Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-((S)-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carbonyl)-5,6-difluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile
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 PubChem ID
CID: 49862741
Canonical SMILES
CC(C)(C#N)[C@H]1OC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C2CCOCC2)c2cc(F)c(F)cc12
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Compound Formula C32H35F4N3O3
Compound Structure
Protein Name
 Protein Info 
Melanocortin receptor 4
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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Melanocortin receptor
Uniprot ID
P32245
Gene Name
MC4R
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
EC50 = 8.4 nM
   TI
   LI
   LO
   TS
2
IC50 = 7.6 nM
   TI
   LI
   LO
   TS