General Information of the Compound
Compound ID
CP0561187
Compound Name
US9493474, 15
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Structure
Formula
C25H27N7O4
Molecular Weight
489.536
Canonical SMILES
Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CC2CCN(CC2C1)C(=O)c1ccc(nc1)-n1cnnn1
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InChI
InChI=1S/C25H27N7O4/c1-15-19(3-4-20-21(15)13-36-25(20)35)22(33)12-30-9-17-6-7-31(11-18(17)10-30)24(34)16-2-5-23(26-8-16)32-14-27-28-29-32/h2-5,8,14,17-18,22,33H,6-7,9-13H2,1H3/t17?,18?,22-/m0/s1
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InChIKey
CDBNEDUFHVAVGB-IRZJEQJZSA-N
Physicochemical Property
logP
1.16362
Rotatable Bonds
5
Heavy Atom Count
36
Polar Areas
126.57
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
10
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71557806
SID: 163557869
ChEMBL ID
CHEMBL3974535
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03667, ATP-sensitive inward rectifier potassium channel 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 200 nM
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