| Compound ID |
Compound Name |
Compound Formula |
|
CP0894409
|
(R)-8-((S)-2-hydroxy-2-(5H-tetrazolo[5,1-a]isoindol-8-yl)ethyl)-3-methyl-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one
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|
C23H26N6O4
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0309072
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1,2-thiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C22H25N3O4S
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0483993
|
5-[9-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3,9-diazaspiro[5.5]undecan-3-yl]pyrazine-2-carbonitrile
Show/Hide
|
C25H29N5O3
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0849648
|
(S)-8-(2-(7-chloro-5H-tetrazolo[5,1-a]isoindol-8-yl)-2-hydroxyethyl)-2-(4-methyl-5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C23H25ClN6O4
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0488458
|
6-[8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-2-yl]pyridine-3-carbonitrile
Show/Hide
|
C25H28N4O3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0378663
|
6-[8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]pyridine-3-carbonitrile
Show/Hide
|
C25H26N4O4
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 10.5 nM
|
|
|
|
CP0410179
|
5-[8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-2-yl]pyridine-3-carbonitrile
Show/Hide
|
C25H28N4O3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0499674
|
5-[8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]pyridine-3-carbonitrile
Show/Hide
|
C25H26N4O4
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0380148
|
5-[8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-2-yl]-3-methylpyridine-2-carbonitrile
Show/Hide
|
C26H30N4O3
|
1
|
| 1 |
IC50 = 10.1 nM
|
|
|
|
CP0904162
|
(R)-8-(2-hydroxy-2-(5H-tetrazolo[5,1-a]isoindol-8-yl)ethyl)-2-(4-methyl-5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C23H26N6O4
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0380397
|
6-[1-hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-2-methylpyridine-3-carbonitrile
Show/Hide
|
C24H28N4O4
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0457579
|
6-[8-[2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]pyridine-3-carbonitrile
Show/Hide
|
C25H26N4O3
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0431399
|
6-[1-hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-(trideuteriomethoxy)pyridine-3-carbonitrile
Show/Hide
|
C24H28N4O5
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0539680
|
6-[9-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3,9-diazaspiro[5.5]undecan-3-yl]pyridazine-3-carbonitrile
Show/Hide
|
C25H29N5O3
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0395931
|
2-[9-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3,9-diazaspiro[5.5]undecan-3-yl]pyrimidine-5-carbonitrile
Show/Hide
|
C25H29N5O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0411000
|
6-[8-[(2R)-2-amino-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]pyridine-3-carbonitrile
Show/Hide
|
C25H27N5O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0447799
|
6-[8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-2-yl]-2-methylpyridine-3-carbonitrile
Show/Hide
|
C26H30N4O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0961545
|
(S)-8-((S)-2-hydroxy-2-(5H-tetrazolo[5,1-a]isoindol-8-yl)ethyl)-3-methyl-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C23H26N6O4
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0132553
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(2-methoxypyrimidin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C24H28N4O5
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0411001
|
4-[8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-2-yl]benzonitrile
Show/Hide
|
C26H29N3O3
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0457578
|
6-[8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-2-yl]-4-methylpyridine-3-carbonitrile
Show/Hide
|
C26H30N4O3
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0888686
|
(R)-8-(2-hydroxy-2-(7-methyl-5H-tetrazolo[5,1-a]isoindol-8-yl)ethyl)-2-(4-methyl-5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C24H28N6O4
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0380126
|
6-[(1S)-1-hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]pyridine-3-carbonitrile
Show/Hide
|
C23H26N4O4
|
2
|
| 1 |
IC50 = 18 nM
|
|
|
| 2 |
IC50 = 140 nM
|
|
|
|
CP0402857
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methyl-1,2-thiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C23H27N3O4S
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0881997
|
(S)-8-(2-hydroxy-2-(5H-tetrazolo[5,1-a]isoindol-8-yl)ethyl)-2-(4-methyl-5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C23H26N6O4
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0563567
|
6-[8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-2-yl]-5-methylpyridine-3-carbonitrile
Show/Hide
|
C26H30N4O3
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0904161
|
(S)-8-((R)-2-hydroxy-2-(5H-tetrazolo[5,1-a]isoindol-8-yl)ethyl)-3-methyl-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C23H26N6O4
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0546796
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1,2-thiazol-4-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C22H25N3O4S
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0455805
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methoxy-1,2,4-thiadiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C22H26N4O5S
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
|
CP0108863
|
US9018211, 52
Show/Hide
|
C24H28N4O5
|
2
|
| 1 |
IC50 = 27 nM
|
|
|
| 2 |
IC50 = 32 nM
|
|
|
|
CP0566739
|
5-[(1R)-1-hydroxy-2-[2-(1,2-thiazol-5-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
|
C22H27N3O3S
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0510717
|
2-fluoro-4-[5-[2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]benzonitrile
Show/Hide
|
C24H21FN4O2
|
1
|
| 1 |
IC50 = 27.46 nM
|
|
|
|
CP0945708
|
(R)-8-(2-(7-chloro-5H-tetrazolo[5,1-a]isoindol-8-yl)-2-hydroxyethyl)-2-(4-methyl-5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C23H25ClN6O4
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0943530
|
(R)-8-((R)-2-hydroxy-2-(5H-tetrazolo[5,1-a]isoindol-8-yl)ethyl)-3-methyl-2-(5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C23H26N6O4
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0380399
|
2-methoxy-4-[2-[4-[2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C25H29N3O3
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0894410
|
(6R)-6-fluoro-8-((R)-2-hydroxy-2-(5H-tetrazolo[5,1-a]isoindol-8-yl)ethyl)-2-(4-methyl-5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C23H25FN6O4
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0309069
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C24H28N4O5
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0543032
|
US9751881, Example 8
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|
C25H29N7O3
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0561521
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methyl-1,2,4-thiadiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C22H26N4O4S
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0380398
|
4-ethoxy-6-[1-hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]pyridine-3-carbonitrile
Show/Hide
|
C25H30N4O5
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0414064
|
5-[(1R)-1-hydroxy-2-[2-(5-methylsulfonylpyridin-2-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
|
C25H31N3O5S
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0565940
|
2-(1-cyclopentyl-6-oxopyridazin-3-yl)-8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C28H34N4O5
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0447201
|
8-[(1R,2S)-1-hydroxy-1-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)propan-2-yl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C25H30N4O5
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0888687
|
(6S)-6-fluoro-8-((R)-2-hydroxy-2-(5H-tetrazolo[5,1-a]isoindol-8-yl)ethyl)-2-(4-methyl-5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C23H25FN6O4
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0441184
|
5-[(1R)-1-hydroxy-2-[2-(5-methylsulfonylpyrazin-2-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
|
C24H30N4O5S
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0378687
|
6-[9-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3,9-diazaspiro[5.5]undecan-3-yl]pyridine-3-carbonitrile
Show/Hide
|
C26H30N4O3
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0455808
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1,2,5-thiadiazol-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C21H24N4O4S
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0484482
|
6-[1-hydroxy-2-[4-[2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methoxypyridine-3-carbonitrile
Show/Hide
|
C24H28N4O4
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0117618
|
2-fluoro-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C23H24FN3O2
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0447200
|
8-[2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C24H28N4O4
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0051541
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-methylsulfonylpyridin-2-yl)-2,8-diazaspiro[4.5]decan-3-one
Show/Hide
|
C25H29N3O6S
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0428135
|
4-cyclopropyl-6-[1-hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]pyridine-3-carbonitrile
Show/Hide
|
C26H30N4O4
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0547947
|
2-(4-chloro-1,2-thiazol-5-yl)-8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C22H24ClN3O4S
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0567121
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(2-methoxypyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C25H29N3O5
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0455809
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-[2-(methylamino)pyrimidin-4-yl]-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C24H29N5O4
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0395892
|
4-[2-[4-[2-fluoro-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-2-methoxybenzonitrile
Show/Hide
|
C25H28FN3O3
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0416450
|
3-[(4-chlorophenyl)sulfamoyl]-4-methoxy-N-[1-(2-methyltriazol-4-yl)ethyl]benzamide
Show/Hide
|
C19H20ClN5O4S
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0402727
|
3-[(4-chlorophenyl)sulfamoyl]-4-methyl-N-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]benzamide
Show/Hide
|
C18H17ClN4O4S
|
1
|
| 1 |
IC50 = 62 nM
|
|
|
|
CP0069452
|
5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
|
C23H24N6O3
|
2
|
| 1 |
IC50 = 64 nM
|
|
|
| 2 |
IC50 = 110 nM
|
|
|
|
CP0361823
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-pyridin-4-yl-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C24H27N3O4
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0546794
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(4-methyl-1,2-thiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C23H27N3O4S
|
1
|
| 1 |
IC50 = 65 nM
|
|
|
|
CP0380125
|
6-[(1R)-1-hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methoxypyridine-3-carbonitrile
Show/Hide
|
C24H28N4O5
|
1
|
| 1 |
IC50 = 67 nM
|
|
|
|
CP0561524
|
6-[8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-2-yl]-2-methylpyridazin-3-one
Show/Hide
|
C24H30N4O4
|
1
|
| 1 |
IC50 = 68 nM
|
|
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CP0428134
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4-[1-hydroxy-2-[4-[2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-2-methoxybenzonitrile
Show/Hide
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C25H29N3O4
|
1
|
| 1 |
IC50 = 70 nM
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CP0051539
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8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-methylsulfonylpyrazin-2-yl)-2,8-diazaspiro[4.5]decan-3-one
Show/Hide
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C24H28N4O6S
|
1
|
| 1 |
IC50 = 74 nM
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CP0424999
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4-methyl-5-[2-[2-(1-oxo-3H-2-benzofuran-5-yl)-6,7-dihydro-4H-[1,3]oxazolo[5,4-c]pyridin-5-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
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C25H22N2O5
|
1
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| 1 |
IC50 = 74.74 nM
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CP0492058
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5-[(1R)-1-hydroxy-2-[2-(6-methyl-5-methylsulfonylpyridin-2-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
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C26H33N3O5S
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1
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| 1 |
IC50 = 76 nM
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CP0565939
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2-(1-ethyl-6-oxopyridazin-3-yl)-8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
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C25H30N4O5
|
1
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| 1 |
IC50 = 77 nM
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CP0356295
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4-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
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C21H24N4O2
|
1
|
| 1 |
IC50 = 79 nM
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CP0465019
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(3R)-6-[(8aS)-2-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-7-yl]-3-methyl-3,4-dihydroisochromen-1-one
Show/Hide
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C28H32N2O5
|
1
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| 1 |
IC50 = 81.43 nM
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CP0571741
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6-[9-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-2-methylpyridazin-3-one
Show/Hide
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C24H30N4O5
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1
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| 1 |
IC50 = 88 nM
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CP0081096
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2-methoxy-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
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C24H27N3O3
|
1
|
| 1 |
IC50 = 89 nM
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CP0442865
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5-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one
Show/Hide
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C22H25N3O4
|
1
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| 1 |
IC50 = 89 nM
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CP0492057
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5-[8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-2-yl]pyridine-2-carbonitrile
Show/Hide
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C25H28N4O3
|
1
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| 1 |
IC50 = 89 nM
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CP0510811
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8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-3-one
Show/Hide
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C24H28N4O5
|
1
|
| 1 |
IC50 = 95 nM
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CP0378661
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6-[7-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,7-diazaspiro[3.5]nonan-2-yl]pyridine-3-carbonitrile
Show/Hide
|
C24H26N4O3
|
1
|
| 1 |
IC50 = 104 nM
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CP0402728
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4-methyl-N-[(1-methyltriazol-4-yl)methyl]-3-[[4-(1,2-oxazol-5-yl)phenyl]sulfamoyl]benzamide
Show/Hide
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C21H20N6O4S
|
1
|
| 1 |
IC50 = 104 nM
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CP0509201
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2-methoxy-4-[2-[4-[2-methoxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C26H31N3O4
|
1
|
| 1 |
IC50 = 110 nM
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|
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CP0431398
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4-[2-[4-[2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-2-methoxybenzonitrile
Show/Hide
|
C25H29N3O4
|
1
|
| 1 |
IC50 = 120 nM
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CP0510807
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-pyridazin-4-yl-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
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C23H26N4O4
|
1
|
| 1 |
IC50 = 120 nM
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CP0565864
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2-(5-ethylsulfonylpyrazin-2-yl)-8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-3-one
Show/Hide
|
C25H30N4O6S
|
1
|
| 1 |
IC50 = 127 nM
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|
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CP0402856
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8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1,2,4-thiadiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
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C21H24N4O4S
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1
|
| 1 |
IC50 = 130 nM
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CP0567134
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2-[1-(difluoromethyl)-6-oxopyridazin-3-yl]-8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C24H26F2N4O5
|
1
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| 1 |
IC50 = 130 nM
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CP0456504
|
2-methoxy-4-[1-[4-[2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]propan-2-yl]benzonitrile
Show/Hide
|
C26H31N3O3
|
1
|
| 1 |
IC50 = 150 nM
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CP0484481
|
2-methoxy-4-[2-[4-[2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)propyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C26H31N3O3
|
1
|
| 1 |
IC50 = 170 nM
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CP0510809
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridazin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C24H28N4O5
|
1
|
| 1 |
IC50 = 180 nM
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CP0471938
|
2-methoxy-4-[2-[4-[2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]propyl]benzonitrile
Show/Hide
|
C26H31N3O3
|
1
|
| 1 |
IC50 = 190 nM
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CP0566741
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(2-methylpyrimidin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C24H28N4O4
|
1
|
| 1 |
IC50 = 190 nM
|
|
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CP0395891
|
4-[2-[4-[2-ethoxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-2-methoxybenzonitrile
Show/Hide
|
C27H33N3O4
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
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CP0389764
|
5-[(1R)-1-hydroxy-2-[2-(6-methylsulfonylpyridin-3-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
|
C25H31N3O5S
|
1
|
| 1 |
IC50 = 226 nM
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|
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CP0143622
|
6-nitro-2-[(6-nitro-1H-benzimidazol-2-yl)methoxymethyl]-1H-benzimidazole
Show/Hide
|
C16H12N6O5
|
1
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| 1 |
IC50 = 240 nM
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|
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CP0402859
|
5-[(1R)-1-hydroxy-2-[2-(3-methyl-1,2,4-thiadiazol-5-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
|
C22H28N4O3S
|
1
|
| 1 |
IC50 = 250 nM
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CP0464084
|
8-[(2R)-2-hydroxy-2-[2-methyl-6-(tetrazol-1-yl)pyridin-3-yl]ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C22H27N9O3
|
1
|
| 1 |
IC50 = 260 nM
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|
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CP0567132
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(4-methyl-5-oxopyrazin-2-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C24H28N4O5
|
1
|
| 1 |
IC50 = 270 nM
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|
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CP0046135
|
4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile
Show/Hide
|
C23H25N3O2
|
1
|
| 1 |
IC50 = 300 nM
|
|
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CP0442862
|
2-methoxy-4-[2-methyl-1-[4-[2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]propan-2-yl]benzonitrile
Show/Hide
|
C27H33N3O3
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
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CP0389782
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(6-methylsulfonylpyridin-3-yl)-2,8-diazaspiro[4.5]decan-3-one
Show/Hide
|
C25H29N3O6S
|
1
|
| 1 |
IC50 = 308 nM
|
|
|
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CP0455807
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-phenyl-1,2-thiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C28H29N3O4S
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
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CP0567133
|
9-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-4-(1-methyl-6-oxopyridazin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-5-one
Show/Hide
|
C24H28N4O6
|
1
|
| 1 |
IC50 = 350 nM
|
|
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CP0539469
|
6-[(1R)-1-hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]pyridine-3-carbonitrile
Show/Hide
|
C23H26N4O4
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
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CP0558797
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridin-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C25H29N3O5
|
1
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| 1 |
IC50 = 420 nM
|
|
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CP0558799
|
5-[(1R)-1-hydroxy-2-[2-(1,2-thiazol-5-yl)-2,7-diazaspiro[3.5]nonan-7-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
|
C21H25N3O3S
|
1
|
| 1 |
IC50 = 420 nM
|
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CP0510806
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-pyrimidin-4-yl-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C23H26N4O4
|
1
|
| 1 |
IC50 = 430 nM
|
|
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CP0510810
|
2-(1,5-dimethyl-6-oxopyridazin-3-yl)-8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C25H30N4O5
|
1
|
| 1 |
IC50 = 430 nM
|
|
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CP0573646
|
3-fluoro-4-[6-[2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]benzonitrile
Show/Hide
|
C25H21FN4O3
|
1
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| 1 |
IC50 = 463 nM
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CP0425000
|
3-methyl-4-[6-[2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-2-yl]benzonitrile
Show/Hide
|
C26H24N4O2
|
1
|
| 1 |
IC50 = 477.1 nM
|
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CP0407218
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3-(1-methyl-6-oxopyridazin-3-yl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one
Show/Hide
|
C23H26N4O6
|
1
|
| 1 |
IC50 = 490 nM
|
|
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CP0546790
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-phenyl-1,2-oxazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C28H29N3O5
|
1
|
| 1 |
IC50 = 510 nM
|
|
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CP0567131
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1,2-thiazol-5-yl)-2,8-diazaspiro[4.5]decan-3-one
Show/Hide
|
C22H25N3O4S
|
1
|
| 1 |
IC50 = 550 nM
|
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CP0407217
|
8-[(2S)-2-hydroxy-2-[6-(tetrazol-1-yl)pyridazin-3-yl]ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C20H24N10O3
|
1
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| 1 |
IC50 = 570 nM
|
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CP0547952
|
6-[9-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3,9-diazaspiro[5.5]undecan-3-yl]-2-methylpyridazin-3-one
Show/Hide
|
C25H32N4O4
|
1
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| 1 |
IC50 = 620 nM
|
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CP0546357
|
5-[(1R)-1-hydroxy-2-[2-(6-methylsulfanylpyridin-3-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
|
C25H31N3O3S
|
1
|
| 1 |
IC50 = 901 nM
|
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CP0476422
|
5-[(1R)-1-hydroxy-2-[2-(6-methoxypyridin-3-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
|
C25H31N3O4
|
1
|
| 1 |
IC50 = 1000 nM
|
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CP0566742
|
2-(1,4-dimethyl-6-oxopyridazin-3-yl)-8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C25H30N4O5
|
1
|
| 1 |
IC50 = 1050 nM
|
|
|
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CP0510808
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3-(1,2-thiazol-5-yl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one
Show/Hide
|
C21H23N3O5S
|
1
|
| 1 |
IC50 = 5100 nM
|
|
|
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CP0499675
|
5-[(1R)-1-hydroxy-2-[2-(6-methylsulfinylpyridin-3-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one
Show/Hide
|
C25H31N3O4S
|
1
|
| 1 |
IC50 = 6400 nM
|
|
|
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CP0383811
|
4-methyl-3-[(4-methylphenyl)sulfamoyl]-N-(pyridin-3-ylmethyl)benzamide
Show/Hide
|
C21H21N3O3S
|
1
|
| 1 |
IC50 = 6500 nM
|
|
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CP0565937
|
8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-2-oxopyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
Show/Hide
|
C25H29N3O5
|
1
|
| 1 |
IC50 = 7600 nM
|
|
|
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CP0511857
|
N-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]-3-[(4-methylphenyl)sulfamoyl]benzamide
Show/Hide
|
C18H18N4O4S
|
1
|
| 1 |
IC50 = 17000 nM
|
|
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CP0881738
|
6-((R)-1-hydroxy-2-(4-((S)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperazin-1-yl)ethyl)nicotinonitrile
Show/Hide
|
C23H26N4O4
|
1
|
| 1 |
IC50 >= 1000 nM
|
|
|
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CP0947021
|
6-((S)-1-hydroxy-2-(4-((S)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperazin-1-yl)ethyl)nicotinonitrile
Show/Hide
|
C23H26N4O4
|
1
|
| 1 |
IC50 >= 1000 nM
|
|
|
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CP0510804
|
6-[7-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,7-diazaspiro[3.5]nonan-2-yl]-2-methylpyridazin-3-one
Show/Hide
|
C23H28N4O4
|
1
|
| 1 |
IC50 > 2000 nM
|
|
|
|
CP0566743
|
9-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-4-(1-methyl-6-oxopyridazin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
Show/Hide
|
C24H28N4O6
|
1
|
| 1 |
IC50 > 2000 nM
|
|
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CP0428138
|
6-[1-hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-2-methoxypyridine-3-carbonitrile
Show/Hide
|
C24H28N4O5
|
1
|
| 1 |
IC50 > 3000 nM
|
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