2.3 nM
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| 2 |
IC50 = 2.5 nM
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CP0493345
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2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(1-hydroxy-2-methylpropan-2-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
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|
C32H38ClF2N3O3
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2
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| 1 |
EC50 = 2.6 nM
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| 2 |
IC50 = 2.8 nM
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CP0283823
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2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
Show/Hide
|
C33H38ClF2N3O3
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2
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| 1 |
EC50 = 2.7 nM
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| 2 |
IC50 = 2 nM
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CP0202447
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N-[(1S)-1-[2-[1-[(3S,4R)-1-tert-butyl-4-(4-chloro-2-fluorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
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|
C31H40Cl2FN3O2
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2
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| 1 |
EC50 = 2.8 nM
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| 2 |
IC50 = 6.2 nM
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CP0464643
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N-[(2R)-1-[[(2R)-1-(4-butanoyl-4-cyclohexylpiperidin-1-yl)-3-(4-chlorophenyl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-2-yl)-1-oxopropan-2-yl]benzamide
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C37H46ClN5O4
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1
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| 1 |
EC50 = 2.9 nM
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CP0487086
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(S)-(6-chloro-3-(2-(3,3-difluoropyrrolidin-1-yl)propan-2-yl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl)methanone
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|
C36H44ClF4N3O3
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2
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| 1 |
EC50 = 2.9 nM
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| 2 |
IC50 = 2.4 nM
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CP0458786
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-2-methyl-N-propan-2-ylpropanamide
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C36H48ClF2N3O2
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2
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| 1 |
EC50 = 2.9 nM
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| 2 |
IC50 = 5.9 nM
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CP0453783
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(S)-(6-chloro-5-methyl-3-(2-(pyrrolidin-1-yl)propan-2-yl)-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl)methanone
Show/Hide
|
C36H46ClF2N3O3
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2
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| 1 |
EC50 = 3.1 nM
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| 2 |
IC50 = 1.6 nM
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CP0401729
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(S)-(6-chloro-3-(2-(ethylamino)propan-2-yl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl)methanone
Show/Hide
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C34H44ClF2N3O3
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2
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| 1 |
EC50 = 3.3 nM
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| 2 |
IC50 = 2.3 nM
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CP0401382
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N-[2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]propan-2-yl]acetamide
Show/Hide
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C34H44ClF2N3O2
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2
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| 1 |
EC50 = 3.3 nM
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| 2 |
IC50 = 4.5 nM
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CP0378145
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[1-(piperidin-3-ylamino)-ethyl]-phenyl}-piperazin-1-yl)-ethyl]-amide
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C36H45ClN6O2
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2
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| 1 |
EC50 = 3.8 nM
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| 2 |
EC50 = 4.7 nM
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CP0398565
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(S)-(6-chloro-5-methyl-3-(2-(methylamino)propan-2-yl)-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl)methanone
Show/Hide
|
C33H42ClF2N3O3
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2
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| 1 |
EC50 = 3.8 nM
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| 2 |
IC50 = 3.6 nM
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CP0436186
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-1-(3,3-difluoropyrrolidin-1-yl)-2-methylpropan-1-one
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C37H46ClF4N3O2
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2
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| 1 |
EC50 = 3.8 nM
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| 2 |
IC50 = 2 nM
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CP0383465
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((3R,4S)-4-(2,4-difluorophenyl)-1-(pyrimidin-4-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
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C28H30F2N4O2
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2
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| 1 |
EC50 = 4 nM
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| 2 |
Ki = 64 nM
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CP0896615
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(3R,4R,5S)-1-{[(3S,4R)-4-(2,4-Difluorophenyl)-1-pyridazin-3-ylpyrrolidin-3-yl]carbonyl}-4-(4-fluorophenyl)-3,5-dimethylpiperidin-4-ol Hydrochloride
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C28H30ClF3N4O2
|
1
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| 1 |
EC50 = 4 nM
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CP0524744
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-2-methyl-N-(2,2,2-trifluoroethyl)propanamide
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C35H43ClF5N3O2
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2
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| 1 |
EC50 = 4.2 nM
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| 2 |
IC50 = 5.4 nM
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CP0458338
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-1-(3,3-difluoroazetidin-1-yl)-2-methylpropan-1-one
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C36H44ClF4N3O2
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2
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| 1 |
EC50 = 4.3 nM
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| 2 |
IC50 = 1.8 nM
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CP0474317
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N-[2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]propan-2-yl]-N-methylacetamide
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C35H46ClF2N3O2
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2
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| 1 |
EC50 = 4.3 nM
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| 2 |
IC50 = 2.5 nM
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CP0161427
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N-[(1S)-1-[2-[1-[(3S,4R)-1-tert-butyl-4-(2-fluoro-4-methoxyphenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
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C32H43ClFN3O3
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2
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| 1 |
EC50 = 4.6 nM
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| 2 |
IC50 = 11.2 nM
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CP0377765
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N-[2-[(1R)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]propan-2-yl]acetamide
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C34H44ClF2N3O2
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2
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| 1 |
EC50 = 4.6 nM
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| 2 |
IC50 = 13 nM
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CP0430472
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((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridin-3-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
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C29H31F2N3O2
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2
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| 1 |
EC50 = 5 nM
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| 2 |
Ki = 50 nM
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CP0382248
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(2S)-2-amino-N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-(oxan-4-yl)pyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]propanamide
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C34H48ClN5O3
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1
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| 1 |
EC50 = 5.2 nM
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CP0149367
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide
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C33H41ClN6O2
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2
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| 1 |
EC50 = 5.7 nM
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| 2 |
IC50 = 1.2 nM
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CP0382253
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3-amino-N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-(oxan-4-yl)pyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]propanamide
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C34H48ClN5O3
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1
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| 1 |
EC50 = 6 nM
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CP0374301
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((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-(3-fluorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
Show/Hide
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C28H35F3N2O2
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2
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| 1 |
EC50 = 6 nM
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| 2 |
Ki = 97 nM
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CP0400031
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((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridazin-3-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
Show/Hide
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C28H30F2N4O2
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2
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| 1 |
EC50 = 6 nM
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| 2 |
Ki = 10 nM
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CP0460887
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-dimethylaminomethyl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide
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C32H38ClN5O2
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1
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| 1 |
EC50 = 7 nM
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CP0430471
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((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridazin-3-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-(pyridin-2-yl)piperidin-1-yl)methanone
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C27H29F2N5O2
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2
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| 1 |
EC50 = 7 nM
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| 2 |
Ki = 52 nM
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CP0415239
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N-[2-[(1S)-5-chloro-1'-[(3S,4R)-4-(2,4-difluorophenyl)-1-(oxan-4-yl)pyrrolidine-3-carbonyl]-6-methylspiro[1H-2-benzofuran-3,4'-piperidine]-1-yl]propan-2-yl]acetamide
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C34H42ClF2N3O4
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2
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| 1 |
EC50 = 7.4 nM
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| 2 |
IC50 = 6.2 nM
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CP0493346
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2-((S)-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carbonyl)-5,6-difluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
Show/Hide
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C32H35F4N3O3
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2
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| 1 |
EC50 = 8.4 nM
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| 2 |
IC50 = 7.6 nM
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CP0372778
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2-amino-N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-(oxan-4-yl)pyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]acetamide
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C33H46ClN5O3
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1
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| 1 |
EC50 = 9.1 nM
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CP0415246
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2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-isopropylpyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
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C31H36ClF2N3O2
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2
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| 1 |
EC50 = 9.8 nM
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| 2 |
IC50 = 6.6 nM
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CP0508622
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N-tert-butyl-2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-2-methylpropanamide
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C37H50ClF2N3O2
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2
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| 1 |
EC50 = 9.9 nM
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| 2 |
IC50 = 12 nM
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CP0377910
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1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[1-((S)-pyrrolidin-3-ylamino)-ethyl]-phenyl}-piperazin-1-yl)-ethyl]-amide
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C35H43ClN6O2
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1
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| 1 |
EC50 = 12 nM
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CP0849936
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(3R,4R,5S)-1-{[(3S,4R)-1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]carbonyl}-3,5-dimethyl-4-phenylpiperidin-4-ol Hydrochloride
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C28H37ClF2N2O2
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2
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| 1 |
EC50 = 12 nM
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| 2 |
Ki = 27 nM
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CP0458784
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2-[(1R)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-N,2-dimethylpropanamide
Show/Hide
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C34H44ClF2N3O2
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2
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| 1 |
EC50 = 12 nM
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| 2 |
IC50 = 47 nM
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CP0853376
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(S)-2-[(R)-2-(4-tert-Butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-methyl-piperazine-1-carboxylic acid tert-butyl ester
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C35H54FN5O5
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2
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| 1 |
EC50 = 13 nM
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| 2 |
IC50 = 18 nM
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CP0462980
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(3R,5S)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,5-diethylpiperazine-1-carboxamide
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C34H54FN5O3
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2
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| 1 |
EC50 = 13 nM
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| 2 |
IC50 = 4.7 nM
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CP0162604
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N-[(1S)-1-[2-[1-[(3R,4S)-4-(4-bromo-2-fluorophenyl)-1-tert-butylpyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
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C31H40BrClFN3O2
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2
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| 1 |
EC50 = 13.4 nM
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| 2 |
IC50 = 4.1 nM
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CP0213531
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(S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}-piperazin-1-yl)-3-(4-chloro-benzyl)-N-cyclobutyl-4-oxo-butyramide
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C31H41ClN4O3
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1
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| 1 |
EC50 = 15 nM
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CP0374520
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-2-(4-{2-[1-((S)-2-amino-cyclohexylamino)-ethyl]-phenyl}-piperazin-1-yl)-1-(4-chloro-benzyl)-2-oxo-ethyl]-amide
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C37H47ClN6O2
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1
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| 1 |
EC50 = 15 nM
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CP0374304
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((3R,4S)-4-(2,4-difluorophenyl)-1-(pyridin-2-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
Show/Hide
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C29H31F2N3O2
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2
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| 1 |
EC50 = 15 nM
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| 2 |
Ki = 79 nM
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CP0845517
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(3R,4R,5S)-1-{[(3S,4R)-1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]carbonyl}-4-(3,4-difluorophenyl)-3,5-dimethylpiperidin-4-ol Hydrochloride
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C28H35ClF4N2O2
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1
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| 1 |
EC50 = 15 nM
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CP0440988
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N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(dimethylamino)propanamide
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C34H50ClN5O2
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1
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| 1 |
EC50 = 16 nM
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CP0440984
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(2R)-2-amino-N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-(oxan-4-yl)pyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]propanamide
Show/Hide
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C34H48ClN5O3
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1
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| 1 |
EC50 = 17 nM
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CP0415240
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2-((S)-5-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carbonyl)-6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
Show/Hide
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C32H35ClF3N3O3
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2
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| 1 |
EC50 = 17.1 nM
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| 2 |
IC50 = 7.3 nM
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CP0316843
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N-[(1S)-1-[2-[1-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
Show/Hide
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C31H40ClF2N3O2
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3
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| 1 |
EC50 = 17.9 nM
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| 2 |
EC50 = 18 nM
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| 3 |
IC50 = 70 nM
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CP0393473
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1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ((R)-1-(4-chloro-benzyl)-2-{4-[2-((S)-2-methyl-5-(S)-methyl-piperazin-1-ylmethyl)-phenyl]-piperazin-1-yl}-2-oxo-ethyl)-amide
Show/Hide
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C36H45ClN6O2
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1
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| 1 |
EC50 = 18 nM
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CP0402318
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((3R,4S)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
Show/Hide
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C29H36F2N2O3
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2
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| 1 |
EC50 = 18 nM
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| 2 |
Ki = 36 nM
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CP0845107
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(3R,4R,5S)-1-{[(3S,4R)-1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]carbonyl}-4-(4-fluorophenyl)-3,5-dimethylpiperidin-4-ol Hydrochloride
Show/Hide
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C28H36ClF3N2O2
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2
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| 1 |
EC50 = 18 nM
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| 2 |
Ki = 36 nM
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CP0378158
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(3R,5R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,5-dimethylpiperazine-1-carboxamide
Show/Hide
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C32H50FN5O3
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2
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| 1 |
EC50 = 18 nM
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| 2 |
IC50 = 11 nM
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CP0433110
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N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-(oxan-4-yl)pyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-2-(methylamino)acetamide
Show/Hide
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C34H48ClN5O3
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1
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| 1 |
EC50 = 19 nM
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CP0505882
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((3R,4S)-4-(2,4-difluorophenyl)-1-propylpyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
Show/Hide
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C27H34F2N2O2
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1
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| 1 |
EC50 = 19 nM
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CP0378167
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(1S,4R,6R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-2-azabicyclo[2.2.2]octane-6-carboxamide
Show/Hide
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C33H49FN4O3
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2
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| 1 |
EC50 = 20 nM
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| 2 |
IC50 = 16 nM
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CP0440983
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N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidine-3-carbonyl]piperazin-1-yl]-3-fluorophenyl]-2-methylpropyl]-3-(dimethylamino)propanamide
Show/Hide
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C33H47ClFN5O2
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1
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| 1 |
EC50 = 20 nM
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CP0845516
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(3R,4R,5S)-1-{[(3S,4R)-4-(2,4-Difluorophenyl)-1-pyridazin-3-ylpyrrolidin-3-yl]carbonyl}-3,5-dimethyl-4-propylpiperidin-4-ol Hydrochloride
Show/Hide
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C25H33ClF2N4O2
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2
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| 1 |
EC50 = 21 nM
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| 2 |
Ki = 56 nM
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CP0315803
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(3S,5R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,5-dimethylpiperazine-1-carboxamide
Show/Hide
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C32H50FN5O3
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2
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| 1 |
EC50 = 22 nM
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| 2 |
IC50 = 4.9 nM
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CP0185277
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(4-(2-((S)-1-amino-2-methylpropyl)-4-methylphenyl)piperazin-1-yl)((3S,4R)-4-(4-chlorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl)methanone
Show/Hide
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C31H43ClN4O2
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1
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| 1 |
EC50 = 24 nM
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CP0440987
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N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)-1-propanoylpyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(dimethylamino)propanamide
Show/Hide
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C34H48ClN5O3
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1
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| 1 |
EC50 = 27 nM
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CP0441550
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2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-2-methyl-N-(2-methylpropyl)propanamide
Show/Hide
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C37H50ClF2N3O2
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2
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| 1 |
EC50 = 27 nM
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| 2 |
IC50 = 6.6 nM
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CP0455734
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2-[(1R)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-N-cyclopropyl-2-methylpropanamide
Show/Hide
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C36H46ClF2N3O2
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2
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| 1 |
EC50 = 28 nM
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| 2 |
IC50 = 55 nM
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CP0877838
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(S)-1-Methyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide dihydrochloride
Show/Hide
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C31H50Cl2FN5O3
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2
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| 1 |
EC50 = 29 nM
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| 2 |
IC50 = 87 nM
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CP0539269
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(2S)-1-[(3S,11S,14S,17S,20R,23S)-3-[[(2S)-2-acetamidohexanoyl]amino]-20-benzyl-17-[3-(diaminomethylideneamino)propyl]-14-(1H-indol-3-ylmethyl)-2,5,13,16,19,22-hexaoxo-1,6,12,15,18,21-hexazabicyclo[21.3.0]hexacosane-11-carbonyl]-N-[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]pyrrolidine-2-carboxamide
Show/Hide
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C59H85N15O11
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1
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| 1 |
EC50 = 29 nM
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CP0401418
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((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-(4-chlorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
Show/Hide
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C28H35ClF2N2O2
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2
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| 1 |
EC50 = 30 nM
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| 2 |
Ki = 48 nM
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CP0374305
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((3R,4S)-1-cyclobutyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
Show/Hide
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C28H34F2N2O2
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2
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| 1 |
EC50 = 32 nM
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| 2 |
Ki = 62 nM
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CP0425031
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2-[(1R)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-N-ethyl-2-methylpropanamide
Show/Hide
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C35H46ClF2N3O2
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2
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| 1 |
EC50 = 32 nM
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| 2 |
IC50 = 53 nM
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CP0398563
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2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(pentan-3-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
Show/Hide
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C33H40ClF2N3O2
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2
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| 1 |
EC50 = 33.6 nM
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| 2 |
IC50 = 11.9 nM
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CP0440318
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1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-2-(4-{2-[1-(4-amino-cyclohexylamino)-ethyl]-phenyl}-piperazin-1-yl)-1-(4-chloro-benzyl)-2-oxo-ethyl]-amide
Show/Hide
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C37H47ClN6O2
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1
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| 1 |
EC50 = 34 nM
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CP0406610
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(1S,4R,6S)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide
Show/Hide
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C34H51FN4O3
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2
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| 1 |
EC50 = 34 nM
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| 2 |
IC50 = 6 nM
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CP0853375
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(S)-4-Isobutyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide; compound with 2 TFA
Show/Hide
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C38H56F7N5O7
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2
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| 1 |
EC50 = 34 nM
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| 2 |
IC50 = 8 nM
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CP0485035
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-(4-{2-[(3-hydroxy-propylamino)-methyl]-phenyl}-piperazin-1-yl)-2-oxo-ethyl]-amide
Show/Hide
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C33H40ClN5O3
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1
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| 1 |
EC50 = 36 nM
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CP0408646
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N-[(2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxopropan-2-yl]-3-(dimethylamino)propanamide
Show/Hide
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C28H41ClN6O2
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1
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| 1 |
EC50 = 40 nM
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CP0421162
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-{[(2-hydroxy-ethyl)-methyl-amino]-methyl}-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide
Show/Hide
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C33H40ClN5O3
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1
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| 1 |
EC50 = 40 nM
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CP0915219
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(3R,4R,5S)-1-{[(3S,4R)-4-(2,4-Difluorophenyl)-1-isopropylpyrrolidin-3-yl]carbonyl}-4-(3-fluorophenyl)-3,5-dimethylpiperidin-4-ol Hydrochloride
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C27H34ClF3N2O2
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1
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| 1 |
EC50 = 40 nM
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CP0458339
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N-benzyl-2-[(1S)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-2-methylpropanamide
Show/Hide
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C40H48ClF2N3O2
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2
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| 1 |
EC50 = 42 nM
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| 2 |
IC50 = 12 nM
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CP0372779
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N-[(1S)-1-[2-[4-[(3S,4R)-1-acetyl-4-(4-chlorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(dimethylamino)propanamide
Show/Hide
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C33H46ClN5O3
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1
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| 1 |
EC50 = 44 nM
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CP0874910
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(+/-)-2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-3-methoxy-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-(4-fluorophenyl)N-isopropylacetamide
Show/Hide
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C31H30FN5O4
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1
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| 1 |
EC50 = 44.67 nM
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CP0462856
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((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-(2,6-difluorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
Show/Hide
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C28H34F4N2O2
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2
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| 1 |
EC50 = 45 nM
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| 2 |
Ki = 99 nM
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CP0402317
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((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-hydroxy-3,5-dimethyl-4-(pyridin-2-yl)piperidin-1-yl)methanone
Show/Hide
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C27H35F2N3O2
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2
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| 1 |
EC50 = 46 nM
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| 2 |
Ki = 350 nM
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CP0421163
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1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-{[(2-methoxy-ethyl)-methyl-amino]-methyl}-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide
Show/Hide
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C34H42ClN5O3
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1
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| 1 |
EC50 = 51 nM
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CP0858959
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(3R,4R,5S)-4-(2,4-Difluorophenyl)-1-{[(3S,4R)-4-(2,4-difluorophenyl)-1-ethylpyrrolidin-3-yl]carbonyl}-3,5-dimethylpiperidin-4-ol Hydrochloride
Show/Hide
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C26H31ClF4N2O2
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1
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| 1 |
EC50 = 51 nM
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CP0406608
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(1S,4S,6S)-2-Aza-bicyclo[2.2.2]octane-6-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide
Show/Hide
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C33H49FN4O3
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2
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| 1 |
EC50 = 52 nM
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| 2 |
IC50 = 14 nM
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CP0869660
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(S)-4-(2,2-Difluoro-ethyl)-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide; compound with 2 TFA
Show/Hide
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C36H50F9N5O7
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2
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| 1 |
EC50 = 52 nM
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| 2 |
IC50 = 13 nM
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CP0895694
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(S)-4-Ethyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide; compound with 2 TFA
Show/Hide
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C36H52F7N5O7
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2
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| 1 |
EC50 = 52 nM
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| 2 |
IC50 = 20 nM
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CP0520424
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((3S,4R)-4-(2,4-difluorophenyl)-1-isopropylpyrrolidin-3-yl)((3S,4R,5R)-4-(4-fluorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
Show/Hide
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C27H33F3N2O2
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1
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| 1 |
EC50 = 52 nM
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CP0859527
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(3R,4R,5S)-1-{[(3S,4R)-1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]carbonyl}-4-(4-methoxyphenyl)-3,5-dimethylpiperidin-4-ol Hydrochloride
Show/Hide
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C29H39ClF2N2O3
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1
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| 1 |
EC50 = 53 nM
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CP0377057
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2-[(1R)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-N,N,2-trimethylpropanamide
Show/Hide
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C35H46ClF2N3O2
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2
|
| 1 |
EC50 = 53 nM
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| 2 |
IC50 = 59 nM
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CP0374306
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((3R,4S)-1-cyclopropyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
Show/Hide
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C27H32F2N2O2
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2
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| 1 |
EC50 = 55 nM
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| 2 |
Ki = 290 nM
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CP0422856
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(3S,5S)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,5-dimethylpiperazine-1-carboxamide
Show/Hide
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C32H50FN5O3
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2
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| 1 |
EC50 = 58 nM
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| 2 |
IC50 = 12 nM
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CP0438966
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(3R,5S)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,4,5-trimethylpiperazine-1-carboxamide
Show/Hide
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C33H52FN5O3
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2
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| 1 |
EC50 = 60 nM
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| 2 |
IC50 = 16 nM
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CP0391026
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((3S,4R)-4-(2,4-difluorophenyl)-1-ethylpyrrolidin-3-yl)((3S,4R,5R)-4-(3-fluorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
Show/Hide
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C26H31F3N2O2
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2
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| 1 |
EC50 = 61 nM
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| 2 |
Ki = 355 nM
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CP0391042
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((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-(2,4-difluorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
Show/Hide
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C28H34F4N2O2
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2
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| 1 |
EC50 = 62 nM
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| 2 |
Ki = 176 nM
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CP0394884
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N-[(1S)-1-[2-[1-[(3S,4R)-1-tert-butyl-4-[4-(trifluoromethyl)phenyl]pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
Show/Hide
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C32H41ClF3N3O2
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2
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| 1 |
EC50 = 67.2 nM
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| 2 |
IC50 = 28.1 nM
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CP0383468
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((3S,4R)-4-(2,4-difluorophenyl)-1-isopropylpyrrolidin-3-yl)((3S,4R,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
Show/Hide
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C27H34F2N2O2
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2
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| 1 |
EC50 = 69 nM
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| 2 |
Ki = 114 nM
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CP0921462
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(3R,4R,5S)-4-(3,4-Difluorophenyl)-1-{[(3S,4R)-4-(2,4-difluorophenyl)-1-ethylpyrrolidin-3-yl]carbonyl}-3,5-dimethylpiperidin-4-ol Hydrochloride
Show/Hide
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C26H31ClF4N2O2
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1
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| 1 |
EC50 = 69 nM
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CP0374532
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1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ((R)-1-(4-chloro-benzyl)-2-{4-[2-(1-cyclopentylamino-ethyl)-phenyl]-piperazin-1-yl}-2-oxo-ethyl)-amide
Show/Hide
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C36H44ClN5O2
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1
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| 1 |
EC50 = 72 nM
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CP0383452
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((3R,4S)-4-(2,4-difluorophenyl)-1-isobutylpyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
Show/Hide
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C28H36F2N2O2
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1
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| 1 |
EC50 = 73 nM
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CP0398564
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2-((3S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(1-methoxypropan-2-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
Show/Hide
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C32H38ClF2N3O3
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2
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| 1 |
EC50 = 73.2 nM
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| 2 |
IC50 = 44.3 nM
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CP0383642
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2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
Show/Hide
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C28H30ClF2N3O2
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2
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| 1 |
EC50 = 78.1 nM
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| 2 |
IC50 = 15 nM
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CP0454311
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N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-chlorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(dimethylamino)propanamide
Show/Hide
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C31H44ClN5O2
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1
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| 1 |
EC50 = 79 nM
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CP0509361
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((3R,4S)-1-(cyclopropylmethyl)-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
Show/Hide
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C28H34F2N2O2
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1
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| 1 |
EC50 = 81 nM
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CP0918361
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(R)-4-Methyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide dihydrochloride
Show/Hide
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C31H50Cl2FN5O3
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2
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| 1 |
EC50 = 82 nM
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| 2 |
IC50 = 52 nM
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CP0849935
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(3R,4R,5S)-4-Cyclopropyl-1-{[(3S,4R)-4-(2,4-difluorophenyl)-1-pyridazin-3-ylpyrrolidin-3-yl]carbonyl}-3,5-dimethylpiperidin-4-ol Hydrochloride
Show/Hide
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C25H31ClF2N4O2
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2
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| 1 |
EC50 = 82 nM
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| 2 |
Ki = 172 nM
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CP0925815
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(3R,4R,5S)-1-{[(3S,4R)-4-(2,4-Difluorophenyl)-1-ethylpyrrolidin-3-yl]carbonyl}-3,5-dimethyl-4-phenylpiperidin-4-ol Hydrochloride
Show/Hide
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C26H33ClF2N2O2
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1
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| 1 |
EC50 = 85 nM
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CP0382157
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N-[(1S)-1-[2-[1-[(3S,4R)-1-tert-butyl-4-[2-fluoro-4-(trifluoromethyl)phenyl]pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
Show/Hide
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C32H40ClF4N3O2
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2
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| 1 |
EC50 = 88.8 nM
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| 2 |
IC50 = 22.7 nM
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CP0896599
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(3R,4R,5S)-1-{[(3S,4R)-4-(2,4-Difluorophenyl)-1-pyridazin-3-ylpyrrolidin-3-yl]carbonyl}-4-isopropyl-3,5-dimethylpiperidin-4-ol Hydrochloride
Show/Hide
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C25H33ClF2N4O2
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1
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| 1 |
EC50 = 89 nM
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CP0421173
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3-{2-[4-((R)-3-(4-Chloro-phenyl)-2-{[(R)-oxo-(1,2,3,4-tetrahydro-isoquinolin-3-yl)-methyl]-amino}-propionyl)-piperazin-1-yl]-benzylamino}-propionic acid
Show/Hide
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C33H38ClN5O4
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1
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| 1 |
EC50 = 90 nM
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CP0421172
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1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-2-(4-{2-[(2-amino-ethylamino)-methyl]-phenyl}-piperazin-1-yl)-1-(4-chloro-benzyl)-2-oxo-ethyl]-amide
Show/Hide
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C32H39ClN6O2
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1
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| 1 |
EC50 = 91 nM
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CP0391023
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((3S,4R,5R)-4-(4-chlorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)((3S,4R)-4-(2,4-difluorophenyl)-1-isopropylpyrrolidin-3-yl)methanone
Show/Hide
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C27H33ClF2N2O2
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1
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| 1 |
EC50 = 91 nM
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CP0439009
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1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-(4-{2-[(methyl-pyridin-3-ylmethyl-amino)-methyl]-phenyl}-piperazin-1-yl)-2-oxo-ethyl]-amide
Show/Hide
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C37H41ClN6O2
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1
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| 1 |
EC50 = 94 nM
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CP0493348
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2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-((tetrahydro-2H-pyran-4-yl)methyl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
Show/Hide
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C34H40ClF2N3O3
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2
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| 1 |
EC50 = 95.9 nM
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| 2 |
IC50 = 52.5 nM
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CP0885254
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(R)-3-(1H-Indazol-3-ylmethylene)-1-[2-oxoethyl-2-(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)]-5-phenyl-1H-1,5-diazepine-2,4-dione
Show/Hide
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C31H29N5O3
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1
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| 1 |
EC50 = 100 nM
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CP0449034
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(4-(2-((S)-1-amino-2-methylpropyl)-4-methylphenyl)piperazin-1-yl)((3S,4R)-4-(4-chlorophenyl)-1-isopropylpyrrolidin-3-yl)methanone
Show/Hide
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C29H41ClN4O
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1
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| 1 |
EC50 = 105 nM
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CP0374314
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((3R,4S)-1-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
Show/Hide
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C28H36F2N2O2
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2
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| 1 |
EC50 = 105 nM
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| 2 |
Ki = 233 nM
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CP0845518
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(3R,4R,5S)-1-{[(3S,4R)-1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]carbonyl}-3,5-dimethyl-4-[4-(trifluoromethyl)phenyl]-piperidin-4-ol Hydrochloride
Show/Hide
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C29H36ClF5N2O2
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1
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| 1 |
EC50 = 108 nM
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CP0535084
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N-[(1S)-1-[2-[1-[(3R,4S)-1-tert-butyl-4-(4-chloro-2-fluorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
Show/Hide
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C31H40Cl2FN3O2
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2
|
| 1 |
EC50 = 110.8 nM
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| 2 |
IC50 = 13.23 nM
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CP0414895
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((3R,4S)-4-(2,4-difluorophenyl)-1-(pyrazin-2-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
Show/Hide
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C28H30F2N4O2
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1
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| 1 |
EC50 = 111 nM
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CP0401416
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((3R,4S)-4-(2,4-difluorophenyl)-1-(pyrimidin-5-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
Show/Hide
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C28H30F2N4O2
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1
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| 1 |
EC50 = 117 nM
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CP0156912
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N-[(1S)-1-[2-[1-[(3S,4R)-1-tert-butyl-4-naphthalen-2-ylpyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
Show/Hide
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C35H44ClN3O2
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2
|
| 1 |
EC50 = 120.5 nM
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| 2 |
IC50 = 76.2 nM
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CP0374312
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((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-hydroxy-3,5-dimethyl-4-propylpiperidin-1-yl)methanone
Show/Hide
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C25H38F2N2O2
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2
|
| 1 |
EC50 = 126 nM
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| 2 |
Ki = 844 nM
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CP0470207
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((3S,4R,5R)-4-(4-chlorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)((3S,4R)-4-(2,4-difluorophenyl)-1-methylpyrrolidin-3-yl)methanone
Show/Hide
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C25H29ClF2N2O2
|
1
|
| 1 |
EC50 = 130 nM
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CP0437355
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N-[(1S)-1-[2-[1-[(3S,4R)-1-tert-butyl-4-(2,4,5-trifluorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
Show/Hide
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C31H39ClF3N3O2
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2
|
| 1 |
EC50 = 130.3 nM
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| 2 |
IC50 = 127.6 nM
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CP0393479
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-{1-[(furan-2-ylmethyl)-amino]-ethyl}-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide
Show/Hide
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C36H40ClN5O3
|
1
|
| 1 |
EC50 = 138 nM
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CP0393472
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1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ((R)-1-(4-chloro-benzyl)-2-oxo-2-{4-[2-(4-pyrrolidin-1-yl-piperidin-1-ylmethyl)-phenyl]-piperazin-1-yl}-ethyl)-amide
Show/Hide
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C39H49ClN6O2
|
1
|
| 1 |
EC50 = 146 nM
|
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CP0919470
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(3R,4R,5S)-1-{[(3S,4R)-4-(2,4-Difluorophenyl)-1-ethylpyrrolidin-3-yl]carbonyl}-4-(4-fluorophenyl)-3,5-dimethylpiperidin-4-ol Hydrochloride
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C26H32ClF3N2O2
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1
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| 1 |
EC50 = 147 nM
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CP0873909
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(+/-)-2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-isopropyl-N-(2-methyl-4-trifluoromethoxy)phenyl)acetamide
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C31H28F3N5O4
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1
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| 1 |
EC50 = 151.36 nM
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CP0437354
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N-[(1S)-1-[2-[1-[(3S,4R)-1-tert-butyl-4-(2,4-dichlorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
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C31H40Cl3N3O2
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2
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| 1 |
EC50 = 155.6 nM
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| 2 |
IC50 = 17.9 nM
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CP0509360
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((3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-(3-fluorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
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C24H27F3N2O2
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1
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| 1 |
EC50 = 159 nM
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CP0487168
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1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-cyclopentylaminomethyl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide
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C35H42ClN5O2
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1
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| 1 |
EC50 = 164 nM
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CP0391988
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(1R,4S,6S)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide
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C34H51FN4O3
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2
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| 1 |
EC50 = 165 nM
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| 2 |
IC50 = 28 nM
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CP0846176
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(+/-)-2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-3-methoxy-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-(4-methoxyphenyl)N-isopropylacetamide
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C32H33N5O5
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1
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| 1 |
EC50 = 165.96 nM
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CP0440312
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ((R)-1-(4-chloro-benzyl)-2-{4-[2-(1-cyclopropylamino-ethyl)-phenyl]-piperazin-1-yl}-2-oxo-ethyl)-amide
Show/Hide
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C34H40ClN5O2
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1
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| 1 |
EC50 = 174 nM
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CP0846974
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(+/-)-2-[2,4-Dioxo-3-(6-fluoro-1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-(4-fluorophenyl)-N-isopropylacetamide
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C30H27F2N5O3
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1
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| 1 |
EC50 = 177.83 nM
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CP0471478
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N-[2-[4-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperazin-1-yl]-3,3-dimethylbutyl]-N-propan-2-ylacetamide
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C30H48F2N4O2
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2
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| 1 |
EC50 = 180 nM
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| 2 |
IC50 = 150 nM
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CP0374527
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide
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C38H43ClN6O2
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1
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| 1 |
EC50 = 190 nM
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CP0398562
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2-((R)-1'-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)-6-chloro-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
Show/Hide
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C32H38ClF2N3O2
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2
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| 1 |
EC50 = 195.6 nM
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| 2 |
IC50 = 31.4 nM
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CP0446667
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-oxo-2-[4-(2-{[(piperidin-4-ylmethyl)-amino]-methyl}-phenyl)-piperazin-1-yl]-ethyl}-amide
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C36H45ClN6O2
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1
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| 1 |
EC50 = 208 nM
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CP0435806
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N-[(1S)-1-[2-[1-[(3S,4R)-1-tert-butyl-4-(2-chloro-4-fluorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
Show/Hide
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C31H40Cl2FN3O2
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2
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| 1 |
EC50 = 214.5 nM
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| 2 |
IC50 = 216.2 nM
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CP0383453
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((3S,4R)-4-(2,4-difluorophenyl)-1-isopropylpyrrolidin-3-yl)((3S,4R,5R)-4-(2,4-difluorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
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C27H32F4N2O2
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1
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| 1 |
EC50 = 220 nM
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CP0391989
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(1S,4R,6S)-2-Aza-bicyclo[2.2.2]octane-6-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide
Show/Hide
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C33H49FN4O3
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2
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| 1 |
EC50 = 238 nM
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| 2 |
IC50 = 41 nM
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CP0370128
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-diethylaminomethyl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide
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C34H42ClN5O2
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1
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| 1 |
EC50 = 240 nM
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CP0400327
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((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)(4-(1-cyclohexyl-2-(isopropylamino)ethyl)piperazin-1-yl) methanone
Show/Hide
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C30H48F2N4O
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2
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| 1 |
EC50 = 240 nM
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| 2 |
IC50 = 310 nM
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CP0374303
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((3R,4S)-4-(2,4-difluorophenyl)-1-(pyrimidin-2-yl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
Show/Hide
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C28H30F2N4O2
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2
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| 1 |
EC50 = 243 nM
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| 2 |
Ki = 300 nM
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CP0458030
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N-[(1S)-1-[2-[1-[(3R,4S)-1-tert-butyl-4-(2-fluoro-4-methoxyphenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
Show/Hide
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C32H43ClFN3O3
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2
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| 1 |
EC50 = 244.7 nM
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| 2 |
IC50 = 37.2 nM
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CP0485972
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-cyclopropylaminomethyl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide
Show/Hide
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C33H38ClN5O2
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1
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| 1 |
EC50 = 253 nM
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CP0539614
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((3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-(4-fluorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
Show/Hide
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C24H27F3N2O2
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1
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| 1 |
EC50 = 255 nM
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CP0383425
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((3S,4R)-4-(2,4-difluorophenyl)-1-isopropylpyrrolidin-3-yl)((3S,4R,5R)-4-(3,4-difluorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
Show/Hide
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C27H32F4N2O2
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1
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| 1 |
EC50 = 257 nM
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CP0378443
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(4-(2-((S)-1-amino-2-methylpropyl)-6-fluorophenyl)piperazin-1-yl)((3S,4R)-4-(4-chlorophenyl)-1-isopropylpyrrolidin-3-yl)methanone
Show/Hide
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C28H38ClFN4O
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1
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| 1 |
EC50 = 270 nM
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CP0918363
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(S)-4-(2-Amino-propionyl)-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide; compound with 2 TFA
Show/Hide
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C37H53F7N6O8
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2
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| 1 |
EC50 = 270 nM
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| 2 |
IC50 = 30 nM
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CP0160526
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(R)-N-((R)-1-(4-(2-(aminomethyl)phenyl)piperazin-1-yl)-3-(4-chlorophenyl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
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C30H34ClN5O2
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1
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| 1 |
EC50 = 274 nM
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CP0509500
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-{[(furan-2-ylmethyl)-amino]-methyl}-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide
Show/Hide
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C35H38ClN5O3
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1
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| 1 |
EC50 = 274 nM
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CP0874312
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(+/-)-2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-(4-fluorophenyl)-Nisopropylacetamide
Show/Hide
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C30H28FN5O3
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1
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| 1 |
EC50 = 281.84 nM
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CP0391024
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((3S,4R,5R)-4-(3,4-difluorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)((3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl)methanone
Show/Hide
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C24H26F4N2O2
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1
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| 1 |
EC50 = 288 nM
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CP0497004
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ((R)-1-(4-chloro-benzyl)-2-oxo-2-{4-[2-(4-phenyl-piperazin-1-ylmethyl)-phenyl]-piperazin-1-yl}-ethyl)-amide
Show/Hide
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C40H45ClN6O2
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1
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| 1 |
EC50 = 300 nM
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CP0493928
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2-[(1R)-1'-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]-5-chloro-6-methylspiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]-2-methyl-N-(2,2,2-trifluoroethyl)propanamide
Show/Hide
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C35H43ClF5N3O2
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2
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| 1 |
EC50 = 307 nM
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| 2 |
IC50 = 93 nM
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CP0874693
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(+/-)-3-(1H-Indazol-3-ylmethylene)-1-[2-oxoethyl-2-(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)]-5-phenyl-1H-1,5-diazepine-2,4-dione
Show/Hide
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C31H29N5O3
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1
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| 1 |
EC50 = 323.59 nM
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CP0897229
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(R)-2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)acetamide
Show/Hide
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C31H31N5O4
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1
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| 1 |
EC50 = 338.84 nM
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CP0454313
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3-(dimethylamino)-N-[(1S)-1-[3-fluoro-2-[4-[(3S,4R)-4-[3-fluoro-4-(trifluoromethyl)phenyl]-1-propan-2-ylpyrrolidine-3-carbonyl]piperazin-1-yl]phenyl]-2-methylpropyl]propanamide
Show/Hide
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C34H46F5N5O2
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1
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| 1 |
EC50 = 340 nM
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CP0504289
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4-((3S,4R,5R)-1-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)-4-hydroxy-3,5-dimethylpiperidin-4-yl)benzonitrile
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C29H35F2N3O2
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1
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| 1 |
EC50 = 347 nM
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CP0453782
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N-[2-[(1R)-5-chloro-1'-[(3S,4R)-4-(2,4-difluorophenyl)-1-(oxan-4-yl)pyrrolidine-3-carbonyl]-6-methylspiro[1H-2-benzofuran-3,4'-piperidine]-1-yl]propan-2-yl]acetamide
Show/Hide
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C34H42ClF2N3O4
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2
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| 1 |
EC50 = 351.7 nM
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| 2 |
IC50 = 150.7 nM
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CP0874344
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(+/-)-2-[2,4-Dioxo-3-(6-fluoro-1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)acetamide
Show/Hide
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C31H30FN5O4
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1
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| 1 |
EC50 = 354.81 nM
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CP0234420
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[(2-thiophen-2-yl-ethylamino)-methyl]-phenyl}-piperazin-1-yl)-ethyl]-amide
Show/Hide
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C36H40ClN5O2S
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1
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| 1 |
EC50 = 357 nM
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CP0401674
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((3S,4R)-4-(2,4-difluorophenyl)-1-methylpyrrolidin-3-yl)((3S,4R,5R)-4-(4-fluorophenyl)-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
Show/Hide
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C25H29F3N2O2
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2
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| 1 |
EC50 = 365 nM
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| 2 |
Ki = 346 nM
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CP0507284
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((3R,4S)-4-(2,4-difluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
Show/Hide
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C27H34F2N2O3
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1
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| 1 |
EC50 = 374 nM
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CP0449031
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(4-(2-((S)-1-amino-2-methylpropyl)-6-fluorophenyl)piperazin-1-yl)((3S,4R)-4-(4-chlorophenyl)-1-cyclopentylpyrrolidin-3-yl)methanone
Show/Hide
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C30H40ClFN4O
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1
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| 1 |
EC50 = 400 nM
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CP0404969
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N-[(1S)-1-[2-[4-[(3S,4R)-4-(3-chloro-4-fluorophenyl)-1-propan-2-ylpyrrolidine-3-carbonyl]piperazin-1-yl]-3-fluorophenyl]-2-methylpropyl]-3-(dimethylamino)propanamide
Show/Hide
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C33H46ClF2N5O2
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1
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| 1 |
EC50 = 410 nM
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CP0861760
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(+/-)-3-(6-Fluoro-1H-indazol-3-ylmethylene)-1-[2-oxoethyl-2-(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)]-5-phenyl-1H-1,5-diazepine-2,4-dione
Show/Hide
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C31H28FN5O3
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1
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| 1 |
EC50 = 436.52 nM
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CP0427925
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(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluoromethyl)phenyl)piperazin-1-yl)((3S,4R)-1-isopropyl-4-(4-methoxyphenyl)pyrrolidin-3-yl)methanone
Show/Hide
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C31H43F3N4O2
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1
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| 1 |
EC50 = 450 nM
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CP0485976
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-{[2-(3-fluoro-phenyl)-ethylamino]-methyl}-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide
Show/Hide
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C38H41ClFN5O2
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1
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| 1 |
EC50 = 460 nM
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CP0383467
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((3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
Show/Hide
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C24H28F2N2O2
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2
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| 1 |
EC50 = 462 nM
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| 2 |
Ki = 264 nM
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CP0480693
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1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-{[2-(4-fluoro-phenyl)-ethylamino]-methyl}-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide
Show/Hide
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C38H41ClFN5O2
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1
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| 1 |
EC50 = 487 nM
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CP0847013
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(+/-)-2-[2,4-Dioxo-3-(6-fluoro-1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-isopropyl-N-phenylacetamide
Show/Hide
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C30H28FN5O3
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1
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| 1 |
EC50 = 537.03 nM
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CP0357814
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N-[(1S)-1-[2-[1-[(3R,4S)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
Show/Hide
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C31H40ClF2N3O2
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2
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| 1 |
EC50 = 565 nM
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| 2 |
IC50 = 640 nM
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CP0499970
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((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)(4-(1-cyclohexyl-2-(diethylamino)ethyl)piperazin-1-yl)methanone
Show/Hide
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C31H50F2N4O
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2
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| 1 |
EC50 = 570 nM
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| 2 |
IC50 = 260 nM
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CP0522544
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[1-(2-thiophen-2-yl-ethylamino)-ethyl]-phenyl}-piperazin-1-yl)-ethyl]-amide
Show/Hide
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C37H42ClN5O2S
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1
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| 1 |
EC50 = 577 nM
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CP0514336
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((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-hydroxy-4-isopropyl-3,5-dimethylpiperidin-1-yl)methanone
Show/Hide
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C25H38F2N2O2
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1
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| 1 |
EC50 = 626 nM
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CP0440310
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(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-2-(4-{2-[(benzyl-methyl-amino)-methyl]-phenyl}-piperazin-1-yl)-1-(4-chloro-benzyl)-2-oxo-ethyl]-amide
Show/Hide
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C38H42ClN5O2
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1
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| 1 |
EC50 = 632 nM
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CP0874634
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3-[(3R,4R,5S)-1-{[(3S,4R)-1-tert-Butyl-4-(2,4-difluorophenyl)-pyrrolidin-3-yl]carbonyl}-4-hydroxy-3,5-dimethylpiperidin-4-yl]-benzonitrile Hydrochloride
Show/Hide
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C29H36ClF2N3O2
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1
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| 1 |
EC50 = 644 nM
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CP0847012
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(+/-)-2-[6-(6-Fluoro-1H-indazol-3-ylmethylene)-5,7-dioxo-4-(3-pyridinyl)-4,5,6,7-tetrahydro-1H-1,4-diazepin-1-yl]-N-(1-methylethyl)-N-[4-(methyloxy)phenyl]acetamide
Show/Hide
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C30H29FN6O4
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1
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| 1 |
EC50 = 660.69 nM
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CP0885253
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(+/-)-2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-isopropyl-N-(4-methoxyphenyl)acetamide
Show/Hide
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C31H31N5O4
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1
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| 1 |
EC50 = 707.95 nM
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CP0469770
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((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)(4-(1-cyclohexyl-2-(dipropylamino)ethyl)piperazin-1-yl)methanone
Show/Hide
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C33H54F2N4O
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2
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| 1 |
EC50 = 710 nM
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| 2 |
IC50 = 200 nM
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CP0858960
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(3R,4R,5S)-1-{[(3S,4R)-4-(2,4-Difluorophenyl)-1-methylpyrrolidin-3-yl]carbonyl}-3,5-dimethyl-4-phenylpiperidin-4-ol Hydrochloride
Show/Hide
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C25H31ClF2N2O2
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2
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| 1 |
EC50 = 717 nM
|
|
|
| 2 |
Ki = 107 nM
|
|
|
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CP0873910
|
(S)-3-(1H-Indazol-3-ylmethylene)-1-[2-oxoethyl-2-(2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)]-5-phenyl-1H-1,5-diazepine-2,4-dione
Show/Hide
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C31H29N5O3
|
1
|
| 1 |
EC50 = 794.33 nM
|
|
|
|
CP0437137
|
1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-{[2-(2-fluoro-phenyl)-ethylamino]-methyl}-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide
Show/Hide
|
C38H41ClFN5O2
|
1
|
| 1 |
EC50 = 910 nM
|
|
|
|
CP0374315
|
((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4R,5R)-4-cyclopropyl-4-hydroxy-3,5-dimethylpiperidin-1-yl)methanone
Show/Hide
|
C25H36F2N2O2
|
1
|
| 1 |
EC50 = 962 nM
|
|
|
|
CP0381200
|
N-(4-hydroxyphenyl)-2-[6-(2H-indazol-3-ylmethyl)-5,7-dioxo-4-phenyl-1,4-diazepin-1-yl]-N-propan-2-ylacetamide
Show/Hide
|
C30H29N5O4
|
1
|
| 1 |
EC50 = 1000 nM
|
|
|
|
CP0874311
|
2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-5-phenyl-2,3.4.5-tetrahydro-1H-1,5-diazepin-1-yl]-N-(4-hydroxyphenyl)-N-isopropylacetamide hydrochloride
Show/Hide
|
C30H30ClN5O4
|
1
|
| 1 |
EC50 = 1000 nM
|
|
|
|
CP0453785
|
(3S,4R)-tert-butyl 3-((S)-6-chloro-3-(2-cyanopropan-2-yl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-ylcarbonyl)-4-(2,4-difluorophenyl)pyrrolidine-1-carboxylate
Show/Hide
|
C33H38ClF2N3O4
|
2
|
| 1 |
EC50 = 1006 nM
|
|
|
| 2 |
IC50 = 479.2 nM
|
|
|
|
CP0885306
|
(+/-)-2-(6-((1H-indazol-3-yl)methyl)-6-((1H-pyrazol-3-yl)methyl)-5,7-dioxo-4-phenyl-4,5,6,7-tetrahydro-1H-1,4-diazepin-1-yl)-N-isopropyl-N-(4-methoxyphenyl)acetamide
Show/Hide
|
C35H35N7O4
|
1
|
| 1 |
EC50 = 1047.13 nM
|
|
|
|
CP0848954
|
(R)-2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-isopropyl-Nphenylacetamide
Show/Hide
|
C30H29N5O3
|
1
|
| 1 |
EC50 = 1071.52 nM
|
|
|
|
CP0464913
|
(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluoromethyl)phenyl)piperazin-1-yl)((3S,4R)-4-(4-chlorophenyl)-1-isopropylpyrrolidin-3-yl)methanone
Show/Hide
|
C30H40ClF3N4O
|
1
|
| 1 |
EC50 = 1100 nM
|
|
|
|
CP0373106
|
1-{[(3S,4R)-1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-carbonyl}-4-phenylpiperidin-4-ol
Show/Hide
|
C26H32F2N2O2
|
1
|
| 1 |
EC50 = 1116 nM
|
|
|
|
CP0921840
|
(R)-2-[2,4-Dioxo-3-(6-fluoro-1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-isopropyl-N-phenylacetamide
Show/Hide
|
C30H28FN5O3
|
1
|
| 1 |
EC50 = 1258.93 nM
|
|
|
|
CP0379001
|
(4-(2-((S)-1-amino-2-methylpropyl)-6-fluorophenyl)piperazin-1-yl)((3S,4R)-4-(4-chlorophenyl)-1-isobutylpyrrolidin-3-yl)methanone
Show/Hide
|
C29H40ClFN4O
|
1
|
| 1 |
EC50 = 1400 nM
|
|
|
|
CP0462566
|
1-((3S,4R)-3-(1-(2-((S)-1-amino-3-methylbutyl)-4-(trifluoromethyl)phenyl)piperazine-4-carbonyl)-4-(4-chlorophenyl)pyrrolidin-1-yl)ethanone
Show/Hide
|
C29H36ClF3N4O2
|
1
|
| 1 |
EC50 = 1900 nM
|
|
|
|
CP0440574
|
N-[(1S)-1-[2-[1-[(3R,4S)-1-tert-butyl-4-naphthalen-2-ylpyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
Show/Hide
|
C35H44ClN3O2
|
2
|
| 1 |
EC50 = 1922 nM
|
|
|
| 2 |
IC50 = 528 nM
|
|
|
|
CP0404723
|
1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-(2-{1-[2-(2-fluoro-phenyl)-ethylamino]-ethyl}-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-amide
Show/Hide
|
C39H43ClFN5O2
|
1
|
| 1 |
EC50 = 2060 nM
|
|
|
|
CP0873848
|
(+/-)-2-[6-(1H-Indazol-3-ylmethyl)-5,7-dioxo-4-(3-pyridinyl)-4,5,6,7-tetrahydro-1H-1,4-diazepin-1-yl]-N-(1-methylethyl)-N-[4-(methyloxy)phenyl]acetamide
Show/Hide
|
C30H30N6O4
|
1
|
| 1 |
EC50 = 2884.03 nM
|
|
|
|
CP0874694
|
(+/-)-2-[2,4-Dioxo-3-(1H-indazol-3-ylmethylene)-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-diazepin-1-yl]-N-isopropyl-Nphenylacetamide
Show/Hide
|
C30H29N5O3
|
1
|
| 1 |
EC50 = 3235.94 nM
|
|
|
|
CP0849922
|
(3R,4R,5S)-1-{[(3S,4R)-1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]carbonyl}-3,5-dimethyl-4-pyridin-3-ylpiperidin-4-ol Dihydrochloride
Show/Hide
|
C27H37Cl2F2N3O2
|
1
|
| 1 |
EC50 = 3630 nM
|
|
|
|
CP0458029
|
N-[(1S)-1-[2-[1-[(3R,4S)-1-tert-butyl-4-(2,4,5-trifluorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
Show/Hide
|
C31H39ClF3N3O2
|
2
|
| 1 |
EC50 = 3702 nM
|
|
|
| 2 |
IC50 = 101.1 nM
|
|
|
|
CP0896614
|
(1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4s,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone
Show/Hide
|
C28H36F2N2O2
|
1
|
| 1 |
EC50 = 3900 nM
|
|
|
|
CP0426053
|
((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)(4-(1-cyclohexyl-2-(diisobutylamino)ethyl)piperazin-1-yl) methanone
Show/Hide
|
C35H58F2N4O
|
2
|
| 1 |
EC50 = 6700 nM
|
|
|
| 2 |
IC50 = 1900 nM
|
|
|
|
CP0427926
|
(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluoromethyl)phenyl)piperazin-1-yl)((3S,4R)-1-benzyl-4-(4-chlorophenyl)pyrrolidin-3-yl)methanone
Show/Hide
|
C34H40ClF3N4O
|
1
|
| 1 |
EC50 = 7300 nM
|
|
|
|
CP0510106
|
(3R,4S,5S)-1-{[(3R,4S)-1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]carbonyl}-3,5-dimethyl-4-phenylpiperidin-4-ol
Show/Hide
|
C28H36F2N2O2
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
|
CP0920690
|
(3R,4R,5S)-1-{[(3S,4R)-1-tert-Butyl-4-(2,4-difluorophenyl)-pyrrolidin-3-yl]carbonyl}-3,5-dimethyl-4-pyrimidin-5-ylpiperidin-4-ol Dihydrochloride
Show/Hide
|
C26H36Cl2F2N4O2
|
1
|
| 1 |
EC50 = 11100 nM
|
|
|
|
CP0041451
|
CAS_75921-69-6
Show/Hide
|
C78H111N21O19
|
1
|
| 1 |
IC50 = 0.15 nM
|
|
|
|
CP0375025
|
(4S)-4-[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoylamino]-5-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Show/Hide
|
C78H111N21O19
|
2
|
| 1 |
IC50 = 0.16 nM
|
|
|
| 2 |
Ki = 0.14 nM
|
|
|
|
CP0459400
|
(3R)-N-[(2R)-3-(4-chlorophenyl)-1-{4-cyclohexyl-4-[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)methyl]piperidin-1-yl}-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Show/Hide
|
C33H42ClN7O2
|
1
|
| 1 |
IC50 = 0.3 nM
|
|
|
|
CP0150320
|
1-[(R)-2-[((1S,2S)-1-Amino-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide
Show/Hide
|
C36H49ClN4O3
|
1
|
| 1 |
IC50 = 0.37 nM
|
|
|
|
CP0537689
|
1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide
Show/Hide
|
C33H41ClN6O2
|
1
|
| 1 |
IC50 = 0.5 nM
|
|
|
|
CP0497448
|
1-[2-[((R)-3-Amino-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide
Show/Hide
|
C36H49ClN4O3
|
1
|
| 1 |
IC50 = 0.56 nM
|
|
|
|
CP0376413
|
(R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(5,5-dimethyl-1,1-dioxo-1lambda*6*-isothiazolidin-2-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide
Show/Hide
|
C36H49ClN4O4S
|
1
|
| 1 |
IC50 = 0.62 nM
|
|
|
|
CP0405831
|
1-[(R)-2-[((1R,2R)-1-Amino-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide
Show/Hide
|
C36H49ClN4O3
|
1
|
| 1 |
IC50 = 0.77 nM
|
|
|
|
CP0378160
|
(3S,5R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-chlorophenyl)-1-oxopropan-2-yl]-3,5-dimethylpiperazine-1-carboxamide
Show/Hide
|
C32H50ClN5O3
|
1
|
| 1 |
IC50 = 0.78 nM
|
|
|
|
CP0451850
|
(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((4,4-dimethyl-2-oxooxazolidin-3-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Show/Hide
|
C36H47ClN4O4
|
1
|
| 1 |
IC50 = 0.8 nM
|
|
|
|
CP0432760
|
(R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(1,1-dioxo-1lambda*6*-isothiazolidin-2-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide
Show/Hide
|
C34H45ClN4O4S
|
1
|
| 1 |
IC50 = 0.91 nM
|
|
|
|
CP0466894
|
1-[(R)-2-[((1S,2S)-1-Amino-1-methyl-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide
Show/Hide
|
C37H51ClN4O3
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0493433
|
1-[(2R)-2-[(5-amino-6,7,8,9-tetrahydro-5H-benzo[7]annulene-6-carbonyl)amino]-3-(4-chlorophenyl)propanoyl]-N-tert-butyl-4-cyclohexylpiperidine-4-carboxamide
Show/Hide
|
C37H51ClN4O3
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0490856
|
(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((2-methyl-2H-tetrazol-5-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Show/Hide
|
C33H42ClN7O2
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0573125
|
(R)-1,2,3,4-Tetrahydro-quinoline-2-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide
Show/Hide
|
C33H41ClN6O2
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0376350
|
(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-(((R)-4-methyl-2-oxooxazolidin-3-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Show/Hide
|
C35H45ClN4O4
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0490759
|
1-[2-[((R)-1-Amino-indane-2-carbonyl)-amino]-3-(4-chloro-phenyl)-propionyl]-4-cyclohexyl-piperidine-4-carboxylic acid tert-butylamide
Show/Hide
|
C35H47ClN4O3
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0376349
|
(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((N-isopropylmethan-2-ylsulfonamido)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Show/Hide
|
C35H49ClN4O4S
|
1
|
| 1 |
IC50 = 2.1 nM
|
|
|
|
CP0496616
|
3-[6-(4-Chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-N-(2-oxo-azepan-3-yl)-propionamide
Show/Hide
|
C26H27ClN4O4S
|
1
|
| 1 |
IC50 = 2.27 nM
|
|
|
|
CP0463791
|
(4R,5S)-4-(4-Chloro-phenyl)-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
|
C33H34Cl2N4O3S
|
1
|
| 1 |
IC50 = 2.4 nM
|
|
|
|
CP0847597
|
(2S,5S)-5-Ethyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide dihydrochloride
Show/Hide
|
C32H52Cl2FN5O3
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0862697
|
(2S,5S)-5-Ethyl-4-methyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide dihydrochloride
Show/Hide
|
C33H54Cl2FN5O3
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0404610
|
(4R,5S)-4-(2,4-Dichloro-phenyl)-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
|
C33H33Cl3N4O3S
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0083437
|
N-[(1S)-1-[2-[1-[(3R,4S)-1-tert-butyl-4-(2,4-dichlorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
Show/Hide
|
C31H40Cl3N3O2
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0496773
|
(4R,5S)-4-(4-Trifluoromethyl-phenyl)-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
|
C34H34ClF3N4O3S
|
1
|
| 1 |
IC50 = 3.8 nM
|
|
|
|
CP0501131
|
(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((2-oxooxazolidin-3-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Show/Hide
|
C34H43ClN4O4
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0845562
|
(2S,5S)-5-Isopropyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide dihydrochloride
Show/Hide
|
C33H54Cl2FN5O3
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0376351
|
(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((3-methyl-2-oxoimidazolidin-1-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Show/Hide
|
C35H46ClN5O3
|
1
|
| 1 |
IC50 = 4.3 nM
|
|
|
|
CP0451849
|
(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-(((S)-4-methyl-2-oxooxazolidin-3-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Show/Hide
|
C35H45ClN4O4
|
1
|
| 1 |
IC50 = 4.5 nM
|
|
|
|
CP0382075
|
(R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(5-oxo-6-oxa-4-aza-spiro[2.4]hept-4-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide
Show/Hide
|
C36H45ClN4O4
|
1
|
| 1 |
IC50 = 4.6 nM
|
|
|
|
CP0390506
|
(4R,5S)-4-(4-Fluoro-phenyl)-1-methyl-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
|
C34H36ClFN4O3S
|
1
|
| 1 |
IC50 = 4.7 nM
|
|
|
|
CP0487182
|
(4R,5S)-4-p-Tolyl-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
|
C34H37ClN4O3S
|
1
|
| 1 |
IC50 = 4.7 nM
|
|
|
|
CP0495900
|
(R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((2-oxoimidazolidin-1-yl)methyl)piperidin-1-yl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Show/Hide
|
C34H44ClN5O3
|
1
|
| 1 |
IC50 = 4.8 nM
|
|
|
|
CP0849385
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(2S,5S)-5-tert-Butyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide dihydrochloride
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C34H56Cl2FN5O3
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1
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| 1 |
IC50 = 5 nM
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CP0855524
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(2S,5S)-5-(1-Methyl-cyclopropyl)-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide dihydrochloride
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C34H54Cl2FN5O3
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1
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| 1 |
IC50 = 5 nM
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CP0378159
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(3R,5R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,5-diethylpiperazine-1-carboxamide
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C34H54FN5O3
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1
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| 1 |
IC50 = 5.1 nM
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CP0507025
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3-[6-(4-Chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-N-(2-phenoxy-ethyl)-propionamide
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C28H26ClN3O4S
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1
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| 1 |
IC50 = 5.598 nM
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CP0871300
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(2S,5S)-5-Methyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide dihydrochloride
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C31H50Cl2FN5O3
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1
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| 1 |
IC50 = 6 nM
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CP0202448
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N-[(1S)-1-[2-[1-[(3R,4S)-1-tert-butyl-4-[4-(trifluoromethyl)phenyl]pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
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C32H41ClF3N3O2
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1
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| 1 |
IC50 = 7.8 nM
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CP0497207
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(R)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(6-oxo-7-oxa-5-aza-spiro[3.4]oct-5-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide
Show/Hide
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C37H47ClN4O4
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1
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| 1 |
IC50 = 7.9 nM
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CP0914841
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(2S,5S)-5-Cyclopropyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide dihydrochloride
Show/Hide
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C33H52Cl2FN5O3
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1
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| 1 |
IC50 = 8 nM
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CP0376348
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ethyl N-[[1-[(2R)-3-(4-chlorophenyl)-2-[[(3R)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl]amino]propanoyl]-4-cyclohexylpiperidin-4-yl]methyl]-N-propan-2-ylcarbamate
Show/Hide
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C37H51ClN4O4
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1
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| 1 |
IC50 = 8.1 nM
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CP0452758
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N-[(1S)-1-[2-[1-[(3R,4S)-1-tert-butyl-4-[2-fluoro-4-(trifluoromethyl)phenyl]pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
Show/Hide
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C32H40ClF4N3O2
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1
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| 1 |
IC50 = 9.8 nM
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CP0445633
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(4R,5S)-4-(4-Fluoro-phenyl)-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C33H34ClFN4O3S
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1
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| 1 |
IC50 = 11 nM
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CP0920216
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(S)-6-Isopropyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide; compound with ditrifluoroacetic acid
Show/Hide
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C37H54F7N5O7
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1
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| 1 |
IC50 = 11 nM
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CP0449079
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(4R,5S)-4-(2-Fluoro-phenyl)-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C33H34ClFN4O3S
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1
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| 1 |
IC50 = 13 nM
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CP0541585
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(4R,5S)-4-Naphthalen-2-yl-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C37H37ClN4O3S
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1
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| 1 |
IC50 = 17 nM
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CP0847598
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(S)-4,7-Diaza-spiro[2.5]octane-6-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide; compound with ditrifluoroacetic acid
Show/Hide
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C36H50F7N5O7
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1
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| 1 |
IC50 = 17 nM
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CP0480658
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(4R,5S)-4-(4-Methoxy-phenyl)-pyrrolidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C33H35ClN4O4S
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1
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| 1 |
IC50 = 19 nM
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CP0926680
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(2S,5R)-5-Isopropyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide; compound with ditrifluoroacetic acid
Show/Hide
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C37H54F7N5O7
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1
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| 1 |
IC50 = 20 nM
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CP0922716
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(2S,5R)-5-(1-Methyl-cyclopropyl)-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide; compound with ditrifluoroacetic acid
Show/Hide
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C38H54F7N5O7
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1
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| 1 |
IC50 = 24 nM
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CP0845644
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(2S,5R)-5-Cyclopropyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide; compound with ditrifluoroacetic acid
Show/Hide
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C38H55F6N5O7
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1
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| 1 |
IC50 = 25 nM
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CP0404631
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6-(4-Chloro-phenylsulfanyl)-4-((R)-3-{[(4R,5S)-4-(4-fluoro-phenyl)-piperidin-3-ylmethyl]-amino}-butyl)-2-(4-methoxy-phenyl)-2H-pyridazin-3-one
Show/Hide
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C33H36ClFN4O2S
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1
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| 1 |
IC50 = 28 nM
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CP0461509
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(4R,5S)-4-p-Tolyl-pyrrolidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C33H35ClN4O3S
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1
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| 1 |
IC50 = 28 nM
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CP0509648
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(S)-1-(4-Fluoro-phenyl)-piperazine-2-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C32H33ClFN5O3S
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1
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| 1 |
IC50 = 28 nM
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CP0874930
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(2S,5R)-5-tert-Butyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide; compound with ditrifluoroacetic acid
Show/Hide
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C38H56F7N5O7
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1
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| 1 |
IC50 = 29 nM
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CP0897048
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(3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide hydrochloride
Show/Hide
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C33H36Cl2N4O3S
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1
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| 1 |
IC50 = 33 nM
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CP0508757
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(3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide; hydrochloride
Show/Hide
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C33H35ClN4O3S
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1
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| 1 |
IC50 = 33 nM
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CP0058988
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1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine
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C30H43ClN4O2
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1
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| 1 |
IC50 = 35 nM
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CP0508758
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(2S,3S)-3-(2,4-Dichloro-phenyl)-piperidine-4-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C33H33Cl3N4O3S
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1
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| 1 |
IC50 = 36 nM
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CP0845645
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(2S,5R)-5-Ethyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide; compound with ditrifluoroacetic acid
Show/Hide
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C36H52F7N5O7
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1
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| 1 |
IC50 = 40 nM
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CP0376520
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(3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C33H35ClN4O3S
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1
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| 1 |
IC50 = 41 nM
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CP0374140
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1-{2-[(1S)-(3-Azetidinylcarboxamido)-2-methylpropyl]-6-fluorophenyl}-4-[(2R)-methyl-3-(2-methoxy-4-chlorophenyl)propionyl]piperazine
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C29H38ClFN4O3
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1
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| 1 |
IC50 = 42 nM
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CP0508759
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(4R,5S)-4-(3-Chloro-phenyl)-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C33H34Cl2N4O3S
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1
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| 1 |
IC50 = 43 nM
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CP0445477
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(4R,5S)-4-(4-Chloro-phenyl)-pyrrolidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C32H32Cl2N4O3S
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1
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| 1 |
IC50 = 45 nM
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CP0445643
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(2S,3S)-3-(4-Cyano-phenyl)-piperidine-4-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C34H34ClN5O3S
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1
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| 1 |
IC50 = 45 nM
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CP0947432
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(2S,5R)-5-Ethyl-4-methyl-piperazine-2-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide dihydrochloride
Show/Hide
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C33H54Cl2FN5O3
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1
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| 1 |
IC50 = 46 nM
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CP0509671
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(2S,3S)-3-(4-Chloro-phenyl)-piperidine-4-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C33H34Cl2N4O3S
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1
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| 1 |
IC50 = 58 nM
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CP0541751
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(4R,5S)-4-(2,4-Difluoro-phenyl)-pyrrolidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C32H31ClF2N4O3S
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1
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| 1 |
IC50 = 60 nM
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CP0059383
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N-[(1S)-1-[2-[4-[(3R,4S)-4-(4-chlorophenyl)-1-(oxan-4-yl)pyrrolidine-3-carbonyl]piperazin-1-yl]-5-methylphenyl]-2-methylpropyl]-3-(dimethylamino)propanamide
Show/Hide
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C36H52ClN5O3
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1
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| 1 |
IC50 = 64 nM
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CP0145641
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(4-(2-((S)-1-amino-2-methylpropyl)-4-methylphenyl)piperazin-1-yl)((3R,4S)-4-(4-chlorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-yl)methanone
Show/Hide
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C31H43ClN4O2
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1
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| 1 |
IC50 = 65 nM
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CP0466535
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(2S,3S)-3-(4-Fluoro-phenyl)-piperidine-4-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C33H34ClFN4O3S
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1
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| 1 |
IC50 = 66 nM
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CP0390508
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(4R,5S)-4-(4-Fluoro-phenyl)-pyrrolidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C32H32ClFN4O3S
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1
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| 1 |
IC50 = 70 nM
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CP0876124
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Ac-Nle4-cyclo(Asp5-His6-D-4-Dip-Pro8-Trp9-Lys10)-NH2
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C55H68N12O9
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1
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| 1 |
IC50 = 74 nM
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CP0437356
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N-[(1S)-1-[2-[1-[(3R,4S)-1-tert-butyl-4-(2-chloro-4-fluorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]propyl]acetamide
Show/Hide
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C31H40Cl2FN3O2
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1
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| 1 |
IC50 = 82.2 nM
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CP0296428
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1-{2-[(1S)-(methylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine
Show/Hide
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C29H41ClN4O2
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1
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| 1 |
IC50 = 87 nM
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CP0541596
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(4R,5S)-4-Naphthalen-1-yl-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C37H37ClN4O3S
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1
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| 1 |
IC50 = 89 nM
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CP0358667
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1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl}-4-[(2R)-methyl-3-(2-methyl-4-chlorophenyl)propionyl]piperazine
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C31H45ClN4O2
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1
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| 1 |
IC50 = 92 nM
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CP0541732
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N-[(2R)-4-[6-(4-chlorophenyl)sulfanyl-2-(4-methoxyphenyl)-3-oxopyridazin-4-yl]butan-2-yl]-4-(4-fluorophenyl)-N-methylpiperidine-3-carboxamide
Show/Hide
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C34H36ClFN4O3S
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1
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| 1 |
IC50 = 93 nM
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CP0392706
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(3R,4S)-4-Phenyl-pyrrolidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide; hydrochloride
Show/Hide
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C32H33ClN4O3S
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2
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| 1 |
IC50 = 98 nM
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| 2 |
IC50 = 380 nM
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CP0390507
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(4R,5S)-4-(3-Trifluoromethyl-phenyl)-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C34H34ClF3N4O3S
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1
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| 1 |
IC50 = 100 nM
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CP0504921
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(2S,3S)-3-(2-Fluoro-phenyl)-piperidine-4-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C33H34ClFN4O3S
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1
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| 1 |
IC50 = 100 nM
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CP0373760
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(2S)-2-amino-3-(1H-imidazol-4-yl)-N-[(2R)-1-{1-methanesulfonyl-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-yl}-3-(naphthalen-2-yl)-1-oxopropan-2-yl]propanamide
Show/Hide
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C32H36N6O4S
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1
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| 1 |
IC50 = 108 nM
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CP0461048
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1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide
Show/Hide
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C33H41ClN6O2
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1
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| 1 |
IC50 = 127 nM
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CP0965108
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(3S,4S)-3-Phenyl-piperidine-4-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide hydrochloride
Show/Hide
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C33H36Cl2N4O3S
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1
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| 1 |
IC50 = 130 nM
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CP0445470
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(3S,4S)-3-Phenyl-piperidine-4-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide; hydrochloride
Show/Hide
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C33H35ClN4O3S
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1
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| 1 |
IC50 = 130 nM
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CP0480670
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(4R,5S)-4-Thiophen-3-yl-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C31H33ClN4O3S2
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1
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| 1 |
IC50 = 130 nM
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CP0448539
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3-[6-(4-Chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-N-((R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-propionamide
Show/Hide
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C30H27ClN4O4S
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1
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| 1 |
IC50 = 144 nM
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CP0386368
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1-{2-[(1S)-(3-Dimethylaminopropionamino)-2-methylpropyl]-4-chlorophenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine
Show/Hide
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C29H40Cl2N4O2
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1
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| 1 |
IC50 = 150 nM
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CP0442623
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1-{2-[(1S)-((2R)-Aminopropionamido)-2-methylpropyl]-4-chlorophenyl}-4-[(2R)-methyl-3-(2-methoxy-4-dichlorophenyl)propionyl]piperazine
Show/Hide
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C28H38Cl2N4O3
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1
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| 1 |
IC50 = 150 nM
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CP0876125
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Ac-Nle4-cyclo(Asp5-Pro6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
Show/Hide
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C55H70N10O9
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1
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| 1 |
IC50 = 160 nM
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CP0514396
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(4R,5S)-4-(2-Fluoro-phenyl)-pyrrolidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
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C32H32ClFN4O3S
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1
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| 1 |
IC50 = 160 nM
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CP0503293
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1-{2-[(1S)-(1-Methyl-3-azetadinylcarbonyl)-amino-2-methylpropyl]-4-chlorophenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine
Show/Hide
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C29H38Cl2N4O2
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1
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| 1 |
IC50 = 160 nM
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CP0925920
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(3R,4S)-4-Phenyl-pyrrolidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide hydrochloride
Show/Hide
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C32H34Cl2N4O3S
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0270338
|
1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl}-4-[(2R)-methyl-3-(2-fluoro-4-chlorophenyl)propionyl]piperazine
Show/Hide
|
C30H42ClFN4O2
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0509676
|
(2S,3S)-3-(4-Trifluoromethyl-phenyl)-piperidine-4-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
|
C34H34ClF3N4O3S
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0442055
|
(R)-N-((R)-1-(4-((1H-tetrazol-5-yl)methyl)-4-cyclohexylpiperidin-1-yl)-3-(4-chlorophenyl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Show/Hide
|
C32H40ClN7O2
|
1
|
| 1 |
IC50 = 238 nM
|
|
|
|
CP0173276
|
1-{2-[(1S)-(3-Dimethylaminopropionamino)-2-methylpropyl]-6-fluorophenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine
Show/Hide
|
C29H40ClFN4O2
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0136197
|
1-{2-[(1S)-(aminopropionyl)amino-2-methylpropyl]-4-methylphenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine
Show/Hide
|
C28H39ClN4O2
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0541731
|
6-(4-Chloro-phenylsulfanyl)-4-((R)-3-{[(4S,5R)-4-(4-fluoro-phenyl)-piperidin-3-ylmethyl]-amino}-butyl)-2-(4-methoxy-phenyl)-2H-pyridazin-3-one
Show/Hide
|
C33H36ClFN4O2S
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0433388
|
1-{2-[(1S)-(Methylaminoacetamido)-2-methylpropyl]-4-chlorophenyl}-4-[(2R)-methyl-3-(2-methoxy-4-dichlorophenyl)propionyl]piperazine
Show/Hide
|
C28H38Cl2N4O3
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0442631
|
1-{2-[(1S)-(Methylaminoacetamido)-2-methylpropyl]-4-chlorophenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine
Show/Hide
|
C27H36Cl2N4O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0496469
|
(3S,4S)-3-Phenyl-piperidine-4-carboxylic acid {3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
|
C33H35ClN4O3S
|
1
|
| 1 |
IC50 = 339 nM
|
|
|
|
CP0415761
|
1-{2-[(1S)-(Methylaminoacetamido)-2-methylpropyl]-6-fluorophenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine
Show/Hide
|
C27H36ClFN4O2
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0435301
|
(2R,3S)-3-(4-Fluoro-benzyl)-piperidine-4-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
|
C34H36ClFN4O3S
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0415759
|
1-{2-[(1S)-(Methylaminoacetamido)-2-methylpropyl]-6-fluorophenyl}-4-[(2R)-methyl-3-(2-methoxy-4-chlorophenyl)propionyl]piperazine
Show/Hide
|
C28H38ClFN4O3
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0058986
|
1-{2-[(1S)-(methylaminoacetamido)-2-methylpropyl]-4-methylphenyl}-4-[(2R)-methyl-3-(2-fluoro-4-chlorophenyl)propionyl]piperazine
Show/Hide
|
C28H38ClFN4O2
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0374139
|
1-{2-[(1S)-(Methylaminoethyl)amino-2-methylpropyl]-6-fluorophenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine
Show/Hide
|
C27H38ClFN4O
|
1
|
| 1 |
IC50 = 480 nM
|
|
|
|
CP0484592
|
1-{2-[(1S)-(3-Dimethylaminopropionyl) amino-2-methylpropyl]phenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine
Show/Hide
|
C29H41ClN4O2
|
1
|
| 1 |
IC50 = 480 nM
|
|
|
|
CP0483601
|
(4R,5S)-4-(3-Fluoro-phenyl)-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
|
C33H34ClFN4O3S
|
1
|
| 1 |
IC50 = 490 nM
|
|
|
|
CP0510887
|
N-[(1S)-1-[2-[4-[(3S,4R)-4-(2,4-dichlorophenyl)-1-propan-2-ylpyrrolidine-3-carbonyl]piperazin-1-yl]-3-fluorophenyl]-2-methylpropyl]-3-(dimethylamino)propanamide
Show/Hide
|
C33H46Cl2FN5O2
|
1
|
| 1 |
IC50 = 560 nM
|
|
|
|
CP0844893
|
Ac-Nle4-cyclo(Asp5-His6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
Show/Hide
|
C56H70N12O9
|
1
|
| 1 |
IC50 = 570 nM
|
|
|
|
CP0422262
|
Ac-Nle4-cyclo(Asp5-His6-D-Phe-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C49H64N12O9
|
1
|
| 1 |
IC50 = 590 nM
|
|
|
|
CP0212906
|
(R)-3-(4-chloro-2-fluorophenyl)-2-methyl-1-(4-(4-methyl-2-((S)-2-methyl-1-(2-(methylamino)ethylamino)propyl)phenyl)piperazin-1-yl)propan-1-one
Show/Hide
|
C28H40ClFN4O
|
1
|
| 1 |
IC50 = 660 nM
|
|
|
|
CP0876424
|
c-Nle4-cyclo(Asp5-Tic6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
Show/Hide
|
C60H72N10O9
|
1
|
| 1 |
IC50 = 720 nM
|
|
|
|
CP0480669
|
(2R,3S)-3-Benzyl-piperidine-4-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
|
C34H37ClN4O3S
|
1
|
| 1 |
IC50 = 750 nM
|
|
|
|
CP0519865
|
1-{2-[(1S)-Amino-2-methylpropyl]-4-chlorophenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]-piperazine
Show/Hide
|
C24H31Cl2N3O
|
1
|
| 1 |
IC50 = 750 nM
|
|
|
|
CP0399828
|
(R)-1-(4-Fluoro-phenyl)-piperazine-2-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
|
C32H33ClFN5O3S
|
1
|
| 1 |
IC50 = 950 nM
|
|
|
|
CP0466853
|
(3R,4S)-4-Phenyl-pyrrolidine-3-carboxylic acid {(S)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
|
C32H33ClN4O3S
|
1
|
| 1 |
IC50 = 975 nM
|
|
|
|
CP0878527
|
Ac-Nle4-cyclo(Asp5-Phg6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
Show/Hide
|
C58H70N10O9
|
1
|
| 1 |
IC50 = 990 nM
|
|
|
|
CP0878544
|
Ac-Nle4-cyclo(Asp5-Pro6-D-4,4'-Bip7-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C54H68N10O9
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0485836
|
(S)-1-(4-Fluoro-phenyl)-piperazine-2-carboxylic acid {(S)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
|
C32H33ClFN5O3S
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0391977
|
(R)-1-(4-Fluoro-phenyl)-piperazine-2-carboxylic acid {(S)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide
Show/Hide
|
C32H33ClFN5O3S
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0922153
|
(3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {(S)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide hydrochloride
Show/Hide
|
C33H36Cl2N4O3S
|
1
|
| 1 |
IC50 = 1197 nM
|
|
|
|
CP0394757
|
Ac-Nle4-cyclo(Asp5-His6-D-4,4'-Bip-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C56H69N11O9
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0505125
|
(3R,4S)-4-Phenyl-pyrrolidine-3-carboxylic acid {3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-propyl}-amide
Show/Hide
|
C31H31ClN4O3S
|
1
|
| 1 |
IC50 = 1245 nM
|
|
|
|
CP0432989
|
Ac-Nle4-cyclo(Asp5-His6-L-Phe-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C49H64N12O9
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
|
CP0879920
|
Ac-Nle4-cyclo(Asp5-Oic6-D-D-pBzlPhe7-Pip8-Trp9-Lys10)-NH2
Show/Hide
|
C60H78N10O9
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
|
CP0505607
|
(4-(2-((S)-1-amino-2-methylpropyl)-4-methylphenyl)piperazin-1-yl)((3S,4R)-4-(4-chlorophenyl)-1-(1-isobutylpiperidin-4-yl)pyrrolidin-3-yl)methanone
Show/Hide
|
C35H52ClN5O
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0486433
|
(3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-propyl}-amide
Show/Hide
|
C32H33ClN4O3S
|
1
|
| 1 |
IC50 = 1970 nM
|
|
|
|
CP0919241
|
(3S,4R)-4-Phenyl-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide hydrochloride
Show/Hide
|
C33H36Cl2N4O3S
|
1
|
| 1 |
IC50 = 2055 nM
|
|
|
|
CP0967345
|
(3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-2-methyl-propyl}-amide hydrochloride
Show/Hide
|
C33H36Cl2N4O3S
|
1
|
| 1 |
IC50 = 2170 nM
|
|
|
|
CP0919118
|
(3R,4R)-4-Phenyl-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide hydrochloride
Show/Hide
|
C33H36Cl2N4O3S
|
1
|
| 1 |
IC50 = 2240 nM
|
|
|
|
CP0270336
|
(R)-1-(4-(2-((S)-1-amino-2-methylpropyl)-4-methylphenyl)piperazin-1-yl)-3-(4-chlorophenyl)-2-methylpropan-1-one
Show/Hide
|
C25H34ClN3O
|
1
|
| 1 |
IC50 = 2400 nM
|
|
|
|
CP0497218
|
(3S,4S)-3-Phenyl-piperidine-4-carboxylic acid {3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-propyl}-amide
Show/Hide
|
C32H33ClN4O3S
|
1
|
| 1 |
IC50 = 2755 nM
|
|
|
|
CP0947547
|
(3S,4R)-4-Phenyl-piperidine-3-carboxylic acid {(S)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide hydrochloride
Show/Hide
|
C33H36Cl2N4O3S
|
1
|
| 1 |
IC50 = 2990 nM
|
|
|
|
CP0541671
|
1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide
Show/Hide
|
C33H41ClN6O2
|
1
|
| 1 |
IC50 = 3050 nM
|
|
|
|
CP0394113
|
Ac-Nle4-cyclo(Asp5-His6-D-Bth-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C53H68N12O9S
|
1
|
| 1 |
IC50 = 3600 nM
|
|
|
|
CP0895117
|
(3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyl}-amide hydrochloride
Show/Hide
|
C33H36Cl2N4O3S
|
1
|
| 1 |
IC50 = 3930 nM
|
|
|
|
CP0394150
|
Ac-Nle4-cyclo(Asp5-His6-D-Phe(4-Cl)-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C49H63ClN12O9
|
1
|
| 1 |
IC50 = 4500 nM
|
|
|
|
CP0855549
|
Ac-Nle4-cyclo(Asp5-Oic6-D-4,4'-Bip7-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C58H74N10O9
|
1
|
| 1 |
IC50 = 4700 nM
|
|
|
|
CP0882669
|
Ac-Nle4-cyclo(Asp5-Val6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
Show/Hide
|
C55H72N10O9
|
1
|
| 1 |
IC50 = 4700 nM
|
|
|
|
CP0425206
|
Ac-Nle4-cyclo(Asp5-His6-D-Nal(2)-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C53H66N12O9
|
1
|
| 1 |
IC50 = 4800 nM
|
|
|
|
CP0877821
|
(S)-4-Methyl-piperazine-2-carboxylic acid [(S)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide dihydrochloride
Show/Hide
|
C31H50Cl2FN5O3
|
1
|
| 1 |
IC50 = 6500 nM
|
|
|
|
CP0377912
|
(1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide
Show/Hide
|
C34H51FN4O3
|
1
|
| 1 |
IC50 = 7000 nM
|
|
|
|
CP0934284
|
(3R,4R)-4-Phenyl-piperidine-3-carboxylic acid {(S)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide hydrochloride
Show/Hide
|
C33H36Cl2N4O3S
|
1
|
| 1 |
IC50 = 9020 nM
|
|
|
|
CP0394108
|
Ac-Nle4-cyclo(Asp5-His6-D-Tyr(Me)-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C50H66N12O10
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0394112
|
Ac-Nle4-cyclo(Asp5-His6-D-Cha-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C49H70N12O9
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0394115
|
Ac-Nle4-cyclo(Asp5-His6-D-Nle-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C46H66N12O9
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0394119
|
Ac-Nle4-cyclo(Asp5-His6-D-Glu-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C45H62N12O11
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0432988
|
Ac-Nle4-cyclo(Asp5-His6-D-Tyr-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C49H64N12O10
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0433726
|
Ac-Nle4-cyclo(Asp5-His6-D-Gln-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C45H63N13O10
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0434012
|
Ac-Nle4-cyclo(Asp5-His6-D-His-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C46H62N14O9
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0855105
|
Ac-Nle4-cyclo(Asp5-Chg6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
Show/Hide
|
C58H76N10O9
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0795225
|
1-(3-Thiophen-2-yl-phenyl)-ethanone, O-(phenylaminocarbonyl)oxime
Show/Hide
|
C19H16N2O2S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0425204
|
Ac-Nle4-cyclo(Asp5-His6-D-Tyr-Pro8-Trp9-Lys10)-NH2
Show/Hide
|
C51H65N13O9
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0844894
|
Ac-Nle4-cyclo(Asp5-Oic6-D-4,4'-Bip7-Pip8-Trp9-Lys10)-NH2
Show/Hide
|
C59H76N10O9
|
1
|
| 1 |
IC50 > 5000 nM
|
|
|
|
CP0544214
|
(2R)-2-(3,5-dimethoxyphenyl)-1-[(2S)-7-methyl-6-(1-methylpyrazol-4-yl)spiro[3,4-dihydro-1H-1,8-naphthyridine-2,3'-pyrrolidine]-1'-yl]propan-1-one
Show/Hide
|
C27H33N5O3
|
1
|
| 1 |
Ki = 0.044 nM
|
|
|
|
CP0568988
|
(2R)-2-(5-chloro-2-methoxypyridin-4-yl)-1-[(2S)-7-methyl-6-(2-methyltetrazol-5-yl)spiro[3,4-dihydro-1H-1,8-naphthyridine-2,3'-pyrrolidine]-1'-yl]propan-1-one
Show/Hide
|
C23H27ClN8O2
|
1
|
| 1 |
Ki = 0.21 nM
|
|
|
|
CP0568735
|
(2R)-2-(5-chloro-2-methoxypyridin-4-yl)-1-[(2S)-7-methyl-6-pyrimidin-2-ylspiro[3,4-dihydro-1H-1,8-naphthyridine-2,3'-pyrrolidine]-1'-yl]propan-1-one
Show/Hide
|
C25H27ClN6O2
|
1
|
| 1 |
Ki = 0.25 nM
|
|
|
|
CP0577051
|
(2R)-2-(5-chloro-2-methoxypyridin-4-yl)-1-[(2S)-7-methyl-6-([1,2,4]triazolo[1,5-a]pyridin-2-yl)spiro[3,4-dihydro-1H-1,8-naphthyridine-2,3'-pyrrolidine]-1'-yl]propan-1-one
Show/Hide
|
C27H28ClN7O2
|
1
|
| 1 |
Ki = 0.28 nM
|
|
|
|
CP0576660
|
(2R)-2-(5-chloro-2-methoxypyridin-4-yl)-1-[(2S)-6-[5-(difluoromethyl)-1-methyl-1,2,4-triazol-3-yl]-7-methylspiro[3,4-dihydro-1H-1,8-naphthyridine-2,3'-pyrrolidine]-1'-yl]propan-1-one
Show/Hide
|
C25H28ClF2N7O2
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0568734
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(2S)-2-[6-(difluoromethoxy)pyridin-3-yl]-1-[(2S)-7-methyl-6-pyrimidin-2-ylspiro[3,4-dihydro-1H-1,8-naphthyridine-2,3'-pyrrolidine]-1'-yl]propan-1-one
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C25H26F2N6O2
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1
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| 1 |
Ki = 0.44 nM
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CP0544213
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(2R)-2-(5-fluoro-2-methoxypyridin-4-yl)-1-[(2S)-7-methyl-6-pyrimidin-2-ylspiro[3,4-dihydro-1H-1,8-naphthyridine-2,3'-pyrrolidine]-1'-yl]propan-1-one
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C25H27FN6O2
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1
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| 1 |
Ki = 0.46 nM
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CP0568985
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(2R)-2-(6-methoxy-2-methylpyrimidin-4-yl)-1-[(2S)-7-methyl-6-(2-methyltetrazol-5-yl)spiro[3,4-dihydro-1H-1,8-naphthyridine-2,3'-pyrrolidine]-1'-yl]propan-1-one
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C23H29N9O2
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1
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| 1 |
Ki = 0.54 nM
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CP0579377
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2-[5-chloro-2-(difluoromethoxy)pyridin-4-yl]-1-[(2S)-7-methyl-6-pyrimidin-2-ylspiro[3,4-dihydro-1H-1,8-naphthyridine-2,3'-pyrrolidine]-1'-yl]propan-1-one
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C25H25ClF2N6O2
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1
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| 1 |
Ki = 0.54 nM
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CP0574481
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(2R)-2-(5-chloro-2-methoxypyridin-4-yl)-1-[(2R)-7-methyl-6-(2-methyltetrazol-5-yl)spiro[3,4-dihydro-1H-1,8-naphthyridine-2,3'-pyrrolidine]-1'-yl]propan-1-one
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C23H27ClN8O2
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1
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| 1 |
Ki = 4.5 nM
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CP0964966
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(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-amino-5-oxo-2-[[(3S,9S,12S,15S,18S,21R,26R,29S,32S,38S,41S,47S)-9,15,32,38-tetrakis(4-aminobutyl)-21-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-12,18-bis(3-amino-3-oxopropyl)-29,41-dibenzyl-2,8,11,14,17,20,28,31,34,37,40,43,46-tridecaoxo-23,24-dithia-1,7,10,13,16,19,27,30,33,36,39,42,45-tridecazatricyclo[45.3.0.03,7]pentacontane-26-carbonyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
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C144H214N38O30S2
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1
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| 1 |
Ki = 6.918 nM
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CP0961058
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(S)-1-((S)-1-((6S,9S,15S,18S,21R,24S,27S,30S,33S,36S)-1-((S)-1-((S)-1-((2S,5S,8S,11S,14R,17S,20S,23S,26S)-20-((1H-imidazol-5-yl)methyl)-26-amino-5,11-bis(3-amino-3-oxopropyl)-2,8-bis(4-aminobutyl)-23-benzyl-14-(carbamoylthiomethyl)-17-(4-hydroxybenzyl)-28-methyl-4,7,10,13,16,19,22,25-octaoxo-3,6,9,12,15,18,21,24-octaazanonacosane)pyrrolidine-2-carbonyl)pyrrolidin-2-yl)-24-(3-amino-3-oxopropyl)-9,15,30-tris(4-aminobutyl)-6,18,27-tribenzyl-21-(carbamoylthiomethyl)-36-(3-guanidinopropyl)-33-isobutyl-1,4,7,10,13,16,19,22,25,28,31,34-dodecaoxo-2,5,8,11,14,17,20,23,26,29,32,35-dodecaazaheptatriacontane)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid
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C146H218N40O32S2
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1
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| 1 |
Ki = 12.59 nM
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CP0568986
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(2S)-2-(6-methoxy-2-methylpyrimidin-4-yl)-1-[(2S)-7-methyl-6-(2-methyltetrazol-5-yl)spiro[3,4-dihydro-1H-1,8-naphthyridine-2,3'-pyrrolidine]-1'-yl]propan-1-one
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C23H29N9O2
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1
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| 1 |
Ki = 30 nM
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CP0574482
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2-[6-(difluoromethoxy)pyridin-3-yl]-1-[(2S)-7-methyl-6-(1-methylpyrazol-4-yl)spiro[3,4-dihydro-1H-1,8-naphthyridine-2,3'-pyrrolidine]-1'-yl]propan-1-one
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C25H28F2N6O2
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1
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| 1 |
Ki = 57 nM
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CP0944118
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(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(3S,9S,12S,15S,18S,21R,26R,29S,32S,38S,41S,47S)-32,38-bis(4-aminobutyl)-21-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-12,18-bis(3-amino-3-oxopropyl)-29,41-dibenzyl-2,8,11,14,17,20,28,31,34,37,40,43,46-tridecaoxo-9,15-di(propan-2-yl)-23,24-dithia-1,7,10,13,16,19,27,30,33,36,39,42,45-tridecazatricyclo[45.3.0.03,7]pentacontane-26-carbonyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
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C142H208N36O30S2
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1
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| 1 |
Ki = 60.26 nM
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CP0944134
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(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(3S,9S,12S,15S,18S,21R,26R,29S,32S,38S,41S,47S)-32,38-bis(4-aminobutyl)-21-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-12,18-bis(3-amino-3-oxopropyl)-29,41-dibenzyl-9,15-bis(hydroxymethyl)-2,8,11,14,17,20,28,31,34,37,40,43,46-tridecaoxo-23,24-dithia-1,7,10,13,16,19,27,30,33,36,39,42,45-tridecazatricyclo[45.3.0.03,7]pentacontane-26-carbonyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
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C138H200N36O32S2
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1
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| 1 |
Ki = 67.61 nM
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CP0574483
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2-(2,4-dichlorophenyl)-1-[(2S)-7-methyl-6-pyrimidin-2-ylspiro[3,4-dihydro-1H-1,8-naphthyridine-2,3'-pyrrolidine]-1'-yl]propan-1-one
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C25H25Cl2N5O
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1
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| 1 |
Ki = 82 nM
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CP0961059
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(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(3S,9S,12S,15S,18S,21R,26R,29S,32S,38S,41S,47S)-32,38-bis(4-aminobutyl)-21-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-12,18-bis(3-amino-3-oxopropyl)-29,41-dibenzyl-9,15-bis(2-methylpropyl)-2,8,11,14,17,20,28,31,34,37,40,43,46-tridecaoxo-23,24-dithia-1,7,10,13,16,19,27,30,33,36,39,42,45-tridecazatricyclo[45.3.0.03,7]pentacontane-26-carbonyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
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C144H212N36O30S2
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1
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| 1 |
Ki = 93.33 nM
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CP0964152
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(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(3S,9S,12S,15S,18S,21R,26R,29S,32S,38S,41S,47S)-32,38-bis(4-aminobutyl)-21-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-12,18-bis(3-amino-3-oxopropyl)-29,41-dibenzyl-9,15-dimethyl-2,8,11,14,17,20,28,31,34,37,40,43,46-tridecaoxo-23,24-dithia-1,7,10,13,16,19,27,30,33,36,39,42,45-tridecazatricyclo[45.3.0.03,7]pentacontane-26-carbonyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
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C138H200N36O30S2
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1
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| 1 |
Ki = 117.49 nM
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CP0944119
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(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(3S,9S,12S,15R,20R,23S,26S,32S,35S,41S)-15-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-5-oxopentanoyl]amino]-26,32-bis(4-aminobutyl)-12-(3-amino-3-oxopropyl)-23,35-dibenzyl-9-methyl-2,8,11,14,22,25,28,31,34,37,40-undecaoxo-17,18-dithia-1,7,10,13,21,24,27,30,33,36,39-undecazatricyclo[39.3.0.03,7]tetratetracontane-20-carbonyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
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C138H200N36O30S2
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1
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| 1 |
Ki = 245.47 nM
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CP0969533
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(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(3S,9R,14R,17S,20S,26S,29S,35S)-9-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-5-oxopentanoyl]amino]propanoyl]amino]-5-oxopentanoyl]amino]-20,26-bis(4-aminobutyl)-17,29-dibenzyl-2,8,16,19,22,25,28,31,34-nonaoxo-11,12-dithia-1,7,15,18,21,24,27,30,33-nonazatricyclo[33.3.0.03,7]octatriacontane-14-carbonyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
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C138H200N36O30S2
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1
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| 1 |
Ki = 245.47 nM
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CP0544212
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(2R)-2-[6-(difluoromethoxy)pyridin-3-yl]-1-[(2S)-7-methyl-6-pyrimidin-2-ylspiro[3,4-dihydro-1H-1,8-naphthyridine-2,3'-pyrrolidine]-1'-yl]propan-1-one
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C25H26F2N6O2
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1
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| 1 |
Ki > 200 nM
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