Protein Information

General Information of the Protein

Protein ID	PT03667
Protein Name	ATP-sensitive inward rectifier potassium channel 1
Secondarily Protein Name	ATP-regulated potassium channel ROM-K Inward rectifier K(+) channel Kir1.1 Potassium channel inwardly rectifying subfamily J member 1
Gene Name	KCNJ1
Secondarily Gene Name	ROMK1
Sequence	MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Ion channel > Voltage-gated ion channel > Potassium channels > Inwardly rectifying potassium channel
Function	In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. Show/Hide
Uniprot ID	Primary ID: P48048 Secondarily ID: B2RMR4 Q6LD67 Show/Hide
Ensembl ID	ENSG00000151704
HGNC ID	HGNC:6255
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0384891 Compound Info	US9206198, 78 Show/Hide	C23H25ClN2O6	1
1	IC50 = 3 nM Bioactivity Info	TI LI LO TS
CP0450009 Compound Info	US9206198, 5 Show/Hide	C23H26N2O6	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0577906 Compound Info	US9206198, 22 Show/Hide	C23H25FN2O6	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0309072 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1,2-thiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one Show/Hide	C22H25N3O4S	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0132553 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(2-methoxypyrimidin-4-yl)-2,8-diazaspiro[4.5]decan-1-one Show/Hide	C24H28N4O5	1
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
CP0260361 Compound Info	US9206198, 7 Show/Hide	C24H28N2O6	2
1	IC50 = 5 nM Bioactivity Info	TI LI LO TS
2	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0518994 Compound Info	US9206198, 25 Show/Hide	C23H25ClN2O6	2
1	IC50 = 6 nM Bioactivity Info	TI LI LO TS
2	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0561521 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methyl-1,2,4-thiadiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one Show/Hide	C22H26N4O4S	1
1	IC50 = 8 nM Bioactivity Info	TI LI LO TS
CP0189728 Compound Info	US9018211, 2A Show/Hide	C26H30N2O6	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0352199 Compound Info	US9018211, 2C Show/Hide	C26H30N2O6	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0384888 Compound Info	US9206198, 9 Show/Hide	C25H30N2O6	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0412507 Compound Info	US9206198, 76 Show/Hide	C26H30N2O6	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0436116 Compound Info	US9206198, 53C Show/Hide	C25H30N2O6	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0450011 Compound Info	US9206198, 80 Show/Hide	C23H25FN2O6	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0545608 Compound Info	US9206198, 74 Show/Hide	C25H30N2O6	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0577907 Compound Info	US9206198, 23 Show/Hide	C24H28N2O6	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0488458 Compound Info	6-[8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-2-yl]pyridine-3-carbonitrile Show/Hide	C25H28N4O3	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0555544 Compound Info	US9493474, 10A Show/Hide	C29H34N2O6	1
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0361823 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-pyridin-4-yl-2,8-diazaspiro[4.5]decan-1-one Show/Hide	C24H27N3O4	1
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0547096 Compound Info	US10513518, Example 11 Show/Hide	C24H28N2O5	1
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0402857 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methyl-1,2-thiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one Show/Hide	C23H27N3O4S	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0503622 Compound Info	US9018211, 2B Show/Hide	C26H30N2O6	1
1	IC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0481152 Compound Info	US9139585, 34B Show/Hide	C23H27N7O4	1
1	IC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0224662 Compound Info	5-[1-hydroxy-2-[4-[2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one Show/Hide	C26H30N2O6	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0575205 Compound Info	US10513518, Example 19 Show/Hide	C25H30N2O5	1
1	IC50 = 15 nM Bioactivity Info	TI LI LO TS
CP0309069 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one Show/Hide	C24H28N4O5	1
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0455805 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(3-methoxy-1,2,4-thiadiazol-5-yl)-2,8-diazaspiro[4.5]decan-1-one Show/Hide	C22H26N4O5S	1
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0441612 Compound Info	US9139585, 38A Show/Hide	C27H32N2O6	1
1	IC50 = 17.5 nM Bioactivity Info	TI LI LO TS
CP0522602 Compound Info	3-[(3R,9aS)-8-[2-[2-(tetrazol-1-yl)pyrimidin-5-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile Show/Hide	C22H22FN9O2	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0508939 Compound Info	US9139585, 44B Show/Hide	C25H30N4O5	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0542846 Compound Info	US9206198, 29 Show/Hide	C25H30N2O6	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0542847 Compound Info	2-(4-ethyl-5-oxo-2H-furan-3-yl)-8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-1-one Show/Hide	C25H30N2O6	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0046632 Compound Info	US9056859, 72 Show/Hide	C23H25N7O3	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0384890 Compound Info	US9206198, 30 Show/Hide	C25H30N2O6	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0423312 Compound Info	US9206198, 66 Show/Hide	C25H30N2O6	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0443044 Compound Info	US9206198, 51 Show/Hide	C24H28N2O6	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0469991 Compound Info	US9206198, 11 Show/Hide	C25H30N2O6	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0545607 Compound Info	US9206198, 17 Show/Hide	C26H32N2O6	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0547580 Compound Info	US9206198, 67 Show/Hide	C25H30N2O6	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0561358 Compound Info	US9206199, 37 Show/Hide	C22H21FN8O2	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0435087 Compound Info	US9139585, 30 Show/Hide	C26H30N2O5	1
1	IC50 = 21 nM Bioactivity Info	TI LI LO TS
CP0481170 Compound Info	US9139585, 36B Show/Hide	C24H29N7O4	1
1	IC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0547102 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(2-methyl-5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-1-one Show/Hide	C24H28N2O6	1
1	IC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0376890 Compound Info	5-[1-fluoro-2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one Show/Hide	C23H24FN7O3	1
1	IC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0551386 Compound Info	5-[(1R)-1-hydroxy-2-[2-(5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one Show/Hide	C23H28N2O5	1
1	IC50 = 26 nM Bioactivity Info	TI LI LO TS
CP0386249 Compound Info	3-[(3R,9aR)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-2-methylbenzonitrile Show/Hide	C23H24N8O2	1
1	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0459494 Compound Info	5-[2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C22H23N7O3	1
1	IC50 = 29 nM Bioactivity Info	TI LI LO TS
CP0462906 Compound Info	US9139585, 38B Show/Hide	C27H32N2O6	1
1	IC50 = 29 nM Bioactivity Info	TI LI LO TS
CP0568948 Compound Info	US9139585, 35A Show/Hide	C24H29N7O4	1
1	IC50 = 29 nM Bioactivity Info	TI LI LO TS
CP0414064 Compound Info	5-[(1R)-1-hydroxy-2-[2-(5-methylsulfonylpyridin-2-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one Show/Hide	C25H31N3O5S	1
1	IC50 = 29 nM Bioactivity Info	TI LI LO TS
CP0499871 Compound Info	US9139585, 20 Show/Hide	C25H28N4O5	1
1	IC50 = 29.5 nM Bioactivity Info	TI LI LO TS
CP0441608 Compound Info	US9139585, 18 Show/Hide	C28H32N2O7	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0529183 Compound Info	US9206198, 12 Show/Hide	C25H30N2O6	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0561459 Compound Info	US9206198, 69 Show/Hide	C26H30N2O6	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0578224 Compound Info	US9206198, 10 Show/Hide	C24H30N2O5	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0412489 Compound Info	US9206199, 13 Show/Hide	C22H22FN9O2	1
1	IC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0475715 Compound Info	US9493474, 13A Show/Hide	C27H31N7O4	1
1	IC50 = 31 nM Bioactivity Info	TI LI LO TS
CP0499873 Compound Info	US9139585, 37B Show/Hide	C27H32N2O6	1
1	IC50 = 31.5 nM Bioactivity Info	TI LI LO TS
CP0441609 Compound Info	US9139585, 22 Show/Hide	C29H34N2O6	1
1	IC50 = 32 nM Bioactivity Info	TI LI LO TS
CP0441611 Compound Info	US9139585, 35B Show/Hide	C24H29N7O4	1
1	IC50 = 32.5 nM Bioactivity Info	TI LI LO TS
CP0072053 Compound Info	3-[(3R,9aS)-8-[2-[5-(tetrazol-1-yl)pyrazin-2-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile Show/Hide	C22H22FN9O2	1
1	IC50 = 33 nM Bioactivity Info	TI LI LO TS
CP0567810 Compound Info	US9139585, 28 Show/Hide	C27H32N2O5	1
1	IC50 = 33 nM Bioactivity Info	TI LI LO TS
CP0051539 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-methylsulfonylpyrazin-2-yl)-2,8-diazaspiro[4.5]decan-3-one Show/Hide	C24H28N4O6S	1
1	IC50 = 34 nM Bioactivity Info	TI LI LO TS
CP0441610 Compound Info	US9139585, 34A Show/Hide	C23H27N7O4	1
1	IC50 = 35 nM Bioactivity Info	TI LI LO TS
CP0386219 Compound Info	3-[(3R,9aS)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile Show/Hide	C23H23FN8O2	1
1	IC50 = 36 nM Bioactivity Info	TI LI LO TS
CP0441184 Compound Info	5-[(1R)-1-hydroxy-2-[2-(5-methylsulfonylpyrazin-2-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one Show/Hide	C24H30N4O5S	1
1	IC50 = 37 nM Bioactivity Info	TI LI LO TS
CP0495033 Compound Info	US9139585, 33 Show/Hide	C26H27F3N2O5	1
1	IC50 = 38 nM Bioactivity Info	TI LI LO TS
CP0115218 Compound Info	3-[(3S,9aS)-8-[2-[2-(tetrazol-1-yl)pyrimidin-5-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile Show/Hide	C22H22FN9O2	1
1	IC50 = 39 nM Bioactivity Info	TI LI LO TS
CP0500946 Compound Info	US9493474, 11A Show/Hide	C26H30N4O4	1
1	IC50 = 39 nM Bioactivity Info	TI LI LO TS
CP0412488 Compound Info	US9206199, 4 Show/Hide	C23H23FN8O2	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0563243 Compound Info	US9206199, 6 Show/Hide	C22H22FN9O2	1
1	IC50 = 40 nM Bioactivity Info	TI LI LO TS
CP0504652 Compound Info	3-[(3S,9aS)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile Show/Hide	C23H23FN8O2	1
1	IC50 = 41 nM Bioactivity Info	TI LI LO TS
CP0493283 Compound Info	US9139585, 2 Show/Hide	C28H34N2O6	1
1	IC50 = 41 nM Bioactivity Info	TI LI LO TS
CP0051541 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-methylsulfonylpyridin-2-yl)-2,8-diazaspiro[4.5]decan-3-one Show/Hide	C25H29N3O6S	1
1	IC50 = 43 nM Bioactivity Info	TI LI LO TS
CP0196247 Compound Info	US9206199, 179 Show/Hide	C21H21N9O3	1
1	IC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0462904 Compound Info	US9139585, 21 Show/Hide	C29H34N2O6	1
1	IC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0525121 Compound Info	US9139585, 7 Show/Hide	C28H32N4O4	1
1	IC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0571857 Compound Info	8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(5-oxo-2H-furan-3-yl)-2,8-diazaspiro[4.5]decan-3-one Show/Hide	C23H26N2O6	1
1	IC50 = 45 nM Bioactivity Info	TI LI LO TS
CP0508937 Compound Info	US9139585, 32 Show/Hide	C27H32N2O5	1
1	IC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0500947 Compound Info	US9493474, 19A Show/Hide	C25H28N6O5S	1
1	IC50 = 46 nM Bioactivity Info	TI LI LO TS
CP0517105 Compound Info	US9493474, 7A Show/Hide	C25H28N4O4	1
1	IC50 = 47 nM Bioactivity Info	TI LI LO TS
CP0117618 Compound Info	2-fluoro-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C23H24FN3O2	1
1	IC50 = 49 nM Bioactivity Info	TI LI LO TS
CP0477756 Compound Info	3-[(3R,9aS)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-2-methylbenzonitrile Show/Hide	C23H24N8O2	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0506843 Compound Info	US9206198, 83 Show/Hide	C25H30N2O7	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0561458 Compound Info	US9206198, 15 Show/Hide	C24H28N2O6	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0389764 Compound Info	5-[(1R)-1-hydroxy-2-[2-(6-methylsulfonylpyridin-3-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one Show/Hide	C25H31N3O5S	1
1	IC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0045919 Compound Info	1,4-bis[2-(4-nitrophenyl)ethyl]piperazine Show/Hide	C20H24N4O4	1
1	IC50 = 52 nM Bioactivity Info	TI LI LO TS
CP0525268 Compound Info	US9108947, 20 Show/Hide	C22H24N4O3	1
1	IC50 = 52 nM Bioactivity Info	TI LI LO TS
CP0119734 Compound Info	2-ethoxy-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C25H29N3O3	1
1	IC50 = 53 nM Bioactivity Info	TI LI LO TS
CP0555501 Compound Info	US9493474, 11B Show/Hide	C26H30N4O4	1
1	IC50 = 53 nM Bioactivity Info	TI LI LO TS
CP0495012 Compound Info	US9139585, 11 Show/Hide	C21H22N4O3	1
1	IC50 = 54 nM Bioactivity Info	TI LI LO TS
CP0558881 Compound Info	US9139585, 16 Show/Hide	C24H26N6O5S	1
1	IC50 = 54 nM Bioactivity Info	TI LI LO TS
CP0495035 Compound Info	US9139585, 36A Show/Hide	C24H29N7O4	1
1	IC50 = 55 nM Bioactivity Info	TI LI LO TS
CP0094626 Compound Info	US9206199, 1 Show/Hide	C24H25N7O4	2
1	IC50 = 57 nM Bioactivity Info	TI LI LO TS
2	IC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0401083 Compound Info	3-[(3R,9aR)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile Show/Hide	C23H23FN8O2	1
1	IC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0450010 Compound Info	US9206198, 52 Show/Hide	C24H26N2O6	1
1	IC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0577905 Compound Info	US9206198, 13 Show/Hide	C26H32N2O6	1
1	IC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0469799 Compound Info	US9206199, 194 Show/Hide	C23H24FN9O	1
1	IC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0559734 Compound Info	US9206199, 26 Show/Hide	C23H23N7O4	1
1	IC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0537444 Compound Info	US9493474, 8A Show/Hide	C24H25N3O5S	1
1	IC50 = 62 nM Bioactivity Info	TI LI LO TS
CP0069452 Compound Info	5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C23H24N6O3	2
1	IC50 = 64 nM Bioactivity Info	TI LI LO TS
2	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0512079 Compound Info	US9139585, 23B Show/Hide	C29H34N2O7	1
1	IC50 = 64 nM Bioactivity Info	TI LI LO TS
CP0515020 Compound Info	US9108947, 18 Show/Hide	C22H24N4O3	1
1	IC50 = 65 nM Bioactivity Info	TI LI LO TS
CP0181333 Compound Info	US9206199, 22 Show/Hide	C24H25N7O4	1
1	IC50 = 65 nM Bioactivity Info	TI LI LO TS
CP0108552 Compound Info	4-methyl-5-[2-[4-[2-[3-methyl-5-(tetrazol-1-yl)pyridin-2-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C24H27N7O3	1
1	IC50 = 66 nM Bioactivity Info	TI LI LO TS
CP0438213 Compound Info	US9139585, 24B Show/Hide	C30H35NO7	1
1	IC50 = 66 nM Bioactivity Info	TI LI LO TS
CP0545170 Compound Info	US9493474, 19B Show/Hide	C25H28N6O5S	1
1	IC50 = 66 nM Bioactivity Info	TI LI LO TS
CP0068097 Compound Info	3-[(3S,9aS)-8-[2-[5-(tetrazol-1-yl)pyridin-2-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile Show/Hide	C23H23FN8O2	1
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0413455 Compound Info	US9206198, 3 Show/Hide	C22H24N2O5	1
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0412490 Compound Info	US9206199, 61 Show/Hide	C23H23FN8O3	1
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0419480 Compound Info	US9206199, 2 Show/Hide	C23H23FN8O2	1
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0084615 Compound Info	5-[2-[4-[2-[2-methyl-4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C24H26N6O3	1
1	IC50 = 71 nM Bioactivity Info	TI LI LO TS
CP0478173 Compound Info	US9139585, 37A Show/Hide	C27H32N2O6	1
1	IC50 = 71 nM Bioactivity Info	TI LI LO TS
CP0095971 Compound Info	4-methyl-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C24H26N6O3	2
1	IC50 = 72 nM Bioactivity Info	TI LI LO TS
2	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0551420 Compound Info	US9206199, 177 Show/Hide	C22H23N9O3	1
1	IC50 = 72 nM Bioactivity Info	TI LI LO TS
CP0155267 Compound Info	3-[(3R,9aS)-8-[2-[5-(tetrazol-1-yl)pyridin-2-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile Show/Hide	C23H23FN8O2	1
1	IC50 = 73 nM Bioactivity Info	TI LI LO TS
CP0046138 Compound Info	2-chloro-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C23H24ClN3O2	1
1	IC50 = 75 nM Bioactivity Info	TI LI LO TS
CP0478174 Compound Info	US9139585, 42A Show/Hide	C28H32N2O6	1
1	IC50 = 78 nM Bioactivity Info	TI LI LO TS
CP0356295 Compound Info	4-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C21H24N4O2	1
1	IC50 = 79 nM Bioactivity Info	TI LI LO TS
CP0561188 Compound Info	US9493474, 18A Show/Hide	C26H30N6O5S	1
1	IC50 = 79 nM Bioactivity Info	TI LI LO TS
CP0115217 Compound Info	6-[(3R,9aS)-8-[2-[4-(tetrazol-1-yl)phenyl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-3,4-dihydroisochromen-1-one Show/Hide	C25H26N6O4	1
1	IC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0563245 Compound Info	US9206199, 33 Show/Hide	C25H27N7O4	1
1	IC50 = 80 nM Bioactivity Info	TI LI LO TS
CP0400396 Compound Info	US9493474, 12A Show/Hide	C29H34N2O6	1
1	IC50 = 82 nM Bioactivity Info	TI LI LO TS
CP0067686 Compound Info	US9206199, 176 Show/Hide	C22H23N9O3	1
1	IC50 = 83 nM Bioactivity Info	TI LI LO TS
CP0333449 Compound Info	US9206199, 23 Show/Hide	C24H25N7O4	1
1	IC50 = 86 nM Bioactivity Info	TI LI LO TS
CP0551422 Compound Info	3-[(3S,9aS)-8-[2-[6-(tetrazol-1-yl)pyridazin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile Show/Hide	C22H22FN9O2	1
1	IC50 = 86 nM Bioactivity Info	TI LI LO TS
CP0237307 Compound Info	US9206199, 21 Show/Hide	C24H25N7O4	1
1	IC50 = 88 nM Bioactivity Info	TI LI LO TS
CP0081096 Compound Info	2-methoxy-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C24H27N3O3	1
1	IC50 = 89 nM Bioactivity Info	TI LI LO TS
CP0200085 Compound Info	4-[4-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethyl]phenyl]-3H-2-benzofuran-1-one Show/Hide	C28H29N3O4	1
1	IC50 = 89 nM Bioactivity Info	TI LI LO TS
CP0356298 Compound Info	5-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C24H26N2O4	1
1	IC50 = 89 nM Bioactivity Info	TI LI LO TS
CP0419995 Compound Info	US9206199, 121 Show/Hide	C23H24FN9O2	1
1	IC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0475716 Compound Info	US9493474, 13B Show/Hide	C27H31N7O4	1
1	IC50 = 94 nM Bioactivity Info	TI LI LO TS
CP0358870 Compound Info	4-methyl-5-[1-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]propan-2-yl]-3H-2-benzofuran-1-one Show/Hide	C24H27N7O3	1
1	IC50 = 95 nM Bioactivity Info	TI LI LO TS
CP0462907 Compound Info	US9139585, 43B Show/Hide	C25H30N2O6S	1
1	IC50 = 95 nM Bioactivity Info	TI LI LO TS
CP0478175 Compound Info	US9139585, 43A Show/Hide	C25H30N2O6S	1
1	IC50 = 95 nM Bioactivity Info	TI LI LO TS
CP0577287 Compound Info	2-(2,4-dimethyl-5-oxo-2H-furan-3-yl)-8-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,8-diazaspiro[4.5]decan-1-one Show/Hide	C25H30N2O6	1
1	IC50 = 98 nM Bioactivity Info	TI LI LO TS
CP0339418 Compound Info	2-bromo-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C23H24BrN3O2	1
1	IC50 = 99 nM Bioactivity Info	TI LI LO TS
CP0447395 Compound Info	US9206199, 166 Show/Hide	C24H25N7O3S	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0469992 Compound Info	US9206198, 14 Show/Hide	C26H32N2O6	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0542216 Compound Info	US9206199, 3 Show/Hide	C23H23FN8O2	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0518323 Compound Info	US9108947, 21 Show/Hide	C23H26N4O3	1
1	IC50 = 103 nM Bioactivity Info	TI LI LO TS
CP0551421 Compound Info	US9206199, 180 Show/Hide	C21H21N9O3	1
1	IC50 = 104 nM Bioactivity Info	TI LI LO TS
CP0558385 Compound Info	US9206199, 24 Show/Hide	C24H25N7O4	1
1	IC50 = 105 nM Bioactivity Info	TI LI LO TS
CP0424012 Compound Info	US9493474, 12B Show/Hide	C29H34N2O6	1
1	IC50 = 105 nM Bioactivity Info	TI LI LO TS
CP0385324 Compound Info	3-[(3S,9aS)-8-[2-[5-(tetrazol-1-yl)pyrazin-2-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-6-fluoro-2-methylbenzonitrile Show/Hide	C22H22FN9O2	1
1	IC50 = 107 nM Bioactivity Info	TI LI LO TS
CP0574121 Compound Info	US9493474, 14 Show/Hide	C26H29N7O4	1
1	IC50 = 108 nM Bioactivity Info	TI LI LO TS
CP0122653 Compound Info	4-fluoro-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C23H23FN6O3	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0370828 Compound Info	1-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]-2-[4-(tetrazol-1-yl)phenyl]ethanone Show/Hide	C21H23N7O3	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0196248 Compound Info	3-[(3S,9aS)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-2-methylbenzonitrile Show/Hide	C23H24N8O2	1
1	IC50 = 112 nM Bioactivity Info	TI LI LO TS
CP0474524 Compound Info	US9139585, 42B Show/Hide	C28H32N2O6	1
1	IC50 = 116 nM Bioactivity Info	TI LI LO TS
CP0474879 Compound Info	US9493474, 1 Show/Hide	C30H36N2O6	1
1	IC50 = 117 nM Bioactivity Info	TI LI LO TS
CP0224661 Compound Info	5-[1-fluoro-2-[4-[2-fluoro-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one Show/Hide	C26H28F2N2O4	1
1	IC50 = 117 nM Bioactivity Info	TI LI LO TS
CP0474880 Compound Info	US9493474, 4B Show/Hide	C28H32N2O6	1
1	IC50 = 117.3 nM Bioactivity Info	TI LI LO TS
CP0420173 Compound Info	5-[2-[1-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperidin-4-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C23H24N6O3	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0493298 Compound Info	US9139585, 41B Show/Hide	C28H32N2O6	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0558882 Compound Info	US9139585, 41A Show/Hide	C28H32N2O6	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0549761 Compound Info	US9206199, 38 Show/Hide	C22H21FN8O2	1
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0539864 Compound Info	US9493474, 4A Show/Hide	C28H32N2O6	1
1	IC50 = 120.3 nM Bioactivity Info	TI LI LO TS
CP0566351 Compound Info	US9493474, 18B Show/Hide	C26H30N6O5S	1
1	IC50 = 125 nM Bioactivity Info	TI LI LO TS
CP0419941 Compound Info	US9139585, 13 Show/Hide	C26H27N7O4	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0481171 Compound Info	US9139585, 40B Show/Hide	C28H32N2O6	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0561360 Compound Info	US9206199, 50 Show/Hide	C24H26N8O3	1
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0493282 Compound Info	US9139585, 1 Show/Hide	C30H36N2O6	1
1	IC50 = 134 nM Bioactivity Info	TI LI LO TS
CP0193431 Compound Info	2-methyl-1,4-bis[2-(4-nitrophenyl)ethyl]piperazine Show/Hide	C21H26N4O4	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0447396 Compound Info	5-[(7S,9aS)-2-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-1,3,4,6,7,8,9,9a-octahydropyrazino[1,2-a]pyrazin-7-yl]-4-methyl-3H-2-benzofuran-1-one Show/Hide	C24H26N8O3	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0508938 Compound Info	US9139585, 40A Show/Hide	C28H32N2O6	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0549873 Compound Info	US9139585, 12 Show/Hide	C24H25N7O4	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0440544 Compound Info	US9139585, 29 Show/Hide	C27H32N2O5	1
1	IC50 = 145 nM Bioactivity Info	TI LI LO TS
CP0567807 Compound Info	US9108947, 14 Show/Hide	C22H23N3O5S	1
1	IC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0567805 Compound Info	US9139585, 15 Show/Hide	C25H28N6O5S	1
1	IC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0568949 Compound Info	US9139585, 39A Show/Hide	C28H32N2O6	1
1	IC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0572326 Compound Info	US9206199, 35 Show/Hide	C25H27N7O4	1
1	IC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0435088 Compound Info	US9139585, 44A Show/Hide	C25H30N4O5	1
1	IC50 = 151 nM Bioactivity Info	TI LI LO TS
CP0133231 Compound Info	1-[4-[2-(2,1,3-benzoxadiazol-5-yl)ethyl]piperazin-1-yl]-2-[4-(tetrazol-1-yl)phenyl]ethanone Show/Hide	C21H22N8O2	1
1	IC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0385323 Compound Info	US9206199, 55 Show/Hide	C24H25N7O4	1
1	IC50 = 165 nM Bioactivity Info	TI LI LO TS
CP0080722 Compound Info	5-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethyl]-2,1,3-benzoxadiazole Show/Hide	C20H23N5O3	1
1	IC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0493285 Compound Info	US9139585, 17A Show/Hide	C24H26N6O5S	1
1	IC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0529413 Compound Info	US9493474, 10B Show/Hide	C29H34N2O6	1
1	IC50 = 184 nM Bioactivity Info	TI LI LO TS
CP0419481 Compound Info	US9206199, 57 Show/Hide	C23H23FN8O3	1
1	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0419939 Compound Info	US9139585, 5 Show/Hide	C27H30N4O4	1
1	IC50 = 197 nM Bioactivity Info	TI LI LO TS
CP0525120 Compound Info	US9139585, 3 Show/Hide	C23H23N3O5S	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0561187 Compound Info	US9493474, 15 Show/Hide	C25H27N7O4	1
1	IC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0500945 Compound Info	US9493474, 6 Show/Hide	C31H38N2O6	1
1	IC50 = 201 nM Bioactivity Info	TI LI LO TS
CP0567227 Compound Info	6-[(3S,9aS)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-3,4-dihydroisochromen-1-one Show/Hide	C24H25N7O4	1
1	IC50 = 205 nM Bioactivity Info	TI LI LO TS
CP0356297 Compound Info	1-[2-(4-nitrophenyl)ethyl]-4-[1-(4-nitrophenyl)propan-2-yl]piperazine Show/Hide	C21H26N4O4	1
1	IC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0133230 Compound Info	6-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3,4-dihydroisochromen-1-one Show/Hide	C24H26N6O3	1
1	IC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0516165 Compound Info	US9108947, 19 Show/Hide	C23H26N6O5S	1
1	IC50 = 245 nM Bioactivity Info	TI LI LO TS
CP0157734 Compound Info	4-chloro-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C23H23ClN6O3	1
1	IC50 = 250 nM Bioactivity Info	TI LI LO TS
CP0155266 Compound Info	US9206199, 145 Show/Hide	C23H24N8O4	1
1	IC50 = 260 nM Bioactivity Info	TI LI LO TS
CP0578662 Compound Info	US9108947, 13 Show/Hide	C25H30N4O4	1
1	IC50 = 269 nM Bioactivity Info	TI LI LO TS
CP0493284 Compound Info	US9139585, 14 Show/Hide	C24H26N6O5S	1
1	IC50 = 270 nM Bioactivity Info	TI LI LO TS
CP0537347 Compound Info	US9493474, 17 Show/Hide	C24H25N7O4	1
1	IC50 = 270 nM Bioactivity Info	TI LI LO TS
CP0531439 Compound Info	US9108947, 4 Show/Hide	C27H32N2O6	1
1	IC50 = 278 nM Bioactivity Info	TI LI LO TS
CP0046139 Compound Info	2-cyclopropyloxy-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C26H29N3O3	1
1	IC50 = 280 nM Bioactivity Info	TI LI LO TS
CP0046135 Compound Info	4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C23H25N3O2	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0133229 Compound Info	4-ethyl-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C25H28N6O3	1
1	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0568947 Compound Info	US9139585, 10 Show/Hide	C23H24N4O3	1
1	IC50 = 316 nM Bioactivity Info	TI LI LO TS
CP0084603 Compound Info	5-[2-[4-[2-[2-cyclopropyl-4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C26H28N6O3	1
1	IC50 = 330 nM Bioactivity Info	TI LI LO TS
CP0178263 Compound Info	1-[2-(4-nitrophenyl)ethyl]-4-[2-(4-nitrophenyl)propyl]piperazine Show/Hide	C21H26N4O4	1
1	IC50 = 340 nM Bioactivity Info	TI LI LO TS
CP0524623 Compound Info	US9108947, 22 Show/Hide	C28H28N4O3	1
1	IC50 = 340 nM Bioactivity Info	TI LI LO TS
CP0474964 Compound Info	US9493474, 5 Show/Hide	C30H36N2O6	1
1	IC50 = 348 nM Bioactivity Info	TI LI LO TS
CP0384889 Compound Info	US9206198, 21 Show/Hide	C23H26N2O6	1
1	IC50 = 390 nM Bioactivity Info	TI LI LO TS
CP0531438 Compound Info	US9108947, 2 Show/Hide	C30H36N2O6	1
1	IC50 = 420 nM Bioactivity Info	TI LI LO TS
CP0242098 Compound Info	2-(methylamino)-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C24H28N4O2	1
1	IC50 = 430 nM Bioactivity Info	TI LI LO TS
CP0368656 Compound Info	4-cyclopropyl-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C26H28N6O3	1
1	IC50 = 430 nM Bioactivity Info	TI LI LO TS
CP0369263 Compound Info	7-fluoro-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C23H23FN6O3	1
1	IC50 = 440 nM Bioactivity Info	TI LI LO TS
CP0515016 Compound Info	US9108947, 6 Show/Hide	C28H34N2O6	1
1	IC50 = 446 nM Bioactivity Info	TI LI LO TS
CP0368106 Compound Info	5-[2-[4-[2-[3-methoxy-4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C24H26N6O4	1
1	IC50 = 450 nM Bioactivity Info	TI LI LO TS
CP0147409 Compound Info	6-methyl-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C24H26N6O3	1
1	IC50 = 460 nM Bioactivity Info	TI LI LO TS
CP0426551 Compound Info	6-fluoro-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C23H23FN6O3	1
1	IC50 = 460 nM Bioactivity Info	TI LI LO TS
CP0368640 Compound Info	3-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C22H23N7O	1
1	IC50 = 470 nM Bioactivity Info	TI LI LO TS
CP0518322 Compound Info	US9108947, 3 Show/Hide	C27H32N2O6	1
1	IC50 = 510 nM Bioactivity Info	TI LI LO TS
CP0351091 Compound Info	5-[2-[4-[2-[4-(tetrazol-1-yl)-2-(trifluoromethyl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C24H23F3N6O3	1
1	IC50 = 520 nM Bioactivity Info	TI LI LO TS
CP0238291 Compound Info	5-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]-2-oxoethyl]-3H-2-benzofuran-1-one Show/Hide	C22H23N3O5	1
1	IC50 = 540 nM Bioactivity Info	TI LI LO TS
CP0178265 Compound Info	2-methylsulfanyl-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C24H27N3O2S	1
1	IC50 = 550 nM Bioactivity Info	TI LI LO TS
CP0366642 Compound Info	5-[2-oxo-2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-2-(tetrazol-1-yl)benzonitrile Show/Hide	C24H23N7O3	1
1	IC50 = 550 nM Bioactivity Info	TI LI LO TS
CP0462905 Compound Info	US9139585, 31 Show/Hide	C26H30N2O5	1
1	IC50 = 564 nM Bioactivity Info	TI LI LO TS
CP0531437 Compound Info	US9108947, 1 Show/Hide	C26H30N2O6	1
1	IC50 = 595 nM Bioactivity Info	TI LI LO TS
CP0351092 Compound Info	5-[2-[4-[2-[3-fluoro-4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C23H23FN6O3	1
1	IC50 = 610 nM Bioactivity Info	TI LI LO TS
CP0248398 Compound Info	4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-2-(trifluoromethoxy)benzonitrile Show/Hide	C24H24F3N3O3	1
1	IC50 = 620 nM Bioactivity Info	TI LI LO TS
CP0539813 Compound Info	US9206198, 24 Show/Hide	C24H30N2O5	1
1	IC50 = 620 nM Bioactivity Info	TI LI LO TS
CP0186433 Compound Info	4-[2-[4-[2-(4-cyanophenyl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C22H24N4	1
1	IC50 = 790 nM Bioactivity Info	TI LI LO TS
CP0147407 Compound Info	7-chloro-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C23H23ClN6O3	1
1	IC50 = 830 nM Bioactivity Info	TI LI LO TS
CP0529377 Compound Info	US9493474, 16 Show/Hide	C24H25N7O4	1
1	IC50 = 850 nM Bioactivity Info	TI LI LO TS
CP0143760 Compound Info	4-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C22H23N7O	1
1	IC50 = 920 nM Bioactivity Info	TI LI LO TS
CP0492668 Compound Info	US9493474, 21 Show/Hide	C27H33N3O6S	1
1	IC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0042837 Compound Info	7-methyl-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C24H26N6O3	1
1	IC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0366643 Compound Info	5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-2,3-dihydroinden-1-one Show/Hide	C24H26N6O2	1
1	IC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0042838 Compound Info	1-[4-[2-(1,3-dihydro-2-benzofuran-5-yl)ethyl]piperazin-1-yl]-2-[4-(tetrazol-1-yl)phenyl]ethanone Show/Hide	C23H26N6O2	1
1	IC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0478168 Compound Info	US9108947, 12 Show/Hide	C23H26N4O4	1
1	IC50 = 1369 nM Bioactivity Info	TI LI LO TS
CP0531441 Compound Info	US9108947, 15 Show/Hide	C22H23N3O5S	1
1	IC50 = 1389 nM Bioactivity Info	TI LI LO TS
CP0368637 Compound Info	4-methoxy-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C24H26N6O4	1
1	IC50 = 1400 nM Bioactivity Info	TI LI LO TS
CP0518209 Compound Info	US9108947, 17A Show/Hide	C28H32N2O6	1
1	IC50 = 1420 nM Bioactivity Info	TI LI LO TS
CP0133228 Compound Info	6-methoxy-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C24H26N6O4	1
1	IC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0541087 Compound Info	2-(4-nitrophenyl)-1-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethanone Show/Hide	C20H22N4O5	1
1	IC50 = 1800 nM Bioactivity Info	TI LI LO TS
CP0561189 Compound Info	US9493474, 23 Show/Hide	C24H26N4O4	1
1	IC50 = 1800 nM Bioactivity Info	TI LI LO TS
CP0248397 Compound Info	4-[2-[4-[2-(2,1,3-benzoxadiazol-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C21H23N5O	1
1	IC50 = 1900 nM Bioactivity Info	TI LI LO TS
CP0531440 Compound Info	US9108947, 10 Show/Hide	C23H26N4O4	1
1	IC50 = 2058 nM Bioactivity Info	TI LI LO TS
CP0042840 Compound Info	1-[2-(4-nitrophenyl)ethyl]-4-[2-[4-(tetrazol-1-yl)phenyl]ethyl]piperazine Show/Hide	C21H25N7O2	1
1	IC50 = 2100 nM Bioactivity Info	TI LI LO TS
CP0046136 Compound Info	5-[2-[4-[2-(2,1,3-benzoxadiazol-5-yl)ethyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C22H24N4O3	1
1	IC50 = 2200 nM Bioactivity Info	TI LI LO TS
CP0474881 Compound Info	US9493474, 7B Show/Hide	C25H28N4O4	1
1	IC50 = 2404 nM Bioactivity Info	TI LI LO TS
CP0567806 Compound Info	US9139585, 23A Show/Hide	C29H34N2O7	1
1	IC50 = 2460 nM Bioactivity Info	TI LI LO TS
CP0262640 Compound Info	5-[2-[4-[2-[4-(tetrazol-1-yl)-3-(trifluoromethyl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C24H23F3N6O3	1
1	IC50 = 2500 nM Bioactivity Info	TI LI LO TS
CP0178261 Compound Info	ethyl 4-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethyl]benzoate Show/Hide	C23H29N3O4	1
1	IC50 = 2900 nM Bioactivity Info	TI LI LO TS
CP0303023 Compound Info	1-[2-(4-fluorophenyl)ethyl]-4-[2-(4-nitrophenyl)ethyl]piperazine Show/Hide	C20H24FN3O2	1
1	IC50 = 3100 nM Bioactivity Info	TI LI LO TS
CP0338387 Compound Info	3-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C21H24N4O2	1
1	IC50 = 3800 nM Bioactivity Info	TI LI LO TS
CP0487011 Compound Info	1-[2-(4-nitrophenyl)ethyl]-4-[3-(4-nitrophenyl)propyl]piperazine Show/Hide	C21H26N4O4	1
1	IC50 = 3800 nM Bioactivity Info	TI LI LO TS
CP0197612 Compound Info	5-[2-[4-[2-(2,1,3-benzoxadiazol-5-yl)ethyl]piperazin-1-yl]ethyl]-2,1,3-benzoxadiazole Show/Hide	C20H22N6O2	1
1	IC50 = 4200 nM Bioactivity Info	TI LI LO TS
CP0193430 Compound Info	2-[4-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethyl]phenyl]-1,3-oxazole Show/Hide	C23H26N4O3	1
1	IC50 = 4300 nM Bioactivity Info	TI LI LO TS
CP0186429 Compound Info	1-[2-(4-methoxyphenyl)ethyl]-4-[2-(4-nitrophenyl)ethyl]piperazine Show/Hide	C21H27N3O3	1
1	IC50 = 4600 nM Bioactivity Info	TI LI LO TS
CP0080721 Compound Info	1-[2-(4-nitrophenyl)ethyl]piperazine Show/Hide	C12H17N3O2	1
1	IC50 = 5200 nM Bioactivity Info	TI LI LO TS
CP0434489 Compound Info	6-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C23H24N6O3	1
1	IC50 = 7100 nM Bioactivity Info	TI LI LO TS
CP0178262 Compound Info	1-[2-(4-methylsulfonylphenyl)ethyl]-4-[2-(4-nitrophenyl)ethyl]piperazine Show/Hide	C21H27N3O4S	1
1	IC50 = 9400 nM Bioactivity Info	TI LI LO TS
CP0396374 Compound Info	1-[2-(4-nitrophenyl)ethyl]-4-[2-[4-(trifluoromethyl)phenyl]ethyl]piperazine Show/Hide	C21H24F3N3O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0435537 Compound Info	1-[2-(4-chlorophenyl)ethyl]-4-[2-(4-nitrophenyl)ethyl]piperazine Show/Hide	C20H24ClN3O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0497477 Compound Info	1-[2-(4-nitrophenyl)ethyl]-4-[(4-nitrophenyl)methyl]piperazine Show/Hide	C19H22N4O4	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0521033 Compound Info	5-[4-[2-[4-[2-(4-nitrophenyl)ethyl]piperazin-1-yl]ethyl]phenyl]pyrimidine Show/Hide	C24H27N5O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0525003 Compound Info	1-[2-(4-nitrophenyl)ethyl]-4-(2-phenylethyl)piperazine Show/Hide	C20H25N3O2	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0247690 Compound Info	2-methylsulfonyl-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C24H27N3O4S	1
1	IC50 = 12000 nM Bioactivity Info	TI LI LO TS
CP0147410 Compound Info	5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-2,3-dihydroisoindol-1-one Show/Hide	C23H25N7O2	1
1	IC50 > 32000 nM Bioactivity Info	TI LI LO TS
CP0069559 Compound Info	5-[2-[4-[2-[3-ethyl-4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C25H28N6O3	1
1	IC50 = 100000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000389 , CHO-DXB11

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0189728 Compound Info	US9018211, 2A Show/Hide	C26H30N2O6	2
1	IC50 = 6 nM
2	IC50 = 68 nM
CP0352199 Compound Info	US9018211, 2C Show/Hide	C26H30N2O6	2
1	IC50 = 10 nM
2	IC50 = 112 nM
CP0045919 Compound Info	1,4-bis[2-(4-nitrophenyl)ethyl]piperazine Show/Hide	C20H24N4O4	3
1	IC50 = 24 nM
2	IC50 = 52 nM
3	IC50 = 66 nM
CP0356298 Compound Info	5-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C24H26N2O4	2
1	IC50 = 26 nM
2	IC50 = 89 nM
CP0117618 Compound Info	2-fluoro-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C23H24FN3O2	2
1	IC50 = 30 nM
2	IC50 = 110 nM
CP0122653 Compound Info	4-fluoro-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C23H23FN6O3	1
1	IC50 = 38 nM
CP0224662 Compound Info	5-[1-hydroxy-2-[4-[2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one Show/Hide	C26H30N2O6	1
1	IC50 = 45 nM
CP0503622 Compound Info	US9018211, 2B Show/Hide	C26H30N2O6	2
1	IC50 = 59 nM
2	IC50 = 134 nM
CP0133230 Compound Info	6-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3,4-dihydroisochromen-1-one Show/Hide	C24H26N6O3	1
1	IC50 = 61 nM
CP0069452 Compound Info	5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C23H24N6O3	1
1	IC50 = 64 nM
CP0095971 Compound Info	4-methyl-5-[2-[4-[2-[4-(tetrazol-1-yl)phenyl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one Show/Hide	C24H26N6O3	2
1	IC50 = 72 nM
2	IC50 = 190 nM
CP0046139 Compound Info	2-cyclopropyloxy-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C26H29N3O3	1
1	IC50 = 81 nM
CP0224661 Compound Info	5-[1-fluoro-2-[4-[2-fluoro-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one Show/Hide	C26H28F2N2O4	1
1	IC50 = 96 nM
CP0046135 Compound Info	4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C23H25N3O2	1
1	IC50 = 300 nM
CP0242098 Compound Info	2-(methylamino)-4-[2-[4-[2-(1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]benzonitrile Show/Hide	C24H28N4O2	1
1	IC50 = 410 nM

Clinical Information about the Protein

Target 1 ( Inward rectifier potassium channel Kir1.1 (KCNJ1) )

Target Type	Patented-recorded Target

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT03661	ATP-sensitive inward rectifier potassium channel 1	Rattus norvegicus, Rat	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han