| Compound ID |
Compound Name |
Compound Formula |
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CP0483315
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[(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-2-(hydroxymethyl)oxolan-3-yl] N-[(5R)-6-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-[[(2S)-2-[[(2S)-3-hydroxy-2-[[(2S)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-oxohexyl]carbamate
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C69H93F2N21O18
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1
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| 1 |
IC50 = 0.11 nM
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|
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CP0091820
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ELIGARD
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C59H84N16O12
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1
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| 1 |
IC50 = 0.2884 nM
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|
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CP0467084
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(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-2-propan-2-ylsulfanylacetyl]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
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C79H100ClN15O14S
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1
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| 1 |
IC50 = 0.31 nM
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CP0464390
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Ac)]-D-[Aph(Ac)]-Leu-ILys-Pro-DAla-NH2
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C80H102ClN15O14
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2
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| 1 |
IC50 = 0.52 nM
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|
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| 2 |
IC50 = 6.8 nM
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CP0467925
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(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-3-(4-chlorophenyl)-1-hydroxy-2-[[(2R)-1-hydroxy-2-(1-hydroxyethylideneamino)-3-naphthalen-2-ylpropylidene]amino]propylidene]amino]-1-hydroxy-3-pyridin-3-ylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-[4-(1-hydroxyethylideneamino)phenyl]propylidene]amino]-1-hydroxy-3-[4-(1-hydroxyethylideneamino)phenyl]propylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(1R)-2-hydroxy-2-imino-1-methylsulfanylethyl]pyrrolidine-2-carboximidic acid
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C80H102ClN15O14S
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1
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| 1 |
IC50 = 0.6 nM
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|
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CP0533537
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[(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methyl N-[(5R)-6-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-[[(2S)-2-[[(2S)-3-hydroxy-2-[[(2S)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-oxohexyl]carbamate
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C69H93F2N21O18
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1
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| 1 |
IC50 = 0.69 nM
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|
|
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CP0457774
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(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-3-(4-chlorophenyl)-1-hydroxy-2-[[(2R)-1-hydroxy-2-(1-hydroxyethylideneamino)-2-naphthalen-2-ylsulfanylethylidene]amino]propylidene]amino]-1-hydroxy-3-pyridin-3-ylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-[4-(1-hydroxyethylideneamino)phenyl]propylidene]amino]-1-hydroxy-3-[4-(1-hydroxyethylideneamino)phenyl]propylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(2R)-1-hydroxy-1-iminopropan-2-yl]pyrrolidine-2-carboximidic acid
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C79H100ClN15O14S
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1
|
| 1 |
IC50 = 0.73 nM
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|
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CP0373562
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(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-4-methylpentanoyl]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(1S)-2-amino-1-methylsulfanyl-2-oxoethyl]pyrrolidine-2-carboxamide
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C80H102ClN15O14S
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1
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| 1 |
IC50 = 0.8 nM
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CP0405513
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(2S)-1-[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-2-propan-2-ylsulfanylacetyl]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
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C79H100ClN15O14S
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1
|
| 1 |
IC50 = 0.81 nM
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CP0553871
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(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-3-(4-chlorophenyl)-1-hydroxy-2-[[(2R)-1-hydroxy-2-(1-hydroxyethylideneamino)-3-naphthalen-2-ylpropylidene]amino]propylidene]amino]-1-hydroxy-3-pyridin-3-ylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-[4-(1-hydroxyethylideneamino)phenyl]propylidene]amino]-1-hydroxy-3-[4-(1-hydroxyethylideneamino)phenyl]propylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(1R)-2-hydroxy-2-imino-1-methylsulfinylethyl]pyrrolidine-2-carboximidic acid
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C80H102ClN15O15S
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1
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| 1 |
IC50 = 0.83 nM
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CP0464389
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(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-4-methylpentanoyl]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(1S)-2-amino-1-methylsulfinyl-2-oxoethyl]pyrrolidine-2-carboxamide
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C80H102ClN15O15S
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1
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| 1 |
IC50 = 0.87 nM
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|
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CP0399513
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(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-2-propan-2-ylsulfinylacetyl]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
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C79H100ClN15O15S
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1
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| 1 |
IC50 = 1.2 nM
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CP0444544
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(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-2-methylsulfanylacetyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-4-methylpentanoyl]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
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C80H102ClN15O13S
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1
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| 1 |
IC50 = 1.2 nM
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|
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CP0916631
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PRAZARELIX ACETATE
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C82H106ClN23O14
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3
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| 1 |
IC50 = 1.36 nM
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|
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| 2 |
IC50 = 1.4 nM
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|
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| 3 |
IC50 = 6.9 nM
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CP0515564
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propan-2-yl 2-[[(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[4-[[(4S)-2,6-dioxo-1,3-diazinane-4-carbonyl]amino]phenyl]propanoyl]amino]-3-[4-(carbamoylamino)phenyl]propanoyl]amino]-4-methylpentanoyl]amino]-5-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-oxopentyl]amino]acetate
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C83H103ClN18O18
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1
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| 1 |
IC50 = 1.38 nM
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CP0511304
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(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-methylamino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
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C83H105ClN18O16
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1
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| 1 |
IC50 = 1.47 nM
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CP0485403
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(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-6-(cyclohexylamino)-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
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C85H107ClN18O16
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1
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| 1 |
IC50 = 1.5 nM
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CP0431233
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propan-2-yl 2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[4-[[(4S)-2,6-dioxo-1,3-diazinane-4-carbonyl]amino]phenyl]propanoyl]amino]-3-[4-(carbamoylamino)phenyl]propanoyl]amino]-4-methylpentanoyl]amino]-3-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-oxopropyl]amino]acetate
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C81H99ClN18O18
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1
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| 1 |
IC50 = 1.54 nM
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CP0455435
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3-[(2R)-2-amino-2-(2-methoxyphenyl)ethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-[4-[[5-(trifluoromethyl)furan-2-yl]methyl]piperazin-1-yl]pyrimidine-2,4-dione
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C31H32F5N5O4
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1
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| 1 |
IC50 = 1.54 nM
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CP0485072
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propan-2-yl 2-[[(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[4-[[(4S)-2,6-dioxo-1,3-diazinane-4-carbonyl]amino]phenyl]propanoyl]amino]-3-[4-(carbamoylamino)phenyl]propanoyl]amino]-4-methylpentanoyl]amino]-4-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-oxobutyl]amino]acetate
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C82H101ClN18O18
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1
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| 1 |
IC50 = 1.56 nM
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CP0455438
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4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[(2-fluoro-6-methylphenyl)methyl]-4-methyl-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]amino]butanoic acid
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C32H33F2N3O5
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1
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| 1 |
IC50 = 1.6 nM
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CP0498005
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(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1,3-dioxo-3-(propan-2-ylamino)propan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
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C79H95ClN18O17
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1
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| 1 |
IC50 = 1.62 nM
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CP0463546
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4-[[(1R)-2-[5-[4-(2-fluoro-3-methoxyphenyl)piperazin-1-yl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]amino]butanoic acid
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C36H38F5N5O5
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2
|
| 1 |
IC50 = 1.63 nM
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| 2 |
IC50 = 5.4 nM
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CP0273422
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(DHor)]-D-[Aph(Cbm)]-Leu-ILys-Pro-DAla-NH2
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C82H103ClN18O16
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2
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| 1 |
IC50 = 1.64 nM
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| 2 |
IC50 = 8.8 nM
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CP0504928
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(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-5-(propan-2-ylamino)pentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
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C81H101ClN18O16
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1
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| 1 |
IC50 = 1.72 nM
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CP0440074
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2-[[(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[4-[[(4S)-2,6-dioxo-1,3-diazinane-4-carbonyl]amino]phenyl]propanoyl]amino]-3-[4-(carbamoylamino)phenyl]propanoyl]amino]-4-methylpentanoyl]amino]-4-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-oxobutyl]amino]-2-cyclohexylacetic acid
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C85H105ClN18O18
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1
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| 1 |
IC50 = 1.77 nM
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CP0483597
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(4R)-N-[(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[4-[[(4S)-2,6-dioxo-1,3-diazinane-4-carbonyl]amino]phenyl]propanoyl]amino]-3-[4-(carbamoylamino)phenyl]propanoyl]amino]-4-methylpentanoyl]amino]-5-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-oxopentyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
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C83H99ClN20O19
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1
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| 1 |
IC50 = 1.77 nM
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CP0504925
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propan-2-yl 2-[[(5S)-5-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[4-[[(4S)-2,6-dioxo-1,3-diazinane-4-carbonyl]amino]phenyl]propanoyl]amino]-3-[4-(carbamoylamino)phenyl]propanoyl]amino]-4-methylpentanoyl]amino]-6-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-6-oxohexyl]amino]acetate
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C84H105ClN18O18
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1
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| 1 |
IC50 = 1.83 nM
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CP0498006
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(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]-methylamino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
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C83H105ClN18O16
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1
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| 1 |
IC50 = 1.85 nM
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CP0540218
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propan-2-yl 3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[4-[[(4S)-2,6-dioxo-1,3-diazinane-4-carbonyl]amino]phenyl]propanoyl]amino]-3-[4-(carbamoylamino)phenyl]propanoyl]amino]-4-methylpentanoyl]amino]-3-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-oxopropyl]-methylamino]propanoate
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C83H103ClN18O18
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1
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| 1 |
IC50 = 1.97 nM
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CP0498004
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propan-2-yl 3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[4-[[(4S)-2,6-dioxo-1,3-diazinane-4-carbonyl]amino]phenyl]propanoyl]amino]-3-[4-(carbamoylamino)phenyl]propanoyl]amino]-4-methylpentanoyl]amino]-3-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-oxopropyl]amino]propanoate
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C82H101ClN18O18
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1
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| 1 |
IC50 = 1.98 nM
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CP0155795
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N-[(2S)-2-[2-[1-(7-azabicyclo[2.2.1]heptan-7-yl)-2-methyl-1-oxopropan-2-yl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl]propyl]-3-phenylpyrrolidine-1-carboxamide
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C38H46N4O2S
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1
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| 1 |
IC50 = 2 nM
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CP0517876
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US9040693, 22
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C22H16ClN3O6S2
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1
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| 1 |
IC50 = 2 nM
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CP0846329
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Degarelix analogue
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C84H103ClN18O18
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1
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| 1 |
IC50 = 2.01 nM
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CP0916740
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Degarelix analogue
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C80H95ClN18O16
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1
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| 1 |
IC50 = 2.11 nM
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CP0425189
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(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-3-(4-chlorophenyl)-1-hydroxy-2-[[(2S)-1-hydroxy-2-(1-hydroxyethylideneamino)-3-naphthalen-2-ylpropylidene]amino]propylidene]amino]-1-hydroxy-3-pyridin-3-ylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-[4-(1-hydroxyethylideneamino)phenyl]propylidene]amino]-1-hydroxy-3-[4-(1-hydroxyethylideneamino)phenyl]propylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(2R)-1-hydroxy-1-iminopropan-2-yl]pyrrolidine-2-carboximidic acid
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C80H102ClN15O14
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1
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| 1 |
IC50 = 2.2 nM
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CP0431261
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(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1,4-dioxo-4-(propan-2-ylamino)butan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
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C80H97ClN18O17
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1
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| 1 |
IC50 = 2.24 nM
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CP0421587
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[(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methyl 4-[[6-[[(5R)-6-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-[[(2S)-2-[[(2S)-3-hydroxy-2-[[(2S)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-oxohexyl]amino]-6-oxohexyl]amino]-4-oxobutanoate
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C78H108F2N22O20
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1
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| 1 |
IC50 = 2.4 nM
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CP0509760
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(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-(pyridin-2-ylmethylamino)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
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C83H106ClN19O16
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1
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| 1 |
IC50 = 2.71 nM
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CP0502553
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Cbm)]-D-[Aph(Cbm)]-Leu-ILys-Pro-DAla-NH2
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C78H100ClN17O14
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1
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| 1 |
IC50 = 2.8 nM
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CP0511262
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Hor)]-D-Pal-Leu-ILys-Pro-DAla-NH2
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C80H100ClN17O15
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1
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| 1 |
IC50 = 2.8 nM
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CP0509761
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(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
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C85H101ClN18O17
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1
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| 1 |
IC50 = 2.85 nM
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CP0460559
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4-[[(1R)-2-[3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxo-5-[4-[[5-(trifluoromethyl)furan-2-yl]methyl]piperazin-1-yl]pyrimidin-1-yl]-1-phenylethyl]amino]butanoic acid
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C35H36F7N5O5
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3
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| 1 |
IC50 = 2.9 nM
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| 2 |
IC50 = 6.32 nM
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| 3 |
IC50 = 13 nM
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CP0476009
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Hor)]-D-[Aph(Cbm)]-Leu-ILys-Pro-DAla-NH2
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C82H103ClN18O16
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1
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| 1 |
IC50 = 3 nM
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CP0444543
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(2S)-1-[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-2-propan-2-ylsulfinylacetyl]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
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C79H100ClN15O15S
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1
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| 1 |
IC50 = 3 nM
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CP0455436
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3-[(2R)-2-amino-2-(5-fluoro-2-methoxyphenyl)ethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-[4-[[5-(trifluoromethyl)furan-2-yl]methyl]piperazin-1-yl]pyrimidine-2,4-dione
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C31H31F6N5O4
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1
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| 1 |
IC50 = 3.03 nM
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CP0957306
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-Arg-D-Glu(Nal)-Leu-ILys-Pro-DAla-NH2
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C82H108ClN17O15
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1
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| 1 |
IC50 = 3.3 nM
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CP0462274
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ABARELIX
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C72H95ClN14O14
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1
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| 1 |
IC50 = 3.5 nM
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CP0498001
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(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-(1H-imidazol-2-ylamino)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
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C80H103ClN20O16
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1
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| 1 |
IC50 = 3.5 nM
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CP0522400
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-Tyr-D-Har(Et2)-Leu-Har(Et2)-Pro-DAla-NH2
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C80H113ClN18O13
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1
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| 1 |
IC50 = 3.6 nM
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CP0497999
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(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-4-(pyridin-2-ylmethylamino)butanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
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C84H108ClN19O16
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1
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| 1 |
IC50 = 3.79 nM
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CP0202958
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5-((4-(2-(4-tert-butylphenyl)-1H-benzo[d]imidazol-4-yl)piperazin-1-yl)methyl)-1-ethylpyrimidine-2,4(1H,3H)-dione
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C28H34N6O2
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1
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| 1 |
IC50 = 4 nM
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CP0501164
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CHEBI:31387
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C72H96ClN17O16
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3
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| 1 |
IC50 = 4.2 nM
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| 2 |
Kd = 0.0017 nM
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| 3 |
Kd = 0.135 nM
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CP0504927
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(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-(quinolin-2-ylamino)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
Show/Hide
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C86H106ClN19O16
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1
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| 1 |
IC50 = 4.25 nM
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CP0373707
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Hor)]-D-[Aph(Ac)]-Leu-ILys-Pro-DAla-NH2
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C83H104ClN17O16
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1
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| 1 |
IC50 = 4.3 nM
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CP0490500
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(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-2-methylsulfinylacetyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-4-methylpentanoyl]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
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C80H102ClN15O14S
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1
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| 1 |
IC50 = 4.6 nM
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CP0473822
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4-[[(1R)-2-[3-[(2,6-difluorophenyl)methyl]-4-methyl-2,6-dioxo-5-[4-[[5-(trifluoromethyl)furan-2-yl]methyl]piperazin-1-yl]pyrimidin-1-yl]-1-(3-fluoro-5-methylphenyl)ethyl]amino]butanoic acid
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C35H37F6N5O5
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1
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| 1 |
IC50 = 4.9 nM
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CP0495014
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(EtCbm)]-D-[Aph(EtCbm)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C82H108ClN17O14
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1
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| 1 |
IC50 = 5 nM
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CP0509759
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(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-[bis(pyridin-2-ylmethyl)amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
Show/Hide
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C89H111ClN20O16
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1
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| 1 |
IC50 = 5.31 nM
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CP0508059
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Hor)]-D-[Amf(Cbm)]-Leu-ILys-Pro-Ala-ol
Show/Hide
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C83H106ClN17O16
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1
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| 1 |
IC50 = 5.5 nM
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CP0540217
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(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-4-(quinolin-2-ylamino)butanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
Show/Hide
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C87H108ClN19O16
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1
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| 1 |
IC50 = 5.52 nM
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CP0408217
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Hor)]-D-[Amf(Cbm)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C83H105ClN18O16
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1
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| 1 |
IC50 = 5.6 nM
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CP0421316
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Hor)]-D-Cit-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C78H103ClN18O16
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1
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| 1 |
IC50 = 5.8 nM
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CP0485828
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Ac)]-D-[Aph(Cbm)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C79H101ClN16O14
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1
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| 1 |
IC50 = 6.1 nM
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CP0525877
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(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-N-[(2S)-1-[[(2S)-3-(4-acetamidophenyl)-1-[[(2R)-3-(4-acetamidophenyl)-1-[[(1S)-2-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-2-oxo-1-propan-2-ylsulfanylethyl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]pentanediamide
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C76H100ClN15O15S
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1
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| 1 |
IC50 = 6.2 nM
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CP0476950
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4-[[(1R)-2-[3-[(2-fluoro-6-methylphenyl)methyl]-4-methyl-2,6-dioxo-5-[4-[[5-(trifluoromethyl)furan-2-yl]methyl]piperazin-1-yl]pyrimidin-1-yl]-1-phenylethyl]amino]butanoic acid
Show/Hide
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C35H39F4N5O5
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1
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| 1 |
IC50 = 6.3 nM
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CP0497295
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Ac)]-D-[Amf(Cbm)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C80H103ClN16O14
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1
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| 1 |
IC50 = 6.4 nM
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CP0511005
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(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-3-(4-chlorophenyl)-1-hydroxy-2-[[(2R)-1-hydroxy-2-(1-hydroxyethylideneamino)-3-naphthalen-2-ylpropylidene]amino]propylidene]amino]-1-hydroxy-3-pyridin-3-ylpropylidene]amino]-1-hydroxy-2-methylsulfinylethylidene]amino]-1-hydroxy-3-[4-(1-hydroxyethylideneamino)phenyl]propylidene]amino]-1-hydroxy-3-[4-(1-hydroxyethylideneamino)phenyl]propylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(2R)-1-hydroxy-1-iminopropan-2-yl]pyrrolidine-2-carboximidic acid
Show/Hide
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C80H102ClN15O14S
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1
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| 1 |
IC50 = 6.9 nM
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CP0514572
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(DHor)]-D-[Amf(Ac)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C84H106ClN17O16
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1
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| 1 |
IC50 = 7 nM
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CP0550826
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[(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methyl 5-[[(5S)-6-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-[[(2S)-2-[[(2S)-3-hydroxy-2-[[(2S)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-oxohexyl]amino]-5-oxopentanoate
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C73H99F2N21O19
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1
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| 1 |
IC50 = 7.1 nM
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CP0511269
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Cbm)]-D-[Aph(Ac)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C79H101ClN16O14
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1
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| 1 |
IC50 = 7.2 nM
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CP0394573
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(DHor)]-D-[Amf(Cbm)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C83H105ClN18O16
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1
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| 1 |
IC50 = 7.7 nM
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CP0522391
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Hor)]-D-[Aph(DHor)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C86H106ClN19O18
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1
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| 1 |
IC50 = 7.7 nM
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CP0501327
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Hor)]-D-[Amf(Cbm)]-Leu-ILys-Pro-DAla-ol
Show/Hide
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C83H106ClN17O16
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1
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| 1 |
IC50 = 7.8 nM
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CP0464788
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Amf(Hor)]-D-[Aph(Ac)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C84H106ClN17O16
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1
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| 1 |
IC50 = 7.9 nM
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CP0469193
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Hor)]-D-[Amf(MeCbm)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C84H107ClN18O16
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1
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| 1 |
IC50 = 7.9 nM
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CP0440076
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Nalpha-Me-Aph(Hor)]-D-[Aph(Ac)]-Leu-ILys-Pro-DAla-NH2
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C84H106ClN17O16
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1
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| 1 |
IC50 = 8.1 nM
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CP0897945
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(D/L-Hya)]-D-[Aph(Ac)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C83H104ClN17O16
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1
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| 1 |
IC50 = 8.1 nM
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CP0448875
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Dhp)]-D-[Aph(Ac)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C83H102ClN17O16
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1
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| 1 |
IC50 = 8.2 nM
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CP0545936
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3-[(2R)-2-amino-2-(3-fluoro-5-methylphenyl)ethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-[4-[[5-(trifluoromethyl)furan-2-yl]methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C31H31F6N5O3
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1
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| 1 |
IC50 = 8.4 nM
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CP0483558
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(DHor)]-D-[Aph(Ac)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C83H104ClN17O16
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1
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| 1 |
IC50 = 8.6 nM
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CP0376133
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Hor)]-D-[Amf(Cbm)]-Leu-ILys-Pro-NHEt
Show/Hide
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C82H104ClN17O15
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1
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| 1 |
IC50 = 8.8 nM
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CP0430089
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(diureidoacetyl)]-D-[Aph(Ac)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C82H106ClN19O16
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1
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| 1 |
IC50 = 8.9 nM
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CP0473819
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3-[(2R)-2-amino-2-phenylethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-[4-[[5-(trifluoromethyl)furan-2-yl]methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C30H30F5N5O3
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1
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| 1 |
IC50 = 8.96 nM
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CP0475866
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(DImz)]-D-[Aph(Ac)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C82H104ClN17O15
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1
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| 1 |
IC50 = 9.1 nM
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CP0498003
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(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[4-[[(4S)-2,6-dioxo-1,3-diazinane-4-carbonyl]amino]phenyl]propanoyl]amino]-3-[4-(carbamoylamino)phenyl]propanoyl]amino]-N-[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]butanediamide
Show/Hide
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C80H98ClN19O17
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1
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| 1 |
IC50 = 9.18 nM
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CP0511259
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Hor)]-D-[Amf(Ac)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C84H106ClN17O16
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1
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| 1 |
IC50 = 9.5 nM
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CP0484128
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US9040693, 146
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C23H17ClN2O5S
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1
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| 1 |
IC50 = 10 nM
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CP0403197
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(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-6-amino-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Show/Hide
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C59H84N18O13
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1
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| 1 |
IC50 = 10.5 nM
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CP0375701
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(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
Show/Hide
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C82H99ClN20O16
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1
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| 1 |
IC50 = 10.64 nM
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CP0393107
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Oro)]-D-[Aph(Ac)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C83H102ClN17O16
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1
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| 1 |
IC50 = 10.7 nM
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CP0460039
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Hor)]-D-[Aph(Hor)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C86H106ClN19O18
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1
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| 1 |
IC50 = 10.8 nM
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CP0921538
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(DImz)]-D-[Aph(Ac)]-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C82H104ClN17O15
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1
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| 1 |
IC50 = 10.8 nM
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CP0482896
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[[5-(trifluoromethyl)furan-2-yl]methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C31H30F7N5O3
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1
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| 1 |
IC50 = 12.6 nM
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CP0554183
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Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Hor)]-D-Nal-Leu-ILys-Pro-DAla-NH2
Show/Hide
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C85H103ClN16O15
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1
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| 1 |
IC50 = 13 nM
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CP0553870
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(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-N-[(2S)-1-[[(2S)-3-(4-acetamidophenyl)-1-[[(2R)-3-(4-acetamidophenyl)-1-[[(1S)-2-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-2-oxo-1-propan-2-ylsulfinylethyl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]pentanediamide
Show/Hide
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C76H100ClN15O16S
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1
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| 1 |
IC50 = 13 nM
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CP0211626
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2-(4-tert-butylphenyl)-4-(4-((1,2-diethyl-5-methyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
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C30H40N6
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1
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| 1 |
IC50 = 13 nM
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CP0498002
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(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-4-(1H-imidazol-2-ylamino)butanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
Show/Hide
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C81H105ClN20O16
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1
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| 1 |
IC50 = 13.47 nM
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CP0091943
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2-(4-tert-butylphenyl)-4-(4-((1-ethyl-5-methyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
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C28H36N6
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1
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| 1 |
IC50 = 14 nM
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CP0469792
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US9040693, 367
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C23H17F3N2O7S
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1
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| 1 |
IC50 = 15 nM
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CP0549937
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US9040693, 233
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C22H15F3N2O7S
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1
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| 1 |
IC50 = 15 nM
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CP0427432
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3-[(2R)-2-amino-2-(2-hydroxyphenyl)ethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-[4-[[5-(trifluoromethyl)furan-2-yl]methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C30H30F5N5O4
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1
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| 1 |
IC50 = 15.2 nM
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CP0532906
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5-[4-[(3-acetylphenyl)methyl]piperazin-1-yl]-3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
Show/Hide
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C34H35F4N5O3
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1
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| 1 |
IC50 = 16.5 nM
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CP0549935
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US9040693, 191
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C23H18F2N2O5S2
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1
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| 1 |
IC50 = 17 nM
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CP0469791
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US9040693, 95
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C21H14ClN3O5S
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1
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| 1 |
IC50 = 19 nM
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CP0549936
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US9040693, 202
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C22H17FN2O6S2
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1
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| 1 |
IC50 = 20 nM
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CP0394597
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3-[(2R)-2-amino-2-(3-fluoro-5-methylphenyl)ethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-[4-[(3-nitrophenyl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C32H33F3N6O4
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1
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| 1 |
IC50 = 22 nM
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CP0445475
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(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-4-(dipyridin-2-ylamino)butanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
Show/Hide
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C88H109ClN20O16
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1
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| 1 |
IC50 = 22.58 nM
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CP0191989
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2-(4-tert-butylphenyl)-4-(4-((1,2-dimethyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
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C27H34N6
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1
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| 1 |
IC50 = 23 nM
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CP0532907
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methyl 3-[[4-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]piperazin-1-yl]methyl]benzoate
Show/Hide
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C34H35F4N5O4
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1
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| 1 |
IC50 = 23.3 nM
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CP0437295
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(2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-3-(4-chlorophenyl)-1-hydroxy-2-[[(2R)-1-hydroxy-2-(1-hydroxyethylideneamino)-3-naphthalen-2-ylpropylidene]amino]propylidene]amino]-1-hydroxy-3-pyridin-3-ylpropylidene]amino]-1-hydroxy-2-methylsulfanylethylidene]amino]-1-hydroxy-3-[4-(1-hydroxyethylideneamino)phenyl]propylidene]amino]-1-hydroxy-3-[4-(1-hydroxyethylideneamino)phenyl]propylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(2R)-1-hydroxy-1-iminopropan-2-yl]pyrrolidine-2-carboximidic acid
Show/Hide
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C80H102ClN15O13S
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1
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| 1 |
IC50 = 25 nM
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CP0404679
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(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[4-[[(4S)-2,6-dioxo-1,3-diazinane-4-carbonyl]amino]phenyl]propanoyl]amino]-3-[4-(carbamoylamino)phenyl]propanoyl]amino]-N-[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]-N'-methylbutanediamide
Show/Hide
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C81H100ClN19O17
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1
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| 1 |
IC50 = 25.79 nM
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CP0440340
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4-[2-[(1R)-1-amino-2-[3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-5-[4-[(3-nitrophenyl)methyl]piperazin-1-yl]-2,6-dioxopyrimidin-1-yl]ethyl]phenoxy]butanoic acid
Show/Hide
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C36H38F4N6O7
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1
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| 1 |
IC50 = 26.9 nM
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CP0033448
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BAY-784
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C29H26ClF4N3O5S2
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3
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| 1 |
IC50 = 27 nM
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| 2 |
Kd = 5.52 nM
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| 3 |
Kd = 9.83 nM
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CP0566195
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2-[2-[(1R)-1-amino-2-[3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-5-[4-[(3-nitrophenyl)methyl]piperazin-1-yl]-2,6-dioxopyrimidin-1-yl]ethyl]phenoxy]acetic acid
Show/Hide
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C34H34F4N6O7
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1
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| 1 |
IC50 = 27.7 nM
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CP0482895
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[[3-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C33H32F7N5O2
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1
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| 1 |
IC50 = 27.9 nM
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CP0559394
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US9040693, 420
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C22H16F3N3O5S
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1
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| 1 |
IC50 = 29 nM
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CP0873833
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US9040693, 48
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C22H16F2N2O6S
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1
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| 1 |
IC50 = 29 nM
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CP0455433
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3-[(2R)-2-amino-2-(5-fluoro-2-methoxyphenyl)ethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-[4-[(3-nitrophenyl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C32H33F3N6O5
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1
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| 1 |
IC50 = 32 nM
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CP0216499
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7-(3-(5-(3,5-dimethylphenyl)-4-(2-(4-(4-ethylhexyl)cyclohexyl)ethyl)-1,6-dihydropentalen-2-yl)-3-methylbut-1-en-2-yl)bicyclo[2.2.1]heptane
Show/Hide
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C37H54N4O2S
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1
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| 1 |
IC50 = 33 nM
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CP0332937
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methyl N-[N-[(2S)-2-[2-[1-(7-azabicyclo[2.2.1]heptan-7-yl)-2-methyl-1-oxopropan-2-yl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl]propyl]-C-(3-pyridin-4-ylpyrrolidin-1-yl)carbonimidoyl]carbamate
Show/Hide
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C39H48N6O3S
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1
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| 1 |
IC50 = 35 nM
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CP0536360
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4-[[(1R)-2-[3-[(2,6-difluorophenyl)methyl]-4-methyl-2,6-dioxo-5-[4-[[5-(trifluoromethyl)furan-2-yl]methyl]piperazin-1-yl]pyrimidin-1-yl]-1-(5-fluoro-2-methoxyphenyl)ethyl]amino]butanoic acid
Show/Hide
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C35H37F6N5O6
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1
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| 1 |
IC50 = 38.5 nM
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CP0467082
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(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-N-[(2S)-1-[[(2S)-3-(4-acetamidophenyl)-1-[[(2R)-3-(4-acetamidophenyl)-1-[[(1R)-2-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-2-oxo-1-propan-2-ylsulfanylethyl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]pentanediamide
Show/Hide
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C76H100ClN15O15S
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1
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| 1 |
IC50 = 39 nM
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CP0518295
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US9040693, 414
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C22H15F3N2O7S
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1
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| 1 |
IC50 = 42 nM
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CP0489963
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3-[[4-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]piperazin-1-yl]methyl]-2-fluorobenzamide
Show/Hide
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C33H33F5N6O3
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1
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| 1 |
IC50 = 42 nM
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CP0152863
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2-(4-tert-butylphenyl)-4-(4-((2-methyl-1-propyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
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C29H38N6
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1
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| 1 |
IC50 = 43 nM
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CP0070868
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2-(4-tert-butylphenyl)-4-(4-((2-methyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
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C26H32N6
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1
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| 1 |
IC50 = 44 nM
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CP0455434
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3-[(2R)-2-amino-2-(2-methoxyphenyl)ethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-[4-[(3-nitrophenyl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C32H34F2N6O5
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1
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| 1 |
IC50 = 45 nM
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CP0375700
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(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[4-[[(4S)-2,6-dioxo-1,3-diazinane-4-carbonyl]amino]phenyl]propanoyl]amino]-3-[4-(carbamoylamino)phenyl]propanoyl]amino]-N-[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]-N',N'-dimethylbutanediamide
Show/Hide
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C82H102ClN19O17
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1
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| 1 |
IC50 = 48.91 nM
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CP0532900
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4-[[(1R)-2-[3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxo-5-[4-[[3-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]pyrimidin-1-yl]-1-phenylethyl]amino]butanoic acid
Show/Hide
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C37H38F7N5O4
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1
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| 1 |
IC50 = 49.5 nM
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CP0532909
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[(3-methylsulfinylphenyl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C33H35F4N5O3S
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1
|
| 1 |
IC50 = 51.2 nM
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CP0503780
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(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]-methylamino]-4-methyl-1-oxopentan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
Show/Hide
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C83H105ClN18O16
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1
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| 1 |
IC50 = 52.24 nM
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CP0463545
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[[3-(1,3-oxazol-2-yl)phenyl]methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C35H34F4N6O3
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1
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| 1 |
IC50 = 53 nM
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CP0269883
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propan-2-yl N-[N-[(2S)-2-[2-[1-(7-azabicyclo[2.2.1]heptan-7-yl)-2-methyl-1-oxopropan-2-yl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl]propyl]-C-(3-pyridin-4-ylpyrrolidin-1-yl)carbonimidoyl]carbamate
Show/Hide
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C41H52N6O3S
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1
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| 1 |
IC50 = 55 nM
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CP0269882
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(S)-N-(2-(2-(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-methyl-1-oxopropan-2-yl)-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl)propyl)-4-(pyridin-4-yl)piperidine-1-carboxamide
Show/Hide
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C38H47N5O2S
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1
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| 1 |
IC50 = 56 nM
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CP0563002
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4-[[(1R)-2-[3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-5-[4-[(3-nitrophenyl)methyl]piperazin-1-yl]-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]amino]butanoic acid
Show/Hide
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C36H38F4N6O6
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1
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| 1 |
IC50 = 60 nM
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CP0489964
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3-[[4-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]piperazin-1-yl]methyl]-2-fluorobenzonitrile
Show/Hide
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C33H31F5N6O2
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1
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| 1 |
IC50 = 61 nM
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CP0468803
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[[5-(trifluoromethyl)thiophen-2-yl]methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C31H30F7N5O2S
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1
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| 1 |
IC50 = 62 nM
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CP0532903
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methyl 5-[[4-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]piperazin-1-yl]methyl]furan-2-carboxylate
Show/Hide
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C32H33F4N5O5
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1
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| 1 |
IC50 = 64 nM
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CP0455437
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4-[[(1R)-2-[3-[(2,6-difluorophenyl)methyl]-4-methyl-2,6-dioxo-5-[4-[[5-(trifluoromethyl)furan-2-yl]methyl]piperazin-1-yl]pyrimidin-1-yl]-1-(2-methoxyphenyl)ethyl]amino]butanoic acid
Show/Hide
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C35H38F5N5O6
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1
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| 1 |
IC50 = 65.2 nM
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CP0071049
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4-(4-((1-butyl-5-methyl-1H-imidazol-4-yl)methyl)piperazin-1-yl)-2-(4-tert-butylphenyl)-1H-benzo[d]imidazole
Show/Hide
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C30H40N6
|
1
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| 1 |
IC50 = 71 nM
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CP0201676
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1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-(2-(4-(2-hydroxy-3-(piperazin-1-yl)propyl)piperazin-1-yl)ethyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one
Show/Hide
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C37H54N6O2S
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1
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| 1 |
IC50 = 74 nM
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CP0337215
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(S)-isopropyl (2-(2-(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-methyl-1-oxopropan-2-yl)-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl)propylamino)(4-(pyridin-4-yl)piperidin-1-yl)methylenecarbamate
Show/Hide
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C42H54N6O3S
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1
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| 1 |
IC50 = 79 nM
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CP0484127
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US9040693, 3
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C21H16ClN3O4S2
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1
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| 1 |
IC50 = 80 nM
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CP0457773
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(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-N-[(2S)-1-[[(2S)-3-(4-acetamidophenyl)-1-[[(2R)-3-(4-acetamidophenyl)-1-[[(1R)-2-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-2-oxo-1-propan-2-ylsulfinylethyl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]pentanediamide
Show/Hide
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C76H100ClN15O16S
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1
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| 1 |
IC50 = 85 nM
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CP0518294
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US9040693, 25
Show/Hide
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C21H15ClN2O5S
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1
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| 1 |
IC50 = 85 nM
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CP0563005
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3-[[4-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]piperazin-1-yl]methyl]benzamide
Show/Hide
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C33H34F4N6O3
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1
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| 1 |
IC50 = 86.5 nM
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CP0046868
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(R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Show/Hide
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C27H24F3N3O3
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2
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| 1 |
IC50 = 87 nM
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| 2 |
Ki = 0.56 nM
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CP0287955
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1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-(2-(3-methyl-4-(morpholine-4-carbonyl)piperidin-1-yl)ethyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one
Show/Hide
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C37H50N4O3S
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1
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| 1 |
IC50 = 88 nM
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CP0427429
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3-[(2R)-2-amino-2-(2-hydroxyphenyl)ethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-[4-[(3-nitrophenyl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C31H32F2N6O5
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1
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| 1 |
IC50 = 89 nM
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CP0482890
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3-[(2R)-2-amino-2-(2-hydroxyphenyl)ethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[(3-nitrophenyl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C32H32F4N6O5
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1
|
| 1 |
IC50 = 89.3 nM
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CP0208880
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N-[(2S)-2-[5-(3,5-dimethylphenyl)-2-(2-methyl-1-oxo-1-pyrrolidin-1-ylpropan-2-yl)-6H-thieno[2,3-b]pyrrol-4-yl]propyl]-3-phenylpyrrolidine-1-carboxamide
Show/Hide
|
C36H44N4O2S
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1
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| 1 |
IC50 = 96 nM
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|
|
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CP0469790
|
US9040693, 17
Show/Hide
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C20H16ClN3O4S2
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1
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| 1 |
IC50 = 101 nM
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CP0494520
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[(3-nitrophenyl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C32H32F4N6O4
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1
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| 1 |
IC50 = 102 nM
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|
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CP0468925
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5-[[4-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]piperazin-1-yl]methyl]furan-2-carbonitrile
Show/Hide
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C31H30F4N6O3
|
1
|
| 1 |
IC50 = 103 nM
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|
|
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CP0460595
|
2-[[4-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]piperazin-1-yl]methyl]-6-fluorobenzonitrile
Show/Hide
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C33H31F5N6O2
|
1
|
| 1 |
IC50 = 108 nM
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|
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CP0489965
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3-[(2R)-2-amino-2-phenylethyl]-5-[4-[(2-fluoro-3-nitrophenyl)methyl]piperazin-1-yl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
Show/Hide
|
C32H31F5N6O4
|
1
|
| 1 |
IC50 = 115 nM
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|
|
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CP0460566
|
3-[[(1R)-2-[3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxo-5-[4-[[5-(trifluoromethyl)furan-2-yl]methyl]piperazin-1-yl]pyrimidin-1-yl]-1-phenylethyl]amino]propane-1-sulfonic acid
Show/Hide
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C34H36F7N5O6S
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1
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| 1 |
IC50 = 122 nM
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CP0155810
|
1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-(2-(4-(2-morpholino-2-oxoethyl)piperidin-1-yl)ethyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one
Show/Hide
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C37H50N4O3S
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1
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| 1 |
IC50 = 132 nM
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CP0478875
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3-[2-amino-2-(2-fluorophenyl)ethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-[4-[(3-nitrophenyl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C31H31F3N6O4
|
1
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| 1 |
IC50 = 142 nM
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CP0476949
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3-[2-amino-2-(3-fluorophenyl)ethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-[4-[(3-nitrophenyl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
|
C31H31F3N6O4
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1
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| 1 |
IC50 = 144 nM
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CP0440348
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3-[[3-[[4-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]piperazin-1-yl]methyl]benzoyl]amino]propanoic acid
Show/Hide
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C36H38F4N6O5
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1
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| 1 |
IC50 = 146 nM
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CP0476948
|
3-[2-amino-2-(3-methylphenyl)ethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-[4-[(3-nitrophenyl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
|
C32H34F2N6O4
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1
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| 1 |
IC50 = 160 nM
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CP0210103
|
1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-(2-(4-(2-morpholino-2-oxoethyl)piperazin-1-yl)ethyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one
Show/Hide
|
C36H49N5O3S
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1
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| 1 |
IC50 = 162 nM
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CP0440347
|
3-[(2R)-2-amino-2-phenylethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-[4-[(3-nitrophenyl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
|
C31H32F2N6O4
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2
|
| 1 |
IC50 = 165 nM
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|
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| 2 |
IC50 = 401 nM
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CP0155808
|
1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-(2-(4-(3-hydroxypiperidine-1-carbonyl)piperidin-1-yl)ethyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one
Show/Hide
|
C37H50N4O3S
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1
|
| 1 |
IC50 = 169 nM
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CP0210101
|
1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-(2-(4-(2-oxo-2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)acetyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one
Show/Hide
|
C36H47N5O3S
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1
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| 1 |
IC50 = 170 nM
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CP0440353
|
3-[[4-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]piperazin-1-yl]methyl]-N-methylbenzamide
Show/Hide
|
C34H36F4N6O3
|
1
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| 1 |
IC50 = 170 nM
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|
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CP0261741
|
1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-(2-(4-(3-methoxypyrrolidine-1-carbonyl)piperidin-1-yl)ethyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one
Show/Hide
|
C37H50N4O3S
|
1
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| 1 |
IC50 = 173 nM
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CP0454090
|
2-(4-(2-(2-(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-methyl-1-oxopropan-2-yl)-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl)ethyl)piperazin-1-yl)-N,N-dimethylacetamide
Show/Hide
|
C34H47N5O2S
|
1
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| 1 |
IC50 = 177 nM
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CP0347627
|
1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-(2-(4-morpholinopiperidin-1-yl)ethyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one
Show/Hide
|
C35H48N4O2S
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1
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| 1 |
IC50 = 178 nM
|
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CP0561527
|
3-[(2R)-2-amino-2-phenylethyl]-5-[4-[(5-chlorofuran-2-yl)methyl]piperazin-1-yl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
Show/Hide
|
C30H30ClF4N5O3
|
1
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| 1 |
IC50 = 178 nM
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|
|
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CP0394885
|
(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2S)-1-[[(2R)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide
Show/Hide
|
C79H97ClN18O16S
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1
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| 1 |
IC50 = 178.19 nM
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CP0261739
|
1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-(2-(4-(4-methoxypiperidine-1-carbonyl)piperidin-1-yl)ethyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one
Show/Hide
|
C38H52N4O3S
|
1
|
| 1 |
IC50 = 184 nM
|
|
|
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CP0468801
|
ethoxy-[3-[[(1R)-2-[3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxo-5-[4-[[5-(trifluoromethyl)furan-2-yl]methyl]piperazin-1-yl]pyrimidin-1-yl]-1-phenylethyl]amino]propyl]phosphinic acid
Show/Hide
|
C36H41F7N5O6P
|
1
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| 1 |
IC50 = 184 nM
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|
|
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CP0869290
|
(S)-1-((S)-2-((S)-2-(1-((3S,6S,9S,12S)-3-((1H-imidazol-4-yl)methyl)-12-((1H-imidazol-5-yl)methyl)-6-((1H-indol-3-yl)methyl)-9-(hydroxymethyl)-1,4,7,10-tetraoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11-tetraazatridecanamido)cyclobutanecarboxamido)-3-(1H-indol-3-yl)propanamido)-3-(4-hydroxyphenyl)propanoyl)-N-(2-amino-2-oxoethyl)pyrrolidine-2-carboxamide
Show/Hide
|
C63H73N17O13
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1
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| 1 |
IC50 = 190.55 nM
|
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CP0440351
|
3-[(2R)-2-amino-2-phenylethyl]-5-[4-[(2-fluoropyridin-3-yl)methyl]piperazin-1-yl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
Show/Hide
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C31H31F5N6O2
|
1
|
| 1 |
IC50 = 193 nM
|
|
|
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CP0210102
|
1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-(2-(4-(2-oxo-2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)ethyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one
Show/Hide
|
C36H49N5O2S
|
1
|
| 1 |
IC50 = 195 nM
|
|
|
|
CP0512080
|
US9040693, 2
Show/Hide
|
C21H16ClN3O4S2
|
1
|
| 1 |
IC50 = 199 nM
|
|
|
|
CP0440331
|
3-[[4-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]piperazin-1-yl]methyl]benzonitrile
Show/Hide
|
C33H32F4N6O2
|
1
|
| 1 |
IC50 = 213 nM
|
|
|
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CP0440352
|
3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[(3-methylsulfonylphenyl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
|
C33H35F4N5O4S
|
1
|
| 1 |
IC50 = 214 nM
|
|
|
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CP0468806
|
3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[[6-(trifluoromethyl)pyridin-2-yl]methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
|
C32H31F7N6O2
|
1
|
| 1 |
IC50 = 217 nM
|
|
|
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CP0537811
|
3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[[2-(trifluoromethyl)pyridin-4-yl]methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
|
C32H31F7N6O2
|
1
|
| 1 |
IC50 = 226 nM
|
|
|
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CP0454337
|
1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-(2-(4-(morpholine-4-carbonyl)piperidin-1-yl)ethyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one
Show/Hide
|
C36H48N4O3S
|
1
|
| 1 |
IC50 = 233 nM
|
|
|
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CP0287931
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propan-2-yl N-[N-[(2S)-2-[2-[1-(dimethylamino)-2-methyl-1-oxopropan-2-yl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl]propyl]-C-(3-pyridin-4-ylpyrrolidin-1-yl)carbonimidoyl]carbamate
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C37H48N6O3S
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1
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| 1 |
IC50 = 244 nM
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CP0561528
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[[3-(trifluoromethoxy)phenyl]methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C33H32F7N5O3
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1
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| 1 |
IC50 = 250 nM
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CP0440344
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3-[(2R)-2-amino-2-phenylethyl]-5-[4-[(2,3-difluorophenyl)methyl]piperazin-1-yl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
Show/Hide
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C32H31F6N5O2
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1
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| 1 |
IC50 = 266 nM
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CP0429113
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US9040693, 31
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C23H19ClN4O5S2
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1
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| 1 |
IC50 = 272 nM
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CP0315341
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N-[[1-[2-[2-[1-(7-azabicyclo[2.2.1]heptan-7-yl)-2-methyl-1-oxopropan-2-yl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl]ethyl]piperidin-4-yl]methyl]morpholine-4-carboxamide
Show/Hide
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C37H51N5O3S
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1
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| 1 |
IC50 = 275 nM
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CP0869214
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(S)-1-((S)-2-((S)-2-(1-((3S,6S,9S,12S)-3-((1H-imidazol-4-yl)methyl)-12-((1H-imidazol-5-yl)methyl)-6-((1H-indol-3-yl)methyl)-9-(hydroxymethyl)-1,4,7,10-tetraoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11-tetraazatridecanamido)cyclopentanecarboxamido)-3-(1H-indol-3-yl)propanamido)-3-(4-hydroxyphenyl)propanoyl)-N-(2-amino-2-oxoethyl)pyrrolidine-2-carboxamide
Show/Hide
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C64H75N17O13
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1
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| 1 |
IC50 = 281.84 nM
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CP0489966
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-(pyridin-3-ylmethyl)piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C31H32F4N6O2
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1
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| 1 |
IC50 = 290 nM
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CP0575830
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3-[(2R)-2-amino-2-phenylethyl]-5-[4-[(3-fluorophenyl)methyl]piperazin-1-yl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
Show/Hide
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C32H32F5N5O2
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1
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| 1 |
IC50 = 321 nM
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CP0468807
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4-[[4-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]piperazin-1-yl]methyl]benzonitrile
Show/Hide
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C33H32F4N6O2
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1
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| 1 |
IC50 = 326 nM
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CP0155812
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1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(4-(2-(4-(3-(4-acetylpiperazin-1-yl)-2-hydroxypropyl)piperazin-1-yl)ethyl)-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one
Show/Hide
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C39H56N6O3S
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1
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| 1 |
IC50 = 331 nM
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CP0510570
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1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-(2-(4-(2-morpholino-2-oxoethoxy)piperidin-1-yl)ethyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one
Show/Hide
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C37H50N4O4S
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1
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| 1 |
IC50 = 338 nM
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CP0463600
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3-[(2R)-2-amino-2-phenylethyl]-5-[4-[(2-fluorophenyl)methyl]piperazin-1-yl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
Show/Hide
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C32H32F5N5O2
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1
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| 1 |
IC50 = 340 nM
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CP0208881
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N-[1-[2-[4-[2-[2-[1-(7-azabicyclo[2.2.1]heptan-7-yl)-2-methyl-1-oxopropan-2-yl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl]ethyl]piperazin-1-yl]acetyl]pyrrolidin-3-yl]acetamide
Show/Hide
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C38H52N6O3S
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1
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| 1 |
IC50 = 345 nM
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CP0440346
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2-[[4-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]piperazin-1-yl]methyl]benzonitrile
Show/Hide
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C33H32F4N6O2
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1
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| 1 |
IC50 = 351 nM
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CP0155809
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1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-(2-(4-(morpholine-4-carbonyl)piperidin-1-yl)acetyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one
Show/Hide
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C36H46N4O4S
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1
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| 1 |
IC50 = 371 nM
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CP0460711
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4-[[3-[[4-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]piperazin-1-yl]methyl]benzoyl]amino]butanoic acid
Show/Hide
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C37H40F4N6O5
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1
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| 1 |
IC50 = 376 nM
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CP0882072
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(S)-1-((S)-2-((S)-2-(1-((3S,6S,9S,12S)-3-((1H-imidazol-4-yl)methyl)-12-((1H-imidazol-5-yl)methyl)-6-((1H-indol-3-yl)methyl)-9-(hydroxymethyl)-1,4,7,10-tetraoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11-tetraazatridecanamido)cyclohexanecarboxamido)-3-(1H-indol-3-yl)propanamido)-3-(4-hydroxyphenyl)propanoyl)-N-(2-amino-2-oxoethyl)pyrrolidine-2-carboxamide
Show/Hide
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C65H77N17O13
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1
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| 1 |
IC50 = 407.38 nM
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CP0532901
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3-[[(1R)-2-[3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxo-5-[4-[[5-(trifluoromethyl)furan-2-yl]methyl]piperazin-1-yl]pyrimidin-1-yl]-1-phenylethyl]amino]propylphosphonic acid
Show/Hide
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C34H37F7N5O6P
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1
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| 1 |
IC50 = 411 nM
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CP0216415
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1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-((4-(2-oxo-2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)methyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one
Show/Hide
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C35H47N5O2S
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1
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| 1 |
IC50 = 495 nM
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CP0460594
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3-[(2R)-2-amino-2-phenylethyl]-5-[4-[(2-chloropyridin-3-yl)methyl]piperazin-1-yl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
Show/Hide
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C31H31ClF4N6O2
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1
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| 1 |
IC50 = 526 nM
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CP0463544
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[(2-methylpyridin-3-yl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C32H34F4N6O2
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1
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| 1 |
IC50 = 543 nM
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CP0860060
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(S)-1-((S)-2-((S)-2-(1-((3S,6S,9S,12S)-3-((1H-imidazol-4-yl)methyl)-6-((1H-indol-3-yl)methyl)-12-(4-hydroxybenzyl)-9-(hydroxymethyl)-1,4,7,10-tetraoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11-tetraazatridecanamido)cyclohexanecarboxamido)-4-methylpentanamido)-5-guanidinopentanoyl)-N-(2-amino-2-oxoethyl)pyrrolidine-2-carboxamide
Show/Hide
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C60H83N17O13
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1
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| 1 |
IC50 = 549.54 nM
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CP0460565
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3-[(2R)-2-amino-2-phenylethyl]-5-[4-[(6-chloropyridin-3-yl)methyl]piperazin-1-yl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
Show/Hide
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C31H31ClF4N6O2
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1
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| 1 |
IC50 = 554 nM
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CP0952058
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(S)-1-((S)-2-((S)-2-(1-((3S,6S,9S,12S)-3-((1H-imidazol-4-yl)methyl)-6-((1H-indol-3-yl)methyl)-12-(4-hydroxybenzyl)-9-(hydroxymethyl)-1,4,7,10-tetraoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11-tetraazatridecanamido)cyclopentanecarboxamido)-4-methylpentanamido)-5-guanidinopentanoyl)-N-(2-amino-2-oxoethyl)pyrrolidine-2-carboxamide
Show/Hide
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C59H81N17O13
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1
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| 1 |
IC50 = 588.84 nM
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CP0332931
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1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-(5-(3,5-dimethylphenyl)-4-(2-(4-(pyrrolidine-1-carbonyl)piperazin-1-yl)ethyl)-6H-thieno[2,3-b]pyrrol-2-yl)-2-methylpropan-1-one
Show/Hide
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C35H47N5O2S
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1
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| 1 |
IC50 = 696 nM
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CP0860061
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(2S)-N-[(1S)-2-[[(1S)-2-[2-[2-[[(1S)-1-[[(1S)-1-[(2S)-2-[(2-amino-2-oxo-ethyl)carbamoyl]pyrrolidine-1-carbonyl]-4-guanidino-butyl]carbamoyl]-3-methyl-butyl]amino]-2-oxo-ethyl]-1-oxo-4-phenyl-2,4,8-triazaspiro[4.5]decan-8-yl]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]amino]-1-(1H-imidazol-4-ylmethyl)-2-oxo-ethyl]-5-oxo-pyrrolidine-2-carboxamide
Show/Hide
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C56H75N17O10
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1
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| 1 |
IC50 = 724.44 nM
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CP0443783
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3-[(2R)-2-amino-2-phenylethyl]-5-[4-(2,1,3-benzoxadiazol-4-ylmethyl)piperazin-1-yl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
Show/Hide
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C32H31F4N7O3
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1
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| 1 |
IC50 = 885 nM
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CP0560373
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-(1,3-thiazol-5-ylmethyl)piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C29H30F4N6O2S
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1
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| 1 |
IC50 = 930 nM
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CP0545933
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3-[2-amino-2-(2-methylphenyl)ethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-[4-[(3-nitrophenyl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C32H34F2N6O4
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1
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| 1 |
IC50 = 1066 nM
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CP0532905
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[(6-oxo-1H-pyridin-3-yl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C31H32F4N6O3
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1
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| 1 |
IC50 = 1090 nM
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CP0537727
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[(5-methylpyridin-3-yl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C32H34F4N6O2
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1
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| 1 |
IC50 = 1180 nM
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CP0490148
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3-[(2R)-2-amino-2-phenylethyl]-5-[4-[(5-fluoropyridin-3-yl)methyl]piperazin-1-yl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
Show/Hide
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C31H31F5N6O2
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1
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| 1 |
IC50 = 1510 nM
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CP0490146
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-(1,3-thiazol-2-ylmethyl)piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C29H30F4N6O2S
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1
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| 1 |
IC50 = 1660 nM
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CP0431707
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3-[(2R)-2-amino-2-(4-fluorophenyl)ethyl]-1-[(2,6-difluorophenyl)methyl]-6-methyl-5-[4-[(3-nitrophenyl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C31H31F3N6O4
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1
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| 1 |
IC50 = 1682 nM
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CP0563003
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[(6-methylpyridin-3-yl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C32H34F4N6O2
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1
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| 1 |
IC50 = 1690 nM
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CP0454206
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(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-N-[(2S)-1-[[(2S)-3-(4-acetamidophenyl)-1-[[(2R)-3-(4-acetamidophenyl)-1-[[(1R)-2-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-2-oxo-1-propan-2-ylsulfonylethyl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]pentanediamide
Show/Hide
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C76H100ClN15O17S
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1
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| 1 |
IC50 = 2004 nM
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CP0440350
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-(pyrazin-2-ylmethyl)piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C30H31F4N7O2
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1
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| 1 |
IC50 = 2050 nM
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CP0468926
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-(1,3-thiazol-4-ylmethyl)piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C29H30F4N6O2S
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1
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| 1 |
IC50 = 2130 nM
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CP0542415
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(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-N-[(2S)-1-[[(2S)-3-(4-acetamidophenyl)-1-[[(2R)-3-(4-acetamidophenyl)-1-[[(1S)-2-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-2-oxo-1-propan-2-ylsulfonylethyl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]pentanediamide
Show/Hide
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C76H100ClN15O17S
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1
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| 1 |
IC50 = 3815 nM
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CP0482894
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3-[(2R)-2-amino-2-phenylethyl]-5-[4-(1,3-benzothiazol-2-ylmethyl)piperazin-1-yl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
Show/Hide
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C33H32F4N6O2S
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1
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| 1 |
IC50 = 4900 nM
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CP0463459
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methyl 2-[[4-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]piperazin-1-yl]methyl]benzoate
Show/Hide
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C34H35F4N5O4
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1
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| 1 |
IC50 > 10000 nM
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CP0470990
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3-[(2R)-2-amino-2-phenylethyl]-5-[4-(1-benzothiophen-7-ylmethyl)piperazin-1-yl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
Show/Hide
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C34H33F4N5O2S
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1
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| 1 |
IC50 = 10230 nM
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CP0434126
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[[6-(trifluoromethyl)pyridin-3-yl]methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C32H31F7N6O2
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1
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| 1 |
IC50 > 300 nM
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CP0440341
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3-[(2R)-2-amino-2-phenylethyl]-5-[4-(1-benzofuran-4-ylmethyl)piperazin-1-yl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
Show/Hide
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C34H33F4N5O3
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1
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| 1 |
IC50 > 300 nM
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CP0440343
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[(6-oxopyran-2-yl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C31H31F4N5O4
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1
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| 1 |
IC50 > 300 nM
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CP0460560
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5-[[4-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]piperazin-1-yl]methyl]furan-2-carboxamide
Show/Hide
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C31H32F4N6O4
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1
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| 1 |
IC50 > 300 nM
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CP0460596
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3-[[4-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]piperazin-1-yl]methyl]-N-ethylbenzamide
Show/Hide
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C35H38F4N6O3
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1
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| 1 |
IC50 > 300 nM
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CP0460712
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3-[(2R)-2-amino-2-phenylethyl]-5-[4-[(5-tert-butylfuran-2-yl)methyl]piperazin-1-yl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
Show/Hide
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C34H39F4N5O3
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1
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| 1 |
IC50 > 300 nM
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CP0463467
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[[2-(trifluoromethyl)pyridin-3-yl]methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C32H31F7N6O2
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1
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| 1 |
IC50 > 300 nM
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CP0468928
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[[4-(trifluoromethyl)furan-2-yl]methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C31H30F7N5O3
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1
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| 1 |
IC50 > 300 nM
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CP0482892
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[(5-methylfuran-2-yl)methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C31H33F4N5O3
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1
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| 1 |
IC50 > 300 nM
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CP0532899
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2-[[3-[[4-[1-[(2R)-2-amino-2-phenylethyl]-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-5-yl]piperazin-1-yl]methyl]benzoyl]amino]acetic acid
Show/Hide
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C35H36F4N6O5
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1
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| 1 |
IC50 > 300 nM
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CP0532902
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]methyl]piperazin-1-yl]pyrimidine-2,4-dione
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C29H28F7N7O3
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1
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| 1 |
IC50 > 300 nM
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CP0532904
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3-[(2R)-2-amino-2-phenylethyl]-5-[4-(1,2-benzoxazol-7-ylmethyl)piperazin-1-yl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
Show/Hide
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C33H32F4N6O3
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1
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| 1 |
IC50 > 300 nM
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CP0560374
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-(pyrimidin-4-ylmethyl)piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C30H31F4N7O2
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1
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| 1 |
IC50 > 300 nM
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CP0440349
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-(1,2-oxazol-3-ylmethyl)piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C29H30F4N6O3
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1
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| 1 |
IC50 > 1000 nM
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CP0463466
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-(1,3-oxazol-4-ylmethyl)piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C29H30F4N6O3
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1
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| 1 |
IC50 > 1000 nM
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CP0468809
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-5-[4-(furan-3-ylmethyl)piperazin-1-yl]-6-methylpyrimidine-2,4-dione
Show/Hide
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C30H31F4N5O3
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1
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| 1 |
IC50 > 1000 nM
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CP0482893
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-(thiophen-2-ylmethyl)piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C30H31F4N5O2S
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1
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| 1 |
IC50 > 1000 nM
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CP0532908
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-5-[4-(furan-2-ylmethyl)piperazin-1-yl]-6-methylpyrimidine-2,4-dione
Show/Hide
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C30H31F4N5O3
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1
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| 1 |
IC50 > 1000 nM
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CP0537809
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3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-5-[4-[[5-methyl-2-(trifluoromethyl)furan-3-yl]methyl]piperazin-1-yl]pyrimidine-2,4-dione
Show/Hide
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C32H32F7N5O3
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1
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| 1 |
IC50 > 1000 nM
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CP0338284
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1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea
Show/Hide
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C29H27F2N7O5S
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2
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| 1 |
Kd = 0.372 nM
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| 2 |
Kd = 0.84 nM
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CP0740587
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ELAGOLIX SODIUM
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C32H29F5N3NaO5
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3
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| 1 |
Kd = 1.19 nM
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| 2 |
Kd = 3.21 nM
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| 3 |
Ki = 0.9 nM
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CP0158198
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(R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Show/Hide
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C28H24F5N3O3
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1
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| 1 |
Ki = 0.5 nM
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CP0496749
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3-((R)-2-Cyclopentyl-2-dimethylamino-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C28H32F3N3O3
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1
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| 1 |
Ki = 0.6 nM
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CP0043839
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(R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione
Show/Hide
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C27H22F5N3O3
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2
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| 1 |
Ki = 0.6 nM
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| 2 |
Ki = 0.64 nM
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CP0900193
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2-chloro-6-fluoro-benzyl)-5-(2-fluoro-phenyl)-6-methyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C28H23ClF5N3O4
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1
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| 1 |
Ki = 0.7 nM
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CP0511176
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7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid (3-phenyl-propyl)-amide
Show/Hide
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C43H45FN6O3
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1
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| 1 |
Ki = 1.1 nM
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CP0247647
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(R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-chloro-6-fluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyric Acid
Show/Hide
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C31H30ClF2N3O5
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1
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| 1 |
Ki = 1.1 nM
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CP0439838
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(R)-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyl-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)propyl)pyrimidine-2,4(1H,3H)-dione
Show/Hide
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C30H32F2N4O3
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2
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| 1 |
Ki = 1.1 nM
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| 2 |
Ki = 5.2 nM
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CP0288327
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(R)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyl-3-(2-(pyridin-2-ylmethylamino)propyl)pyrimidine-2,4(1H,3H)-dione
Show/Hide
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C28H27F3N4O3
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1
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| 1 |
Ki = 1.1 nM
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CP0515174
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7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C36H38FN5O4
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1
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| 1 |
Ki = 1.2 nM
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CP0039736
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(R)-4-(2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-5-(2-fluoro-3-methoxyphenyl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethylamino)butanoic acid
Show/Hide
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C31H28F5N3O5
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1
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| 1 |
Ki = 1.2 nM
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CP0080596
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1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-((R)-4-methyl-2-methylamino-pentyl)-1H-pyrimidine-2,4-dione
Show/Hide
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C26H30F3N3O3
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1
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| 1 |
Ki = 1.2 nM
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CP0197703
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(R)-5-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)pentanoic acid
Show/Hide
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C32H30F5N3O5
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1
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| 1 |
Ki = 1.2 nM
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CP0345019
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(R)-5-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-3-(2-(methylamino)-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)pentanoic acid
Show/Hide
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C33H32F5N3O5
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1
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| 1 |
Ki = 1.2 nM
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CP0268718
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(R)-6-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)hexanoic acid
Show/Hide
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C33H32F5N3O5
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1
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| 1 |
Ki = 1.3 nM
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CP0167737
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1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-bromo-6-fluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C25H21BrF2N4O4
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1
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| 1 |
Ki = 2 nM
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CP0410510
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7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-[(methyl-phenethyl-amino)-methyl]-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 1-ethyl-propyl ester
Show/Hide
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C40H45FN4O4
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1
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| 1 |
Ki = 2.1 nM
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CP0371030
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(R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2,6-difluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyric Acid
Show/Hide
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C31H30F3N3O5
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1
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| 1 |
Ki = 2.1 nM
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CP0169141
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(R)-6-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenoxy)hexanoic acid
Show/Hide
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C33H33F4N3O5
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1
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| 1 |
Ki = 2.1 nM
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CP0439518
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3-[(2R)-2-amino-2-phenylethyl]-1-[(2,6-difluorophenyl)methyl]-5-(3-methoxyphenyl)-1,3,5-triazinane-2,4-dione
Show/Hide
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C25H24F2N4O3
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1
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| 1 |
Ki = 2.3 nM
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CP0498425
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3-((S)-2-Cyclopentyl-2-dimethylamino-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C28H32F3N3O3
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1
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| 1 |
Ki = 2.4 nM
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CP0182660
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7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 1-ethyl-propyl ester
Show/Hide
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C39H44FN5O4
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1
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| 1 |
Ki = 2.7 nM
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CP0457217
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7-(4-Acetylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 1-ethyl-propyl ester
Show/Hide
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C37H40FN5O4
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1
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| 1 |
Ki = 2.8 nM
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CP0439870
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1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-fluoro-3-methoxy-phenyl)-5-(2-fluoro-6-trifluoromethyl-benzyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C26H21F5N4O4
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1
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| 1 |
Ki = 3 nM
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CP0496410
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1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C29H29F3N4O3
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1
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| 1 |
Ki = 3 nM
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CP0403931
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7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid hexylamide
Show/Hide
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C40H47FN6O3
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1
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| 1 |
Ki = 3.3 nM
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CP0319307
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4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]-methylamino]butanoic acid
Show/Hide
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C33H32F5N3O5
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1
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| 1 |
Ki = 3.7 nM
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CP0448811
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6-[(Benzyl-methyl-amino)-methyl]-7-(4-butyrylamino-phenyl)-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 1-ethyl-propyl ester
Show/Hide
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C39H43FN4O4
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1
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| 1 |
Ki = 3.8 nM
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CP0176635
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(R)-1-(2,6-difluorobenzyl)-3-(1-(2-methoxybenzylamino)propan-2-yl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Show/Hide
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C30H30F3N3O4
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1
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| 1 |
Ki = 3.9 nM
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CP0448475
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7-(4-Acetylamino-phenyl)-6-[(benzyl-methyl-amino)-methyl]-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 1-ethyl-propyl ester
Show/Hide
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C37H39FN4O4
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1
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| 1 |
Ki = 4 nM
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CP0857953
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3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)-6-methyl-1-(2-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C29H24F7N3O4
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1
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| 1 |
Ki = 4 nM
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CP0395046
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1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-{(S)-2-[(3-methyl-thiophen-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C28H28F3N3O3S
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1
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| 1 |
Ki = 4 nM
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CP0522122
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3-((R)-2-Cyclohexyl-2-dimethylamino-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C29H34F3N3O3
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1
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| 1 |
Ki = 4.1 nM
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CP0418511
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1-(2,6-Difluoro-benzyl)-3-[(S)-2-(1-ethyl-propylamino)-propyl]-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C27H32F3N3O3
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1
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| 1 |
Ki = 4.1 nM
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CP0201536
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(R)-5-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)phenoxy)pentanoic acid
Show/Hide
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C32H31F4N3O5
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1
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| 1 |
Ki = 4.1 nM
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CP0291044
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methyl 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]amino]butanoate
Show/Hide
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C33H32F5N3O5
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1
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| 1 |
Ki = 4.2 nM
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CP0156900
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(S)-1-(2,6-difluorobenzyl)-3-(2-(cyclopentylamino)propyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidine-2,4(1H,3H)-dione
Show/Hide
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C27H30F3N3O3
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1
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| 1 |
Ki = 4.5 nM
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CP0467000
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1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-chloro-6-fluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C25H21ClF2N4O4
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1
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| 1 |
Ki = 5 nM
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CP0288325
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(S)-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyl-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)propyl)pyrimidine-2,4(1H,3H)-dione
Show/Hide
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C30H32F2N4O3
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2
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| 1 |
Ki = 5 nM
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| 2 |
Ki = 890 nM
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CP0845482
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3-[2-((S)-Cyclobutylamino)-propyl]-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione hydrochloride
Show/Hide
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C26H29ClF3N3O3
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1
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| 1 |
Ki = 5 nM
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CP0088206
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(R)-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyl-3-(2-(methyl(pyridin-2-ylmethyl)amino)propyl)pyrimidine-2,4(1H,3H)-dione
Show/Hide
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C29H30F2N4O3
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1
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| 1 |
Ki = 5.5 nM
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CP0124188
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(R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione
Show/Hide
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C26H22F3N3O3
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1
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| 1 |
Ki = 5.6 nM
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CP0459312
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7-(4-Butyrylamino-phenyl)-6-{[(2-diethylamino-ethyl)-methyl-amino]-methyl}-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 1-ethyl-propyl ester
Show/Hide
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C38H50FN5O4
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1
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| 1 |
Ki = 5.8 nM
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CP0885926
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-phenyl)-6-methyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C28H23F6N3O4
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1
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| 1 |
Ki = 6 nM
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CP0165712
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5-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl)-N-(2,4,6-trimethoxyphenyl)furan-2-carboxamide
Show/Hide
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C30H37NO5
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1
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| 1 |
Ki = 6 nM
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CP0290843
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3-((R)-2-Amino-4-methyl-pentyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C25H28F3N3O3
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1
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| 1 |
Ki = 6.4 nM
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CP0080593
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3-((R)-2-Amino-2-cyclohexyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C27H30F3N3O3
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1
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| 1 |
Ki = 6.5 nM
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CP0488210
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1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-[(R)-1-methyl-2-(2-methyl-benzylamino)-ethyl]-1H-pyrimidine-2,4-dione
Show/Hide
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C30H30F3N3O3
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1
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| 1 |
Ki = 7 nM
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CP0064486
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(R)-5-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}pentanoic acid
Show/Hide
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C33H32F5N3O5
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1
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| 1 |
Ki = 7.6 nM
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CP0367573
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1-(2,6-Difluoro-benzyl)-3-((S)-2-dimethylamino-3-phenyl-propyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C30H30F3N3O3
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1
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| 1 |
Ki = 7.9 nM
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CP0167736
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(S)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyl-3-(2-(methylamino)-3-phenylpropyl)pyrimidine-2,4(1H,3H)-dione
Show/Hide
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C29H28F3N3O3
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1
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| 1 |
Ki = 8.1 nM
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CP0292322
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(R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(2-fluoro-3-methoxyphenyl)-1,3,5-triazinane-2,4,6-trione
Show/Hide
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C25H21F3N4O4
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1
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| 1 |
Ki = 9 nM
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CP0521209
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7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid cyclopentylamide
Show/Hide
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C39H43FN6O3
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1
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| 1 |
Ki = 9.2 nM
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CP0501100
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7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid butylamide
Show/Hide
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C38H43FN6O3
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1
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| 1 |
Ki = 10 nM
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CP0531987
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3-((R)-2-Amino-2-cyclopentyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C26H28F3N3O3
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1
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| 1 |
Ki = 10 nM
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CP0503932
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1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-fluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C25H22F2N4O4
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1
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| 1 |
Ki = 11 nM
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CP0488135
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C30H32F2N4O3
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1
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| 1 |
Ki = 12 nM
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CP0214400
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(R)-3-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}propionic Acid
Show/Hide
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C31H28F5N3O5
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1
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| 1 |
Ki = 12 nM
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CP0399382
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1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-3-((R)-2-isopropylamino-4-methyl-pentyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C28H34F3N3O3
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1
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| 1 |
Ki = 12 nM
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CP0503007
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3-((R)-2-Cyclopentyl-2-isopropylamino-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C29H34F3N3O3
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1
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| 1 |
Ki = 12 nM
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CP0263178
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2-[3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-3-methoxy-phenyl)-2,4,6-trioxo-[1,3,5]triazinan-1-ylmethyl]-benzonitrile
Show/Hide
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C26H22FN5O4
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1
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| 1 |
Ki = 13 nM
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CP0488102
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1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-{(R)-2-[(thiazol-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C26H25F3N4O3S
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1
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| 1 |
Ki = 13 nM
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CP0511158
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1-(2-Fluoro-benzyl)-7-(4-isobutyrylamino-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C36H38FN5O4
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1
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| 1 |
Ki = 14 nM
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CP0515211
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1-(2-Fluoro-benzyl)-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 1-ethyl-propyl ester
Show/Hide
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C36H39FN4O4
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1
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| 1 |
Ki = 14 nM
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CP0288326
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(R)-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-methyl-3-(2-(pyridin-2-ylmethylamino)propyl)pyrimidine-2,4(1H,3H)-dione
Show/Hide
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C28H28F2N4O3
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1
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| 1 |
Ki = 15 nM
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CP0511198
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1-(2,6-Difluoro-benzyl)-3-{(S)-2-[(5-ethyl-furan-2-ylmethyl)-amino]-propyl}-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C29H30F3N3O4
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1
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| 1 |
Ki = 15 nM
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CP0247290
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(R)-5-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-(dimethylamino)-2-phenylethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)pentanoic acid
Show/Hide
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C34H34F5N3O5
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1
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| 1 |
Ki = 15 nM
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CP0046850
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3-((S)-2-Amino-3-phenyl-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C28H26F3N3O3
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1
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| 1 |
Ki = 16 nM
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CP0403012
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6-[(Benzyl-methyl-amino)-methyl]-7-(4-butyrylamino-phenyl)-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid (3-phenyl-propyl)-amide
Show/Hide
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C43H44FN5O3
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1
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| 1 |
Ki = 17 nM
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CP0521996
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-[2-(methyl-pyridin-2-ylmethyl-amino)-propyl]-1H-pyrimidine-2,4-dione
Show/Hide
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C29H30F2N4O3
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1
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| 1 |
Ki = 18 nM
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CP0370351
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1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-fluoro-3-methoxy-phenyl)-5-(2-trifluoromethoxy-benzyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C26H22F4N4O5
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1
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| 1 |
Ki = 18 nM
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CP0375954
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1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-chloro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C25H22ClFN4O4
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1
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| 1 |
Ki = 20 nM
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CP0514505
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1-[2-Amino-2-(2-fluoro-phenyl)-ethyl]-3-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C25H20F4N4O4
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1
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| 1 |
Ki = 20 nM
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CP0381307
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1-(2,6-Difluoro-benzyl)-3-[(R)-2-(3-methoxy-benzylamino)-1-methyl-ethyl]-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C30H31F2N3O4
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1
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| 1 |
Ki = 20 nM
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CP0392685
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1-(2,6-Difluoro-benzyl)-3-[(R)-2-(2-methoxy-benzylamino)-1-methyl-ethyl]-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C30H31F2N3O4
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1
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| 1 |
Ki = 20 nM
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CP0520588
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-{(R)-1-methyl-2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C30H32F2N4O3
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1
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| 1 |
Ki = 20 nM
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CP0946241
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2-fluoro-benzyl)-5-(2-fluoro-phenyl)-6-methyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C28H24F5N3O4
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1
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| 1 |
Ki = 20 nM
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CP0395149
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7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid (1-ethyl-propyl)-amide
Show/Hide
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C39H45FN6O3
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1
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| 1 |
Ki = 21 nM
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CP0449417
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3-((R)-2-Cyclohexyl-2-isopropylamino-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C30H36F3N3O3
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1
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| 1 |
Ki = 23 nM
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CP0497359
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1-((S)-3-Amino-3-phenyl-propyl)-3-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C26H23F3N4O4
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1
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| 1 |
Ki = 24 nM
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CP0276324
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1-(2,6-difluoro-benzyl)-5-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C30H30F2N4O4
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1
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| 1 |
Ki = 24 nM
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CP0203583
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8-Cyano-1-(2-fluoro-benzyl)-7-(4-isobutoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 1-ethyl-propyl ester
Show/Hide
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C40H44FN5O4
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1
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| 1 |
Ki = 25 nM
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CP0460869
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3-((S)-2-Benzylamino-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C29H28F3N3O3
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2
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| 1 |
Ki = 25 nM
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| 2 |
Ki = 51 nM
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CP0376094
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1-(3-Amino-3-thiophen-2-yl-propyl)-3-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C24H22F2N4O4S
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1
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| 1 |
Ki = 27 nM
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CP0911375
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2-chloro-benzyl)-5-(2-fluoro-phenyl)-6-methyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C28H24ClF4N3O4
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1
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| 1 |
Ki = 27 nM
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CP0376129
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1-(3-Amino-2-phenyl-propyl)-3-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C26H24F2N4O4
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1
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| 1 |
Ki = 28 nM
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CP0399802
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1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-fluoro-3-methoxy-phenyl)-5-(2-methyl-benzyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C26H25FN4O4
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1
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| 1 |
Ki = 29 nM
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CP0357753
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8-Cyano-7-(4-cyclopentyloxy-phenyl)-1-(2-fluoro-benzyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 1-ethyl-propyl ester
Show/Hide
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C41H44FN5O4
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1
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| 1 |
Ki = 31 nM
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CP0410511
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7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid cyclohexylamide
Show/Hide
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C40H45FN6O3
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1
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| 1 |
Ki = 32 nM
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CP0505778
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-((R)-1-pyridin-2-ylmethyl-pyrrolidin-2-ylmethyl)-1H-pyrimidine-2,4-dione
Show/Hide
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C30H30F2N4O3
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1
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| 1 |
Ki = 32 nM
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CP0124192
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(R)-methyl 4-(2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-5-(2-fluoro-3-methoxyphenyl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethylamino)butanoate
Show/Hide
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C32H30F5N3O5
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1
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| 1 |
Ki = 32 nM
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CP0174047
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8-Cyano-7-(4-cyclopentyloxy-phenyl)-1-(2-fluoro-benzyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid cyclopentyl ester
Show/Hide
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C41H42FN5O4
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1
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| 1 |
Ki = 33 nM
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CP0886054
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2-chloro-4-fluoro-benzyl)-5-(2-fluoro-phenyl)-6-methyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C28H23ClF5N3O4
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1
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| 1 |
Ki = 33 nM
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CP0206995
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(R)-6-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)hexanoic acid
Show/Hide
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C32H30F5N3O5
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1
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| 1 |
Ki = 33 nM
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CP0371780
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C29H30F2N4O3
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1
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| 1 |
Ki = 34 nM
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CP0268676
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(R)-5-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-fluorophenoxy)pentanoic acid
Show/Hide
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C31H28F5N3O5
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1
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| 1 |
Ki = 34 nM
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CP0947270
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3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)-6-methyl-1-(2-methyl-benzyl)-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C29H27F4N3O4
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1
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| 1 |
Ki = 35 nM
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CP0514156
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1-((R)-2-Amino-2-phenyl-ethyl)-3-(2,6-dichloro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C25H21Cl2FN4O4
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1
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| 1 |
Ki = 36 nM
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CP0039878
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(R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(3-methoxyphenyl)-1,3,5-triazinane-2,4,6-trione
Show/Hide
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C25H22F2N4O4
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1
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| 1 |
Ki = 37 nM
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CP0266590
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5-Benzo[1,3]dioxol-5-yl-1-(2,6-difluoro-benzyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C29H28F2N4O4
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1
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| 1 |
Ki = 38 nM
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CP0167734
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3-((S)-2-Amino-4-methyl-pentyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C25H28F3N3O3
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1
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| 1 |
Ki = 39 nM
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CP0449175
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7-(4-Acetylamino-phenyl)-6-[(benzyl-methyl-amino)-methyl]-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C34H33FN4O4
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1
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| 1 |
Ki = 42 nM
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CP0344191
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6-[(Benzyl-methyl-amino)-methyl]-1-(2-fluoro-benzyl)-7-(4-isobutyrylamino-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C36H37FN4O4
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1
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| 1 |
Ki = 44 nM
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CP0363522
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3-((S)-2-Amino-2-cyclohexyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C27H30F3N3O3
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1
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| 1 |
Ki = 46 nM
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CP0167735
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3-((R)-2-Amino-3-methyl-butyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C24H26F3N3O3
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1
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| 1 |
Ki = 51 nM
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CP0492850
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-{2-[(pyridin-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C28H28F2N4O3
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1
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| 1 |
Ki = 53 nM
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CP0057956
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1-(2-Fluoro-benzyl)-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C33H33FN4O4
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1
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| 1 |
Ki = 55 nM
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CP0946232
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3-((R)-2-Amino-2-phenyl-ethyl)-1-benzyl-5-(2-fluoro-phenyl)-6-methyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C28H25F4N3O4
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1
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| 1 |
Ki = 57 nM
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CP0535304
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6-[(Benzyl-methyl-amino)-methyl]-1-(2-fluoro-benzyl)-7-(4-methoxy-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 1-ethyl-propyl ester
Show/Hide
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C36H38FN3O4
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1
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| 1 |
Ki = 62 nM
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CP0460342
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3-(4-tert-Butyl-4,5-dihydro-oxazol-2-yl)-1-(2-fluoro-benzyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-7-(4-nitro-phenyl)-1H-pyrrolo[1,2-a]pyrimidin-4-one
Show/Hide
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C36H35FN6O4
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1
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| 1 |
Ki = 64 nM
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CP0381402
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1-[3-Amino-3-(3-fluoro-phenyl)-propyl]-3-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C26H23F3N4O4
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1
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| 1 |
Ki = 66 nM
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CP0487488
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1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-chloro-pyridin-3-ylmethyl)-5-(2-fluoro-3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C24H21ClFN5O4
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1
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| 1 |
Ki = 66 nM
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CP0363519
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3-((R)-2-Amino-3-phenyl-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C28H26F3N3O3
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1
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| 1 |
Ki = 66 nM
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CP0860236
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(3-fluoro-benzyl)-5-(2-fluoro-phenyl)-6-methyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C28H24F5N3O4
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1
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| 1 |
Ki = 67 nM
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CP0492860
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1-(3-Amino-3-phenyl-propyl)-3-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C26H24F2N4O4
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1
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| 1 |
Ki = 70 nM
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CP0503583
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-[(R)-1-methyl-2-(2-methyl-benzylamino)-ethyl]-1H-pyrimidine-2,4-dione
Show/Hide
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C30H31F2N3O3
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1
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| 1 |
Ki = 70 nM
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CP0270137
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(R)-2-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}acetic Acid
Show/Hide
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C30H26F5N3O5
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1
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| 1 |
Ki = 71 nM
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CP0395072
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3-((R)-2-Amino-4,4-dimethyl-pentyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C26H30F3N3O3
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1
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| 1 |
Ki = 71 nM
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CP0541673
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2-[3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-3-methoxy-phenyl)-2,4,6-trioxo-[1,3,5]triazinan-1-ylmethyl]-3-chloro-benzonitrile
Show/Hide
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C26H21ClFN5O4
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1
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| 1 |
Ki = 73 nM
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CP0436420
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1-(3-Amino-3-o-tolyl-propyl)-3-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C27H26F2N4O4
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1
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| 1 |
Ki = 75 nM
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CP0535075
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3-((R)-2-Benzylamino-1-methyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C29H29F2N3O3
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1
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| 1 |
Ki = 75 nM
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CP0878592
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(4-fluoro-benzyl)-5-(2-fluoro-phenyl)-6-methyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C28H24F5N3O4
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1
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| 1 |
Ki = 75 nM
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CP0860150
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3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)-6-methyl-1-pyridin-2-ylmethyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C27H24F4N4O4
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1
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| 1 |
Ki = 77 nM
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CP0380328
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-[(R)-2-(2-pyridin-2-yl-ethylamino)-propyl]-1H-pyrimidine-2,4-dione
Show/Hide
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C29H30F2N4O3
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1
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| 1 |
Ki = 79 nM
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CP0458670
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1-(2,6-Difluoro-benzyl)-3-[2-(3-isobutoxy-propylamino)-propyl]-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C29H37F2N3O4
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1
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| 1 |
Ki = 81 nM
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CP0525398
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1-(2,6-Difluoro-benzyl)-5-(2-fluoro-phenyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C28H27F3N4O2
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1
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| 1 |
Ki = 81 nM
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CP0461643
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1-[3-Amino-3-(4-fluoro-phenyl)-propyl]-3-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C26H23F3N4O4
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1
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| 1 |
Ki = 83 nM
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CP0541684
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1-(2,6-Difluoro-benzyl)-3-[(R)-2-(3-fluoro-benzylamino)-1-methyl-ethyl]-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C29H28F3N3O3
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1
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| 1 |
Ki = 85 nM
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CP0497311
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1-((R)-2-Amino-2-phenyl-ethyl)-3-(2,6-difluoro-benzyl)-5-(2-fluoro-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C24H19F3N4O3
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1
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| 1 |
Ki = 89 nM
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CP0467540
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1-(2,6-Difluoro-benzyl)-3-[(R)-2-(2-fluoro-benzylamino)-1-methyl-ethyl]-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C29H28F3N3O3
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1
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| 1 |
Ki = 90 nM
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CP0503759
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3-((S)-2-Amino-2-cyclopentyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C26H28F3N3O3
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1
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| 1 |
Ki = 94 nM
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CP0458682
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-[2-(methyl-pyridin-2-ylmethyl-amino)-ethyl]-1H-pyrimidine-2,4-dione
Show/Hide
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C28H28F2N4O3
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1
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| 1 |
Ki = 96 nM
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CP0112996
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8-Cyano-1-(2-fluoro-benzyl)-7-(4-isobutoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C37H38FN5O4
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1
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| 1 |
Ki = 100 nM
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CP0500377
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7-(4-Amino-phenyl)-6-[(benzyl-methyl-amino)-methyl]-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 1-ethyl-propyl ester
Show/Hide
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C35H37FN4O3
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1
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| 1 |
Ki = 100 nM
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CP0540246
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1-(2,6-Difluoro-benzyl)-5-(4-isopropyl-phenyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C31H34F2N4O2
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1
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| 1 |
Ki = 110 nM
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CP0137688
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(R)-ethyl 2-(4-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzylamino)acetate
Show/Hide
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C31H30F4N4O4
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1
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| 1 |
Ki = 110 nM
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CP0448861
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1-[2-Amino-2-(2-fluoro-phenyl)-ethyl]-3-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C25H21F3N4O4
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1
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| 1 |
Ki = 120 nM
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CP0515789
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1-((R)-2-Amino-2-phenyl-ethyl)-3-(2-fluoro-3-methoxy-phenyl)-5-(2-methoxy-benzyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C26H25FN4O5
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1
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| 1 |
Ki = 120 nM
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CP0500804
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1-(2-Amino-2-phenyl-ethyl)-3-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C25H22F2N4O4
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1
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| 1 |
Ki = 120 nM
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CP0418514
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1-(2,6-Difluoro-benzyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-5-(4-methylsulfanyl-phenyl)-1H-pyrimidine-2,4-dione
Show/Hide
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C29H30F2N4O2S
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1
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| 1 |
Ki = 120 nM
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CP0448145
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7-(4-Butyrylamino-phenyl)-6-dimethylaminomethyl-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 1-ethyl-propyl ester
Show/Hide
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C33H39FN4O4
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1
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| 1 |
Ki = 130 nM
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CP0503373
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3-((R)-2-Benzylamino-propyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C29H29F2N3O3
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1
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| 1 |
Ki = 130 nM
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CP0404755
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3-((S)-2-Benzylamino-propyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C29H29F2N3O3
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1
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| 1 |
Ki = 140 nM
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CP0917700
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3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)-6-methyl-1-(1-phenyl-ethyl)-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C29H27F4N3O4
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1
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| 1 |
Ki = 140 nM
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CP0441670
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3-[(R)-2-(Benzyl-methyl-amino)-1-methyl-ethyl]-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C30H31F2N3O3
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1
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| 1 |
Ki = 150 nM
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CP0505891
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6-[(Benzyl-methyl-amino)-methyl]-7-(4-butyrylamino-phenyl)-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid butylamide
Show/Hide
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C38H42FN5O3
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1
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| 1 |
Ki = 154 nM
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CP0507649
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-[2-(2-pyridin-2-yl-ethylamino)-propyl]-1H-pyrimidine-2,4-dione
Show/Hide
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C29H30F2N4O3
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1
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| 1 |
Ki = 170 nM
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CP0460180
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5-Dibenzofuran-2-yl-1-(2,6-difluoro-benzyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C34H30F2N4O3
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1
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| 1 |
Ki = 170 nM
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CP0343074
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8-Cyano-1-(2-fluoro-benzyl)-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid 1-ethyl-propyl ester
Show/Hide
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C37H38FN5O4
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1
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| 1 |
Ki = 180 nM
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CP0497301
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1-[3-Amino-3-(2-chloro-phenyl)-propyl]-3-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C26H23ClF2N4O4
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1
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| 1 |
Ki = 180 nM
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CP0397569
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7-(4-Amino-phenyl)-6-[(benzyl-methyl-amino)-methyl]-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C32H31FN4O3
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1
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| 1 |
Ki = 190 nM
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CP0425029
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1-(2,6-Difluoro-benzyl)-3-((R)-2-isobutylamino-1-methyl-ethyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C26H31F2N3O3
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1
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| 1 |
Ki = 190 nM
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CP0945308
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3-((R)-2-Amino-2-phenyl-ethyl)-1-cyclohexylmethyl-5-(2-fluoro-phenyl)-6-methyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C28H31F4N3O4
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1
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| 1 |
Ki = 200 nM
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CP0505779
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-((S)-1-pyridin-2-ylmethyl-pyrrolidin-2-ylmethyl)-1H-pyrimidine-2,4-dione
Show/Hide
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C30H30F2N4O3
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1
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| 1 |
Ki = 210 nM
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CP0469220
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1-((R)-2-Amino-2-phenyl-ethyl)-3-(2,6-difluoro-benzyl)-5-(2,6-difluoro-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C24H18F4N4O3
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1
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| 1 |
Ki = 220 nM
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CP0416482
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1-(2,6-Difluoro-benzyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-5-p-tolyl-1H-pyrimidine-2,4-dione
Show/Hide
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C29H30F2N4O2
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1
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| 1 |
Ki = 220 nM
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CP0889374
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3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)-1-(2-methoxy-benzyl)-6-methyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C29H27F4N3O5
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1
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| 1 |
Ki = 230 nM
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CP0953779
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3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)-6-methyl-1-pentyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C26H29F4N3O4
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1
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| 1 |
Ki = 230 nM
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CP0186211
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1-(2,6-Difluoro-benzyl)-5-(4-methoxy-phenyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C29H30F2N4O3
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1
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| 1 |
Ki = 230 nM
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CP0500936
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1-(2,6-Difluoro-benzyl)-3-{2-[(3-isobutoxy-propyl)-methyl-amino]-propyl}-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C30H39F2N3O4
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1
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| 1 |
Ki = 240 nM
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CP0416423
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1-(2,6-Difluoro-benzyl)-5-(3-isopropyl-phenyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C31H34F2N4O2
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1
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| 1 |
Ki = 240 nM
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CP0404413
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3-[(S)-2-(Benzyl-methyl-amino)-propyl]-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C30H31F2N3O3
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1
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| 1 |
Ki = 250 nM
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CP0382302
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1-(2,6-Difluoro-benzyl)-3-[(R)-2-(4-fluoro-benzylamino)-1-methyl-ethyl]-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C29H28F3N3O3
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1
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| 1 |
Ki = 250 nM
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CP0377646
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8-Cyano-1-(2-fluoro-benzyl)-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid cyclopentyl ester
Show/Hide
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C37H36FN5O4
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1
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| 1 |
Ki = 260 nM
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CP0895217
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3-((R)-2-Amino-2-phenyl-ethyl)-1-cyclohexyl-5-(2-fluoro-phenyl)-6-methyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C27H29F4N3O4
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1
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| 1 |
Ki = 260 nM
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CP0460351
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3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-1-(2-fluoro-benzyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-7-(4-nitro-phenyl)-1H-pyrrolo[1,2-a]pyrimidin-4-one
Show/Hide
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C34H33FN6O4
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1
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| 1 |
Ki = 270 nM
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CP0380322
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3-(2-Benzylamino-propyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C29H29F2N3O3
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1
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| 1 |
Ki = 280 nM
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CP0515826
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3-(1-Benzyl-pyrrolidin-3-yl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C30H29F2N3O3
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1
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| 1 |
Ki = 280 nM
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CP0448899
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3-[2-(Benzyl-methyl-amino)-propyl]-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C30H31F2N3O3
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1
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| 1 |
Ki = 310 nM
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CP0415102
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1-(2,6-Difluoro-benzyl)-3-[(S)-2-(2-methoxy-benzylamino)-1-methyl-ethyl]-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C30H31F2N3O4
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1
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| 1 |
Ki = 320 nM
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CP0520305
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3-[(R)-2-(Benzyl-methyl-amino)-propyl]-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C30H31F2N3O3
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1
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| 1 |
Ki = 330 nM
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CP0528853
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1-(2,6-Difluoro-benzyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-5-(4-vinyl-phenyl)-1H-pyrimidine-2,4-dione
Show/Hide
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C30H30F2N4O2
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1
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| 1 |
Ki = 340 nM
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CP0475766
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3-((S)-2-Benzylamino-1-methyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C29H29F2N3O3
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1
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| 1 |
Ki = 370 nM
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CP0463520
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5-(3-Chloro-phenyl)-1-(2,6-difluoro-benzyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C28H27ClF2N4O2
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1
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| 1 |
Ki = 370 nM
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CP0496864
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1-[2-Amino-3-(1H-indol-3-yl)-propyl]-3-(2,6-difluoro-benzyl)-5-(2,6-difluoro-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C27H21F4N5O3
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1
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| 1 |
Ki = 380 nM
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CP0524116
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8-Cyano-1-(2,4-difluoro-benzyl)-7-(4-isobutoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C37H37F2N5O4
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1
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| 1 |
Ki = 400 nM
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CP0527487
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8-Cyano-1-(2-fluoro-benzyl)-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid isopropyl ester
Show/Hide
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C35H34FN5O4
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1
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| 1 |
Ki = 400 nM
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CP0454437
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6-[(Benzyl-methyl-amino)-methyl]-1-(2-fluoro-benzyl)-7-(4-methoxy-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C33H32FN3O4
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1
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| 1 |
Ki = 400 nM
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CP0528857
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-[(S)-1-methyl-2-(2-methyl-benzylamino)-ethyl]-1H-pyrimidine-2,4-dione
Show/Hide
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C30H31F2N3O3
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1
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| 1 |
Ki = 400 nM
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CP0190830
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1-(2,6-Difluoro-benzyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-5-phenyl-1H-pyrimidine-2,4-dione
Show/Hide
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C28H28F2N4O2
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1
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| 1 |
Ki = 400 nM
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CP0505497
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1-((R)-2-Amino-2-phenyl-ethyl)-3-benzo[1,2,5]thiadiazol-5-yl-5-(2,6-difluoro-benzyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C24H18F2N6O3S
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1
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| 1 |
Ki = 410 nM
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CP0378541
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3-((R)-2-Cyclopentylamino-1-methyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C27H31F2N3O3
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1
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| 1 |
Ki = 430 nM
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CP0845671
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3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)-6-methyl-1-(5-methyl-furan-2-ylmethyl)-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C27H25F4N3O5
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1
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| 1 |
Ki = 430 nM
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CP0539522
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7-(4-Butyrylamino-phenyl)-6-{[(2-diethylamino-ethyl)-methyl-amino]-methyl}-1-(2-fluoro-benzyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid butylamide
Show/Hide
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C37H49FN6O3
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1
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| 1 |
Ki = 440 nM
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CP0420334
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6-[(Benzyl-methyl-amino)-methyl]-1-(2-fluoro-benzyl)-7-(4-nitro-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C32H29FN4O5
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1
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| 1 |
Ki = 450 nM
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CP0481559
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-{(S)-2-[(pyridin-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C28H28F2N4O3
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1
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| 1 |
Ki = 460 nM
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CP0510304
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1-(2,6-Difluoro-benzyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-5-naphthalen-2-yl-1H-pyrimidine-2,4-dione
Show/Hide
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C32H30F2N4O2
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1
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| 1 |
Ki = 460 nM
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CP0417276
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-[(S)-2-(methyl-pyridin-2-ylmethyl-amino)-propyl]-1H-pyrimidine-2,4-dione
Show/Hide
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C29H30F2N4O3
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1
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| 1 |
Ki = 470 nM
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CP0432211
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5-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-1-(2,6-difluoro-benzyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C29H26F4N4O4
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1
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| 1 |
Ki = 470 nM
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CP0500531
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8-Cyano-1-(2-fluoro-benzyl)-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C34H32FN5O4
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1
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| 1 |
Ki = 500 nM
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CP0855874
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3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)-1-isobutyl-6-methyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C25H27F4N3O4
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1
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| 1 |
Ki = 500 nM
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CP0376085
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-{2-[(pyridin-2-ylmethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C27H26F2N4O3
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1
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| 1 |
Ki = 550 nM
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CP0535698
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1-(2,6-Difluoro-benzyl)-3-[(S)-2-(2-fluoro-benzylamino)-1-methyl-ethyl]-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C29H28F3N3O3
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1
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| 1 |
Ki = 550 nM
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CP0490056
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1-(3-Amino-3-pyridin-3-yl-propyl)-3-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C25H23F2N5O4
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1
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| 1 |
Ki = 580 nM
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CP0383353
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3-[(R)-2-(Cyclopropylmethyl-methyl-amino)-1-methyl-ethyl]-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C27H31F2N3O3
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1
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| 1 |
Ki = 590 nM
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CP0080594
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3-((R)-2-Amino-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C22H22F3N3O3
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1
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| 1 |
Ki = 595 nM
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CP0404705
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1-(2-Amino-4-methyl-pentyl)-3-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C23H25F3N4O4
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1
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| 1 |
Ki = 620 nM
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CP0409716
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7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid (2-methoxy-ethyl)-amide
Show/Hide
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C37H41FN6O4
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1
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| 1 |
Ki = 630 nM
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CP0492569
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1-((R)-2-Amino-2-phenyl-ethyl)-3-[1-(2,6-difluoro-phenyl)-ethyl]-5-(2-fluoro-3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C26H23F3N4O4
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1
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| 1 |
Ki = 630 nM
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CP0481592
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1-(2,6-Difluoro-benzyl)-5-(4-ethoxy-phenyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C30H32F2N4O3
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1
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| 1 |
Ki = 680 nM
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CP0894037
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3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)-6-methyl-1-pyridin-3-ylmethyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C27H24F4N4O4
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1
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| 1 |
Ki = 700 nM
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CP0403504
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1-(2,6-Difluoro-benzyl)-3-[(R)-2-(4-methoxy-benzylamino)-1-methyl-ethyl]-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C30H31F2N3O4
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1
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| 1 |
Ki = 720 nM
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CP0451028
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-[(S)-2-(2-pyridin-2-yl-ethylamino)-propyl]-1H-pyrimidine-2,4-dione
Show/Hide
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C29H30F2N4O3
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1
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| 1 |
Ki = 780 nM
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CP0523371
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3-[(R)-2-(Cyclopropylmethyl-amino)-1-methyl-ethyl]-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C26H29F2N3O3
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1
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| 1 |
Ki = 780 nM
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CP0539507
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8-Cyano-1-(2,6-difluoro-benzyl)-7-(4-isobutoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C37H37F2N5O4
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1
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| 1 |
Ki = 800 nM
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CP0529759
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1-[3-Amino-3-(2-fluoro-phenyl)-propyl]-3-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C26H23F3N4O4
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1
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| 1 |
Ki = 800 nM
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CP0524548
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3-((S)-2-Cyclopentylamino-1-methyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C27H31F2N3O3
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1
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| 1 |
Ki = 950 nM
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CP0382315
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3-((S)-2-Amino-4-phenyl-butyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C29H28F3N3O3
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1
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| 1 |
Ki = 965 nM
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CP0363523
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3-((S)-2-Amino-3-methyl-butyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C24H26F3N3O3
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1
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| 1 |
Ki = 973 nM
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CP0860251
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3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)-6-methyl-1-phenethyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C29H27F4N3O4
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1
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| 1 |
Ki = 1000 nM
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CP0257980
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-[2-(2-pyridin-2-yl-ethylamino)-ethyl]-1H-pyrimidine-2,4-dione
Show/Hide
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C28H28F2N4O3
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1
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| 1 |
Ki = 1100 nM
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CP0918282
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3-((R)-2-Amino-2-phenyl-ethyl)-1-cyclopropylmethyl-5-(2-fluoro-phenyl)-6-methyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C25H25F4N3O4
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1
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| 1 |
Ki = 1100 nM
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CP0451111
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8-Cyano-1-(2,5-difluoro-benzyl)-7-(4-isobutoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C37H37F2N5O4
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1
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| 1 |
Ki = 1200 nM
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CP0401485
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1-(2,6-Difluoro-benzyl)-3-((S)-2-isobutylamino-1-methyl-ethyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C26H31F2N3O3
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1
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| 1 |
Ki = 1200 nM
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CP0544924
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1-(2,6-Difluoro-benzyl)-5-(3-fluoro-phenyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C28H27F3N4O2
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1
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| 1 |
Ki = 1200 nM
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CP0551283
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1-(2,6-Difluoro-benzyl)-5-(4-methoxymethyl-phenyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C30H32F2N4O3
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1
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| 1 |
Ki = 1400 nM
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CP0501157
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1-((R)-3-Amino-5-methyl-hexyl)-3-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C24H27F3N4O4
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1
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| 1 |
Ki = 1500 nM
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CP0494999
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1-(2,6-Difluoro-benzyl)-5-(3-methoxymethyl-phenyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C30H32F2N4O3
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1
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| 1 |
Ki = 1500 nM
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CP0465330
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3-[(S)-2-(Cyclopropylmethyl-amino)-1-methyl-ethyl]-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C26H29F2N3O3
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1
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| 1 |
Ki = 1600 nM
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CP0889315
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3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)-1-(2-methoxy-ethyl)-6-methyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C24H25F4N3O5
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1
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| 1 |
Ki = 1700 nM
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CP0378293
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6-[(Benzyl-methyl-amino)-methyl]-8-cyano-1-(2-fluoro-benzyl)-7-(4-methoxy-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C34H31FN4O4
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1
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| 1 |
Ki = 1800 nM
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CP0490512
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-{(S)-1-methyl-2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C30H32F2N4O3
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1
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| 1 |
Ki = 1800 nM
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CP0383251
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8-Cyano-1-(2,6-difluoro-benzyl)-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C34H31F2N5O4
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1
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| 1 |
Ki = 2000 nM
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CP0505647
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3-[(S)-2-(Benzyl-methyl-amino)-1-methyl-ethyl]-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C30H31F2N3O3
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1
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| 1 |
Ki = 2000 nM
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CP0496386
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8-Cyano-1-(2-fluoro-benzyl)-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid tetrahydro-furan-3-yl ester
Show/Hide
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C36H34FN5O5
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1
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| 1 |
Ki = 2100 nM
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CP0524122
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8-Cyano-7-(4-isobutoxy-phenyl)-1-(2-methoxy-benzyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C38H41N5O5
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1
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| 1 |
Ki = 2200 nM
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CP0530363
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8-Cyano-1-(2,3-difluoro-benzyl)-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C34H31F2N5O4
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1
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| 1 |
Ki = 2400 nM
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CP0448614
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8-Cyano-1-(2-fluoro-benzyl)-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid dicyclopropylmethyl ester
Show/Hide
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C39H38FN5O4
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1
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| 1 |
Ki = 2500 nM
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CP0488140
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3-((R)-2-Amino-propyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C22H23F2N3O3
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1
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| 1 |
Ki = 2500 nM
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CP0431364
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1-Benzyl-8-cyano-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C34H33N5O4
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1
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| 1 |
Ki = 2600 nM
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CP0530229
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8-Cyano-1-(2,4-difluoro-benzyl)-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C34H31F2N5O4
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1
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| 1 |
Ki = 3700 nM
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CP0137685
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(R)-2-(4-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzylamino)acetic acid
Show/Hide
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C29H26F4N4O4
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1
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| 1 |
Ki = 3900 nM
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CP0524418
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1-(2,6-Difluoro-benzyl)-3-(3-methoxy-phenyl)-5-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C27H27F2N5O4
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1
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| 1 |
Ki = 4200 nM
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CP0397733
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1-(2,6-Difluoro-benzyl)-5-(3,4-dimethoxy-phenyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
Show/Hide
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C30H32F2N4O4
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1
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| 1 |
Ki = 4800 nM
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CP0501231
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8-Cyano-1-(2-cyano-benzyl)-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C35H32N6O4
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1
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| 1 |
Ki = 4900 nM
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CP0554891
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8-Cyano-1-(2,5-difluoro-benzyl)-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C34H31F2N5O4
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1
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| 1 |
Ki = 6000 nM
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CP0384181
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8-Cyano-1-(2-methoxy-benzyl)-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C35H35N5O5
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1
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| 1 |
Ki = 6600 nM
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CP0496142
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3-[(S)-2-(Cyclopropylmethyl-methyl-amino)-1-methyl-ethyl]-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
Show/Hide
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C27H31F2N3O3
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1
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| 1 |
Ki = 7000 nM
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CP0467128
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-[1-(2-pyridin-2-yl-ethyl)-pyrrolidin-3-yl]-1H-pyrimidine-2,4-dione
Show/Hide
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C30H30F2N4O3
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1
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| 1 |
Ki = 8300 nM
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CP0535295
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1-(2-Chloro-benzyl)-8-cyano-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
Show/Hide
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C34H32ClN5O4
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1
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| 1 |
Ki = 8500 nM
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CP0541672
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1-((R)-2-Amino-2-phenyl-ethyl)-3-cyclohexylmethyl-5-(2-fluoro-3-methoxy-phenyl)-[1,3,5]triazinane-2,4,6-trione
Show/Hide
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C25H29FN4O4
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1
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| 1 |
Ki > 10000 nM
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CP0861122
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3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)-6-methyl-1-(2-pyridin-2-yl-ethyl)-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C28H26F4N4O4
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1
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| 1 |
Ki > 10000 nM
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CP0885393
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3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)-1-(2-hydroxy-ethyl)-6-methyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C23H23F4N3O5
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1
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| 1 |
Ki > 10000 nM
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CP0892583
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3-((R)-2-Amino-2-phenyl-ethyl)-1-(2-dimethylamino-ethyl)-5-(2-fluoro-phenyl)-6-methyl-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C25H28F4N4O4
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1
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| 1 |
Ki > 10000 nM
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CP0920730
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3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)-6-methyl-1-(2-piperazin-1-yl-ethyl)-1H-pyrimidine-2,4-dione TFA
Show/Hide
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C27H31F4N5O4
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1
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| 1 |
Ki > 10000 nM
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CP0080595
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3-((S)-2-Amino-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
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C22H22F3N3O3
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1
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| 1 |
Ki > 10000 nM
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CP0504665
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1-(2,6-Difluoro-benzyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-5-(3,4,5-trimethoxy-phenyl)-1H-pyrimidine-2,4-dione
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C31H34F2N4O5
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1
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| 1 |
Ki = 10800 nM
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CP0372891
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1-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-pyrrolidin-3-yl-1H-pyrimidine-2,4-dione
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C23H23F2N3O3
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1
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| 1 |
Ki = 15000 nM
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CP0548632
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3-((S)-2-Amino-propyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione
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C22H23F2N3O3
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1
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| 1 |
Ki = 18000 nM
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CP0379238
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3-(2,6-Difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione
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C29H30F2N4O3
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1
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| 1 |
Ki > 20000 nM
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CP0392464
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8-Cyano-1-(2,4-difluoro-benzyl)-7-(4-isobutoxy-phenyl)-6-{[methyl-(2-pyridin-3-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
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C37H37F2N5O4
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1
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| 1 |
Ki = 28000 nM
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CP0487107
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1-Benzyl-6-[(benzyl-methyl-amino)-methyl]-8-cyano-7-(4-methoxy-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
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C34H32N4O4
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1
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| 1 |
Ki = 42000 nM
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CP0373162
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1-Benzyl-8-cyano-6-dimethylaminomethyl-7-(4-methoxy-phenyl)-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
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C28H28N4O4
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1
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| 1 |
Ki > 50000 nM
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CP0440478
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8-Cyano-1-cyclopropylmethyl-7-(4-methoxy-phenyl)-6-{[methyl-(2-pyridin-2-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
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C31H33N5O4
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1
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| 1 |
Ki > 50000 nM
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CP0507467
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8-Cyano-1-(2,4-difluoro-benzyl)-7-(4-isobutoxy-phenyl)-6-{[methyl-(2-pyridin-4-yl-ethyl)-amino]-methyl}-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
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C37H37F2N5O4
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1
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| 1 |
Ki > 50000 nM
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CP0526573
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8-Cyano-1-(2,4-difluoro-benzyl)-7-(4-isobutoxy-phenyl)-6-[(methyl-phenethyl-amino)-methyl]-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
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C38H38F2N4O4
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1
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| 1 |
Ki > 50000 nM
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