Brief Information of the Compound and Protein
Compound Name
 Compound Info 
8-[(1S)-1-cyclopropylethyl]-2-(4-cyclopropyl-6-methylpyrimidin-5-yl)-6-[(2-ethylsulfonylspiro[3.3]heptan-6-yl)methylamino]pteridin-7-one
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Canonical SMILES
CCS(=O)(=O)C1CC2(CC(CNc3nc4cnc(nc4n([C@@H](C)C4CC4)c3=O)-c3c(C)ncnc3C3CC3)C2)C1
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Compound Formula C29H37N7O3S
Compound Structure
Protein Name
 Protein Info 
Nuclear receptor ROR-gamma
Protein Classification
Transcription factor
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Nuclear receptor
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Nuclear hormone receptor subfamily 1
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Nuclear hormone receptor subfamily 1 group F
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Nuclear hormone receptor subfamily 1 group F member 3
Uniprot ID
P51449
Gene Name
RORC
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 370 nM
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