Compound ID |
Compound Name |
Compound Formula |
CP0534361
|
4-[[(2S)-6-[3-(difluoromethoxy)-5-fluorophenyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]methyl]oxane-4-carboxylic acid
Show/Hide
|
C29H25F6NO7S
|
1
|
1 |
EC50 = 58 nM
|
|
|
CP0420011
|
3-[(2S)-6-[3-(difluoromethoxy)-5-fluorophenyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C25H19F6NO6S
|
1
|
1 |
EC50 = 76 nM
|
|
|
CP0487451
|
3-[(2S)-6-(3-chloro-2-fluorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C26H22ClF4NO5S
|
1
|
1 |
EC50 = 79 nM
|
|
|
CP0138560
|
4-[[(2S)-6-(3-chloro-2-fluorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]methyl]oxane-4-carboxylic acid
Show/Hide
|
C28H24ClF4NO6S
|
1
|
1 |
EC50 = 103 nM
|
|
|
CP0060756
|
3-[(2S)-6-[3-(difluoromethoxy)-5-fluorophenyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C27H23F6NO6S
|
1
|
1 |
EC50 = 120 nM
|
|
|
CP0471268
|
3-[(2S)-6-(2-chloro-3,5-difluorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C24H17ClF5NO5S
|
1
|
1 |
EC50 = 120 nM
|
|
|
CP0420013
|
3-[[(2S)-6-[3-(difluoromethoxy)-5-fluorophenyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]methyl]oxetane-3-carboxylic acid
Show/Hide
|
C27H21F6NO7S
|
1
|
1 |
EC50 = 123 nM
|
|
|
CP0552378
|
3-[(2S)-6-(2-chloro-5-fluorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C24H18ClF4NO5S
|
1
|
1 |
EC50 = 124 nM
|
|
|
CP0351090
|
(2R)-3-[(2S)-6-(2,5-difluorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]-2-methylpropanoic acid
Show/Hide
|
C25H20F5NO5S
|
1
|
1 |
EC50 = 126 nM
|
|
|
CP0553547
|
3-[(2S)-6-(2-chloro-3-fluorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C24H18ClF4NO5S
|
1
|
1 |
EC50 = 144 nM
|
|
|
CP0552370
|
(2R)-4-[(2S)-6-(2,5-difluorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]-2-hydroxybutanoic acid
Show/Hide
|
C25H20F5NO6S
|
1
|
1 |
EC50 = 166 nM
|
|
|
CP0549139
|
3-[(2S)-6-(3,5-difluorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C24H18F5NO5S
|
1
|
1 |
EC50 = 174 nM
|
|
|
CP0471269
|
3-[[(2S)-6-(2,5-difluorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]methyl]oxetane-3-carboxylic acid
Show/Hide
|
C26H20F5NO6S
|
1
|
1 |
EC50 = 179 nM
|
|
|
CP0534099
|
3-[(2S)-6-(2,5-difluorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C24H18F5NO5S
|
1
|
1 |
EC50 = 181 nM
|
|
|
CP0471267
|
3-[(2S)-6-(3-methoxyphenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C25H22F3NO6S
|
1
|
1 |
EC50 = 197 nM
|
|
|
CP0189596
|
3-[(2S)-6-[(E)-2-(2-chloro-6-fluorophenyl)prop-1-enyl]-4-[(2-ethoxy-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)sulfonyl]-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C29H31ClFN3O6S
|
1
|
1 |
EC50 = 199 nM
|
|
|
CP0552379
|
3-[(2S)-6-(3-fluoro-5-methoxyphenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C25H21F4NO6S
|
1
|
1 |
EC50 = 217 nM
|
|
|
CP0138637
|
3-[(2S)-6-[(E)-2-[2-chloro-6-(trifluoromethyl)phenyl]ethenyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C27H20ClF6NO5S
|
1
|
1 |
EC50 = 229 nM
|
|
|
CP0564257
|
3-[(2S)-6-[3-(difluoromethoxy)phenyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C25H20F5NO6S
|
1
|
1 |
EC50 = 278 nM
|
|
|
CP0471271
|
3-[(2S)-6-[(E)-2-(2-chloro-6-fluorophenyl)prop-1-enyl]-4-[3-(difluoromethoxy)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C27H23ClF3NO6S
|
1
|
1 |
EC50 = 280 nM
|
|
|
CP0534098
|
3-[(2S)-6-[(E)-2-(2-methylphenyl)prop-1-enyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C28H26F3NO5S
|
1
|
1 |
EC50 = 285 nM
|
|
|
CP0552372
|
3-[(2S)-6-[(E)-2-[2-(trifluoromethyl)phenyl]prop-1-enyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C28H23F6NO5S
|
1
|
1 |
EC50 = 290 nM
|
|
|
CP0546383
|
3-[(2S)-6-(3-chlorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C24H19ClF3NO5S
|
1
|
1 |
EC50 = 309 nM
|
|
|
CP0471263
|
3-[(2S)-6-[(E)-2-(2-chloro-6-fluorophenyl)prop-1-enyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C27H22ClF4NO5S
|
1
|
1 |
EC50 = 324 nM
|
|
|
CP0138639
|
3-[(2S)-6-[(E)-2-(2-methoxyphenyl)prop-1-enyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C28H26F3NO6S
|
1
|
1 |
EC50 = 328 nM
|
|
|
CP0471273
|
3-[(2S)-6-(2,5-difluorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C26H22F5NO5S
|
1
|
1 |
EC50 = 344 nM
|
|
|
CP0138557
|
3-[(2S)-6-[(E)-2-(2-chloro-6-fluorophenyl)prop-1-enyl]-4-[[2-(2-hydroxyethoxy)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl]sulfonyl]-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C29H31ClFN3O7S
|
1
|
1 |
EC50 = 381 nM
|
|
|
CP0168528
|
4-[4-[[benzylsulfonyl(2-methylpropyl)amino]methyl]phenyl]benzamide
Show/Hide
|
C25H28N2O3S
|
1
|
1 |
EC50 = 400 nM
|
|
|
CP0539745
|
3-[(2S)-6-(3-fluorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C24H19F4NO5S
|
1
|
1 |
EC50 = 408 nM
|
|
|
CP0550332
|
3-[(2S)-6-[(E)-2-(2-chloro-6-fluorophenyl)prop-1-enyl]-4-[4-fluoro-3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C27H21ClF5NO5S
|
1
|
1 |
EC50 = 411 nM
|
|
|
CP0552384
|
3-[(2S)-6-(2-chlorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C24H19ClF3NO5S
|
1
|
1 |
EC50 = 414 nM
|
|
|
CP0257822
|
N-(2-methylpropyl)-N-[[4-(4-methylsulfonylphenyl)phenyl]methyl]-1-phenylmethanesulfonamide
Show/Hide
|
C25H29NO4S2
|
1
|
1 |
EC50 = 450 nM
|
|
|
CP0059785
|
N-[[4-[4-(methanesulfonamido)phenyl]phenyl]methyl]-N-(2-methylpropyl)-1-phenylmethanesulfonamide
Show/Hide
|
C25H30N2O4S2
|
1
|
1 |
EC50 = 470 nM
|
|
|
CP0527541
|
3-[(2S)-6-[(E)-2-(2,6-dichlorophenyl)prop-1-enyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C27H22Cl2F3NO5S
|
1
|
1 |
EC50 = 487 nM
|
|
|
CP0557795
|
(2S)-3-[(2S)-6-(2,5-difluorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]-2-methylpropanoic acid
Show/Hide
|
C25H20F5NO5S
|
1
|
1 |
EC50 = 489 nM
|
|
|
CP0552371
|
3-[(2S)-6-[(E)-2-(2-chloro-6-fluorophenyl)prop-1-enyl]-4-(3-cyclopropyl-4-fluorophenyl)sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C29H26ClF2NO5S
|
1
|
1 |
EC50 = 495 nM
|
|
|
CP0471264
|
(2S)-4-[(2S)-6-(2,5-difluorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]-2-hydroxybutanoic acid
Show/Hide
|
C25H20F5NO6S
|
1
|
1 |
EC50 = 501 nM
|
|
|
CP0487452
|
3-[(2S)-6-[(E)-2-(2-chloro-6-fluorophenyl)prop-1-enyl]-4-(4-fluoro-3-methoxyphenyl)sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C27H24ClF2NO6S
|
1
|
1 |
EC50 = 520 nM
|
|
|
CP0550333
|
3-[(2S)-6-[(E)-2-(2-chloro-6-fluorophenyl)ethenyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C26H20ClF4NO5S
|
1
|
1 |
EC50 = 617 nM
|
|
|
CP0534360
|
3-[(2S)-6-[(E)-2-phenylprop-1-enyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C27H24F3NO5S
|
1
|
1 |
EC50 = 631 nM
|
|
|
CP0234135
|
N-(2-methylpropyl)-N-[[5-(4-methylsulfonylphenyl)thiophen-2-yl]methyl]-1-phenylmethanesulfonamide
Show/Hide
|
C23H27NO4S3
|
1
|
1 |
EC50 = 1000 nM
|
|
|
CP0562991
|
[3-[[(2S)-6-bromo-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]methyl]oxetan-3-yl]methanol
Show/Hide
|
C20H19BrF3NO5S
|
1
|
1 |
EC50 = 1000 nM
|
|
|
CP0059780
|
N-(2-methylpropyl)-N-[[5-(3-methylsulfonylphenyl)thiophen-2-yl]methyl]-1-phenylmethanesulfonamide
Show/Hide
|
C23H27NO4S3
|
1
|
1 |
EC50 = 2400 nM
|
|
|
CP0189594
|
3-[(2S)-6-[(E)-2-(2-chlorophenyl)prop-1-enyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C27H23ClF3NO5S
|
1
|
1 |
EC50 = 2740 nM
|
|
|
CP0205289
|
N-[5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]sulfamoyl]-4-methyl-1,3-thiazol-2-yl]acetamide
Show/Hide
|
C15H13F6N3O4S2
|
1
|
1 |
EC50 = 4000 nM
|
|
|
CP0138638
|
3-[(2S)-6-(4-propan-2-ylphenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C27H26F3NO5S
|
1
|
1 |
EC50 > 10000 nM
|
|
|
CP0527539
|
4-[[(2S)-6-(2,5-difluorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]methyl]oxane-4-carboxylic acid
Show/Hide
|
C28H24F5NO6S
|
1
|
1 |
EC50 > 10000 nM
|
|
|
CP0546382
|
3-[(2S)-6-[(E)-2-(4-methylphenyl)ethenyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C27H24F3NO5S
|
1
|
1 |
EC50 > 10000 nM
|
|
|
CP0546458
|
3-[(2S)-6-[3-(2-hydroxyethoxy)phenyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C26H24F3NO7S
|
1
|
1 |
EC50 > 10000 nM
|
|
|
CP0546643
|
3-[(2S)-6-[(E)-2-(4-chloro-2-fluorophenyl)ethenyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]propanoic acid
Show/Hide
|
C26H20ClF4NO5S
|
1
|
1 |
EC50 > 10000 nM
|
|
|
CP0411472
|
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-N-(2-fluorophenyl)-2-methylpropanamide
Show/Hide
|
C26H27FN2O4S
|
1
|
1 |
IC50 = 4.4 nM
|
|
|
CP0489514
|
N-(4-chloropyridin-2-yl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methylpropanamide
Show/Hide
|
C25H26ClN3O4S
|
1
|
1 |
IC50 = 8.2 nM
|
|
|
CP0411477
|
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-N-(3-fluorophenyl)-2-methylpropanamide
Show/Hide
|
C26H27FN2O4S
|
1
|
1 |
IC50 = 9.8 nM
|
|
|
CP0262112
|
N-[4-[1-(2,3-dihydroindol-1-yl)-2-methyl-1-oxopropan-2-yl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide
Show/Hide
|
C28H30N2O4S
|
1
|
1 |
IC50 = 10 nM
|
|
|
CP0168881
|
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methyl-N-phenylpropanamide
Show/Hide
|
C26H28N2O4S
|
1
|
1 |
IC50 = 14 nM
|
|
|
CP0262111
|
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-N,2-dimethyl-N-phenylpropanamide
Show/Hide
|
C27H30N2O4S
|
1
|
1 |
IC50 = 14 nM
|
|
|
CP0116135
|
N-(4-cyanopyridin-2-yl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]-2-fluorophenyl]-2-methylpropanamide
Show/Hide
|
C26H25FN4O4S
|
1
|
1 |
IC50 = 16 nM
|
|
|
CP0262113
|
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]-2-fluorophenyl]-N-(4-fluorophenyl)-2-methylpropanamide
Show/Hide
|
C26H26F2N2O4S
|
1
|
1 |
IC50 = 25 nM
|
|
|
CP0440462
|
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methyl-N-[4-(trifluoromethyl)pyridin-2-yl]propanamide
Show/Hide
|
C26H26F3N3O4S
|
1
|
1 |
IC50 = 25 nM
|
|
|
CP0116165
|
N-(2,4-difluorophenyl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]-2-fluorophenyl]-2-methylpropanamide
Show/Hide
|
C26H25F3N2O4S
|
1
|
1 |
IC50 = 29 nM
|
|
|
CP0411468
|
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-N-(4-fluoropyridin-2-yl)-2-methylpropanamide
Show/Hide
|
C25H26FN3O4S
|
1
|
1 |
IC50 = 31 nM
|
|
|
CP0116134
|
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-N-(4-fluorophenyl)-2-methylpropanamide
Show/Hide
|
C26H27FN2O4S
|
1
|
1 |
IC50 = 33 nM
|
|
|
CP0392911
|
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methyl-N-pyridin-2-ylpropanamide
Show/Hide
|
C25H27N3O4S
|
1
|
1 |
IC50 = 40 nM
|
|
|
CP0407819
|
N-(4-cyanopyridin-2-yl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methylpropanamide
Show/Hide
|
C26H26N4O4S
|
1
|
1 |
IC50 = 40 nM
|
|
|
CP0577410
|
US9598415, 201
Show/Hide
|
C28H32N8O3S
|
1
|
1 |
IC50 = 74 nM
|
|
|
CP0566256
|
US9598415, 158
Show/Hide
|
C27H30N8O3S
|
1
|
1 |
IC50 = 90 nM
|
|
|
CP0440463
|
N-(2,4-difluorophenyl)-2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methylpropanamide
Show/Hide
|
C26H26F2N2O4S
|
1
|
1 |
IC50 = 95 nM
|
|
|
CP0490584
|
US9598415, 138
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|
C27H36N8O3S
|
1
|
1 |
IC50 = 110 nM
|
|
|
CP0553078
|
US9598415, 113
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|
C27H27F3N8O4S
|
1
|
1 |
IC50 = 110 nM
|
|
|
CP0485005
|
US9598415, 17
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|
C26H30N8O4S
|
1
|
1 |
IC50 = 130 nM
|
|
|
CP0411464
|
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methyl-N-(2-methylphenyl)propanamide
Show/Hide
|
C27H30N2O4S
|
1
|
1 |
IC50 = 140 nM
|
|
|
CP0440464
|
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methyl-N-pyridin-3-ylpropanamide
Show/Hide
|
C25H27N3O4S
|
1
|
1 |
IC50 = 150 nM
|
|
|
CP0423733
|
US9598415, 136
Show/Hide
|
C26H28N8O3S
|
1
|
1 |
IC50 = 150 nM
|
|
|
CP0558782
|
US9598415, 128
Show/Hide
|
C26H28N8O3S
|
1
|
1 |
IC50 = 150 nM
|
|
|
CP0243406
|
N-[4-[1-(azetidin-1-yl)-2-methyl-1-oxopropan-2-yl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide
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|
C23H28N2O4S
|
1
|
1 |
IC50 = 180 nM
|
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CP0566255
|
8-[(1S)-1-cyclopropylethyl]-2-(4-cyclopropyl-6-methylpyrimidin-5-yl)-6-[(5-methylsulfonylpyrazin-2-yl)methylamino]pteridin-7-one
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|
C25H27N9O3S
|
1
|
1 |
IC50 = 180 nM
|
|
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CP0479578
|
US9598415, 69
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C27H30N8O3S
|
1
|
1 |
IC50 = 190 nM
|
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CP0553077
|
US9598415, 9
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C25H28N8O4S
|
1
|
1 |
IC50 = 190 nM
|
|
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CP0558868
|
US9598415, 214
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C25H27N9O3S
|
1
|
1 |
IC50 = 220 nM
|
|
|
CP0540108
|
US9598415, 8
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C26H30N8O4S
|
1
|
1 |
IC50 = 230 nM
|
|
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CP0571442
|
US9598415, 170
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C27H32N8O4S
|
1
|
1 |
IC50 = 230 nM
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CP0361258
|
N-[4-[1-(1,3-dihydroisoindol-2-yl)-2-methyl-1-oxopropan-2-yl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide
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|
C28H30N2O4S
|
1
|
1 |
IC50 = 260 nM
|
|
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CP0552040
|
US9598415, 137
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|
C27H29N7O3S
|
1
|
1 |
IC50 = 260 nM
|
|
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CP0552579
|
6-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-2-[(5-ethylsulfonylpyridin-2-yl)methylamino]-4-propan-2-ylpyrido[2,3-b]pyrazin-3-one
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|
C26H29N7O4S
|
1
|
1 |
IC50 = 260 nM
|
|
|
CP0537560
|
US9598415, 70
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|
C26H29N9O3S
|
1
|
1 |
IC50 = 270 nM
|
|
|
CP0558861
|
US9598415, 142
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C25H29N9O3S
|
1
|
1 |
IC50 = 280 nM
|
|
|
CP0558858
|
US9598415, 253
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C26H30N8O4S
|
1
|
1 |
IC50 = 290 nM
|
|
|
CP0528374
|
US9598415, 11
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C25H28N8O3S
|
1
|
1 |
IC50 = 300 nM
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CP0396018
|
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-N-(3-fluoropyridin-2-yl)-2-methylpropanamide
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|
C25H26FN3O4S
|
1
|
1 |
IC50 = 310 nM
|
|
|
CP0495610
|
US9598415, 15
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C27H30N8O3S
|
1
|
1 |
IC50 = 310 nM
|
|
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CP0553079
|
US9598415, 12
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|
C27H32N8O4S
|
1
|
1 |
IC50 = 310 nM
|
|
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CP0490585
|
US9598415, 103
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C25H28N8O3S2
|
1
|
1 |
IC50 = 320 nM
|
|
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CP0479580
|
US9598415, 68
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C27H30N8O4S
|
1
|
1 |
IC50 = 330 nM
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CP0558866
|
7-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-3-[(5-ethylsulfonylpyridin-2-yl)methylamino]-1-propan-2-ylquinoxalin-2-one
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|
C27H30N6O4S
|
1
|
1 |
IC50 = 350 nM
|
|
|
CP0484643
|
US9598415, 22
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C27H32N8O4S
|
1
|
1 |
IC50 = 360 nM
|
|
|
CP0560908
|
US9598415, 21
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C26H30N8O3S
|
1
|
1 |
IC50 = 360 nM
|
|
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CP0407763
|
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-N,N,2-trimethylpropanamide
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|
C22H28N2O4S
|
1
|
1 |
IC50 = 370 nM
|
|
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CP0558869
|
8-[(1S)-1-cyclopropylethyl]-2-(4-cyclopropyl-6-methylpyrimidin-5-yl)-6-[(2-ethylsulfonylspiro[3.3]heptan-6-yl)methylamino]pteridin-7-one
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|
C29H37N7O3S
|
1
|
1 |
IC50 = 370 nM
|
|
|
CP0555726
|
6-[[[8-[(1S)-1-cyclopropylethyl]-2-(4-cyclopropyl-6-methylpyrimidin-5-yl)-7-oxopteridin-6-yl]amino]methyl]-N-methylpyridine-3-sulfonamide
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|
C26H29N9O3S
|
1
|
1 |
IC50 = 380 nM
|
|
|
CP0552577
|
US9598415, 24
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|
C27H32N8O4S
|
1
|
1 |
IC50 = 390 nM
|
|
|
CP0116164
|
ethyl 2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methylpropanoate
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C22H27NO5S
|
1
|
1 |
IC50 = 400 nM
|
|
|
CP0423455
|
US9598415, 74
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C27H30N8O4S
|
1
|
1 |
IC50 = 410 nM
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|
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CP0552580
|
5-(4-hydroxy-2-methylphenyl)-N-[[4-(methylsulfamoyl)phenyl]methyl]spiro[2H-pyrrolo[3,2-b]pyridine-3,1'-cyclopentane]-1-carboxamide
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|
C27H30N4O4S
|
1
|
1 |
IC50 = 410 nM
|
|
|
CP0495609
|
US9598415, 52
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|
C26H28N8O4S
|
1
|
1 |
IC50 = 420 nM
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|
CP0085610
|
2-(4-ethylsulfonylphenyl)-N-[4-(2-methyl-1-oxo-1-piperidin-1-ylpropan-2-yl)phenyl]acetamide
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|
C25H32N2O4S
|
1
|
1 |
IC50 = 430 nM
|
|
|
CP0560909
|
US9598415, 146
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|
C24H28N8O3S
|
1
|
1 |
IC50 = 440 nM
|
|
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CP0361257
|
N-[4-[1-(2-azaspiro[3.3]heptan-2-yl)-2-methyl-1-oxopropan-2-yl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide
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|
C26H32N2O4S
|
1
|
1 |
IC50 = 470 nM
|
|
|
CP0485006
|
US9598415, 61
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|
C25H25F3N8O4S
|
1
|
1 |
IC50 = 470 nM
|
|
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CP0553080
|
6-[(5-ethylsulfonylpyridin-2-yl)methylamino]-2-(6-methoxyquinolin-5-yl)-8-propan-2-ylpteridin-7-one
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|
C27H27N7O4S
|
1
|
1 |
IC50 = 480 nM
|
|
|
CP0536883
|
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methyl-N-[6-(trifluoromethyl)pyridin-2-yl]propanamide
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|
C26H26F3N3O4S
|
1
|
1 |
IC50 = 500 nM
|
|
|
CP0552110
|
US9598415, 249
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|
C28H30N8O3S
|
1
|
1 |
IC50 = 520 nM
|
|
|
CP0528375
|
8-[(1S)-1-cyclopropylethyl]-2-(4-cyclopropyl-6-methylpyrimidin-5-yl)-6-[[5-(methylsulfonimidoyl)pyridin-2-yl]methylamino]pteridin-7-one
Show/Hide
|
C26H29N9O2S
|
1
|
1 |
IC50 = 540 nM
|
|
|
CP0556065
|
8-tert-butyl-2-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-6-[(5-ethylsulfonylpyridin-2-yl)methylamino]pteridin-7-one
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|
C26H30N8O4S
|
1
|
1 |
IC50 = 670 nM
|
|
|
CP0558867
|
US9598415, 204
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|
C27H28N8O2
|
1
|
1 |
IC50 = 670 nM
|
|
|
CP0459436
|
5-butyl-9-chloro-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6-one
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|
C20H16ClF6NO2
|
1
|
1 |
IC50 = 690 nM
|
|
|
CP0540107
|
US9598415, 34
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|
C26H30N8O5S
|
1
|
1 |
IC50 = 740 nM
|
|
|
CP0553081
|
US9598415, 141
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|
C23H26N8O5S
|
1
|
1 |
IC50 = 800 nM
|
|
|
CP0487873
|
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-9-methylphenanthridin-6-one
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|
C21H19F6NO2
|
1
|
1 |
IC50 = 1000 nM
|
|
|
CP0488049
|
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-9-methoxyphenanthridin-6-one
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|
C21H19F6NO3
|
1
|
1 |
IC50 = 1100 nM
|
|
|
CP0248164
|
1-[4-[[3-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]methyl]-2,2-dioxo-2lambda6,1,3-benzothiadiazol-1-yl]methyl]piperidin-1-yl]-2-methylpropan-1-one
Show/Hide
|
C26H29F6N3O4S
|
1
|
1 |
IC50 = 1100 nM
|
|
|
CP0560910
|
6-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-2-[(5-ethylsulfonylpyridin-2-yl)methylamino]-4-propan-2-ylpyrazino[2,3-b]pyrazin-3-one
Show/Hide
|
C25H28N8O4S
|
1
|
1 |
IC50 = 1200 nM
|
|
|
CP0141496
|
1-[3-[[3-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]methyl]-2,2-dioxo-2lambda6,1,3-benzothiadiazol-1-yl]methyl]piperidin-1-yl]propan-1-one
Show/Hide
|
C25H27F6N3O4S
|
1
|
1 |
IC50 = 1300 nM
|
|
|
CP0558865
|
7-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-3-[(5-ethylsulfonylpyridin-2-yl)methylamino]-1-propan-2-ylpyrido[3,4-b]pyrazin-2-one
Show/Hide
|
C26H29N7O4S
|
1
|
1 |
IC50 = 1300 nM
|
|
|
CP0565059
|
1-(4-fluorophenyl)-7-methoxy-N-[[4-(methylsulfamoyl)phenyl]methyl]pyrazolo[3,4-c]pyridine-4-carboxamide
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|
C22H20FN5O4S
|
1
|
1 |
IC50 = 1600 nM
|
|
|
CP0411475
|
2-[4-[[2-(4-ethylsulfonylphenyl)acetyl]amino]phenyl]-2-methyl-N-pyridin-4-ylpropanamide
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|
C25H27N3O4S
|
1
|
1 |
IC50 = 1800 nM
|
|
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CP0335474
|
4-[3-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]methyl]-2,2-dioxo-2lambda6,1,3-benzothiadiazol-1-yl]-1-pyrrolidin-1-ylbutan-1-one
Show/Hide
|
C24H25F6N3O4S
|
1
|
1 |
IC50 = 1900 nM
|
|
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CP0558860
|
2-(3-cyclopropylpyrazin-2-yl)-6-[(5-ethylsulfonylpyridin-2-yl)methylamino]-8-propan-2-ylpteridin-7-one
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|
C24H26N8O3S
|
1
|
1 |
IC50 = 2000 nM
|
|
|
CP0247502
|
4-[3-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]methyl]-2,2-dioxo-2lambda6,1,3-benzothiadiazol-1-yl]-N-methyl-N-[(2-methylphenyl)methyl]butanamide
Show/Hide
|
C29H29F6N3O4S
|
1
|
1 |
IC50 = 2200 nM
|
|
|
CP0459435
|
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-9-(trifluoromethyl)phenanthridin-6-one
Show/Hide
|
C21H16F9NO2
|
1
|
1 |
IC50 = 2600 nM
|
|
|
CP0558859
|
6-[(5-ethylsulfonylpyridin-2-yl)methylamino]-2-(4-fluoro-2-methylphenyl)-8-propan-2-ylpteridin-7-one
Show/Hide
|
C24H25FN6O3S
|
1
|
1 |
IC50 = 2800 nM
|
|
|
CP0528373
|
2-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-6-[(5-ethylsulfonylpyridin-2-yl)methylamino]-8-propylpteridin-7-one
Show/Hide
|
C25H28N8O4S
|
1
|
1 |
IC50 = 3000 nM
|
|
|
CP0260030
|
4-[2,2-dioxo-3-[(4-pentan-3-ylphenyl)methyl]-2lambda6,1,3-benzothiadiazol-1-yl]-1-pyrrolidin-1-ylbutan-1-one
Show/Hide
|
C26H35N3O3S
|
1
|
1 |
IC50 = 3400 nM
|
|
|
CP0484642
|
2-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-6-[(5-ethylsulfonylpyridin-2-yl)methylamino]-8-phenylpteridin-7-one
Show/Hide
|
C28H26N8O4S
|
1
|
1 |
IC50 = 3800 nM
|
|
|
CP0380839
|
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6-one
Show/Hide
|
C20H17F6NO2
|
2
|
1 |
IC50 = 3900 nM
|
|
|
2 |
IC50 = 4700 nM
|
|
|
CP0524496
|
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-9-hydroxyphenanthridin-6-one
Show/Hide
|
C20H17F6NO3
|
1
|
1 |
IC50 = 4100 nM
|
|
|
CP0334820
|
4-[3-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]methyl]-2,2-dioxo-2lambda6,1,3-benzothiadiazol-1-yl]-N-[(3-methoxyphenyl)methyl]-N-methylbutanamide
Show/Hide
|
C29H29F6N3O5S
|
1
|
1 |
IC50 = 4100 nM
|
|
|
CP0484644
|
7-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-3-[(5-ethylsulfonylpyridin-2-yl)methylamino]-1-propan-2-ylpyrido[2,3-b]pyrazin-2-one
Show/Hide
|
C26H29N7O4S
|
1
|
1 |
IC50 = 4100 nM
|
|
|
CP0395440
|
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-propylphenanthridin-6-one
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|
C19H15F6NO2
|
1
|
1 |
IC50 = 4200 nM
|
|
|
CP0381823
|
2-(5,5-diethylbenzo[b][1]benzosilol-2-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Show/Hide
|
C19H18F6OSi
|
1
|
1 |
IC50 = 4200 nM
|
|
|
CP0456138
|
2-(5-butyl-5-methylbenzo[b][1]benzosilol-2-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Show/Hide
|
C20H20F6OSi
|
1
|
1 |
IC50 = 4400 nM
|
|
|
CP0003740
|
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
Show/Hide
|
C17H12F9NO3S
|
2
|
1 |
IC50 = 4400 nM
|
|
|
2 |
IC50 = 6500 nM
|
|
|
CP0481996
|
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-hexylphenanthridin-6-one
Show/Hide
|
C22H21F6NO2
|
1
|
1 |
IC50 = 4700 nM
|
|
|
CP0401199
|
2-(5,5-dimethylbenzo[b][1]benzosilol-2-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Show/Hide
|
C17H14F6OSi
|
1
|
1 |
IC50 = 5400 nM
|
|
|
CP0389304
|
2-(5,5-dibutylbenzo[b][1]benzosilol-2-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Show/Hide
|
C23H26F6OSi
|
1
|
1 |
IC50 = 5500 nM
|
|
|
CP0089428
|
4-[2,2-dioxo-3-[(4-propan-2-ylphenyl)methyl]-2lambda6,1,3-benzothiadiazol-1-yl]-1-pyrrolidin-1-ylbutan-1-one
Show/Hide
|
C24H31N3O3S
|
1
|
1 |
IC50 = 5600 nM
|
|
|
CP0473976
|
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-10-methoxyphenanthridin-6-one
Show/Hide
|
C21H19F6NO3
|
1
|
1 |
IC50 = 5700 nM
|
|
|
CP0129839
|
4-[3-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]methyl]-2,2-dioxo-2lambda6,1,3-benzothiadiazol-1-yl]-N-(4-hydroxybutan-2-yl)-N-methylbutanamide
Show/Hide
|
C25H29F6N3O5S
|
1
|
1 |
IC50 = 5700 nM
|
|
|
CP0552578
|
5-[(1S)-1-cyclopropylethyl]-3-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-7-[(5-ethylsulfonylpyridin-2-yl)methylamino]pyrazino[2,3-c]pyridazin-6-one
Show/Hide
|
C27H30N8O4S
|
1
|
1 |
IC50 = 5700 nM
|
|
|
CP0488050
|
5-(cyclohexylmethyl)-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6-one
Show/Hide
|
C23H21F6NO2
|
1
|
1 |
IC50 = 5800 nM
|
|
|
CP0467808
|
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-propan-2-ylphenanthridin-6-one
Show/Hide
|
C19H15F6NO2
|
1
|
1 |
IC50 = 6000 nM
|
|
|
CP0499213
|
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-(2,2,2-trifluoroethyl)phenanthridin-6-one
Show/Hide
|
C18H10F9NO2
|
1
|
1 |
IC50 = 9000 nM
|
|
|
CP0380838
|
5-butyl-2-ethylphenanthridin-6-one
Show/Hide
|
C19H21NO
|
1
|
1 |
IC50 = 9200 nM
|
|
|
CP0395912
|
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-3-methoxyphenanthridin-6-one
Show/Hide
|
C21H19F6NO3
|
1
|
1 |
IC50 = 9200 nM
|
|
|
CP0459432
|
5-(cyclopropylmethyl)-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6-one
Show/Hide
|
C20H15F6NO2
|
1
|
1 |
IC50 = 9300 nM
|
|
|
CP0467810
|
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4-methoxyphenanthridin-6-one
Show/Hide
|
C21H19F6NO3
|
1
|
1 |
IC50 > 10000 nM
|
|
|
CP0487874
|
5-butyl-2-tert-butylphenanthridin-6-one
Show/Hide
|
C21H25NO
|
1
|
1 |
IC50 = 10400 nM
|
|
|
CP0385671
|
N-[4-[hydroxy(dimethyl)silyl]phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
Show/Hide
|
C16H18F3NO3SSi
|
1
|
1 |
IC50 = 11000 nM
|
|
|
CP0467809
|
5-butyl-2-propan-2-ylphenanthridin-6-one
Show/Hide
|
C20H23NO
|
1
|
1 |
IC50 = 11900 nM
|
|
|
CP0459431
|
5-butyl-2-hexylphenanthridin-6-one
Show/Hide
|
C23H29NO
|
1
|
1 |
IC50 = 13000 nM
|
|
|
CP0553082
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1-butan-2-yl-7-[cyclohexyl(methyl)amino]-3-(4-methylpiperazin-1-yl)pyrido[3,4-b]pyrazin-2-one
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C23H36N6O
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1
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1 |
IC50 = 13000 nM
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CP0417384
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5-butylphenanthridin-6-one
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C17H17NO
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1
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1 |
IC50 = 14500 nM
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CP0334821
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4-[2,2-dioxo-3-[[4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl]methyl]-2lambda6,1,3-benzothiadiazol-1-yl]-1-pyrrolidin-1-ylbutan-1-one
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C23H26F3N3O4S
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1
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1 |
IC50 = 16000 nM
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CP0459433
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5-butyl-2-methylphenanthridin-6-one
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C18H19NO
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1
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1 |
IC50 = 16800 nM
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CP0577430
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2-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-6-[(5-ethylsulfonylpyridin-2-yl)methylamino]-8-(2-hydroxypropan-2-yl)pteridin-7-one
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C25H28N8O5S
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1
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1 |
IC50 = 17000 nM
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CP0152535
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4-(3-benzyl-2,2-dioxo-2lambda6,1,3-benzothiadiazol-1-yl)-1-pyrrolidin-1-ylbutan-1-one
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C21H25N3O3S
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1
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1 |
IC50 = 18000 nM
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CP0395918
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2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-nonylphenanthridin-6-one
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C25H27F6NO2
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1
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1 |
IC50 > 20000 nM
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CP0395919
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5-ethyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6-one
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C18H13F6NO2
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1
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1 |
IC50 > 20000 nM
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CP0397540
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2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-methylphenanthridin-6-one
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C17H11F6NO2
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1
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1 |
IC50 > 20000 nM
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CP0459434
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5-butyl-2-(hydroxymethyl)phenanthridin-6-one
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C18H19NO2
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1
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1 |
IC50 > 20000 nM
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CP0478004
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2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5H-phenanthridin-6-one
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C16H9F6NO2
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1
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1 |
IC50 > 20000 nM
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CP0394583
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2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4-methyl-5H-phenanthridin-6-one
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C17H11F6NO2
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1
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1 |
IC50 > 20000 nM
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CP0390984
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N-butyl-N-[4-[hydroxy(dimethyl)silyl]phenyl]benzenesulfonamide
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C18H25NO3SSi
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1
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1 |
IC50 > 30000 nM
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CP0396597
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N-[4-(2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
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C17H18F3NO3S
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1
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1 |
IC50 > 30000 nM
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CP0396599
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N-[4-[hydroxy(dimethyl)silyl]phenyl]-N-(2-phenylethyl)benzenesulfonamide
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C22H25NO3SSi
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1
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1 |
IC50 > 30000 nM
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CP0396600
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N-benzyl-N-[4-[hydroxy(dimethyl)silyl]phenyl]benzenesulfonamide
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C21H23NO3SSi
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1
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1 |
IC50 > 30000 nM
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CP0466299
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N-ethyl-N-[4-[hydroxy(dimethyl)silyl]phenyl]benzenesulfonamide
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C16H21NO3SSi
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1
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1 |
IC50 > 30000 nM
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CP0555785
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methyl 2-[N-(benzenesulfonyl)-4-(2-hydroxypropan-2-yl)anilino]acetate
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C18H21NO5S
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1
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1 |
IC50 > 30000 nM
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CP0558863
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2-(4-cyclopropyl-6-oxo-1H-pyrimidin-5-yl)-6-[(5-ethylsulfonylpyridin-2-yl)methylamino]-8-propan-2-ylpteridin-7-one
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C24H26N8O4S
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1
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1 |
IC50 > 30000 nM
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CP0558864
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6-[(5-ethylsulfonylpyridin-2-yl)methylamino]-8-propan-2-yl-2-pyrimidin-5-ylpteridin-7-one
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C21H22N8O3S
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1
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1 |
IC50 > 30000 nM
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