Brief Information of the Compound and Protein
Compound Name
8-[(2S)-2-hydroxy-2-[6-(tetrazol-1-yl)pyridazin-3-yl]ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one
    Show/Hide
PubChem ID
CID: 137659238
Canonical SMILES
Cn1nc(ccc1=O)N1CCC2(CCN(C[C@H](O)c3ccc(nn3)-n3cnnn3)CC2)C1=O
    Show/Hide
Compound Formula C20H24N10O3
Compound Structure
Protein Name
ATP-sensitive inward rectifier potassium channel 1
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Potassium channels
>
Inwardly rectifying potassium channel
Uniprot ID
P48048
Gene Name
KCNJ1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 570 nM
   TI
   LI
   LO
   TS